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UniProtKB - O43497 (CAC1G_HUMAN)

Entry version 177 (17 Jun 2020)
Sequence version 3 (01 Dec 2000)
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Protein

Voltage-dependent T-type calcium channel subunit alpha-1G

Gene

CACNA1G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei354Calcium ion selectivity and permeabilityBy similarity1
Sitei924Calcium ion selectivity and permeabilityBy similarity1
Sitei1465Calcium ion selectivity and permeabilityBy similarity1
Sitei1770Calcium ion selectivity and permeabilityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-419037 NCAM1 interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alpha-1G
Alternative name(s):
Cav3.1c
NBR13
Voltage-gated calcium channel subunit alpha Cav3.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CACNA1G
Synonyms:KIAA1123
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000006283.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:1394 CACNA1G

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604065 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43497

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 80CytoplasmicSequence analysisAdd BLAST80
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei81 – 101Helical; Name=S1 of repeat ISequence analysisAdd BLAST21
Topological domaini102 – 119ExtracellularSequence analysisAdd BLAST18
Transmembranei120 – 141Helical; Name=S2 of repeat ISequence analysisAdd BLAST22
Topological domaini142 – 150CytoplasmicSequence analysis9
Transmembranei151 – 170Helical; Name=S3 of repeat ISequence analysisAdd BLAST20
Topological domaini171 – 175ExtracellularSequence analysis5
Transmembranei176 – 193Helical; Name=S4 of repeat ISequence analysisAdd BLAST18
Topological domaini194 – 213CytoplasmicSequence analysisAdd BLAST20
Transmembranei214 – 234Helical; Name=S5 of repeat ISequence analysisAdd BLAST21
Topological domaini235 – 370ExtracellularSequence analysisAdd BLAST136
Transmembranei371 – 395Helical; Name=S6 of repeat ISequence analysisAdd BLAST25
Topological domaini396 – 743CytoplasmicSequence analysisAdd BLAST348
Transmembranei744 – 764Helical; Name=S1 of repeat IISequence analysisAdd BLAST21
Topological domaini765 – 777ExtracellularSequence analysisAdd BLAST13
Transmembranei778 – 799Helical; Name=S2 of repeat IISequence analysisAdd BLAST22
Topological domaini800 – 805CytoplasmicSequence analysis6
Transmembranei806 – 824Helical; Name=S3 of repeat IISequence analysisAdd BLAST19
Topological domaini825 – 832ExtracellularSequence analysis8
Transmembranei833 – 856Helical; Name=S4 of repeat IISequence analysisAdd BLAST24
Topological domaini857 – 867CytoplasmicSequence analysisAdd BLAST11
Transmembranei868 – 888Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini889 – 939ExtracellularSequence analysisAdd BLAST51
Transmembranei940 – 964Helical; Name=S6 of repeat IISequence analysisAdd BLAST25
Topological domaini965 – 1272CytoplasmicSequence analysisAdd BLAST308
Transmembranei1273 – 1295Helical; Name=S1 of repeat IIISequence analysisAdd BLAST23
Topological domaini1296 – 1313ExtracellularSequence analysisAdd BLAST18
Transmembranei1314 – 1334Helical; Name=S2 of repeat IIISequence analysisAdd BLAST21
Topological domaini1335 – 1344CytoplasmicSequence analysis10
Transmembranei1345 – 1364Helical; Name=S3 of repeat IIISequence analysisAdd BLAST20
Topological domaini1365 – 1378ExtracellularSequence analysisAdd BLAST14
Transmembranei1379 – 1400Helical; Name=S4 of repeat IIISequence analysisAdd BLAST22
Topological domaini1401 – 1410CytoplasmicSequence analysis10
Transmembranei1411 – 1434Helical; Name=S5 of repeat IIISequence analysisAdd BLAST24
Topological domaini1435 – 1511ExtracellularSequence analysisAdd BLAST77
Transmembranei1512 – 1537Helical; Name=S6 of repeat IIISequence analysisAdd BLAST26
Topological domaini1538 – 1610CytoplasmicSequence analysisAdd BLAST73
Transmembranei1611 – 1631Helical; Name=S1 of repeat IVSequence analysisAdd BLAST21
Topological domaini1632 – 1645ExtracellularSequence analysisAdd BLAST14
Transmembranei1646 – 1667Helical; Name=S2 of repeat IVSequence analysisAdd BLAST22
Topological domaini1668 – 1674CytoplasmicSequence analysis7
Transmembranei1675 – 1693Helical; Name=S3 of repeat IVSequence analysisAdd BLAST19
Topological domaini1694 – 1707ExtracellularSequence analysisAdd BLAST14
Transmembranei1708 – 1731Helical; Name=S4 of repeat IVSequence analysisAdd BLAST24
Topological domaini1732 – 1745CytoplasmicSequence analysisAdd BLAST14
Transmembranei1746 – 1766Helical; Name=S5 of repeat IVSequence analysisAdd BLAST21
Topological domaini1767 – 1826ExtracellularSequence analysisAdd BLAST60
Transmembranei1827 – 1854Helical; Name=S6 of repeat IVSequence analysisAdd BLAST28
Topological domaini1855 – 2377CytoplasmicSequence analysisAdd BLAST523

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spinocerebellar ataxia 42 (SCA42)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA42 is a slowly progressive, autosomal dominant form with variable severity.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0762921715R → H in SCA42; changed voltage-gated calcium channel activity; membrane potential dependency is shifted toward more positive potentials. 2 PublicationsCorresponds to variant dbSNP:rs755221106EnsemblClinVar.1
Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits (SCA42ND)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA42ND is an early-onset, severe form associated with motor and cognitive impairment, cerebellar atrophy as well as variable features such as facial dysmorphisms, digital anomalies, microcephaly and epilepsy. SCA42ND inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081177961A → T in SCA42ND; gain-of-function mutation; results in slower channel inactivation and negatively shifted potential for half-inactivation. 1 PublicationCorresponds to variant dbSNP:rs886041505EnsemblClinVar.1
Natural variantiVAR_0811781531M → V in SCA42ND; gain-of-function mutation; results in slower channel inactivation and negatively shifted potential for half-inactivation. 1 PublicationCorresponds to variant dbSNP:rs1555558553EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Spinocerebellar ataxia

