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UniProtKB - O43520 (AT8B1_HUMAN)

Entry version 199 (11 Dec 2019)
Sequence version 3 (05 May 2009)
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Protein

Phospholipid-transporting ATPase IC

Gene

ATP8B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both. In cooperation with ABCB4 may be involved in establishing integrity of the canalicular membrane thus protecting hepatocytes from bile salts. Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Required for the preservation of cochlear hair cells in the inner ear. May act as cardiolipin transporter during inflammatory injury.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). EC:7.6.2.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4544-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi893MagnesiumBy similarity1
Metal bindingi897MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processHearing, Lipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.6.3.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.3.8.11 the p-type atpase (p-atpase) superfamily

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000342

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid-transporting ATPase IC (EC:7.6.2.1)
Alternative name(s):
ATPase class I type 8B member 1
Familial intrahepatic cholestasis type 1
P4-ATPase flippase complex alpha subunit ATP8B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP8B1
Synonyms:ATPIC, FIC1, PFIC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000081923.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:3706 ATP8B1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602397 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43520

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 108CytoplasmicSequence analysisAdd BLAST108
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei109 – 130HelicalSequence analysisAdd BLAST22
Topological domaini131 – 136Exoplasmic loopSequence analysis6
Transmembranei137 – 156HelicalSequence analysisAdd BLAST20
Topological domaini157 – 340CytoplasmicSequence analysisAdd BLAST184
Transmembranei341 – 362HelicalSequence analysisAdd BLAST22
Topological domaini363 – 389Exoplasmic loopSequence analysisAdd BLAST27
Transmembranei390 – 411HelicalSequence analysisAdd BLAST22
Topological domaini412 – 949CytoplasmicSequence analysisAdd BLAST538
Transmembranei950 – 970HelicalSequence analysisAdd BLAST21
Topological domaini971 – 982Exoplasmic loopSequence analysisAdd BLAST12
Transmembranei983 – 1002HelicalSequence analysisAdd BLAST20
Topological domaini1003 – 1032CytoplasmicSequence analysisAdd BLAST30
Transmembranei1033 – 1054HelicalSequence analysisAdd BLAST22
Topological domaini1055 – 1068Exoplasmic loopSequence analysisAdd BLAST14
Transmembranei1069 – 1091HelicalSequence analysisAdd BLAST23
Topological domaini1092 – 1097CytoplasmicSequence analysis6
Transmembranei1098 – 1118HelicalSequence analysisAdd BLAST21
Topological domaini1119 – 1138Exoplasmic loopSequence analysisAdd BLAST20
Transmembranei1139 – 1163HelicalSequence analysisAdd BLAST25
Topological domaini1164 – 1251CytoplasmicSequence analysisAdd BLAST88

