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UniProtKB - O43502 (RA51C_HUMAN)

Entry version 185 (07 Apr 2021)
Sequence version 1 (01 Jun 1998)
Previous versions | rss
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Protein

DNA repair protein RAD51 homolog 3

Gene

RAD51C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.8 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi125 – 132ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43502

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5685942, HDR through Homologous Recombination (HRR)
R-HSA-5693554, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568, Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579, Homologous DNA Pairing and Strand Exchange
R-HSA-5693616, Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-912446, Meiotic recombination
R-HSA-983231, Factors involved in megakaryocyte development and platelet production

SIGNOR Signaling Network Open Resource

More...SIGNORi		O43502

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein RAD51 homolog 3
Short name:
R51H3
Alternative name(s):
RAD51 homolog C
RAD51-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAD51C
Synonyms:RAD51L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9820, RAD51C

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602774, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43502

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000108384.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Fanconi anemia complementation group O (FANCO)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064032258R → H in FANCO; possibly hypomorphic allele; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 PublicationsCorresponds to variant dbSNP:rs267606997EnsemblClinVar.1
Breast-ovarian cancer, familial, 3 (BROVCA3)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063838125G → V in BROVCA3. 1 PublicationCorresponds to variant dbSNP:rs267606998EnsemblClinVar.1
Natural variantiVAR_063840138L → F in BROVCA3; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 PublicationsCorresponds to variant dbSNP:rs267606999EnsemblClinVar.1
Natural variantiVAR_068017162G → E in BROVCA3. 1 PublicationCorresponds to variant dbSNP:rs35151472EnsemblClinVar.1
Natural variantiVAR_068019178Q → P in BROVCA3. 1 Publication1
Natural variantiVAR_020520287T → A in BROVCA3. 3 PublicationsCorresponds to variant dbSNP:rs28363317EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi131K → A: Significant loss of function; abolishes Holliday junction resolution activity. 2 Publications1
Mutagenesisi131K → R: Partial loss of function. 2 Publications1

Keywords - Diseasei

Disease variant, Fanconi anemia

Organism-specific databases

DisGeNET

More...DisGeNETi		5889

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		RAD51C

MalaCards human disease database

More...MalaCardsi		RAD51C
MIMi613390, phenotype
613399, phenotype

Open Targets

More...OpenTargetsi		ENSG00000108384

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		84, Fanconi anemia
145, Hereditary breast and ovarian cancer syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34177

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43502, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RAD51C

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001229411 – 376DNA repair protein RAD51 homolog 3Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-3250
CPTAC-3287

Encyclopedia of Proteome Dynamics

More...EPDi		O43502

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43502

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43502

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43502

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43502

PeptideAtlas

More...PeptideAtlasi		O43502

PRoteomics IDEntifications database

More...PRIDEi		O43502

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48995 [O43502-1]
48996 [O43502-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43502

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43502

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Stress-induced increase in the mitochondrial levels is seen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108384, Expressed in female gonad and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43502, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43502, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000108384, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the Rad21 paralog protein complexes BCDX2 and CX3; the complexes have a ring-like structure arranged into a flat disc around a central channel. The BCDX2 complex consits of RAD51B, RAD51C, RAD51D and XRCC2; the CX3 complex consists of RAD51C and XRCC3. The BCDX2 subcomplex RAD51B:RAD51C interacts with RAD51.

Interacts with SWSAP1; involved in homologous recombination repair.

Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.

10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111826, 33 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O43502

Database of interacting proteins

More...DIPi		DIP-41247N

Protein interaction database and analysis system

More...IntActi		O43502, 19 interactors

Molecular INTeraction database

More...MINTi		O43502

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000336701

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43502, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 126Required for Holliday junction resolution activityAdd BLAST126
Regioni79 – 136Interaction with RAD51B, RAD51D and XRCC31 PublicationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi366 – 370Nuclear localization signalSequence analysis5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1434, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156805

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43502

Identification of Orthologs from Complete Genome Data

More...OMAi		RLILYWN

Database of Orthologous Groups

More...OrthoDBi		1345899at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43502

TreeFam database of animal gene trees

More...TreeFami		TF101220

Family and domain databases

Conserved Domains Database

More...CDDi		cd01123, Rad51_DMC1_radA, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013632, DNA_recomb/repair_Rad51_C
IPR016467, DNA_recomb/repair_RecA-like
IPR027417, P-loop_NTPase
IPR033925, Rad51_DMC1_RadA
IPR020588, RecA_ATP-bd