Organism-specific databases

DisGeNET

More...DisGeNETi		8913

MalaCards human disease database

More...MalaCardsi		CACNA1G
MIMi616795 phenotype
618087 phenotype

Open Targets

More...OpenTargetsi		ENSG00000006283

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		458803 Spinocerebellar ataxia type 42

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA381

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43497 Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4641

Drug and drug target database

More...DrugBanki		DB09231 Benidipine
DB13746 Bioallethrin
DB11148 Butamben
DB11093 Calcium Citrate
DB11348 Calcium Phosphate
DB14481 Calcium phosphate dihydrate
DB09061 Cannabidiol
DB00568 Cinnarizine
DB00153 Ergocalciferol
DB00593 Ethosuximide
DB04841 Flunarizine
DB09238 Manidipine
DB14009 Medical Cannabis
DB05246 Methsuximide
DB01388 Mibefradil
DB14011 Nabiximols
DB00421 Spironolactone
DB09089 Trimebutine
DB00347 Trimethadione
DB00661 Verapamil
DB00909 Zonisamide

DrugCentral

More...DrugCentrali		O43497

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		535

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CACNA1G

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539521 – 2377Voltage-dependent T-type calcium channel subunit alpha-1GAdd BLAST2377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei467PhosphoserineBy similarity1
Modified residuei715PhosphoserineBy similarity1
Modified residuei1139PhosphoserineBy similarity1
Modified residuei1145PhosphoserineBy similarity1
Modified residuei1146PhosphoserineBy similarity1
Glycosylationi1448N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1451N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1698N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43497

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43497

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43497

PeptideAtlas

More...PeptideAtlasi		O43497

PRoteomics IDEntifications database

More...PRIDEi		O43497

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48982 [O43497-1]
48983 [O43497-10]
48984 [O43497-11]
48985 [O43497-12]
48986 [O43497-13]
48987 [O43497-2]
48988 [O43497-3]
48989 [O43497-4]
48990 [O43497-5]
48991 [O43497-6]
48992 [O43497-7]
48993 [O43497-8]
48994 [O43497-9]
61180
61181
61182
61183
61184
61185
61186
61187
61188
61189
61190
61191
61192
61193
61194
61195
61196
61197

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43497

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43497

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 4, isoform 7, isoform 18, isoform 19, isoform 24, isoform 25 and isoform 31 are adult-specific. Isoform 8, isoform 14, isoform 15, isoform 16, isoform 17, isoform 20, isoform 21, isoform 22, isoform 23, isoform 26, isoform 27, isoform 28, isoform 29 and isoform 30 are fetal-specific. Isoform 1, isoform 2, isoform 6, isoform 9, isoform 11, isoform 12 and isoform 13 are expressed in both fetus and adult.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000006283 Expressed in lateral nuclear group of thalamus and 143 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43497 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43497 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000006283 Tissue enhanced (brain, cervix, uterine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114427, 3 interactors

Protein interaction database and analysis system

More...IntActi		O43497, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000352011

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O43497

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43497 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43497

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati68 – 398IAdd BLAST331
Repeati729 – 967IIAdd BLAST239
Repeati1263 – 1540IIIAdd BLAST278
Repeati1596 – 1854IVAdd BLAST259

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi290 – 295Poly-Gly6
Compositional biasi496 – 506Poly-HisAdd BLAST11

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
The linker region between repeat III and IV probably plays a role in the inactivation of the channel. The C-terminal part may be implicated in the anchoring of the protein to the membrane by interfering with or restricting its lateral diffusion.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2302 Eukaryota
ENOG410XNP6 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159664

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000540_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43497

KEGG Orthology (KO)

More...KOi		K04854

Identification of Orthologs from Complete Genome Data

More...OMAi		RCLIAVY

Database of Orthologous Groups

More...OrthoDBi		172471at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43497