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cholestasis, progressive familial intrahepatic, 1 (PFIC1)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043046127L → P in PFIC1. 1 Publication1
Natural variantiVAR_071045209P → T in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs515726138EnsemblClinVar.1
Natural variantiVAR_008809288L → S in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs121909099EnsemblClinVar.1
Natural variantiVAR_008810308G → V in PFIC1; greatly reduced expression due to proteosomal degradation; abolishes interaction with TMEM30A. 2 PublicationsCorresponds to variant dbSNP:rs111033609EnsemblClinVar.1
Natural variantiVAR_043053403S → Y in PFIC1. 1 Publication1
Natural variantiVAR_043054412R → P in PFIC1. 1 Publication1
Natural variantiVAR_043058456T → M in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs121909104EnsemblClinVar.1
Natural variantiVAR_043059500Y → H in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs147642236EnsemblClinVar.1
Natural variantiVAR_043060529Missing in PFIC1. 1 Publication1
Natural variantiVAR_043061535H → L in PFIC1. 1 Publication1
Natural variantiVAR_015423554D → N in PFIC1; greatly reduced expression due to proteosomal degradation; abolishes interaction with TMEM30A. 3 PublicationsCorresponds to variant dbSNP:rs121909101EnsemblClinVar.1
Natural variantiVAR_008811645 – 699Missing in PFIC1. 1 PublicationAdd BLAST55
Natural variantiVAR_008812661I → T in BRIC1 and PFIC1; common mutation; reduces interaction with TMEM30A. 4 PublicationsCorresponds to variant dbSNP:rs121909100EnsemblClinVar.1
Natural variantiVAR_043067688D → G in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs1337978497Ensembl.1
Natural variantiVAR_043069733G → R in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs1350369369Ensembl.1
Natural variantiVAR_043071853F → S in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs773092889Ensembl.1
Natural variantiVAR_008813892G → R in PFIC1 and BRIC1. 2 PublicationsCorresponds to variant dbSNP:rs121909098EnsemblClinVar.1
Natural variantiVAR_0710461012S → I in PFIC1. 1 Publication1
Natural variantiVAR_0430731040G → R in PFIC1; greatly reduces interaction with TMEM30A. 2 PublicationsCorresponds to variant dbSNP:rs1438249656Ensembl.1
Cholestasis, benign recurrent intrahepatic, 1 (BRIC1)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration. Patients are asymptomatic between episodes, both clinically and biochemically.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04304570D → N in BRIC1; compound heterozygote with Q-600; uncertain pathological significance; may be associated with ICP; reduces interaction with TMEM30A. 3 PublicationsCorresponds to variant dbSNP:rs34719006EnsemblClinVar.1
Natural variantiVAR_043049308G → D in BRIC1. 1 PublicationCorresponds to variant dbSNP:rs111033609EnsemblClinVar.1
Natural variantiVAR_043050344I → F in BRIC1. 1 PublicationCorresponds to variant dbSNP:rs140665115Ensembl.1
Natural variantiVAR_043056453S → Y in BRIC1. 1 Publication1
Natural variantiVAR_043057454D → G in BRIC1. 1 Publication1
Natural variantiVAR_043063600R → Q in BRIC1; compound heterozygote with N-70. 1 PublicationCorresponds to variant dbSNP:rs1202682161EnsemblClinVar.1
Natural variantiVAR_043064600R → W in BRIC1. 1 PublicationCorresponds to variant dbSNP:rs780186596Ensembl.1
Natural variantiVAR_043065628R → W in BRIC1. 1 PublicationCorresponds to variant dbSNP:rs752045131Ensembl.1
Natural variantiVAR_008812661I → T in BRIC1 and PFIC1; common mutation; reduces interaction with TMEM30A. 4 PublicationsCorresponds to variant dbSNP:rs121909100EnsemblClinVar.1
Natural variantiVAR_043068694I → T in BRIC1. 1 PublicationCorresponds to variant dbSNP:rs541474497Ensembl.1
Natural variantiVAR_008814795 – 797Missing in BRIC1. 1 Publication3
Natural variantiVAR_008813892G → R in PFIC1 and BRIC1. 2 PublicationsCorresponds to variant dbSNP:rs121909098EnsemblClinVar.1
Cholestasis of pregnancy, intrahepatic 1 (ICP1)3 Publications
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA liver disorder of pregnancy. It presents during the second or, more commonly, the third trimester of pregnancy with intense pruritus which becomes more severe with advancing gestation and cholestasis. Cholestasis results from abnormal biliary transport from the liver into the small intestine. ICP1 causes fetal distress, spontaneous premature delivery and intrauterine death. ICP1 patients have spontaneous and progressive disappearance of cholestasis after delivery.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04304445N → T in ICP1. 1 PublicationCorresponds to variant dbSNP:rs146599962EnsemblClinVar.1
Natural variantiVAR_043047203K → E in ICP1. 1 PublicationCorresponds to variant dbSNP:rs56355310EnsemblClinVar.1
Natural variantiVAR_043072867R → C in ICP1; reduces interaction with TMEM30A. 2 PublicationsCorresponds to variant dbSNP:rs121909103EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi454D → A: Greatly reduced expression due to proteosomal degradation; abolishes interaction with TMEM30A. 1 Publication1

