TGOLN2

Functionⁱ

May be involved in regulating membrane traffic to and from trans-Golgi network.

Enzyme and pathway databases

PathwayCommonsⁱ	O43493
Reactomeⁱ	R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-432722, Golgi Associated Vesicle Biogenesis R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-8957275, Post-translational protein phosphorylation

PathwayCommonsⁱ

Reactomeⁱ

R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-432722, Golgi Associated Vesicle Biogenesis
R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-8957275, Post-translational protein phosphorylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Trans-Golgi network integral membrane protein 2Curated Alternative name(s): Trans-Golgi network glycoprotein 461 Publication Short name: TGN38 homolog1 Publication Short name: hTGN461 Publication Trans-Golgi network glycoprotein 481 Publication Short name: hTGN481 Publication Trans-Golgi network glycoprotein 511 Publication Short name: hTGN511 Publication Trans-Golgi network protein 2Imported
Gene namesⁱ	Name:TGOLN2Imported Synonyms:TGN46, TGN51
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15450, TGOLN2
MIMⁱ	603062, gene
neXtProtⁱ	NX_O43493
VEuPathDBⁱ	HostDB:ENSG00000152291

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 381	ExtracellularSequence analysisAdd BLAST	360
Transmembraneⁱ	382 – 402	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	403 – 437	CytoplasmicSequence analysisAdd BLAST	35

Keywords - Cellular componentⁱ

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	430	Y → A: Loss of relocalization to the trans-Golgi. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10618
Open Targets More...OpenTargetsⁱ	ENSG00000152291
PharmGKBⁱ	PA37959

Miscellaneous databases

Pharosⁱ	O43493, Tbio

Pharosⁱ

O43493, Tbio

Genetic variation databases

BioMutaⁱ	TGOLN2

BioMutaⁱ

TGOLN2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_0000022486	22 – 437	Trans-Golgi network integral membrane protein 2Add BLAST		416

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	39	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	71	Phosphoserine; by FAM20CCombined sources1 Publication	1
Glycosylationⁱ	82	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	96	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	152	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	180	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	208	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	221	Phosphoserine; by FAM20C1 Publication	1
Glycosylationⁱ	222	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	298	Phosphoserine; by FAM20CCombined sources1 Publication	1
Modified residueⁱ	302	Phosphothreonine; by FAM20C1 Publication	1
Modified residueⁱ	351	Phosphoserine; by FAM20CCombined sources1 Publication	1
Glycosylationⁱ	373	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	377	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	O43493
jPOSTⁱ	O43493
MassIVEⁱ	O43493
PaxDbⁱ	O43493
PeptideAtlas More...PeptideAtlasⁱ	O43493
PRIDEⁱ	O43493
ProteomicsDBⁱ	30219 30837 48977 [O43493-2] 48978 [O43493-3] 48979 [O43493-4] 48980 [O43493-5] 48981 [O43493-6]

PTM databases

GlyConnectⁱ	2945, 3 N-Linked glycans (1 site)
GlyGenⁱ	O43493, 13 sites, 1 O-linked glycan (4 sites)
iPTMnetⁱ	O43493
PhosphoSitePlusⁱ	O43493

Expressionⁱ

Tissue specificityⁱ

Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.

Gene expression databases

Bgeeⁱ	ENSG00000152291, Expressed in adult mammalian kidney and 257 other tissues
Genevisibleⁱ	O43493, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000152291, Low tissue specificity

HPAⁱ

ENSG00000152291, Low tissue specificity

Interactionⁱ

Binary interactionsⁱ

Hide details

O43493

With	#Exp.	IntAct
KRTAP10-9 [P60411]	3	EBI-1752146,EBI-10172052
NCK1 [P16333]	3	EBI-1752146,EBI-389883

Isoform 5 [O43493-5]

