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Protein

DNA repair protein RAD51 homolog 3

Gene

RAD51C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.8 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi125 – 132ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • crossover junction endodeoxyribonuclease activity Source: Ensembl
  • DNA binding Source: ProtInc
  • DNA-dependent ATPase activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-912446 Meiotic recombination
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

SIGNOR Signaling Network Open Resource

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SIGNORi
O43502

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein RAD51 homolog 3
Short name:
R51H3
Alternative name(s):
RAD51 homolog C
RAD51-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAD51C
Synonyms:RAD51L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000108384.14

Human Gene Nomenclature Database

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HGNCi
HGNC:9820 RAD51C

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602774 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O43502

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Fanconi anemia complementation group O (FANCO)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
See also OMIM:613390
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064032258R → H in FANCO; possibly hypomorphic allele; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 PublicationsCorresponds to variant dbSNP:rs267606997EnsemblClinVar.1
Breast-ovarian cancer, familial, 3 (BROVCA3)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate.
See also OMIM:613399
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063838125G → V in BROVCA3. 1 PublicationCorresponds to variant dbSNP:rs267606998EnsemblClinVar.1
Natural variantiVAR_063840138L → F in BROVCA3; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 PublicationsCorresponds to variant dbSNP:rs267606999EnsemblClinVar.1
Natural variantiVAR_068017162G → E in BROVCA3. 1 PublicationCorresponds to variant dbSNP:rs35151472EnsemblClinVar.1
Natural variantiVAR_068019178Q → P in BROVCA3. 1 Publication1
Natural variantiVAR_020520287T → A in BROVCA3. 3 PublicationsCorresponds to variant dbSNP:rs28363317EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi131K → A: Significant loss of function; abolishes Holliday junction resolution activity. 2 Publications1
Mutagenesisi131K → R: Partial loss of function. 2 Publications1

Keywords - Diseasei

Disease mutation, Fanconi anemia

Organism-specific databases

DisGeNET

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DisGeNETi
5889

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
RAD51C

MalaCards human disease database

More...
MalaCardsi
RAD51C
MIMi613390 phenotype
613399 phenotype

Open Targets

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OpenTargetsi
ENSG00000108384

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
84 Fanconi anemia
145 Hereditary breast and ovarian cancer syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34177

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RAD51C

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001229411 – 376DNA repair protein RAD51 homolog 3Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O43502

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O43502

MaxQB - The MaxQuant DataBase

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MaxQBi
O43502

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O43502

PeptideAtlas

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PeptideAtlasi
O43502

PRoteomics IDEntifications database

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PRIDEi
O43502

ProteomicsDB human proteome resource

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ProteomicsDBi
48995
48996 [O43502-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O43502

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O43502

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Stress-induced increase in the mitochondrial levels is seen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000108384 Expressed in 216 organ(s), highest expression level in female gonad

CleanEx database of gene expression profiles

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CleanExi
HS_RAD51C

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43502 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43502 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA045198

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the Rad21 paralog protein complexes BCDX2 and CX3; the complexes have a ring-like structure arranged into a flat disc around a central channel. The BCDX2 complex consits of RAD51B, RAD51C, RAD51D and XRCC2; the CX3 complex consists of RAD51C and XRCC3. The BCDX2 subcomplex RAD51B:RAD51C interacts with RAD51. Interacts with SWSAP1; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111826, 29 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O43502

Database of interacting proteins

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DIPi
DIP-41247N

Protein interaction database and analysis system

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IntActi
O43502, 10 interactors

Molecular INTeraction database

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MINTi
O43502

STRING: functional protein association networks

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STRINGi
9606.ENSP00000336701

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O43502

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43502

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 126Required for Holliday junction resolution activityAdd BLAST126
Regioni79 – 136Interaction with RAD51B, RAD51D and XRCC31 PublicationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi366 – 370Nuclear localization signalSequence analysis5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1434 Eukaryota
COG0468 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156805

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000227426

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG055764

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43502

KEGG Orthology (KO)

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KOi
K10870

Identification of Orthologs from Complete Genome Data

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OMAi
HWDQKQR

Database of Orthologous Groups

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OrthoDBi
1345899at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O43502