Keywords - Diseasei

Disease mutation, Intrahepatic cholestasis

Organism-specific databases

DisGeNET

More...DisGeNETi		5205

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		ATP8B1

MalaCards human disease database

More...MalaCardsi		ATP8B1
MIMi147480 phenotype
211600 phenotype
243300 phenotype

Open Targets

More...OpenTargetsi		ENSG00000081923

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		99960 Benign recurrent intrahepatic cholestasis type 1
69665 Intrahepatic cholestasis of pregnancy
79306 Progressive familial intrahepatic cholestasis type 1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA265

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43520 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATP8B1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000463641 – 1251Phospholipid-transporting ATPase ICAdd BLAST1251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1223PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43520

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43520

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43520

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43520

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43520

PeptideAtlas

More...PeptideAtlasi		O43520

PRoteomics IDEntifications database

More...PRIDEi		O43520

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49008

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43520

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43520

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in most tissues except brain and skeletal muscle. Most abundant in pancreas and small intestine.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000081923 Expressed in 239 organ(s), highest expression level in cerebellar vermis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43520 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43520 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA018673
HPA018674

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). The probable flippase ATP8B1:TMEM30A complex can form an intermediate phosphoenzyme in vitro.

Also interacts with beta subunit TMEM30B.

Curated4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9NV963EBI-9524729,EBI-2836942

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111227, 4 interactors

Protein interaction database and analysis system

More...IntActi		O43520, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000445359

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43520 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410ITKD Eukaryota
ENOG410XPYK LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158002

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000202528

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43520

KEGG Orthology (KO)

More...KOi		K01530

Identification of Orthologs from Complete Genome Data

More...OMAi		VECEEPN

Database of Orthologous Groups

More...OrthoDBi		587717at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43520

TreeFam database of animal gene trees

More...TreeFami		TF300654

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.1110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030346 ATP8B1
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c