With	#Exp.	IntAct
AGT [P01019]	3	EBI-25830716,EBI-751728
CCT2 [P78371]	3	EBI-25830716,EBI-357407
KLKB1 [P03952]	3	EBI-25830716,EBI-10087153
LPL [P06858]	3	EBI-25830716,EBI-715909
VHL - isoform 2 [P40337-2]	3	EBI-25830716,EBI-12157263

Protein-protein interaction databases

BioGRIDⁱ	115864, 466 interactors
IntActⁱ	O43493, 455 interactors
Molecular INTeraction database More...MINTⁱ	O43493
STRINGⁱ	9606.ENSP00000386443

Miscellaneous databases

RNActⁱ	O43493, protein

RNActⁱ

O43493, protein

Structureⁱ

3D structure databases

SMRⁱ	O43493
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	54 – 67	1Add BLAST	14
Repeatⁱ	68 – 81	2Add BLAST	14
Repeatⁱ	82 – 95	3Add BLAST	14
Repeatⁱ	96 – 109	4Add BLAST	14
Repeatⁱ	110 – 123	5Add BLAST	14
Repeatⁱ	124 – 137	6Add BLAST	14
Repeatⁱ	138 – 151	7Add BLAST	14
Repeatⁱ	152 – 165	8Add BLAST	14
Repeatⁱ	166 – 179	9Add BLAST	14
Repeatⁱ	180 – 193	10Add BLAST	14
Repeatⁱ	194 – 207	11Add BLAST	14
Repeatⁱ	208 – 221	12Add BLAST	14
Repeatⁱ	222 – 234	13Add BLAST	13
Repeatⁱ	235 – 249	14Add BLAST	15

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	27 – 377	DisorderedSequence analysisAdd BLAST		351
Regionⁱ	54 – 249	14 X 14 AA tandem repeatsAdd BLAST		196

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	395 – 398	Endocytosis signal; in isoform TGN51	4
Motifⁱ	418 – 421	Endocytosis signal; in isoform TGN51	4
Motifⁱ	430 – 433	Endocytosis signal; in isoform TGN46 and isoform TGN48	4

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	38 – 203	Polar residuesSequence analysisAdd BLAST	166
Compositional biasⁱ	238 – 252	Polar residuesSequence analysisAdd BLAST	15
Compositional biasⁱ	253 – 268	Basic and acidic residuesSequence analysisAdd BLAST	16
Compositional biasⁱ	321 – 335	Acidic residuesSequence analysisAdd BLAST	15
Compositional biasⁱ	336 – 350	Basic and acidic residuesSequence analysisAdd BLAST	15
Compositional biasⁱ	351 – 377	Polar residuesSequence analysisAdd BLAST	27

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG502S6YU, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064712
HOGENOMⁱ	CLU_047350_0_0_1
InParanoidⁱ	O43493
OMAⁱ	MATCGNM
Database of Orthologous Groups More...OrthoDBⁱ	1481309at2759
PhylomeDBⁱ	O43493
TreeFamⁱ	TF332514

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform TGN46 (identifier: O43493-2) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRFVVALVLL NVAAAGAVPL LATESVKQEE AGVRPSAGNV STHPSLSQRP 
        60         70         80         90        100
GGSTKSHPEP QTPKDSPSKS SAEAQTPEDT PNKSGAEAKT QKDSSNKSGA 
       110        120        130        140        150
EAKTQKGSTS KSGSEAQTTK DSTSKSHPEL QTPKDSTGKS GAEAQTPEDS 
       160        170        180        190        200
PNRSGAEAKT QKDSPSKSGS EAQTTKDVPN KSGADGQTPK DGSSKSGAED 
       210        220        230        240        250
QTPKDVPNKS GAEKQTPKDG SNKSGAEEQG PIDGPSKSGA EEQTSKDSPN 
       260        270        280        290        300
KVVPEQPSRK DHSKPISNPS DNKELPKADT NQLADKGKLS PHAFKTESGE 
       310        320        330        340        350
ETDLISPPQE EVKSSEPTED VEPKEAEDDD TGPEEGSPPK EEKEKMSGSA 
       360        370        380        390        400
SSENREGTLS DSTGSEKDDL YPNGSGNGSA ESSHFFAYLV TAAILVAVLY 
       410        420        430 
IAHHNKRKII AFVLEGKRSK VTRRPKASDY QRLDQKS