TreeFam database of animal gene trees

More...TreeFami		TF313555

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR002077 VDCCAlpha1
IPR043203 VGCC_Ca_Na
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR10037 PTHR10037, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00167 CACHANNEL
PR01629 TVDCCALPHA1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (35+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 35 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 35 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 5 (identifier: O43497-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG 
        60         70         80         90        100
LPYPALAPVV FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM 
       110        120        130        140        150
FRPCEDIACD SQRCRILQAF DDFIFAFFAV EMVVKMVALG IFGKKCYLGD 
       160        170        180        190        200
TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR TVRVLRPLRA INRVPSMRIL 
       210        220        230        240        250
VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR CFLPENFSLP 
       260        270        280        290        300
LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 
       310        320        330        340        350
DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV 
       360        370        380        390        400
ITLEGWVDIM YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE 
       410        420        430        440        450
TKQRESQLMR EQRVRFLSNA STLASFSEPG SCYEELLKYL VYILRKAARR 
       460        470        480        490        500
LAQVSRAAGV RVGLLSSPAP LGGQETQPSS SCSRSHRRLS VHHLVHHHHH 
       510        520        530        540        550
HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP ALSGAPPGGA 
       560        570        580        590        600
ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 
       610        620        630        640        650
TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI 
       660        670        680        690        700
SSPCLKADSG ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA 
       710        720        730        740        750
QHSDLRDPHS RRQRSLGPDA EPSSVLAFWR LICDTFRKIV DSKYFGRGIM 
       760        770        780        790        800
IAILVNTLSM GIEYHEQPEE LTNALEISNI VFTSLFALEM LLKLLVYGPF 
       810        820        830        840        850
GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR VLKLVRFLPA 
       860        870        880        890        900
LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 
       910        920        930        940        950
PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF 
       960        970        980        990       1000
GNYVLFNLLV AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE 
      1010       1020       1030       1040       1050
SEPDFFSPSL DGDGDRKKCL ALVSLGEHPE LRKSLLPPLI IHTAATPMSL 
      1060       1070       1080       1090       1100
PKSTSTGLGE ALGPASRRTS SSGSAEPGAA HEMKSPPSAR SSPHSPWSAA 
      1110       1120       1130       1140       1150
SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ DEEESSEEER 
      1160       1170       1180       1190       1200
ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN 
      1210       1220       1230       1240       1250
GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE 
      1260       1270       1280       1290       1300
RDSWSAYIFP PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI 
      1310       1320       1330       1340       1350
DPHSAERIFL TLSNYIFTAV FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD 
      1360       1370       1380       1390       1400
GLLVLISVID ILVSMVSDSG TKILGMLRVL RLLRTLRPLR VISRAQGLKL 
      1410       1420       1430       1440       1450
VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV CQGEDTRNIT 
      1460       1470       1480       1490       1500
NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG 
      1510       1520       1530       1540       1550
VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE 
      1560       1570       1580       1590       1600
EARRREEKRL RRLEKKRRNL MLDDVIASGS SASAASEAQC KPYYSDYSRF 
      1610       1620       1630       1640       1650
RLLVHHLCTS HYLDLFITGV IGLNVVTMAM EHYQQPQILD EALKICNYIF 
      1660       1670       1680       1690       1700
TVIFVLESVF KLVAFGFRRF FQDRWNQLDL AIVLLSIMGI TLEEIEVNAS 
      1710       1720       1730       1740       1750
LPINPTIIRI MRVLRIARVL KLLKMAVGMR ALLDTVMQAL PQVGNLGLLF 
      1760       1770       1780       1790       1800
MLLFFIFAAL GVELFGDLEC DETHPCEGLG RHATFRNFGM AFLTLFRVST 
      1810       1820       1830       1840       1850
GDNWNGIMKD TLRDCDQEST CYNTVISPIY FVSFVLTAQF VLVNVVIAVL 
      1860       1870       1880       1890       1900
MKHLEESNKE AKEEAELEAE LELEMKTLSP QPHSPLGSPF LWPGVEGPDS 
      1910       1920       1930       1940       1950
PDSPKPGALH PAAHARSASH FSLEHPTDRQ LFDTISLLIQ GSLEWELKLM 
      1960       1970       1980       1990       2000
DELAGPGGQP SAFPSAPSLG GSDPQIPLAE MEALSLTSEI VSEPSCSLAL 
      2010       2020       2030       2040       2050
TDDSLPDDMH TLLLSALESN MQPHPTELPG PDLLTVRKSG VSRTHSLPND 
      2060       2070       2080       2090       2100
SYMCRHGSTA EGPLGHRGWG LPKAQSGSVL SVHSQPADTS YILQLPKDAP 
      2110       2120       2130       2140       2150
HLLQPHSAPT WGTIPKLPPP GRSPLAQRPL RRQAAIRTDS LDVQGLGSRE 
      2160       2170       2180       2190       2200
DLLAEVSGPS PPLARAYSFW GQSSTQAQQH SRSHSKISKH MTPPAPCPGP 
      2210       2220       2230       2240       2250
EPNWGKGPPE TRSSLELDTE LSWISGDLLP PGGQEEPPSP RDLKKCYSVE 
      2260       2270       2280       2290       2300
AQSCQRRPTS WLDEQRRHSI AVSCLDSGSQ PHLGTDPSNL GGQPLGGPGS 
      2310       2320       2330       2340       2350
RPKKKLSPPS ITIDPPESQG PRTPPSPGIC LRRRAPSSDS KDPLASGPPD 
      2360       2370 
SMAASPSPKK DVLSLSGLSS DPADLDP
Length:2,377
Mass (Da):262,472
Last modified:December 1, 2000 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C9F7C557D9D32DF
GO
Isoform 1 (identifier: O43497-2) [UniParc]FASTAAdd to basket
Also known as: Variant 89

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.

Show »
Length:2,250
Mass (Da):249,333
Checksum:iACDCB167AA5DF18F
GO
Isoform 2 (identifier: O43497-3) [UniParc]FASTAAdd to basket
Also known as: Variant 25

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1587: NLMLDDVIASGSSASAASE → K
     1928-2020: Missing.

Show »
Length:2,243
Mass (Da):248,529
Checksum:i74FA50071A5F9FBD
GO
Isoform 3 (identifier: O43497-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.

Show »
Length:2,354
Mass (Da):260,029
Checksum:i2F13189AF179C9E2
GO
Isoform 4 (identifier: O43497-5) [UniParc]FASTAAdd to basket
Also known as: Variant 88

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.
     2156-2234: Missing.

Show »
Length:2,171
Mass (Da):240,920
Checksum:i1C5BEDD83C1C8FB7
GO
Isoform 6 (identifier: O43497-6) [UniParc]FASTAAdd to basket
Also known as: Variant 217

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.

Show »
Length:2,273
Mass (Da):251,776
Checksum:iBBE93AF4CCAC8F8D
GO
Isoform 7 (identifier: O43497-7) [UniParc]FASTAAdd to basket
Also known as: Variant 221

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1976-2020: Missing.

Show »
Length:2,321
Mass (Da):256,828
Checksum:i2051A97223D0081D
GO
Isoform 8 (identifier: O43497-8) [UniParc]FASTAAdd to basket
Also known as: Variant 93

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1976-2020: Missing.

Show »
Length:2,298
Mass (Da):254,386
Checksum:iEF51D26EC38F66F8
GO
Isoform 9 (identifier: O43497-9) [UniParc]FASTAAdd to basket
Also known as: Variant 57

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1928-2020: Missing.

Show »
Length:2,261
Mass (Da):250,221
Checksum:iDCA090B5433D83E1
GO
Isoform 10 (identifier: O43497-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1928-1975: Missing.

Show »
Length:2,306
Mass (Da):254,976
Checksum:i943D153CFCC75CF8
GO
Isoform 11 (identifier: O43497-11) [UniParc]FASTAAdd to basket
Also known as: Variant 185

The sequence of this isoform differs from the canonical sequence as follows:
     1928-2020: Missing.

Show »
Length:2,284
Mass (Da):252,664
Checksum:iFCB59420799A126E
GO
Isoform 12 (identifier: O43497-12) [UniParc]FASTAAdd to basket
Also known as: Variant 189

The sequence of this isoform differs from the canonical sequence as follows:
     1976-2020: Missing.

Show »
Length:2,332
Mass (Da):257,716
Checksum:i74F41CEA601E8CBC
GO
Isoform 13 (identifier: O43497-13) [UniParc]FASTAAdd to basket
Also known as: Variant 153

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1587: NLMLDDVIASGSSASAASE → K
     1928-2020: Missing.

Show »
Length:2,266
Mass (Da):250,972
Checksum:i66E3563375ED61DA
GO
Isoform 14 (identifier: O43497-15) [UniParc]FASTAAdd to basket
Also known as: Variant 137

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1587: NLMLDDVIASGSSASAASE → K
     1737-1743: Missing.
     1928-2020: Missing.