The PANTHER Classification System

More...PANTHERi		PTHR24092 PTHR24092, 1 hit
PTHR24092:SF48 PTHR24092:SF48, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O43520-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTERDSETT FDEDSQPNDE VVPYSDDETE DELDDQGSAV EPEQNRVNRE 
        60         70         80         90        100
AEENREPFRK ECTWQVKAND RKYHEQPHFM NTKFLCIKES KYANNAIKTY 
       110        120        130        140        150
KYNAFTFIPM NLFEQFKRAA NLYFLALLIL QAVPQISTLA WYTTLVPLLV 
       160        170        180        190        200
VLGVTAIKDL VDDVARHKMD KEINNRTCEV IKDGRFKVAK WKEIQVGDVI 
       210        220        230        240        250
RLKKNDFVPA DILLLSSSEP NSLCYVETAE LDGETNLKFK MSLEITDQYL 
       260        270        280        290        300
QREDTLATFD GFIECEEPNN RLDKFTGTLF WRNTSFPLDA DKILLRGCVI 
       310        320        330        340        350
RNTDFCHGLV IFAGADTKIM KNSGKTRFKR TKIDYLMNYM VYTIFVVLIL 
       360        370        380        390        400
LSAGLAIGHA YWEAQVGNSS WYLYDGEDDT PSYRGFLIFW GYIIVLNTMV 
       410        420        430        440        450
PISLYVSVEV IRLGQSHFIN WDLQMYYAEK DTPAKARTTT LNEQLGQIHY 
       460        470        480        490        500
IFSDKTGTLT QNIMTFKKCC INGQIYGDHR DASQHNHNKI EQVDFSWNTY 
       510        520        530        540        550
ADGKLAFYDH YLIEQIQSGK EPEVRQFFFL LAVCHTVMVD RTDGQLNYQA 
       560        570        580        590        600
ASPDEGALVN AARNFGFAFL ARTQNTITIS ELGTERTYNV LAILDFNSDR 
       610        620        630        640        650
KRMSIIVRTP EGNIKLYCKG ADTVIYERLH RMNPTKQETQ DALDIFANET 
       660        670        680        690        700
LRTLCLCYKE IEEKEFTEWN KKFMAASVAS TNRDEALDKV YEEIEKDLIL 
       710        720        730        740        750
LGATAIEDKL QDGVPETISK LAKADIKIWV LTGDKKETAE NIGFACELLT 
       760        770        780        790        800
EDTTICYGED INSLLHARME NQRNRGGVYA KFAPPVQESF FPPGGNRALI 
       810        820        830        840        850
ITGSWLNEIL LEKKTKRNKI LKLKFPRTEE ERRMRTQSKR RLEAKKEQRQ 
       860        870        880        890        900
KNFVDLACEC SAVICCRVTP KQKAMVVDLV KRYKKAITLA IGDGANDVNM 
       910        920        930        940        950
IKTAHIGVGI SGQEGMQAVM SSDYSFAQFR YLQRLLLVHG RWSYIRMCKF 
       960        970        980        990       1000
LRYFFYKNFA FTLVHFWYSF FNGYSAQTAY EDWFITLYNV LYTSLPVLLM 
      1010       1020       1030       1040       1050
GLLDQDVSDK LSLRFPGLYI VGQRDLLFNY KRFFVSLLHG VLTSMILFFI 
      1060       1070       1080       1090       1100
PLGAYLQTVG QDGEAPSDYQ SFAVTIASAL VITVNFQIGL DTSYWTFVNA 
      1110       1120       1130       1140       1150
FSIFGSIALY FGIMFDFHSA GIHVLFPSAF QFTGTASNAL RQPYIWLTII 
      1160       1170       1180       1190       1200
LAVAVCLLPV VAIRFLSMTI WPSESDKIQK HRKRLKAEEQ WQRRQQVFRR 
      1210       1220       1230       1240       1250
GVSTRRSAYA FSHQRGYADL ISSGRSIRKK RSPLDAIVAD GTAEYRRTGD 