Length:437

Mass (Da):45,880

Last modified:September 18, 2019 - v4

Checksum:ⁱ6F72467FED83A1A3

GO

Isoform TGN48 (identifier: O43493-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
437-437: S → IFSPPSPNRMVYSSGKR

« Hide

        10         20         30         40         50
MRFVVALVLL NVAAAGAVPL LATESVKQEE AGVRPSAGNV STHPSLSQRP 
        60         70         80         90        100
GGSTKSHPEP QTPKDSPSKS SAEAQTPEDT PNKSGAEAKT QKDSSNKSGA 
       110        120        130        140        150
EAKTQKGSTS KSGSEAQTTK DSTSKSHPEL QTPKDSTGKS GAEAQTPEDS 
       160        170        180        190        200
PNRSGAEAKT QKDSPSKSGS EAQTTKDVPN KSGADGQTPK DGSSKSGAED 
       210        220        230        240        250
QTPKDVPNKS GAEKQTPKDG SNKSGAEEQG PIDGPSKSGA EEQTSKDSPN 
       260        270        280        290        300
KVVPEQPSRK DHSKPISNPS DNKELPKADT NQLADKGKLS PHAFKTESGE 
       310        320        330        340        350
ETDLISPPQE EVKSSEPTED VEPKEAEDDD TGPEEGSPPK EEKEKMSGSA 
       360        370        380        390        400
SSENREGTLS DSTGSEKDDL YPNGSGNGSA ESSHFFAYLV TAAILVAVLY 
       410        420        430        440        450
IAHHNKRKII AFVLEGKRSK VTRRPKASDY QRLDQKIFSP PSPNRMVYSS 

GKR

Show »

Length:453

Mass (Da):47,698

Checksum:ⁱE3D3878CA946D0A3

GO

Isoform 4 (identifier: O43493-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
251-309: KVVPEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEETDLISPPQ → K

« Hide

        10         20         30         40         50
MRFVVALVLL NVAAAGAVPL LATESVKQEE AGVRPSAGNV STHPSLSQRP 
        60         70         80         90        100
GGSTKSHPEP QTPKDSPSKS SAEAQTPEDT PNKSGAEAKT QKDSSNKSGA 
       110        120        130        140        150
EAKTQKGSTS KSGSEAQTTK DSTSKSHPEL QTPKDSTGKS GAEAQTPEDS 
       160        170        180        190        200
PNRSGAEAKT QKDSPSKSGS EAQTTKDVPN KSGADGQTPK DGSSKSGAED 
       210        220        230        240        250
QTPKDVPNKS GAEKQTPKDG SNKSGAEEQG PIDGPSKSGA EEQTSKDSPN 
       260        270        280        290        300
KEEVKSSEPT EDVEPKEAED DDTGPEEGSP PKEEKEKMSG SASSENREGT 
       310        320        330        340        350
LSDSTGSEKD DLYPNGSGNG SAESSHFFAY LVTAAILVAV LYIAHHNKRK 
       360        370 
IIAFVLEGKR SKVTRRPKAS DYQRLDQKS

Show »

Length:379

Mass (Da):39,563

Checksum:ⁱD8BA8D5EB4EE7562

GO

Isoform 5 (identifier: O43493-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
437-437: S → VRKEEPGPWEG