Show »
Length:2,259
Mass (Da):250,204
Checksum:i4DB0EDC2873FB788
GO
Isoform 15 (identifier: O43497-16) [UniParc]FASTAAdd to basket
Also known as: Variant 157

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1587: NLMLDDVIASGSSASAASE → K
     1976-2020: Missing.

Show »
Length:2,314
Mass (Da):256,024
Checksum:i8C9D69B5A3C86C21
GO
Isoform 16 (identifier: O43497-17) [UniParc]FASTAAdd to basket
Also known as: Variant 169

The sequence of this isoform differs from the canonical sequence as follows:
     1737-1743: Missing.
     1928-2020: Missing.

Show »
Length:2,277
Mass (Da):251,896
Checksum:iB942CD535E125104
GO
Isoform 17 (identifier: O43497-18) [UniParc]FASTAAdd to basket
Also known as: Variant 184

The sequence of this isoform differs from the canonical sequence as follows:
     1928-2020: Missing.
     2156-2234: Missing.

Show »
Length:2,205
Mass (Da):244,250
Checksum:iE059BCB89C6929DA
GO
Isoform 18 (identifier: O43497-19) [UniParc]FASTAAdd to basket
Also known as: Variant 216

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.
     2156-2234: Missing.

Show »
Length:2,194
Mass (Da):243,362
Checksum:i1A2CC9E24EDDECA1
GO
Isoform 19 (identifier: O43497-20) [UniParc]FASTAAdd to basket
Also known as: Variant 223

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA

Show »
Length:2,366
Mass (Da):261,584
Checksum:i2CBDED941FB8B793
GO
Isoform 20 (identifier: O43497-21) [UniParc]FASTAAdd to basket
Also known as: Variant 249

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1569: N → SKEKQMAD
     1928-2020: Missing.

Show »
Length:2,291
Mass (Da):253,467
Checksum:i031D1E0372857147
GO
Isoform 21 (identifier: O43497-22) [UniParc]FASTAAdd to basket
Also known as: Variant 313

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1505-1538: Missing.
     1928-2020: Missing.

Show »
Length:2,227
Mass (Da):246,224
Checksum:iE0F263D2479502B0
GO
Isoform 22 (identifier: O43497-23) [UniParc]FASTAAdd to basket
Also known as: Variant 409

The sequence of this isoform differs from the canonical sequence as follows:
     1505-1538: Missing.
     1569-1587: NLMLDDVIASGSSASAASE → K
     1928-2020: Missing.

Show »
Length:2,232
Mass (Da):246,975
Checksum:iCC32AACAC448BE1A
GO
Isoform 23 (identifier: O43497-24) [UniParc]FASTAAdd to basket
Also known as: Variant 441

The sequence of this isoform differs from the canonical sequence as follows:
     1505-1538: Missing.
     1928-2020: Missing.

Show »
Length:2,250
Mass (Da):248,667
Checksum:i3196A2446C52D0D5
GO
Isoform 24 (identifier: O43497-25) [UniParc]FASTAAdd to basket
Also known as: Variant 477

The sequence of this isoform differs from the canonical sequence as follows:
     1505-1538: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1976-2020: Missing.

Show »
Length:2,287
Mass (Da):252,831
Checksum:i38379DC69AAACA57
GO
Isoform 25 (identifier: O43497-26) [UniParc]FASTAAdd to basket
Also known as: Variant 473

The sequence of this isoform differs from the canonical sequence as follows:
     1505-1538: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.

Show »
Length:2,239
Mass (Da):247,779
Checksum:i15CBEF30957AAB27
GO
Isoform 26 (identifier: O43497-27) [UniParc]FASTAAdd to basket
Also known as: Variant 17

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1587: NLMLDDVIASGSSASAASE → K
     1743-1776: VGNLGLLFMLLFFIFAALGVELFGDLECDETHPC → LWAWSSLETWSVTRHTPVRAWAVMPPFGTLAWPS
     1777-2377: Missing.

Show »
Length:1,735
Mass (Da):194,084
Checksum:iF8C3FE1FDB00B3A8
GO
Isoform 27 (identifier: O43497-28) [UniParc]FASTAAdd to basket
Also known as: Variant 33

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1736-1769: VMQALPQVGNLGLLFMLLFFIFAALGVELFGDLE → LWAWSSLETWSVTRHTPVRAWAVMPPFGTLAWPS
     1770-2377: Missing.

Show »
Length:1,746
Mass (Da):195,008
Checksum:iF7562C646DF6275D
GO
Isoform 28 (identifier: O43497-29) [UniParc]FASTAAdd to basket
Also known as: Variant 49

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1743-1776: VGNLGLLFMLLFFIFAALGVELFGDLECDETHPC → LWAWSSLETWSVTRHTPVRAWAVMPPFGTLAWPS
     1777-2377: Missing.

Show »
Length:1,753
Mass (Da):195,776
Checksum:i0A6D75AA5418BCCA
GO
Isoform 29 (identifier: O43497-30) [UniParc]FASTAAdd to basket
Also known as: Variant 145

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1587: NLMLDDVIASGSSASAASE → K
     1743-1776: VGNLGLLFMLLFFIFAALGVELFGDLECDETHPC → LWAWSSLETWSVTRHTPVRAWAVMPPFGTLAWPS
     1777-2377: Missing.

Show »
Length:1,758
Mass (Da):196,527
Checksum:i79746C4F53C48A96
GO
Isoform 30 (identifier: O43497-31) [UniParc]FASTAAdd to basket
Also known as: Variant 177

The sequence of this isoform differs from the canonical sequence as follows:
     1743-1776: VGNLGLLFMLLFFIFAALGVELFGDLECDETHPC → LWAWSSLETWSVTRHTPVRAWAVMPPFGTLAWPS
     1777-2377: Missing.

Show »
Length:1,776
Mass (Da):198,218
Checksum:i8A58FF574B070494
GO
Isoform 31 (identifier: O43497-32) [UniParc]FASTAAdd to basket
Also known as: Variant 209

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1743-1776: VGNLGLLFMLLFFIFAALGVELFGDLECDETHPC → LWAWSSLETWSVTRHTPVRAWAVMPPFGTLAWPS
     1777-2377: Missing.