S
Length:1,251
Mass (Da):143,695
Last modified:May 5, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i770FEF3946CB579F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y5C5A0A2R8Y5C5_HUMAN
Phospholipid-transporting ATPase
ATP8B1
946Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRQ1A0A3B3IRQ1_HUMAN
Phospholipid-transporting ATPase
ATP8B1
498Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQC4K7EQC4_HUMAN
Phospholipid-transporting ATPase IC
ATP8B1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESK2K7ESK2_HUMAN
Phospholipid-transporting ATPase IC
ATP8B1
11Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1016P → L in AAH03534 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04304445N → T in ICP1. 1 PublicationCorresponds to variant dbSNP:rs146599962EnsemblClinVar.1
Natural variantiVAR_04304570D → N in BRIC1; compound heterozygote with Q-600; uncertain pathological significance; may be associated with ICP; reduces interaction with TMEM30A. 3 PublicationsCorresponds to variant dbSNP:rs34719006EnsemblClinVar.1
Natural variantiVAR_02927178H → Q. Corresponds to variant dbSNP:rs3745079EnsemblClinVar.1
Natural variantiVAR_043046127L → P in PFIC1. 1 Publication1
Natural variantiVAR_043047203K → E in ICP1. 1 PublicationCorresponds to variant dbSNP:rs56355310EnsemblClinVar.1
Natural variantiVAR_071045209P → T in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs515726138EnsemblClinVar.1
Natural variantiVAR_008809288L → S in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs121909099EnsemblClinVar.1
Natural variantiVAR_043048305F → I1 PublicationCorresponds to variant dbSNP:rs150860808EnsemblClinVar.1
Natural variantiVAR_043049308G → D in BRIC1. 1 PublicationCorresponds to variant dbSNP:rs111033609EnsemblClinVar.1
Natural variantiVAR_008810308G → V in PFIC1; greatly reduced expression due to proteosomal degradation; abolishes interaction with TMEM30A. 2 PublicationsCorresponds to variant dbSNP:rs111033609EnsemblClinVar.1
Natural variantiVAR_043050344I → F in BRIC1. 1 PublicationCorresponds to variant dbSNP:rs140665115Ensembl.1
Natural variantiVAR_043051384R → H. Corresponds to variant dbSNP:rs2271260Ensembl.1
Natural variantiVAR_043052393I → V. Corresponds to variant dbSNP:rs34315917EnsemblClinVar.1
Natural variantiVAR_043053403S → Y in PFIC1. 1 Publication1
Natural variantiVAR_043054412R → P in PFIC1. 1 Publication1
Natural variantiVAR_043055429E → A1 PublicationCorresponds to variant dbSNP:rs34018205EnsemblClinVar.1
Natural variantiVAR_043056453S → Y in BRIC1. 1 Publication1
Natural variantiVAR_043057454D → G in BRIC1. 1 Publication1
Natural variantiVAR_043058456T → M in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs121909104EnsemblClinVar.1
Natural variantiVAR_043059500Y → H in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs147642236EnsemblClinVar.1
Natural variantiVAR_043060529Missing in PFIC1. 1 Publication1
Natural variantiVAR_043061535H → L in PFIC1. 1 Publication1
Natural variantiVAR_015423554D → N in PFIC1; greatly reduced expression due to proteosomal degradation; abolishes interaction with TMEM30A. 3 PublicationsCorresponds to variant dbSNP:rs121909101EnsemblClinVar.1
Natural variantiVAR_029272577I → V. Corresponds to variant dbSNP:rs3745078EnsemblClinVar.1
Natural variantiVAR_043062580S → N. Corresponds to variant dbSNP:rs33963153EnsemblClinVar.1
Natural variantiVAR_043063600R → Q in BRIC1; compound heterozygote with N-70. 1 PublicationCorresponds to variant dbSNP:rs1202682161EnsemblClinVar.1
Natural variantiVAR_043064600R → W in BRIC1. 1 PublicationCorresponds to variant dbSNP:rs780186596Ensembl.1
Natural variantiVAR_043065628R → W in BRIC1. 1 PublicationCorresponds to variant dbSNP:rs752045131Ensembl.1
Natural variantiVAR_008811645 – 699Missing in PFIC1. 1 PublicationAdd BLAST55
Natural variantiVAR_008812661I → T in BRIC1 and PFIC1; common mutation; reduces interaction with TMEM30A. 4 PublicationsCorresponds to variant dbSNP:rs121909100EnsemblClinVar.1
Natural variantiVAR_043066674M → T. Corresponds to variant dbSNP:rs35470719EnsemblClinVar.1
Natural variantiVAR_043067688D → G in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs1337978497Ensembl.1
Natural variantiVAR_043068694I → T in BRIC1. 1 PublicationCorresponds to variant dbSNP:rs541474497Ensembl.1
Natural variantiVAR_043069733G → R in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs1350369369Ensembl.1
Natural variantiVAR_008814795 – 797Missing in BRIC1. 1 Publication3
Natural variantiVAR_043070814K → N. Corresponds to variant dbSNP:rs34018300EnsemblClinVar.1
Natural variantiVAR_043071853F → S in PFIC1. 1 PublicationCorresponds to variant dbSNP:rs773092889Ensembl.1
Natural variantiVAR_043072867R → C in ICP1; reduces interaction with TMEM30A. 2 PublicationsCorresponds to variant dbSNP:rs121909103EnsemblClinVar.1
Natural variantiVAR_036499886A → V in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs767398921Ensembl.1
Natural variantiVAR_008813892G → R in PFIC1 and BRIC1. 2 PublicationsCorresponds to variant dbSNP:rs121909098EnsemblClinVar.1
Natural variantiVAR_029273952R → Q2 PublicationsCorresponds to variant dbSNP:rs12968116EnsemblClinVar.1
Natural variantiVAR_0710461012S → I in PFIC1. 1 Publication1
Natural variantiVAR_0430731040G → R in PFIC1; greatly reduces interaction with TMEM30A. 2 PublicationsCorresponds to variant dbSNP:rs1438249656Ensembl.1
Natural variantiVAR_0550451152A → T2 PublicationsCorresponds to variant dbSNP:rs222581Ensembl.1
Natural variantiVAR_0365001178I → M in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF038007 mRNA Translation: AAC63461.1
AC027097 Genomic DNA No translation available.
AF032442 mRNA Translation: AAC04328.1
BC003534 mRNA Translation: AAH03534.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11965.1