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08423, Rad51, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005856, Rad51, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50162, RECA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43502-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV 
        60         70         80         90        100
GISKAEALET LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI 
       110        120        130        140        150
ITFCSALDDI LGGGVPLMKT TEICGAPGVG KTQLCMQLAV DVQIPECFGG 
       160        170        180        190        200
VAGEAVFIDT EGSFMVDRVV DLATACIQHL QLIAEKHKGE EHRKALEDFT 
       210        220        230        240        250
LDNILSHIYY FRCRDYTELL AQVYLLPDFL SEHSKVRLVI VDGIAFPFRH 
       260        270        280        290        300
DLDDLSLRTR LLNGLAQQMI SLANNHRLAV ILTNQMTTKI DRNQALLVPA 
       310        320        330        340        350
LGESWGHAAT IRLIFHWDRK QRLATLYKSP SQKECTVLFQ IKPQGFRDTV 
       360        370 
VTSACSLQTE GSLSTRKRSR DPEEEL
Length:376
Mass (Da):42,190
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AAADD3C1C0851E0
GO
Isoform 2 (identifier: O43502-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: C → W
     136-376: Missing.

Show »
Length:135
Mass (Da):14,883
Checksum:i56657E563509D90F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QKK3J3QKK3_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
346Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1R0H7C1R0_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2Q5H7C2Q5_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLQ2J3QLQ2_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR58J3QR58_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7KZJ0Q7KZJ0_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C hCG_2000975
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ35A0A087WZ35_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI66E9PI66_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLB5J3QLB5_HUMAN
DNA repair protein RAD51 homolog 3
RAD51C
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0638373G → R1 PublicationCorresponds to variant dbSNP:rs376403182EnsemblClinVar.1
Natural variantiVAR_06801452I → L1 PublicationCorresponds to variant dbSNP:rs730881927EnsemblClinVar.1
Natural variantiVAR_068015103Missing 1 Publication1
Natural variantiVAR_068016114G → V1 PublicationCorresponds to variant dbSNP:rs1555593767EnsemblClinVar.1
Natural variantiVAR_063838125G → V in BROVCA3. 1 PublicationCorresponds to variant dbSNP:rs267606998EnsemblClinVar.1
Natural variantiVAR_063839126A → T2 PublicationsCorresponds to variant dbSNP:rs61758784EnsemblClinVar.1
Natural variantiVAR_063840138L → F in BROVCA3; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 PublicationsCorresponds to variant dbSNP:rs267606999EnsemblClinVar.1
Natural variantiVAR_020518144I → T1 PublicationCorresponds to variant dbSNP:rs28363307EnsemblClinVar.1
Natural variantiVAR_063841159D → N Reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 Publications1
Natural variantiVAR_068017162G → E in BROVCA3. 1 PublicationCorresponds to variant dbSNP:rs35151472EnsemblClinVar.1
Natural variantiVAR_063842169V → A2 PublicationsCorresponds to variant dbSNP:rs587780256EnsemblClinVar.1
Natural variantiVAR_068018175A → T1 PublicationCorresponds to variant dbSNP:rs587780838EnsemblClinVar.1
Natural variantiVAR_068019178Q → P in BROVCA3. 1 Publication1
Natural variantiVAR_020519249R → C2 PublicationsCorresponds to variant dbSNP:rs28363311EnsemblClinVar.1
Natural variantiVAR_064032258R → H in FANCO; possibly hypomorphic allele; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 PublicationsCorresponds to variant dbSNP:rs267606997EnsemblClinVar.1
Natural variantiVAR_068020262L → V1 PublicationCorresponds to variant dbSNP:rs149331537EnsemblClinVar.1
Natural variantiVAR_063843264G → S2 PublicationsCorresponds to variant dbSNP:rs147241704EnsemblClinVar.1
Natural variantiVAR_063844264G → V1 PublicationCorresponds to variant dbSNP:rs1283065191EnsemblClinVar.1
Natural variantiVAR_020520287T → A in BROVCA3. 3 PublicationsCorresponds to variant dbSNP:rs28363317EnsemblClinVar.1
Natural variantiVAR_063845366R → Q1 PublicationCorresponds to variant dbSNP:rs577852020EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043656135C → W in isoform 2. 1 Publication1
Alternative sequenceiVSP_043657136 – 376Missing in isoform 2. 1 PublicationAdd BLAST241