Show »
Length:1,765
Mass (Da):197,330
Checksum:iC26247C1EAE03CFE
GO
Isoform 32 (identifier: O43497-33) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA

Show »
Length:2,343
Mass (Da):259,141
Checksum:i01E1315F5E43FF9C
GO
Isoform 33 (identifier: O43497-34) [UniParc]FASTAAdd to basket
Also known as: Variant 441-d81

The sequence of this isoform differs from the canonical sequence as follows:
     1505-1531: Missing.
     1928-2020: Missing.

Show »
Length:2,257
Mass (Da):249,396
Checksum:i7271F3B05E9438BA
GO
Isoform 34 (identifier: O43497-35) [UniParc]FASTAAdd to basket
Also known as: Variant 473-d75

The sequence of this isoform differs from the canonical sequence as follows:
     1505-1529: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.

Show »
Length:2,248
Mass (Da):248,754
Checksum:i302BC6EC72A65A1F
GO
Isoform 35 (identifier: O43497-36) [UniParc]FASTAAdd to basket
Also known as: Variant 473-d81

The sequence of this isoform differs from the canonical sequence as follows:
     1505-1531: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.

Show »
Length:2,246
Mass (Da):248,509
Checksum:iF99DA2229E40387E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAN0H0YAN0_HUMAN
Voltage-dependent T-type calcium ch...
CACNA1G
337Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J1X2A0A0B4J1X2_HUMAN
Voltage-dependent T-type calcium ch...
CACNA1G
1,555Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2W8I3L2W8_HUMAN
Voltage-dependent T-type calcium ch...
CACNA1G
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1345S → I in AAD12731 (PubMed:9495342).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081177961A → T in SCA42ND; gain-of-function mutation; results in slower channel inactivation and negatively shifted potential for half-inactivation. 1 PublicationCorresponds to variant dbSNP:rs886041505EnsemblClinVar.1
Natural variantiVAR_0811781531M → V in SCA42ND; gain-of-function mutation; results in slower channel inactivation and negatively shifted potential for half-inactivation. 1 PublicationCorresponds to variant dbSNP:rs1555558553EnsemblClinVar.1
Natural variantiVAR_0762921715R → H in SCA42; changed voltage-gated calcium channel activity; membrane potential dependency is shifted toward more positive potentials. 2 PublicationsCorresponds to variant dbSNP:rs755221106EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000940971 – 993Missing in isoform 1, isoform 2, isoform 3, isoform 4, isoform 8, isoform 9, isoform 10, isoform 21, isoform 26, isoform 27, isoform 28 and isoform 32. 4 PublicationsAdd BLAST23
Alternative sequenceiVSP_0475451505 – 1538Missing in isoform 21, isoform 22, isoform 23, isoform 24 and isoform 25. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_0475461505 – 1531Missing in isoform 33 and isoform 35. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_0475471505 – 1529Missing in isoform 34. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0009441569 – 1587NLMLD…SAASE → K in isoform 2, isoform 13, isoform 14, isoform 15, isoform 22, isoform 26 and isoform 29. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_0009431569 – 1586NLMLD…ASAAS → SKEKQMA in isoform 1, isoform 4, isoform 6, isoform 7, isoform 8, isoform 18, isoform 19, isoform 24, isoform 25, isoform 31, isoform 32, isoform 34 and isoform 35. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_0475481569N → SKEKQMAD in isoform 20. 1 Publication1
Alternative sequenceiVSP_0475491736 – 1769VMQAL…FGDLE → LWAWSSLETWSVTRHTPVRA WAVMPPFGTLAWPS in isoform 27. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_0475501737 – 1743Missing in isoform 14 and isoform 16. 1 Publication7
Alternative sequenceiVSP_0475511743 – 1776VGNLG…ETHPC → LWAWSSLETWSVTRHTPVRA WAVMPPFGTLAWPS in isoform 26, isoform 28, isoform 29, isoform 30 and isoform 31. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_0475521770 – 2377Missing in isoform 27. 1 PublicationAdd BLAST608
Alternative sequenceiVSP_0475531777 – 2377Missing in isoform 26, isoform 28, isoform 29, isoform 30 and isoform 31. 1 PublicationAdd BLAST601
Alternative sequenceiVSP_0009461928 – 2020Missing in isoform 1, isoform 2, isoform 4, isoform 6, isoform 9, isoform 11, isoform 13, isoform 14, isoform 16, isoform 17, isoform 18, isoform 20, isoform 21, isoform 22, isoform 23, isoform 25, isoform 33, isoform 34 and isoform 35. 4 PublicationsAdd BLAST93
Alternative sequenceiVSP_0009451928 – 1975Missing in isoform 10. CuratedAdd BLAST48
Alternative sequenceiVSP_0009471976 – 2020Missing in isoform 7, isoform 8, isoform 12, isoform 15 and isoform 24. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0009482156 – 2234Missing in isoform 4, isoform 17 and isoform 18. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF124351 mRNA Translation: AAD34352.1
AF134985 mRNA Translation: AAF19346.1
AF134986 mRNA Translation: AAF19347.1
AF190860 mRNA Translation: AAF35287.1
AF126965 mRNA Translation: AAD29400.1
AF126966 mRNA Translation: AAD29401.1
AF227744 mRNA Translation: AAF37689.1
AF227745 mRNA Translation: AAF37690.1
AF227746 mRNA Translation: AAF37691.1
AF227747 mRNA Translation: AAF37692.1
AF227748 mRNA Translation: AAF37693.1
AF227749 mRNA Translation: AAF37694.1
AF227750 mRNA Translation: AAF37695.1
AF227751 mRNA Translation: AAF37696.1
DQ494449 mRNA Translation: ABF69900.1
DQ494450 mRNA Translation: ABF69901.1
DQ494451 mRNA Translation: ABF69902.1
DQ494452 mRNA Translation: ABF69903.1
DQ494453 mRNA Translation: ABF69904.1
DQ494454 mRNA Translation: ABF69905.1
DQ494455 mRNA Translation: ABF69906.1
DQ494456 mRNA Translation: ABF69907.1
DQ494457 mRNA Translation: ABF69908.1
DQ494458 mRNA Translation: ABF69909.1
DQ494459 mRNA Translation: ABF69910.1
DQ494460 mRNA Translation: ABF69911.1
DQ494461 mRNA Translation: ABF69912.1
DQ494462 mRNA Translation: ABF69913.1
DQ494463 mRNA Translation: ABF69914.1
DQ494464 mRNA Translation: ABF69915.1
DQ494465 mRNA Translation: ABF69916.1
DQ494466 mRNA Translation: ABF69917.1
DQ494467 mRNA Translation: ABF69918.1
DQ494468 mRNA Translation: ABF69919.1
DQ494469 mRNA Translation: ABF69920.1
DQ494470 mRNA Translation: ABF69921.1
DQ494471 mRNA Translation: ABF69922.1
DQ494472 mRNA Translation: ABF69923.1
DQ494473 mRNA Translation: ABF69924.1
DQ494474 mRNA Translation: ABF69925.1
DQ494475 mRNA Translation: ABF69926.1
DQ494476 mRNA Translation: ABF69927.1
DQ494477 mRNA Translation: ABF69928.1
DQ494478 mRNA Translation: ABF69929.1
DQ494479 mRNA Translation: ABF69930.1
AC004590 Genomic DNA No translation available.
AC021491 Genomic DNA No translation available.
BC110995 mRNA Translation: AAI10996.1
AB032949 mRNA Translation: BAA86437.2
AF029228 mRNA Translation: AAD12731.1
AF029229 mRNA Translation: AAD12732.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45730.1 [O43497-1]
CCDS45731.1 [O43497-12]
CCDS45732.1 [O43497-11]
CCDS45733.1 [O43497-13]
CCDS45734.1 [O43497-33]
CCDS45735.1 [O43497-2]
CCDS45736.1 [O43497-5]
CCDS45737.1 [O43497-10]
CCDS54142.1 [O43497-7]
CCDS54143.1 [O43497-6]
CCDS54144.1 [O43497-9]
CCDS54145.1 [O43497-3]
CCDS54146.1 [O43497-8]
CCDS58565.1 [O43497-17]
CCDS58566.1 [O43497-18]
CCDS58567.1 [O43497-15]
CCDS58568.1 [O43497-16]
CCDS58569.1 [O43497-21]
CCDS58570.1 [O43497-20]
CCDS58571.1 [O43497-19]
CCDS58572.1 [O43497-24]
CCDS58573.1 [O43497-23]
CCDS58574.1 [O43497-25]
CCDS58575.1 [O43497-26]
CCDS58576.1 [O43497-22]