« Hide

        10         20         30         40         50
MRFVVALVLL NVAAAGAVPL LATESVKQEE AGVRPSAGNV STHPSLSQRP 
        60         70         80         90        100
GGSTKSHPEP QTPKDSPSKS SAEAQTPEDT PNKSGAEAKT QKDSSNKSGA 
       110        120        130        140        150
EAKTQKGSTS KSGSEAQTTK DSTSKSHPEL QTPKDSTGKS GAEAQTPEDS 
       160        170        180        190        200
PNRSGAEAKT QKDSPSKSGS EAQTTKDVPN KSGADGQTPK DGSSKSGAED 
       210        220        230        240        250
QTPKDVPNKS GAEKQTPKDG SNKSGAEEQG PIDGPSKSGA EEQTSKDSPN 
       260        270        280        290        300
KVVPEQPSRK DHSKPISNPS DNKELPKADT NQLADKGKLS PHAFKTESGE 
       310        320        330        340        350
ETDLISPPQE EVKSSEPTED VEPKEAEDDD TGPEEGSPPK EEKEKMSGSA 
       360        370        380        390        400
SSENREGTLS DSTGSEKDDL YPNGSGNGSA ESSHFFAYLV TAAILVAVLY 
       410        420        430        440 
IAHHNKRKII AFVLEGKRSK VTRRPKASDY QRLDQKVRKE EPGPWEG

Show »

Length:447

Mass (Da):47,058

Checksum:ⁱ557721E4618F7331

GO

Isoform 6 (identifier: O43493-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
71-168: Missing.
252-309: Missing.

« Hide

        10         20         30         40         50
MRFVVALVLL NVAAAGAVPL LATESVKQEE AGVRPSAGNV STHPSLSQRP 
        60         70         80         90        100
GGSTKSHPEP QTPKDSPSKS GSEAQTTKDV PNKSGADGQT PKDGSSKSGA 
       110        120        130        140        150
EDQTPKDVPN KSGAEKQTPK DGSNKSGAEE QGPIDGPSKS GAEEQTSKDS 
       160        170        180        190        200
PNKEEVKSSE PTEDVEPKEA EDDDTGPEEG SPPKEEKEKM SGSASSENRE 
       210        220        230        240        250
GTLSDSTGSE KDDLYPNGSG NGSAESSHFF AYLVTAAILV AVLYIAHHNK 
       260        270        280 
RKIIAFVLEG KRSKVTRRPK ASDYQRLDQK S

Show »

Length:281

Mass (Da):29,541

Checksum:ⁱ537C9B3CFADF7222

GO

Isoform 7 (identifier: O43493-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
437-437: S → YVLILNVFPAPPKRSFFP

« Hide

        10         20         30         40         50
MRFVVALVLL NVAAAGAVPL LATESVKQEE AGVRPSAGNV STHPSLSQRP 
        60         70         80         90        100
GGSTKSHPEP QTPKDSPSKS SAEAQTPEDT PNKSGAEAKT QKDSSNKSGA 
       110        120        130        140        150
EAKTQKGSTS KSGSEAQTTK DSTSKSHPEL QTPKDSTGKS GAEAQTPEDS 
       160        170        180        190        200
PNRSGAEAKT QKDSPSKSGS EAQTTKDVPN KSGADGQTPK DGSSKSGAED 
       210        220        230        240        250
QTPKDVPNKS GAEKQTPKDG SNKSGAEEQG PIDGPSKSGA EEQTSKDSPN 
       260        270        280        290        300
KVVPEQPSRK DHSKPISNPS DNKELPKADT NQLADKGKLS PHAFKTESGE 
       310        320        330        340        350
ETDLISPPQE EVKSSEPTED VEPKEAEDDD TGPEEGSPPK EEKEKMSGSA 
       360        370        380        390        400
SSENREGTLS DSTGSEKDDL YPNGSGNGSA ESSHFFAYLV TAAILVAVLY 
       410        420        430        440        450
IAHHNKRKII AFVLEGKRSK VTRRPKASDY QRLDQKYVLI LNVFPAPPKR 

SFFP

Show »