TreeFam database of animal gene trees

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TreeFami
TF101220

Family and domain databases

Conserved Domains Database

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CDDi
cd01123 Rad51_DMC1_radA, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd

Pfam protein domain database

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Pfami
View protein in Pfam
PF08423 Rad51, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF005856 Rad51, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50162 RECA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43502-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV
60 70 80 90 100
GISKAEALET LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI
110 120 130 140 150
ITFCSALDDI LGGGVPLMKT TEICGAPGVG KTQLCMQLAV DVQIPECFGG
160 170 180 190 200
VAGEAVFIDT EGSFMVDRVV DLATACIQHL QLIAEKHKGE EHRKALEDFT
210 220 230 240 250
LDNILSHIYY FRCRDYTELL AQVYLLPDFL SEHSKVRLVI VDGIAFPFRH
260 270 280 290 300
DLDDLSLRTR LLNGLAQQMI SLANNHRLAV ILTNQMTTKI DRNQALLVPA
310 320 330 340 350
LGESWGHAAT IRLIFHWDRK QRLATLYKSP SQKECTVLFQ IKPQGFRDTV
360 370
VTSACSLQTE GSLSTRKRSR DPEEEL
Length:376
Mass (Da):42,190
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AAADD3C1C0851E0
GO
Isoform 2 (identifier: O43502-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: C → W
     136-376: Missing.

Show »
Length:135
Mass (Da):14,883
Checksum:i56657E563509D90F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QKK3J3QKK3_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
346Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1R0H7C1R0_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2Q5H7C2Q5_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7KZJ0Q7KZJ0_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C hCG_2000975
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR58J3QR58_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ35A0A087WZ35_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLQ2J3QLQ2_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLB5J3QLB5_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI66E9PI66_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0638373G → R1 PublicationCorresponds to variant dbSNP:rs376403182EnsemblClinVar.1
Natural variantiVAR_06801452I → L1 PublicationCorresponds to variant dbSNP:rs730881927EnsemblClinVar.1
Natural variantiVAR_068015103Missing 1 Publication1
Natural variantiVAR_068016114G → V1 Publication1
Natural variantiVAR_063838125G → V in BROVCA3. 1 PublicationCorresponds to variant dbSNP:rs267606998EnsemblClinVar.1
Natural variantiVAR_063839126A → T2 PublicationsCorresponds to variant dbSNP:rs61758784EnsemblClinVar.1
Natural variantiVAR_063840138L → F in BROVCA3; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 PublicationsCorresponds to variant dbSNP:rs267606999EnsemblClinVar.1
Natural variantiVAR_020518144I → T1 PublicationCorresponds to variant dbSNP:rs28363307EnsemblClinVar.1
Natural variantiVAR_063841159D → N Reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 Publications1
Natural variantiVAR_068017162G → E in BROVCA3. 1 PublicationCorresponds to variant dbSNP:rs35151472EnsemblClinVar.1
Natural variantiVAR_063842169V → A2 PublicationsCorresponds to variant dbSNP:rs587780256EnsemblClinVar.1
Natural variantiVAR_068018175A → T1 PublicationCorresponds to variant dbSNP:rs587780838EnsemblClinVar.1
Natural variantiVAR_068019178Q → P in BROVCA3. 1 Publication1
Natural variantiVAR_020519249R → C2 PublicationsCorresponds to variant dbSNP:rs28363311EnsemblClinVar.1
Natural variantiVAR_064032258R → H in FANCO; possibly hypomorphic allele; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 PublicationsCorresponds to variant dbSNP:rs267606997EnsemblClinVar.1
Natural variantiVAR_068020262L → V1 PublicationCorresponds to variant dbSNP:rs149331537EnsemblClinVar.1
Natural variantiVAR_063843264G → S2 PublicationsCorresponds to variant dbSNP:rs147241704EnsemblClinVar.1
Natural variantiVAR_063844264G → V1 Publication1
Natural variantiVAR_020520287T → A in BROVCA3. 3 PublicationsCorresponds to variant dbSNP:rs28363317EnsemblClinVar.1
Natural variantiVAR_063845366R → Q1 PublicationCorresponds to variant dbSNP:rs577852020EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043656135C → W in isoform 2. 1 Publication1
Alternative sequenceiVSP_043657136 – 376Missing in isoform 2. 1 PublicationAdd BLAST241