NCBI Reference Sequences

More...RefSeqi		NP_001243253.1, NM_001256324.1 [O43497-16]
NP_001243254.1, NM_001256325.1 [O43497-21]
NP_001243255.1, NM_001256326.1 [O43497-25]
NP_001243256.1, NM_001256327.1 [O43497-17]
NP_001243257.1, NM_001256328.1 [O43497-15]
NP_001243258.1, NM_001256329.1 [O43497-24]
NP_001243259.1, NM_001256330.1 [O43497-26]
NP_001243260.1, NM_001256331.1 [O43497-23]
NP_001243261.1, NM_001256332.1 [O43497-22]
NP_001243262.1, NM_001256333.1 [O43497-18]
NP_001243263.1, NM_001256334.1 [O43497-19]
NP_001243288.1, NM_001256359.1 [O43497-34]
NP_001243289.1, NM_001256360.1 [O43497-35]
NP_001243290.1, NM_001256361.1 [O43497-36]
NP_061496.2, NM_018896.4 [O43497-1]
NP_938190.1, NM_198376.2 [O43497-5]
NP_938191.2, NM_198377.2 [O43497-20]
NP_938192.1, NM_198378.2 [O43497-6]
NP_938193.1, NM_198379.2 [O43497-8]
NP_938194.1, NM_198380.2 [O43497-7]
NP_938196.1, NM_198382.2 [O43497-9]
NP_938197.1, NM_198383.2 [O43497-10]
NP_938198.1, NM_198384.2 [O43497-11]
NP_938199.1, NM_198385.2 [O43497-12]
NP_938200.1, NM_198386.2 [O43497-13]
NP_938201.1, NM_198387.2 [O43497-2]
NP_938202.1, NM_198388.2 [O43497-3]
NP_938406.1, NM_198396.2 [O43497-33]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000352832; ENSP00000339302; ENSG00000006283 [O43497-2]
ENST00000354983; ENSP00000347078; ENSG00000006283 [O43497-33]
ENST00000358244; ENSP00000350979; ENSG00000006283 [O43497-5]
ENST00000359106; ENSP00000352011; ENSG00000006283 [O43497-1]
ENST00000360761; ENSP00000353990; ENSG00000006283 [O43497-9]
ENST00000429973; ENSP00000414388; ENSG00000006283 [O43497-13]
ENST00000442258; ENSP00000409759; ENSG00000006283 [O43497-3]
ENST00000502264; ENSP00000425522; ENSG00000006283 [O43497-10]
ENST00000503436; ENSP00000427231; ENSG00000006283 [O43497-29]
ENST00000503485; ENSP00000427238; ENSG00000006283 [O43497-24]
ENST00000503607; ENSP00000426558; ENSG00000006283 [O43497-27]
ENST00000504076; ENSP00000425153; ENSG00000006283 [O43497-32]
ENST00000505165; ENSP00000422268; ENSG00000006283 [O43497-18]
ENST00000506406; ENSP00000426313; ENSG00000006283 [O43497-31]
ENST00000507336; ENSP00000420918; ENSG00000006283 [O43497-20]
ENST00000507510; ENSP00000423112; ENSG00000006283 [O43497-12]
ENST00000507609; ENSP00000423045; ENSG00000006283 [O43497-17]
ENST00000507896; ENSP00000421518; ENSG00000006283 [O43497-19]
ENST00000510115; ENSP00000427173; ENSG00000006283 [O43497-8]
ENST00000510366; ENSP00000426814; ENSG00000006283 [O43497-23]
ENST00000511765; ENSP00000427247; ENSG00000006283 [O43497-30]
ENST00000511768; ENSP00000424664; ENSG00000006283 [O43497-28]
ENST00000512389; ENSP00000426261; ENSG00000006283 [O43497-6]
ENST00000513689; ENSP00000426172; ENSG00000006283 [O43497-25]
ENST00000513964; ENSP00000425451; ENSG00000006283 [O43497-26]
ENST00000514079; ENSP00000423317; ENSG00000006283 [O43497-21]
ENST00000514181; ENSP00000425698; ENSG00000006283 [O43497-15]
ENST00000514717; ENSP00000422407; ENSG00000006283 [O43497-22]
ENST00000515165; ENSP00000426098; ENSG00000006283 [O43497-11]
ENST00000515411; ENSP00000423155; ENSG00000006283 [O43497-16]
ENST00000515765; ENSP00000426232; ENSG00000006283 [O43497-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8913