Length:454

Mass (Da):47,880

Checksum:ⁱ8B6A2E45C93DB9C0

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A5F9UY30	A0A5F9UY30_HUMAN	Trans-Golgi network integral membra... Trans-Golgi network integral membrane protein 2	TGOLN2	453	Annotation score:
A0A5H1ZRP2	A0A5H1ZRP2_HUMAN	Trans-Golgi network integral membra... Trans-Golgi network integral membrane protein 2	TGOLN2	479	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	30	E → D in AAH08461 (PubMed:15489334).Curated	1
Sequence conflictⁱ	71	S → G in BAD96549 (Ref. 4) Curated	1
Sequence conflictⁱ	74	A → P in BAD96783 (Ref. 4) Curated	1
Sequence conflictⁱ	158	A → P in AAB96906 (PubMed:9422759).Curated	1
Sequence conflictⁱ	158	A → P in AAB96907 (PubMed:9422759).Curated	1
Sequence conflictⁱ	158	A → P in AAB96908 (PubMed:9422759).Curated	1
Sequence conflictⁱ	158	A → P in AAC39539 (PubMed:9422759).Curated	1
Sequence conflictⁱ	158	A → P in AAC39541 (PubMed:9422759).Curated	1
Sequence conflictⁱ	158	A → P in AAC39542 (PubMed:9422759).Curated	1
Sequence conflictⁱ	386	F → S in CAE45926 (PubMed:17974005).Curated	1
Isoform TGN48 (identifier: O43493-3)
Sequence conflictⁱ	439	S → F in AAC39541 (PubMed:9422759).	1
Sequence conflictⁱ	439	S → F in AAB96907 (PubMed:9422759).	1
Isoform 7 (identifier: O43493-7)
Sequence conflictⁱ	453	F → L in AAB96908 (PubMed:9422759).	1
Sequence conflictⁱ	453	F → L in AAC39542 (PubMed:9422759).	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034724	10	L → V1 PublicationCorresponds to variant dbSNP:rs1128140Ensembl.	1
Natural variantⁱVAR_034725	86	A → G1 PublicationCorresponds to variant dbSNP:rs1044962Ensembl.	1
Natural variantⁱVAR_034726	91	Q → L1 PublicationCorresponds to variant dbSNP:rs1044963Ensembl.	1
Natural variantⁱVAR_034727	103	K → Q1 PublicationCorresponds to variant dbSNP:rs1044964Ensembl.	1
Natural variantⁱVAR_034728	105	Q → P1 PublicationCorresponds to variant dbSNP:rs1573051515Ensembl.	1
Natural variantⁱVAR_034729	259	R → W4 PublicationsCorresponds to variant dbSNP:rs4247303Ensembl.	1
Natural variantⁱVAR_034730	322	E → G1 PublicationCorresponds to variant dbSNP:rs1044969Ensembl.	1
Isoform TGN48 (identifier: O43493-3)
Natural variantⁱVAR_082887	441	P → LCuratedCorresponds to variant dbSNP:rs4240199Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_060318	71 – 168	Missing in isoform 6. Add BLAST	98
Alternative sequenceⁱVSP_060319	251 – 309	KVVPE…ISPPQ → K in isoform 4. Add BLAST	59
Alternative sequenceⁱVSP_060320	252 – 309	Missing in isoform 6. Add BLAST	58
Alternative sequenceⁱVSP_060321	437	S → VRKEEPGPWEG in isoform 5.	1
Alternative sequenceⁱVSP_060322	437	S → YVLILNVFPAPPKRSFFP in isoform 7.	1
Alternative sequenceⁱVSP_060323	437	S → IFSPPSPNRMVYSSGKR in isoform TGN48. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF029316 AF029315 Genomic DNA Translation: AAB96906.1 AF029316 AF029315 Genomic DNA Translation: AAB96907.1 AF029316 AF029315 Genomic DNA Translation: AAB96908.1 U62390 mRNA Translation: AAC39539.1 AF027515 mRNA Translation: AAC39541.1 AF027516 mRNA Translation: AAC39542.1 X94333 mRNA Translation: CAA64002.1 AK126465 mRNA Translation: BAC86559.1 AK222829 mRNA Translation: BAD96549.1 AK223063 mRNA Translation: BAD96783.1 AK312479 mRNA Translation: BAG35383.1 BX640868 mRNA Translation: CAE45926.1 AC093162 Genomic DNA Translation: AAY24095.1 CH471053 Genomic DNA Translation: EAW99535.1 CH471053 Genomic DNA Translation: EAW99536.1 CH471053 Genomic DNA Translation: EAW99539.1 BC008461 mRNA Translation: AAH08461.1 BC028219 mRNA Translation: AAH28219.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46351.1 [O43493-2] CCDS56126.1 [O43493-3] CCDS56127.1 [O43493-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001193769.1, NM_001206840.1 NP_001193770.1, NM_001206841.1 NP_001193773.1, NM_001206844.1 [O43493-4] NP_006455.2, NM_006464.3 [O43493-2]

