RAD51C

Functionⁱ

Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.8 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	125 – 132	ATPSequence analysis		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
crossover junction endodeoxyribonuclease activity Source: Ensembl
DNA binding
Source: ProtInc
Traceable author statementⁱ
- 9469824
DNA-dependent ATPase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation Source: Reactome
DNA recombination
Source: UniProtKB
Inferred from direct assayⁱ
- 19451272
DNA repair
Source: UniProtKB
Inferred from direct assayⁱ
- 19451272
double-strand break repair via homologous recombination
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23149936
female meiosis sister chromatid cohesion Source: Ensembl
male meiosis I Source: Ensembl
positive regulation of G2/M transition of mitotic cell cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23108668
reciprocal meiotic recombination
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sister chromatid cohesion Source: UniProtKB
spermatogenesis Source: Ensembl
telomere maintenance via recombination Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	DNA damage, DNA recombination, DNA repair
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5685942 HDR through Homologous Recombination (HRR) R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693579 Homologous DNA Pairing and Strand Exchange R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-912446 Meiotic recombination R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORⁱ	O43502

Reactomeⁱ

R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-912446 Meiotic recombination
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

SIGNORⁱ

O43502

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA repair protein RAD51 homolog 3 Short name: R51H3 Alternative name(s): RAD51 homolog C RAD51-like protein 2
Gene namesⁱ	Name:RAD51C Synonyms:RAD51L2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108384.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9820 RAD51C
MIMⁱ	602774 gene
neXtProtⁱ	NX_O43502

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Fanconi anemia complementation group O (FANCO)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_064032	258	R → H in FANCO; possibly hypomorphic allele; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 PublicationsCorresponds to variant dbSNP:rs267606997EnsemblClinVar.		1

Breast-ovarian cancer, familial, 3 (BROVCA3)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_063838	125	G → V in BROVCA3. 1 PublicationCorresponds to variant dbSNP:rs267606998EnsemblClinVar.	1
Natural variantⁱVAR_063840	138	L → F in BROVCA3; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 PublicationsCorresponds to variant dbSNP:rs267606999EnsemblClinVar.	1
Natural variantⁱVAR_068017	162	G → E in BROVCA3. 1 PublicationCorresponds to variant dbSNP:rs35151472EnsemblClinVar.	1
Natural variantⁱVAR_068019	178	Q → P in BROVCA3. 1 Publication	1
Natural variantⁱVAR_020520	287	T → A in BROVCA3. 3 PublicationsCorresponds to variant dbSNP:rs28363317EnsemblClinVar.	1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	131	K → A: Significant loss of function; abolishes Holliday junction resolution activity. 2 Publications		1
Mutagenesisⁱ	131	K → R: Partial loss of function. 2 Publications		1

Keywords - Diseaseⁱ

Disease mutation, Fanconi anemia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5889
GeneReviewsⁱ	RAD51C
MalaCards human disease database More...MalaCardsⁱ	RAD51C
MIMⁱ	613390 phenotype 613399 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000108384
Orphanetⁱ	84 Fanconi anemia 145 Hereditary breast and ovarian cancer syndrome
PharmGKBⁱ	PA34177

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000122941	1 – 376	DNA repair protein RAD51 homolog 3Add BLAST		376

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	20	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O43502
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43502
PaxDbⁱ	O43502
PeptideAtlas More...PeptideAtlasⁱ	O43502
PRIDEⁱ	O43502
ProteomicsDBⁱ	48995 48996 [O43502-2]

PTM databases

iPTMnetⁱ	O43502
PhosphoSitePlusⁱ	O43502

Expressionⁱ

Tissue specificityⁱ

Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.

Inductionⁱ

Stress-induced increase in the mitochondrial levels is seen.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000108384 Expressed in 216 organ(s), highest expression level in female gonad
CleanExⁱ	HS_RAD51C
ExpressionAtlasⁱ	O43502 baseline and differential
Genevisibleⁱ	O43502 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045198

HPAⁱ

HPA045198

Interactionⁱ

Subunit structureⁱ

Part of the Rad21 paralog protein complexes BCDX2 and CX3; the complexes have a ring-like structure arranged into a flat disc around a central channel. The BCDX2 complex consits of RAD51B, RAD51C, RAD51D and XRCC2; the CX3 complex consists of RAD51C and XRCC3. The BCDX2 subcomplex RAD51B:RAD51C interacts with RAD51. Interacts with SWSAP1; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.10 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
HELQ	Q8TDG4	6	EBI-2267048,EBI-2802156
PALB2	Q86YC2	10	EBI-2267048,EBI-1222653
RAD51	Q06609	6	EBI-2267048,EBI-297202
RAD51B	O15315	10	EBI-2267048,EBI-2824089
RAD51D	O75771	6	EBI-2267048,EBI-1055693
SWSAP1	Q6NVH7	2	EBI-2267048,EBI-5281637
XRCC2	O43543	2	EBI-2267048,EBI-3918457
XRCC3	O43542	9	EBI-2267048,EBI-2849976