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF029669 mRNA Translation: AAC39604.1
AF029670 mRNA Translation: AAC39605.1
AY623112 Genomic DNA Translation: AAT38108.1
AC011195 Genomic DNA No translation available.
AC025521 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94432.1
BC107753 mRNA Translation: AAI07754.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11611.1 [O43502-1]
CCDS45745.1 [O43502-2]

NCBI Reference Sequences

More...
RefSeqi
NP_002867.1, NM_002876.3 [O43502-2]
NP_478123.1, NM_058216.2 [O43502-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.412587

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337432; ENSP00000336701; ENSG00000108384 [O43502-1]
ENST00000421782; ENSP00000391450; ENSG00000108384 [O43502-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5889

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5889

UCSC genome browser

More...
UCSCi
uc002iwt.3 human [O43502-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
RAD51 homolog C (S.cerevisiae) (RAD51C)

Leiden Open Variation Database (LOVD)

RAD51 homolog C (S.cerevisiae) (RAD51C)

ZJU-CGGM and BGI-Shenzhen

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029669 mRNA Translation: AAC39604.1
AF029670 mRNA Translation: AAC39605.1
AY623112 Genomic DNA Translation: AAT38108.1
AC011195 Genomic DNA No translation available.
AC025521 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94432.1
BC107753 mRNA Translation: AAI07754.1
CCDSiCCDS11611.1 [O43502-1]
CCDS45745.1 [O43502-2]
RefSeqiNP_002867.1, NM_002876.3 [O43502-2]
NP_478123.1, NM_058216.2 [O43502-1]
UniGeneiHs.412587

3D structure databases

ProteinModelPortaliO43502
SMRiO43502
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111826, 29 interactors
CORUMiO43502
DIPiDIP-41247N
IntActiO43502, 10 interactors
MINTiO43502
STRINGi9606.ENSP00000336701

PTM databases

iPTMnetiO43502
PhosphoSitePlusiO43502

Polymorphism and mutation databases

BioMutaiRAD51C

Proteomic databases

EPDiO43502
jPOSTiO43502
MaxQBiO43502
PaxDbiO43502
PeptideAtlasiO43502
PRIDEiO43502
ProteomicsDBi48995
48996 [O43502-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5889
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337432; ENSP00000336701; ENSG00000108384 [O43502-1]
ENST00000421782; ENSP00000391450; ENSG00000108384 [O43502-2]
GeneIDi5889
KEGGihsa:5889
UCSCiuc002iwt.3 human [O43502-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5889
DisGeNETi5889
EuPathDBiHostDB:ENSG00000108384.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RAD51C
GeneReviewsiRAD51C
HGNCiHGNC:9820 RAD51C
HPAiHPA045198
MalaCardsiRAD51C
MIMi602774 gene
613390 phenotype
613399 phenotype
neXtProtiNX_O43502
OpenTargetsiENSG00000108384
Orphaneti84 Fanconi anemia
145 Hereditary breast and ovarian cancer syndrome
PharmGKBiPA34177

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1434 Eukaryota
COG0468 LUCA
GeneTreeiENSGT00940000156805
HOGENOMiHOG000227426
HOVERGENiHBG055764
InParanoidiO43502
KOiK10870
OMAiHWDQKQR
OrthoDBi1345899at2759
PhylomeDBiO43502
TreeFamiTF101220

Enzyme and pathway databases

ReactomeiR-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-912446 Meiotic recombination
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORiO43502

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RAD51C human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RAD51C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5889

Protein Ontology

More...
PROi
PR:O43502

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108384 Expressed in 216 organ(s), highest expression level in female gonad
CleanExiHS_RAD51C
ExpressionAtlasiO43502 baseline and differential
GenevisibleiO43502 HS

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
PIRSFiPIRSF005856 Rad51, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRA51C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43502
Secondary accession number(s): O43503, Q3B783
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: January 16, 2019
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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