Genome annotation databases

Ensemblⁱ	ENST00000377386; ENSP00000366603; ENSG00000152291 [O43493-2] ENST00000398263; ENSP00000381312; ENSG00000152291 [O43493-4] ENST00000409015; ENSP00000387035; ENSG00000152291 [O43493-7] ENST00000444342; ENSP00000391190; ENSG00000152291 [O43493-5]
GeneIDⁱ	10618
KEGGⁱ	hsa:10618
UCSC genome browser More...UCSCⁱ	uc002soz.4, human [O43493-2] uc021vjw.2, human

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43493	TGOLN2 isoform 1		PONAB		481	UniRef90_O43493
Uncharacterized protein		NOMLE		481
Trans-Golgi network integral membrane protein 2		HUMAN		479
Isoform 7 of Trans-Golgi network integral membrane protein 2		HUMAN		454
Isoform TGN48 of Trans-Golgi network integral membrane protein 2		HUMAN		453
+17
O43493-4	TGOLN2 isoform 1		PANTR		462	UniRef90_O43493-4
TGOLN2 isoform 5		PANTR		452
TGOLN2 isoform 4		PANTR		448
TGOLN2 isoform 6		PANTR		442
Trans-golgi network protein 2		PANTR		432
+5

Protein	Similar proteins		Species	Score	Length	Source
O43493	TGOLN2 isoform 1		PONAB		481	UniRef50_O43493
Uncharacterized protein		NOMLE		481
Trans-Golgi network integral membrane protein 2		HUMAN		479
Trans-golgi network protein 2		GORGO		378
Trans-golgi network protein 2		MACNE		417
+78

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF029316 AF029315 Genomic DNA Translation: AAB96906.1 AF029316 AF029315 Genomic DNA Translation: AAB96907.1 AF029316 AF029315 Genomic DNA Translation: AAB96908.1 U62390 mRNA Translation: AAC39539.1 AF027515 mRNA Translation: AAC39541.1 AF027516 mRNA Translation: AAC39542.1 X94333 mRNA Translation: CAA64002.1 AK126465 mRNA Translation: BAC86559.1 AK222829 mRNA Translation: BAD96549.1 AK223063 mRNA Translation: BAD96783.1 AK312479 mRNA Translation: BAG35383.1 BX640868 mRNA Translation: CAE45926.1 AC093162 Genomic DNA Translation: AAY24095.1 CH471053 Genomic DNA Translation: EAW99535.1 CH471053 Genomic DNA Translation: EAW99536.1 CH471053 Genomic DNA Translation: EAW99539.1 BC008461 mRNA Translation: AAH08461.1 BC028219 mRNA Translation: AAH28219.1
CCDSⁱ	CCDS46351.1 [O43493-2] CCDS56126.1 [O43493-3] CCDS56127.1 [O43493-4]
RefSeqⁱ	NP_001193769.1, NM_001206840.1 NP_001193770.1, NM_001206841.1 NP_001193773.1, NM_001206844.1 [O43493-4] NP_006455.2, NM_006464.3 [O43493-2]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6YAF	electron microscopy	9.10	P	420-434	[»]
SMRⁱ	O43493
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	115864, 466 interactors
IntActⁱ	O43493, 455 interactors
MINTⁱ	O43493
STRINGⁱ	9606.ENSP00000386443