Protein-protein interaction databases

BioGridⁱ	111826, 29 interactors
CORUMⁱ	O43502
Database of interacting proteins More...DIPⁱ	DIP-41247N
IntActⁱ	O43502, 10 interactors
Molecular INTeraction database More...MINTⁱ	O43502
STRINGⁱ	9606.ENSP00000336701

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43502
SMRⁱ	O43502
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 126	Required for Holliday junction resolution activityAdd BLAST		126
Regionⁱ	79 – 136	Interaction with RAD51B, RAD51D and XRCC31 PublicationAdd BLAST		58

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	366 – 370	Nuclear localization signalSequence analysis		5

Sequence similaritiesⁱ

Belongs to the RecA family. RAD51 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1434 Eukaryota COG0468 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133731
HOGENOMⁱ	HOG000227426
HOVERGENⁱ	HBG055764
InParanoidⁱ	O43502
KEGG Orthology (KO) More...KOⁱ	K10870
OMAⁱ	HWDQKQR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q7R
PhylomeDBⁱ	O43502
TreeFamⁱ	TF101220

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01123 Rad51_DMC1_radA, 1 hit
InterProⁱ	View protein in InterPro IPR013632 DNA_recomb/repair_Rad51_C IPR016467 DNA_recomb/repair_RecA-like IPR027417 P-loop_NTPase IPR033925 Rad51_DMC1_RadA IPR020588 RecA_ATP-bd
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08423 Rad51, 1 hit
PIRSFⁱ	PIRSF005856 Rad51, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50162 RECA_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O43502-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV 
        60         70         80         90        100
GISKAEALET LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI 
       110        120        130        140        150
ITFCSALDDI LGGGVPLMKT TEICGAPGVG KTQLCMQLAV DVQIPECFGG 
       160        170        180        190        200
VAGEAVFIDT EGSFMVDRVV DLATACIQHL QLIAEKHKGE EHRKALEDFT 
       210        220        230        240        250
LDNILSHIYY FRCRDYTELL AQVYLLPDFL SEHSKVRLVI VDGIAFPFRH 
       260        270        280        290        300
DLDDLSLRTR LLNGLAQQMI SLANNHRLAV ILTNQMTTKI DRNQALLVPA 
       310        320        330        340        350
LGESWGHAAT IRLIFHWDRK QRLATLYKSP SQKECTVLFQ IKPQGFRDTV 
       360        370 
VTSACSLQTE GSLSTRKRSR DPEEEL

Length:376

Mass (Da):42,190

Last modified:June 1, 1998 - v1

Checksum:ⁱ3AAADD3C1C0851E0

GO

Isoform 2 (identifier: O43502-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
135-135: C → W
136-376: Missing.

« Hide

        10         20         30         40         50
MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV 
        60         70         80         90        100
GISKAEALET LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI 
       110        120        130 
ITFCSALDDI LGGGVPLMKT TEICGAPGVG KTQLW

Show »

