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Protein

Mediator of RNA polymerase II transcription subunit 7

Gene

MED7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functioni

  • transcription coactivator activity Source: ProtInc
  • ubiquitin protein ligase activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 7
Short name:
hMED7
Alternative name(s):
Activator-recruited cofactor 34 kDa component
Short name:
ARC34
Cofactor required for Sp1 transcriptional activation subunit 9
Short name:
CRSP complex subunit 9
Mediator complex subunit 7
RNA polymerase transcriptional regulation mediator subunit 7 homolog
Transcriptional coactivator CRSP33
Gene namesi
Name:MED7
Synonyms:ARC34, CRSP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000155868.7
HGNCiHGNC:2378 MED7
MIMi605045 gene
neXtProtiNX_O43513

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9443
OpenTargetsiENSG00000155868
PharmGKBiPA162395669

Polymorphism and mutation databases

BioMutaiMED7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794081 – 233Mediator of RNA polymerase II transcription subunit 7Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei194PhosphoserineCombined sources1

Post-translational modificationi

Constitutively sumoylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43513
PaxDbiO43513
PeptideAtlasiO43513
PRIDEiO43513
ProteomicsDBi49002

PTM databases

iPTMnetiO43513
PhosphoSitePlusiO43513

Expressioni

Gene expression databases

BgeeiENSG00000155868 Expressed in 226 organ(s), highest expression level in oviduct epithelium
CleanExiHS_MED7
ExpressionAtlasiO43513 baseline and differential
GenevisibleiO43513 HS

Organism-specific databases

HPAiHPA067181

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi114833, 62 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiO43513
IntActiO43513, 19 interactors
MINTiO43513
STRINGi9606.ENSP00000286317

Structurei

3D structure databases

ProteinModelPortaliO43513
SMRiO43513
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 7 family.Curated

Phylogenomic databases

eggNOGiKOG0570 Eukaryota
ENOG410ZFRU LUCA
GeneTreeiENSGT00530000064187
HOGENOMiHOG000241102
HOVERGENiHBG002997
InParanoidiO43513
KOiK15148
OMAiKRLYPQH
OrthoDBiEOG091G0N9D
PhylomeDBiO43513
TreeFamiTF314411

Family and domain databases

InterProiView protein in InterPro
IPR037212 Med7/Med21-like
IPR009244 Mediatior_Med7
PANTHERiPTHR21428 PTHR21428, 1 hit
PfamiView protein in Pfam
PF05983 Med7, 1 hit
SUPFAMiSSF140718 SSF140718, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O43513-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEPQQVSAL PPPPMQYIKE YTDENIQEGL APKPPPPIKD SYMMFGNQFQ
60 70 80 90 100
CDDLIIRPLE SQGIERLHPM QFDHKKELRK LNMSILINFL DLLDILIRSP
110 120 130 140 150
GSIKREEKLE DLKLLFVHVH HLINEYRPHQ ARETLRVMME VQKRQRLETA
160 170 180 190 200
ERFQKHLERV IEMIQNCLAS LPDDLPHSEA GMRVKTEPMD ADDSNNCTGQ
210 220 230
NEHQRENSGH RRDQIIEKDA ALCVLIDEMN ERP
Length:233
Mass (Da):27,245
Last modified:June 1, 1998 - v1
Checksum:i9D95A2A8360B9C62
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIE8E5RIE8_HUMAN
Mediator of RNA polymerase II trans...
MED7
195Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031383 mRNA Translation: AAC52115.1
AF104251 mRNA Translation: AAD12720.1
BC005250 mRNA No translation available.
CCDSiCCDS4334.1
RefSeqiNP_001094286.1, NM_001100816.1
NP_004261.1, NM_004270.4
UniGeneiHs.279902
Hs.744244

Genome annotation databases

EnsembliENST00000286317; ENSP00000286317; ENSG00000155868
ENST00000420343; ENSP00000401046; ENSG00000155868
GeneIDi9443
KEGGihsa:9443

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031383 mRNA Translation: AAC52115.1
AF104251 mRNA Translation: AAD12720.1
BC005250 mRNA No translation available.
CCDSiCCDS4334.1
RefSeqiNP_001094286.1, NM_001100816.1
NP_004261.1, NM_004270.4
UniGeneiHs.279902
Hs.744244

3D structure databases

ProteinModelPortaliO43513
SMRiO43513
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114833, 62 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiO43513
IntActiO43513, 19 interactors
MINTiO43513
STRINGi9606.ENSP00000286317

PTM databases

iPTMnetiO43513
PhosphoSitePlusiO43513

Polymorphism and mutation databases

BioMutaiMED7

Proteomic databases

EPDiO43513
PaxDbiO43513
PeptideAtlasiO43513
PRIDEiO43513
ProteomicsDBi49002

Protocols and materials databases

DNASUi9443
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286317; ENSP00000286317; ENSG00000155868
ENST00000420343; ENSP00000401046; ENSG00000155868
GeneIDi9443
KEGGihsa:9443

Organism-specific databases

CTDi9443
DisGeNETi9443
EuPathDBiHostDB:ENSG00000155868.7
GeneCardsiMED7
HGNCiHGNC:2378 MED7
HPAiHPA067181
MIMi605045 gene
neXtProtiNX_O43513
OpenTargetsiENSG00000155868
PharmGKBiPA162395669
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0570 Eukaryota
ENOG410ZFRU LUCA
GeneTreeiENSGT00530000064187
HOGENOMiHOG000241102
HOVERGENiHBG002997
InParanoidiO43513
KOiK15148
OMAiKRLYPQH
OrthoDBiEOG091G0N9D
PhylomeDBiO43513
TreeFamiTF314411

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

GeneWikiiMED7
GenomeRNAii9443
PROiPR:O43513
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155868 Expressed in 226 organ(s), highest expression level in oviduct epithelium
CleanExiHS_MED7
ExpressionAtlasiO43513 baseline and differential
GenevisibleiO43513 HS

Family and domain databases

InterProiView protein in InterPro
IPR037212 Med7/Med21-like
IPR009244 Mediatior_Med7
PANTHERiPTHR21428 PTHR21428, 1 hit
PfamiView protein in Pfam
PF05983 Med7, 1 hit
SUPFAMiSSF140718 SSF140718, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMED7_HUMAN
AccessioniPrimary (citable) accession number: O43513
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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