PTM databases

GlyConnectⁱ	2945, 3 N-Linked glycans (1 site)
GlyGenⁱ	O43493, 13 sites, 1 O-linked glycan (4 sites)
iPTMnetⁱ	O43493
PhosphoSitePlusⁱ	O43493

Genetic variation databases

BioMutaⁱ	TGOLN2

BioMutaⁱ

TGOLN2

Proteomic databases

EPDⁱ	O43493
jPOSTⁱ	O43493
MassIVEⁱ	O43493
PaxDbⁱ	O43493
PeptideAtlasⁱ	O43493
PRIDEⁱ	O43493
ProteomicsDBⁱ	30219 30837 48977 [O43493-2] 48978 [O43493-3] 48979 [O43493-4] 48980 [O43493-5] 48981 [O43493-6]

Protocols and materials databases

Antibodypediaⁱ	2516, 329 antibodies
The DNASU plasmid repository More...DNASUⁱ	10618

Genome annotation databases

Ensemblⁱ	ENST00000377386; ENSP00000366603; ENSG00000152291 [O43493-2] ENST00000398263; ENSP00000381312; ENSG00000152291 [O43493-4] ENST00000409015; ENSP00000387035; ENSG00000152291 [O43493-7] ENST00000444342; ENSP00000391190; ENSG00000152291 [O43493-5]
GeneIDⁱ	10618
KEGGⁱ	hsa:10618
UCSCⁱ	uc002soz.4, human [O43493-2] uc021vjw.2, human

Organism-specific databases

CTDⁱ	10618
DisGeNETⁱ	10618
GeneCardsⁱ	TGOLN2
HGNCⁱ	HGNC:15450, TGOLN2
HPAⁱ	ENSG00000152291, Low tissue specificity
MIMⁱ	603062, gene
neXtProtⁱ	NX_O43493
OpenTargetsⁱ	ENSG00000152291
PharmGKBⁱ	PA37959
VEuPathDBⁱ	HostDB:ENSG00000152291
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502S6YU, Eukaryota
GeneTreeⁱ	ENSGT00530000064712
HOGENOMⁱ	CLU_047350_0_0_1
InParanoidⁱ	O43493
OMAⁱ	MATCGNM
OrthoDBⁱ	1481309at2759
PhylomeDBⁱ	O43493
TreeFamⁱ	TF332514

Enzyme and pathway databases

PathwayCommonsⁱ	O43493
Reactomeⁱ	R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-432722, Golgi Associated Vesicle Biogenesis R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-8957275, Post-translational protein phosphorylation

PathwayCommonsⁱ

O43493

Reactomeⁱ

R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-432722, Golgi Associated Vesicle Biogenesis
R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-8957275, Post-translational protein phosphorylation

Miscellaneous databases

BioGRID-ORCSⁱ	10618, 5 hits in 1023 CRISPR screens
ChiTaRSⁱ	TGOLN2, human
GeneWikiⁱ	TGOLN2
GenomeRNAiⁱ	10618
Pharosⁱ	O43493, Tbio
Protein Ontology More...PROⁱ	PR:O43493
RNActⁱ	O43493, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000152291, Expressed in adult mammalian kidney and 257 other tissues
Genevisibleⁱ	O43493, HS

Family and domain databases

MobiDBⁱ	Search...

MobiDBⁱ

Search...

Entry informationⁱ

Entry nameⁱ	TGON2_HUMAN
Accessionⁱ	O43493Primary (citable) accession number: O43493 Secondary accession number(s): B2R686 Q96QL2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	September 18, 2019
	Last modified:	September 29, 2021
	This is version 178 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O43493 (TGON2_HUMAN)

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Trans-Golgi network integral membrane protein 2

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O43493

Isoform 5 [O43493-5]

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