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8913

UCSC genome browser

More...UCSCi		uc002irj.3 human [O43497-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124351 mRNA Translation: AAD34352.1
AF134985 mRNA Translation: AAF19346.1
AF134986 mRNA Translation: AAF19347.1
AF190860 mRNA Translation: AAF35287.1
AF126965 mRNA Translation: AAD29400.1
AF126966 mRNA Translation: AAD29401.1
AF227744 mRNA Translation: AAF37689.1
AF227745 mRNA Translation: AAF37690.1
AF227746 mRNA Translation: AAF37691.1
AF227747 mRNA Translation: AAF37692.1
AF227748 mRNA Translation: AAF37693.1
AF227749 mRNA Translation: AAF37694.1
AF227750 mRNA Translation: AAF37695.1
AF227751 mRNA Translation: AAF37696.1
DQ494449 mRNA Translation: ABF69900.1
DQ494450 mRNA Translation: ABF69901.1
DQ494451 mRNA Translation: ABF69902.1
DQ494452 mRNA Translation: ABF69903.1
DQ494453 mRNA Translation: ABF69904.1
DQ494454 mRNA Translation: ABF69905.1
DQ494455 mRNA Translation: ABF69906.1
DQ494456 mRNA Translation: ABF69907.1
DQ494457 mRNA Translation: ABF69908.1
DQ494458 mRNA Translation: ABF69909.1
DQ494459 mRNA Translation: ABF69910.1
DQ494460 mRNA Translation: ABF69911.1
DQ494461 mRNA Translation: ABF69912.1
DQ494462 mRNA Translation: ABF69913.1
DQ494463 mRNA Translation: ABF69914.1
DQ494464 mRNA Translation: ABF69915.1
DQ494465 mRNA Translation: ABF69916.1
DQ494466 mRNA Translation: ABF69917.1
DQ494467 mRNA Translation: ABF69918.1
DQ494468 mRNA Translation: ABF69919.1
DQ494469 mRNA Translation: ABF69920.1
DQ494470 mRNA Translation: ABF69921.1
DQ494471 mRNA Translation: ABF69922.1
DQ494472 mRNA Translation: ABF69923.1
DQ494473 mRNA Translation: ABF69924.1
DQ494474 mRNA Translation: ABF69925.1
DQ494475 mRNA Translation: ABF69926.1
DQ494476 mRNA Translation: ABF69927.1
DQ494477 mRNA Translation: ABF69928.1
DQ494478 mRNA Translation: ABF69929.1
DQ494479 mRNA Translation: ABF69930.1
AC004590 Genomic DNA No translation available.
AC021491 Genomic DNA No translation available.
BC110995 mRNA Translation: AAI10996.1
AB032949 mRNA Translation: BAA86437.2
AF029228 mRNA Translation: AAD12731.1
AF029229 mRNA Translation: AAD12732.1
CCDSiCCDS45730.1 [O43497-1]
CCDS45731.1 [O43497-12]
CCDS45732.1 [O43497-11]
CCDS45733.1 [O43497-13]
CCDS45734.1 [O43497-33]
CCDS45735.1 [O43497-2]
CCDS45736.1 [O43497-5]
CCDS45737.1 [O43497-10]
CCDS54142.1 [O43497-7]
CCDS54143.1 [O43497-6]
CCDS54144.1 [O43497-9]
CCDS54145.1 [O43497-3]
CCDS54146.1 [O43497-8]
CCDS58565.1 [O43497-17]
CCDS58566.1 [O43497-18]
CCDS58567.1 [O43497-15]
CCDS58568.1 [O43497-16]
CCDS58569.1 [O43497-21]
CCDS58570.1 [O43497-20]
CCDS58571.1 [O43497-19]
CCDS58572.1 [O43497-24]
CCDS58573.1 [O43497-23]
CCDS58574.1 [O43497-25]
CCDS58575.1 [O43497-26]
CCDS58576.1 [O43497-22]
RefSeqiNP_001243253.1, NM_001256324.1 [O43497-16]
NP_001243254.1, NM_001256325.1 [O43497-21]
NP_001243255.1, NM_001256326.1 [O43497-25]
NP_001243256.1, NM_001256327.1 [O43497-17]
NP_001243257.1, NM_001256328.1 [O43497-15]
NP_001243258.1, NM_001256329.1 [O43497-24]
NP_001243259.1, NM_001256330.1 [O43497-26]
NP_001243260.1, NM_001256331.1 [O43497-23]
NP_001243261.1, NM_001256332.1 [O43497-22]
NP_001243262.1, NM_001256333.1 [O43497-18]
NP_001243263.1, NM_001256334.1 [O43497-19]
NP_001243288.1, NM_001256359.1 [O43497-34]
NP_001243289.1, NM_001256360.1 [O43497-35]
NP_001243290.1, NM_001256361.1 [O43497-36]
NP_061496.2, NM_018896.4 [O43497-1]
NP_938190.1, NM_198376.2 [O43497-5]
NP_938191.2, NM_198377.2 [O43497-20]
NP_938192.1, NM_198378.2 [O43497-6]
NP_938193.1, NM_198379.2 [O43497-8]
NP_938194.1, NM_198380.2 [O43497-7]
NP_938196.1, NM_198382.2 [O43497-9]
NP_938197.1, NM_198383.2 [O43497-10]
NP_938198.1, NM_198384.2 [O43497-11]
NP_938199.1, NM_198385.2 [O43497-12]
NP_938200.1, NM_198386.2 [O43497-13]
NP_938201.1, NM_198387.2 [O43497-2]
NP_938202.1, NM_198388.2 [O43497-3]
NP_938406.1, NM_198396.2 [O43497-33]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6KZOelectron microscopy3.30A1-2377[»]
6KZPelectron microscopy3.10A2-2377[»]
SMRiO43497
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114427, 3 interactors
IntActiO43497, 2 interactors
STRINGi9606.ENSP00000352011

