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Protein

Ragulator complex protein LAMTOR5

Gene

LAMTOR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.2 Publications

Miscellaneous

Suppression of caspase activation by the BIRC5/HBXIP complex is increased in the presence of HBX.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
R-HSA-165159 mTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORiO43504

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR5
Alternative name(s):
Hepatitis B virus X-interacting protein
Short name:
HBV X-interacting protein
Short name:
HBX-interacting protein
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
Gene namesi
Name:LAMTOR5
Synonyms:HBXIP, XIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134248.13
HGNCiHGNC:17955 LAMTOR5
MIMi608521 gene
neXtProtiNX_O43504

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lysosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi12T → A: No change. 1 Publication1
Mutagenesisi36T → A: No interaction with XABX14-154 (truncated form of HBX). 1 Publication1

Organism-specific databases

DisGeNETi10542
OpenTargetsiENSG00000134248
PharmGKBiPA29211

Polymorphism and mutation databases

BioMutaiLAMTOR5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000660071 – 91Ragulator complex protein LAMTOR5Add BLAST91

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43504
MaxQBiO43504
PaxDbiO43504
PeptideAtlasiO43504
PRIDEiO43504
ProteomicsDBi48997
TopDownProteomicsiO43504

PTM databases

iPTMnetiO43504
PhosphoSitePlusiO43504

Expressioni

Tissue specificityi

Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.

Gene expression databases

BgeeiENSG00000134248 Expressed in 224 organ(s), highest expression level in nephron tubule
CleanExiHS_HBXIP
ExpressionAtlasiO43504 baseline and differential
GenevisibleiO43504 HS

Interactioni

Subunit structurei

Homodimer (Probable). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus.Curated6 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115796, 84 interactors
DIPiDIP-61482N
IntActiO43504, 62 interactors
MINTiO43504
STRINGi9606.ENSP00000256644

Structurei

Secondary structure

191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43504
SMRiO43504
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43504

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMTOR5 family.Curated

Phylogenomic databases

eggNOGiENOG410IZVH Eukaryota
ENOG4111WFD LUCA
GeneTreeiENSGT00390000006247
HOGENOMiHOG000045746
HOVERGENiHBG010343
InParanoidiO43504
KOiK16344
PhylomeDBiO43504
TreeFamiTF324433

Family and domain databases

InterProiView protein in InterPro
IPR024135 LAMTOR5
PANTHERiPTHR13342 PTHR13342, 1 hit
PfamiView protein in Pfam
PF16672 LAMTOR5, 1 hit
PRINTSiPR02092 HEPBVIRUSXIP

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O43504-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEATLEQHLE DTMKNPSIVG VLCTDSQGLN LGCRGTLSDE HAGVISVLAQ
60 70 80 90
QAAKLTSDPT DIPVVCLESD NGNIMIQKHD GITVAVHKMA S
Length:91
Mass (Da):9,614
Last modified:June 1, 1998 - v1
Checksum:i01D9E762ABC63980
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGV4A0A0C4DGV4_HUMAN
Hepatitis B virus x interacting pro...
LAMTOR5 HBXIP, hCG_40252
173Annotation score:
R4GMU8R4GMU8_HUMAN
Ragulator complex protein LAMTOR5
LAMTOR5
79Annotation score:
E9PLX3E9PLX3_HUMAN
Ragulator complex protein LAMTOR5
LAMTOR5
90Annotation score:

Sequence cautioni

The sequence AAH62619 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029890 mRNA Translation: AAC52032.1
AY623819 mRNA Translation: AAV30683.1
CR456866 mRNA Translation: CAG33147.1
CR542130 mRNA Translation: CAG46927.1
AL390797 Genomic DNA No translation available.
BC062619 mRNA Translation: AAH62619.2 Different initiation.
RefSeqiNP_006393.2, NM_006402.2
UniGeneiHs.439815

Genome annotation databases

EnsembliENST00000602318; ENSP00000473439; ENSG00000134248
GeneIDi10542
KEGGihsa:10542
UCSCiuc001dzr.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029890 mRNA Translation: AAC52032.1
AY623819 mRNA Translation: AAV30683.1
CR456866 mRNA Translation: CAG33147.1
CR542130 mRNA Translation: CAG46927.1
AL390797 Genomic DNA No translation available.
BC062619 mRNA Translation: AAH62619.2 Different initiation.
RefSeqiNP_006393.2, NM_006402.2
UniGeneiHs.439815

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MS6X-ray2.08A1-91[»]
3MSHX-ray1.51A1-91[»]
5VOKX-ray2.89A/C/E/G1-91[»]
5X6UX-ray2.40C1-91[»]
5X6VX-ray2.02C1-91[»]
5Y38X-ray2.80A1-91[»]
5Y39X-ray2.65E/J1-90[»]
5Y3AX-ray2.90E/J1-91[»]
6EHPX-ray2.30C1-91[»]
6EHRX-ray2.90C1-91[»]
ProteinModelPortaliO43504
SMRiO43504
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115796, 84 interactors
DIPiDIP-61482N
IntActiO43504, 62 interactors
MINTiO43504
STRINGi9606.ENSP00000256644

PTM databases

iPTMnetiO43504
PhosphoSitePlusiO43504

Polymorphism and mutation databases

BioMutaiLAMTOR5

Proteomic databases

EPDiO43504
MaxQBiO43504
PaxDbiO43504
PeptideAtlasiO43504
PRIDEiO43504
ProteomicsDBi48997
TopDownProteomicsiO43504

Protocols and materials databases

DNASUi10542
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000602318; ENSP00000473439; ENSG00000134248
GeneIDi10542
KEGGihsa:10542
UCSCiuc001dzr.4 human

Organism-specific databases

CTDi10542
DisGeNETi10542
EuPathDBiHostDB:ENSG00000134248.13
GeneCardsiLAMTOR5
H-InvDBiHIX0029151
HGNCiHGNC:17955 LAMTOR5
MIMi608521 gene
neXtProtiNX_O43504
OpenTargetsiENSG00000134248
PharmGKBiPA29211
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZVH Eukaryota
ENOG4111WFD LUCA
GeneTreeiENSGT00390000006247
HOGENOMiHOG000045746
HOVERGENiHBG010343
InParanoidiO43504
KOiK16344
PhylomeDBiO43504
TreeFamiTF324433

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
R-HSA-165159 mTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORiO43504

Miscellaneous databases

ChiTaRSiLAMTOR5 human
EvolutionaryTraceiO43504
GeneWikiiHBXIP
GenomeRNAii10542
PROiPR:O43504
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134248 Expressed in 224 organ(s), highest expression level in nephron tubule
CleanExiHS_HBXIP
ExpressionAtlasiO43504 baseline and differential
GenevisibleiO43504 HS

Family and domain databases

InterProiView protein in InterPro
IPR024135 LAMTOR5
PANTHERiPTHR13342 PTHR13342, 1 hit
PfamiView protein in Pfam
PF16672 LAMTOR5, 1 hit
PRINTSiPR02092 HEPBVIRUSXIP
ProtoNetiSearch...

Entry informationi

Entry nameiLTOR5_HUMAN
AccessioniPrimary (citable) accession number: O43504
Secondary accession number(s): Q6IBD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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