Length:135

Mass (Da):14,883

Checksum:ⁱ56657E563509D90F

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3QKK3	J3QKK3_HUMAN	DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 3	RAD51C	346	Annotation score:
H7C1R0	H7C1R0_HUMAN	DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 3	RAD51C	257	Annotation score:
H7C2Q5	H7C2Q5_HUMAN	DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 3	RAD51C	213	Annotation score:
J3QR58	J3QR58_HUMAN	DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 3	RAD51C	135	Annotation score:
A0A087WZ35	A0A087WZ35_HUMAN	DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 3	RAD51C	131	Annotation score:
Q7KZJ0	Q7KZJ0_HUMAN	DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 3 (RAD51 homolog C (S. cerevisiae)) (RAD51 homolog C (S. cerevisiae), isoform CRA_a) (RAD51C protein) (cDNA FLJ76539, highly similar to Homo sapiens RAD51 homolog C (S. cerevisiae) (RAD51C), transcript variant 3, mRNA)	RAD51C hCG_2000975	134	Annotation score:
J3QLQ2	J3QLQ2_HUMAN	DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 3	RAD51C	107	Annotation score:
J3QLB5	J3QLB5_HUMAN	DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 3	RAD51C	47	Annotation score:
E9PI66	E9PI66_HUMAN	DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 3	RAD51C	52	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_063837	3	G → R1 PublicationCorresponds to variant dbSNP:rs376403182EnsemblClinVar.	1
Natural variantⁱVAR_068014	52	I → L1 PublicationCorresponds to variant dbSNP:rs730881927EnsemblClinVar.	1
Natural variantⁱVAR_068015	103	Missing 1 Publication	1
Natural variantⁱVAR_068016	114	G → V1 Publication	1
Natural variantⁱVAR_063838	125	G → V in BROVCA3. 1 PublicationCorresponds to variant dbSNP:rs267606998EnsemblClinVar.	1
Natural variantⁱVAR_063839	126	A → T2 PublicationsCorresponds to variant dbSNP:rs61758784EnsemblClinVar.	1
Natural variantⁱVAR_063840	138	L → F in BROVCA3; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 PublicationsCorresponds to variant dbSNP:rs267606999EnsemblClinVar.	1
Natural variantⁱVAR_020518	144	I → T1 PublicationCorresponds to variant dbSNP:rs28363307EnsemblClinVar.	1
Natural variantⁱVAR_063841	159	D → N Reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 Publications	1
Natural variantⁱVAR_068017	162	G → E in BROVCA3. 1 PublicationCorresponds to variant dbSNP:rs35151472EnsemblClinVar.	1
Natural variantⁱVAR_063842	169	V → A2 PublicationsCorresponds to variant dbSNP:rs587780256EnsemblClinVar.	1
Natural variantⁱVAR_068018	175	A → T1 PublicationCorresponds to variant dbSNP:rs587780838EnsemblClinVar.	1
Natural variantⁱVAR_068019	178	Q → P in BROVCA3. 1 Publication	1
Natural variantⁱVAR_020519	249	R → C2 PublicationsCorresponds to variant dbSNP:rs28363311EnsemblClinVar.	1
Natural variantⁱVAR_064032	258	R → H in FANCO; possibly hypomorphic allele; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 PublicationsCorresponds to variant dbSNP:rs267606997EnsemblClinVar.	1
Natural variantⁱVAR_068020	262	L → V1 PublicationCorresponds to variant dbSNP:rs149331537EnsemblClinVar.	1
Natural variantⁱVAR_063843	264	G → S2 PublicationsCorresponds to variant dbSNP:rs147241704EnsemblClinVar.	1
Natural variantⁱVAR_063844	264	G → V1 Publication	1
Natural variantⁱVAR_020520	287	T → A in BROVCA3. 3 PublicationsCorresponds to variant dbSNP:rs28363317EnsemblClinVar.	1
Natural variantⁱVAR_063845	366	R → Q1 PublicationCorresponds to variant dbSNP:rs577852020EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043656	135	C → W in isoform 2. 1 Publication		1
Alternative sequenceⁱVSP_043657	136 – 376	Missing in isoform 2. 1 PublicationAdd BLAST		241

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF029669 mRNA Translation: AAC39604.1 AF029670 mRNA Translation: AAC39605.1 AY623112 Genomic DNA Translation: AAT38108.1 AC011195 Genomic DNA No translation available. AC025521 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94432.1 BC107753 mRNA Translation: AAI07754.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11611.1 [O43502-1] CCDS45745.1 [O43502-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_002867.1, NM_002876.3 [O43502-2] NP_478123.1, NM_058216.2 [O43502-1]
UniGeneⁱ	Hs.412587

Genome annotation databases

Ensemblⁱ	ENST00000337432; ENSP00000336701; ENSG00000108384 [O43502-1] ENST00000421782; ENSP00000391450; ENSG00000108384 [O43502-2]
GeneIDⁱ	5889
KEGGⁱ	hsa:5889
UCSC genome browser More...UCSCⁱ	uc002iwt.3 human [O43502-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43502	RAD51 paralog C		SAIBB		386	UniRef90_O43502
Uncharacterized protein		PAPAN		379
Uncharacterized protein		MACNE		377
Uncharacterized protein (Fragment)		MACFA		374
Uncharacterized protein		MANLE		377
+35
O43502-2	RAD51C isoform 16 (Fragment)		PONAB		135	UniRef90_O43502-2
RAD51C isoform 16 (Fragment)		PANTR		135
Uncharacterized protein		CALJA		126
Uncharacterized protein		RABIT		126
UPI0005335974		RHIRO		86
+4

Protein	Similar proteins		Species	Score	Length	Source
O43502	DNA repair protein RAD51 homolog 3		CRIGR		366	UniRef50_O43502
DNA repair protein RAD51 homolog 3		MOUSE		366
RAD51 paralog C		SAIBB		386
Uncharacterized protein		PAPAN		379
Uncharacterized protein		MANLE		377
+303
O43502-2	RAD51C isoform 16 (Fragment)		PONAB		135	UniRef50_O43502-2
RAD51C isoform 16 (Fragment)		PANTR		135
Uncharacterized protein		RABIT		126
Uncharacterized protein		CALJA		126
UPI0005335974		RHIRO		86
+5