Chemistry databases

BindingDBiO43497
ChEMBLiCHEMBL4641
DrugBankiDB09231 Benidipine
DB13746 Bioallethrin
DB11148 Butamben
DB11093 Calcium Citrate
DB11348 Calcium Phosphate
DB14481 Calcium phosphate dihydrate
DB09061 Cannabidiol
DB00568 Cinnarizine
DB00153 Ergocalciferol
DB00593 Ethosuximide
DB04841 Flunarizine
DB09238 Manidipine
DB14009 Medical Cannabis
DB05246 Methsuximide
DB01388 Mibefradil
DB14011 Nabiximols
DB00421 Spironolactone
DB09089 Trimebutine
DB00347 Trimethadione
DB00661 Verapamil
DB00909 Zonisamide
DrugCentraliO43497
GuidetoPHARMACOLOGYi535

PTM databases

iPTMnetiO43497
PhosphoSitePlusiO43497

Polymorphism and mutation databases

BioMutaiCACNA1G

Proteomic databases

jPOSTiO43497
MassIVEiO43497
PaxDbiO43497
PeptideAtlasiO43497
PRIDEiO43497
ProteomicsDBi48982 [O43497-1]
48983 [O43497-10]
48984 [O43497-11]
48985 [O43497-12]
48986 [O43497-13]
48987 [O43497-2]
48988 [O43497-3]
48989 [O43497-4]
48990 [O43497-5]
48991 [O43497-6]
48992 [O43497-7]
48993 [O43497-8]
48994 [O43497-9]
61180
61181
61182
61183
61184
61185
61186
61187
61188
61189
61190
61191
61192
61193
61194
61195
61196
61197

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		O43497 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1340 313 antibodies

Genome annotation databases

EnsembliENST00000352832; ENSP00000339302; ENSG00000006283 [O43497-2]
ENST00000354983; ENSP00000347078; ENSG00000006283 [O43497-33]
ENST00000358244; ENSP00000350979; ENSG00000006283 [O43497-5]
ENST00000359106; ENSP00000352011; ENSG00000006283 [O43497-1]
ENST00000360761; ENSP00000353990; ENSG00000006283 [O43497-9]
ENST00000429973; ENSP00000414388; ENSG00000006283 [O43497-13]
ENST00000442258; ENSP00000409759; ENSG00000006283 [O43497-3]
ENST00000502264; ENSP00000425522; ENSG00000006283 [O43497-10]
ENST00000503436; ENSP00000427231; ENSG00000006283 [O43497-29]
ENST00000503485; ENSP00000427238; ENSG00000006283 [O43497-24]
ENST00000503607; ENSP00000426558; ENSG00000006283 [O43497-27]
ENST00000504076; ENSP00000425153; ENSG00000006283 [O43497-32]
ENST00000505165; ENSP00000422268; ENSG00000006283 [O43497-18]
ENST00000506406; ENSP00000426313; ENSG00000006283 [O43497-31]
ENST00000507336; ENSP00000420918; ENSG00000006283 [O43497-20]
ENST00000507510; ENSP00000423112; ENSG00000006283 [O43497-12]
ENST00000507609; ENSP00000423045; ENSG00000006283 [O43497-17]
ENST00000507896; ENSP00000421518; ENSG00000006283 [O43497-19]
ENST00000510115; ENSP00000427173; ENSG00000006283 [O43497-8]
ENST00000510366; ENSP00000426814; ENSG00000006283 [O43497-23]
ENST00000511765; ENSP00000427247; ENSG00000006283 [O43497-30]
ENST00000511768; ENSP00000424664; ENSG00000006283 [O43497-28]
ENST00000512389; ENSP00000426261; ENSG00000006283 [O43497-6]
ENST00000513689; ENSP00000426172; ENSG00000006283 [O43497-25]
ENST00000513964; ENSP00000425451; ENSG00000006283 [O43497-26]
ENST00000514079; ENSP00000423317; ENSG00000006283 [O43497-21]
ENST00000514181; ENSP00000425698; ENSG00000006283 [O43497-15]
ENST00000514717; ENSP00000422407; ENSG00000006283 [O43497-22]
ENST00000515165; ENSP00000426098; ENSG00000006283 [O43497-11]
ENST00000515411; ENSP00000423155; ENSG00000006283 [O43497-16]
ENST00000515765; ENSP00000426232; ENSG00000006283 [O43497-7]
GeneIDi8913
KEGGihsa:8913
UCSCiuc002irj.3 human [O43497-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8913
DisGeNETi8913
EuPathDBiHostDB:ENSG00000006283.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		CACNA1G
HGNCiHGNC:1394 CACNA1G
HPAiENSG00000006283 Tissue enhanced (brain, cervix, uterine)
MalaCardsiCACNA1G
MIMi604065 gene
616795 phenotype
618087 phenotype
neXtProtiNX_O43497
OpenTargetsiENSG00000006283
Orphaneti458803 Spinocerebellar ataxia type 42
PharmGKBiPA381

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2302 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00940000159664
HOGENOMiCLU_000540_2_0_1
InParanoidiO43497
KOiK04854
OMAiRCLIAVY
OrthoDBi172471at2759
PhylomeDBiO43497
TreeFamiTF313555

Enzyme and pathway databases

ReactomeiR-HSA-419037 NCAM1 interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8913 9 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CACNA1G human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CACNA1G

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8913
PharosiO43497 Tclin

Protein Ontology

More...PROi		PR:O43497
RNActiO43497 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000006283 Expressed in lateral nuclear group of thalamus and 143 other tissues
ExpressionAtlasiO43497 baseline and differential
GenevisibleiO43497 HS

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR002077 VDCCAlpha1
IPR043203 VGCC_Ca_Na
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037 PTHR10037, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01629 TVDCCALPHA1

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1G_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43497
Secondary accession number(s): D6RA64
, E7EPR0, O43498, O94770, Q19QY8, Q19QY9, Q19QZ0, Q19QZ1, Q19QZ2, Q19QZ3, Q19QZ4, Q19QZ5, Q19QZ6, Q19QZ7, Q19QZ8, Q19QZ9, Q19R00, Q19R01, Q19R02, Q19R03, Q19R04, Q19R05, Q19R06, Q19R07, Q19R08, Q19R09, Q19R10, Q19R11, Q19R12, Q19R13, Q19R15, Q19R16, Q19R17, Q19R18, Q2TAC4, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 1, 2000
Last modified: June 17, 2020
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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