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF029669 mRNA Translation: AAC39604.1
AF029670 mRNA Translation: AAC39605.1
AY623112 Genomic DNA Translation: AAT38108.1
AC011195 Genomic DNA No translation available.
AC025521 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94432.1
BC107753 mRNA Translation: AAI07754.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11611.1 [O43502-1]
CCDS45745.1 [O43502-2]

NCBI Reference Sequences

More...RefSeqi		NP_002867.1, NM_002876.3 [O43502-2]
NP_478123.1, NM_058216.2 [O43502-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000337432; ENSP00000336701; ENSG00000108384 [O43502-1]
ENST00000421782; ENSP00000391450; ENSG00000108384 [O43502-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5889

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5889

UCSC genome browser

More...UCSCi		uc002iwt.3, human [O43502-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
RAD51 homolog C (S.cerevisiae) (RAD51C)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029669 mRNA Translation: AAC39604.1
AF029670 mRNA Translation: AAC39605.1
AY623112 Genomic DNA Translation: AAT38108.1
AC011195 Genomic DNA No translation available.
AC025521 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94432.1
BC107753 mRNA Translation: AAI07754.1
CCDSiCCDS11611.1 [O43502-1]
CCDS45745.1 [O43502-2]
RefSeqiNP_002867.1, NM_002876.3 [O43502-2]
NP_478123.1, NM_058216.2 [O43502-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi111826, 33 interactors
CORUMiO43502
DIPiDIP-41247N
IntActiO43502, 19 interactors
MINTiO43502
STRINGi9606.ENSP00000336701

PTM databases

iPTMnetiO43502
PhosphoSitePlusiO43502

Genetic variation databases

BioMutaiRAD51C

Proteomic databases

CPTACiCPTAC-3250
CPTAC-3287
EPDiO43502
jPOSTiO43502
MassIVEiO43502
MaxQBiO43502
PaxDbiO43502
PeptideAtlasiO43502
PRIDEiO43502
ProteomicsDBi48995 [O43502-1]
48996 [O43502-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18441, 381 antibodies

The CPTC Antibody Portal

More...CPTCi		O43502, 2 antibodies

The DNASU plasmid repository

More...DNASUi		5889

Genome annotation databases

EnsembliENST00000337432; ENSP00000336701; ENSG00000108384 [O43502-1]
ENST00000421782; ENSP00000391450; ENSG00000108384 [O43502-2]
GeneIDi5889
KEGGihsa:5889
UCSCiuc002iwt.3, human [O43502-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5889
DisGeNETi5889

GeneCards: human genes, protein and diseases

More...GeneCardsi		RAD51C
GeneReviewsiRAD51C
HGNCiHGNC:9820, RAD51C
HPAiENSG00000108384, Low tissue specificity
MalaCardsiRAD51C
MIMi602774, gene
613390, phenotype
613399, phenotype
neXtProtiNX_O43502
OpenTargetsiENSG00000108384
Orphaneti84, Fanconi anemia
145, Hereditary breast and ovarian cancer syndrome
PharmGKBiPA34177
VEuPathDBiHostDB:ENSG00000108384.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1434, Eukaryota
GeneTreeiENSGT00940000156805
InParanoidiO43502
OMAiRLILYWN
OrthoDBi1345899at2759
PhylomeDBiO43502
TreeFamiTF101220

Enzyme and pathway databases

PathwayCommonsiO43502
ReactomeiR-HSA-5685942, HDR through Homologous Recombination (HRR)
R-HSA-5693554, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568, Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579, Homologous DNA Pairing and Strand Exchange
R-HSA-5693616, Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-912446, Meiotic recombination
R-HSA-983231, Factors involved in megakaryocyte development and platelet production
SIGNORiO43502

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5889, 525 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RAD51C, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RAD51C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5889
PharosiO43502, Tbio

Protein Ontology

More...PROi		PR:O43502
RNActiO43502, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108384, Expressed in female gonad and 230 other tissues
ExpressionAtlasiO43502, baseline and differential
GenevisibleiO43502, HS

Family and domain databases

CDDicd01123, Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR013632, DNA_recomb/repair_Rad51_C
IPR016467, DNA_recomb/repair_RecA-like
IPR027417, P-loop_NTPase
IPR033925, Rad51_DMC1_RadA
IPR020588, RecA_ATP-bd
PfamiView protein in Pfam
PF08423, Rad51, 1 hit
PIRSFiPIRSF005856, Rad51, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50162, RECA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRA51C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43502
Secondary accession number(s): O43503, Q3B783
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: April 7, 2021
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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