NCBI Reference Sequences

More...RefSeqi		NP_005594.1, NM_005603.4
XP_006722544.1, XM_006722481.3
XP_011524324.1, XM_011526022.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000648908; ENSP00000497896; ENSG00000081923

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5205

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5205

UCSC genome browser

More...UCSCi		uc002lgw.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038007 mRNA Translation: AAC63461.1
AC027097 Genomic DNA No translation available.
AF032442 mRNA Translation: AAC04328.1
BC003534 mRNA Translation: AAH03534.1
CCDSiCCDS11965.1
RefSeqiNP_005594.1, NM_005603.4
XP_006722544.1, XM_006722481.3
XP_011524324.1, XM_011526022.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi111227, 4 interactors
IntActiO43520, 2 interactors
STRINGi9606.ENSP00000445359

Chemistry databases

SwissLipidsiSLP:000000342

Protein family/group databases

TCDBi3.A.3.8.11 the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetiO43520
PhosphoSitePlusiO43520

Polymorphism and mutation databases

BioMutaiATP8B1

Proteomic databases

EPDiO43520
jPOSTiO43520
MassIVEiO43520
MaxQBiO43520
PaxDbiO43520
PeptideAtlasiO43520
PRIDEiO43520
ProteomicsDBi49008

Genome annotation databases

EnsembliENST00000648908; ENSP00000497896; ENSG00000081923
GeneIDi5205
KEGGihsa:5205
UCSCiuc002lgw.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5205
DisGeNETi5205
EuPathDBiHostDB:ENSG00000081923.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATP8B1
GeneReviewsiATP8B1
HGNCiHGNC:3706 ATP8B1
HPAiHPA018673
HPA018674
MalaCardsiATP8B1
MIMi147480 phenotype
211600 phenotype
243300 phenotype
602397 gene
neXtProtiNX_O43520
OpenTargetsiENSG00000081923
Orphaneti99960 Benign recurrent intrahepatic cholestasis type 1
69665 Intrahepatic cholestasis of pregnancy
79306 Progressive familial intrahepatic cholestasis type 1
PharmGKBiPA265

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410ITKD Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00940000158002
HOGENOMiHOG000202528
InParanoidiO43520
KOiK01530
OMAiVECEEPN
OrthoDBi587717at2759
PhylomeDBiO43520
TreeFamiTF300654

Enzyme and pathway databases

BRENDAi3.6.3.1 2681
ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATP8B1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ATP8B1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5205
PharosiO43520 Tbio

Protein Ontology

More...PROi		PR:O43520
RNActiO43520 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000081923 Expressed in 239 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiO43520 baseline and differential
GenevisibleiO43520 HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR030346 ATP8B1
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF48 PTHR24092:SF48, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT8B1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43520
Secondary accession number(s): Q9BTP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 5, 2009
Last modified: December 11, 2019
This is version 199 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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