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

RAD51 homolog C (S.cerevisiae) (RAD51C)

Leiden Open Variation Database (LOVD)

RAD51 homolog C (S.cerevisiae) (RAD51C)

ZJU-CGGM and BGI-Shenzhen

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF029669 mRNA Translation: AAC39604.1 AF029670 mRNA Translation: AAC39605.1 AY623112 Genomic DNA Translation: AAT38108.1 AC011195 Genomic DNA No translation available. AC025521 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94432.1 BC107753 mRNA Translation: AAI07754.1
CCDSⁱ	CCDS11611.1 [O43502-1] CCDS45745.1 [O43502-2]
RefSeqⁱ	NP_002867.1, NM_002876.3 [O43502-2] NP_478123.1, NM_058216.2 [O43502-1]
UniGeneⁱ	Hs.412587

3D structure databases

ProteinModelPortalⁱ	O43502
SMRⁱ	O43502
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111826, 29 interactors
CORUMⁱ	O43502
DIPⁱ	DIP-41247N
IntActⁱ	O43502, 10 interactors
MINTⁱ	O43502
STRINGⁱ	9606.ENSP00000336701

PTM databases

iPTMnetⁱ	O43502
PhosphoSitePlusⁱ	O43502

Proteomic databases

EPDⁱ	O43502
MaxQBⁱ	O43502
PaxDbⁱ	O43502
PeptideAtlasⁱ	O43502
PRIDEⁱ	O43502
ProteomicsDBⁱ	48995 48996 [O43502-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5889
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000337432; ENSP00000336701; ENSG00000108384 [O43502-1] ENST00000421782; ENSP00000391450; ENSG00000108384 [O43502-2]
GeneIDⁱ	5889
KEGGⁱ	hsa:5889
UCSCⁱ	uc002iwt.3 human [O43502-1]

Organism-specific databases

CTDⁱ	5889
DisGeNETⁱ	5889
EuPathDBⁱ	HostDB:ENSG00000108384.14
GeneCardsⁱ	RAD51C
GeneReviewsⁱ	RAD51C
HGNCⁱ	HGNC:9820 RAD51C
HPAⁱ	HPA045198
MalaCardsⁱ	RAD51C
MIMⁱ	602774 gene 613390 phenotype 613399 phenotype
neXtProtⁱ	NX_O43502
OpenTargetsⁱ	ENSG00000108384
Orphanetⁱ	84 Fanconi anemia 145 Hereditary breast and ovarian cancer syndrome
PharmGKBⁱ	PA34177
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1434 Eukaryota COG0468 LUCA
GeneTreeⁱ	ENSGT00860000133731
HOGENOMⁱ	HOG000227426
HOVERGENⁱ	HBG055764
InParanoidⁱ	O43502
KOⁱ	K10870
OMAⁱ	HWDQKQR
OrthoDBⁱ	EOG091G0Q7R
PhylomeDBⁱ	O43502
TreeFamⁱ	TF101220

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5685942 HDR through Homologous Recombination (HRR) R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693579 Homologous DNA Pairing and Strand Exchange R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-912446 Meiotic recombination R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORⁱ	O43502

Reactomeⁱ

R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-912446 Meiotic recombination
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

SIGNORⁱ

O43502

Miscellaneous databases

ChiTaRSⁱ	RAD51C human
GeneWikiⁱ	RAD51C
GenomeRNAiⁱ	5889
Protein Ontology More...PROⁱ	PR:O43502
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108384 Expressed in 216 organ(s), highest expression level in female gonad
CleanExⁱ	HS_RAD51C
ExpressionAtlasⁱ	O43502 baseline and differential
Genevisibleⁱ	O43502 HS

Family and domain databases

CDDⁱ	cd01123 Rad51_DMC1_radA, 1 hit
InterProⁱ	View protein in InterPro IPR013632 DNA_recomb/repair_Rad51_C IPR016467 DNA_recomb/repair_RecA-like IPR027417 P-loop_NTPase IPR033925 Rad51_DMC1_RadA IPR020588 RecA_ATP-bd
Pfamⁱ	View protein in Pfam PF08423 Rad51, 1 hit
PIRSFⁱ	PIRSF005856 Rad51, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50162 RECA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RA51C_HUMAN
Accessionⁱ	O43502Primary (citable) accession number: O43502 Secondary accession number(s): O43503, Q3B783
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	June 1, 1998
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Keywords - Technical termⁱ

Complete proteome, Reference proteome

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SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - O43502 (RA51C_HUMAN)

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DNA repair protein RAD51 homolog 3

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Functionⁱ

GO - Molecular functionⁱ

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