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Entry version 198 (29 Sep 2021)
Sequence version 3 (14 Nov 2003)
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Protein

Aflatoxin B1 aldehyde reductase member 2

Gene

AKR7A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

2 Publications

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=20 µM for succinic semialdehyde1 Publication
  2. KM=17 µM for 2-carboxybenzaldehyde1 Publication
  3. KM=8 µM for 9,10-phenanthrenequinone1 Publication
  4. KM=102 µM for 1,2-naphthoquinone1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei72NADP1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei77Proton donorBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei105Lowers pKa of active site TyrBy similarity1
Binding sitei141SubstrateBy similarity1
Binding sitei197NADP1 Publication1
Binding sitei250NADP1 Publication1
Binding sitei260SubstrateBy similarity1
Binding sitei263SubstrateBy similarity1
Binding sitei359SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi171 – 172NADP1 Publication2
Nucleotide bindingi226 – 236NADP1 PublicationAdd BLAST11
Nucleotide bindingi318 – 326NADP1 Publication9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000053371-MONOMER

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O43488

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5423646, Aflatoxin activation and detoxification

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O43488

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aflatoxin B1 aldehyde reductase member 2 (EC:1.1.1.n11)
Alternative name(s):
AFB1 aldehyde reductase 1
Short name:
AFB1-AR 1
Aldoketoreductase 7
Succinic semialdehyde reductase
Short name:
SSA reductase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKR7A2
Synonyms:AFAR, AFAR1, AKR7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:389, AKR7A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603418, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43488

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000053371

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8574

Open Targets

More...
OpenTargetsi
ENSG00000053371

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24682

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O43488, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AKR7A2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000703751 – 359Aflatoxin B1 aldehyde reductase member 2Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40PhosphoserineBy similarity1
Modified residuei128N6-acetyllysineBy similarity1
Modified residuei236N6-succinyllysineBy similarity1
Modified residuei255PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43488

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43488

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O43488

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43488

PeptideAtlas

More...
PeptideAtlasi
O43488

PRoteomics IDEntifications database

More...
PRIDEi
O43488

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
48966

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00305978
O43488

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
O43488

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43488

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
O43488

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43488

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O43488

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000053371, Expressed in nephron tubule and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O43488, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43488, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000053371, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114142, 50 interactors

Protein interaction database and analysis system

More...
IntActi
O43488, 46 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000235835

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O43488, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O43488

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O43488

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QU2T, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000164191

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023205_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43488

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCKYNGW

Database of Orthologous Groups

More...
OrthoDBi
1226539at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43488

TreeFam database of animal gene trees

More...
TreeFami
TF329173

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023210, NADP_OxRdtase_dom
IPR036812, NADP_OxRdtase_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00248, Aldo_ket_red, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51430, SSF51430, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O43488-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSAASRVVS RAAVHCALRS PPPEARALAM SRPPPPRVAS VLGTMEMGRR
60 70 80 90 100
MDAPASAAAV RAFLERGHTE LDTAFMYSDG QSETILGGLG LGLGGGDCRV
110 120 130 140 150
KIATKANPWD GKSLKPDSVR SQLETSLKRL QCPQVDLFYL HAPDHGTPVE
160 170 180 190 200
ETLHACQRLH QEGKFVELGL SNYASWEVAE ICTLCKSNGW ILPTVYQGMY
210 220 230 240 250
NATTRQVETE LFPCLRHFGL RFYAYNPLAG GLLTGKYKYE DKDGKQPVGR
260 270 280 290 300
FFGNSWAETY RNRFWKEHHF EAIALVEKAL QAAYGASAPS VTSAALRWMY
310 320 330 340 350
HHSQLQGAHG DAVILGMSSL EQLEQNLAAT EEGPLEPAVV DAFNQAWHLV

AHECPNYFR
Length:359
Mass (Da):39,589
Last modified:November 14, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C9775FE4B977D2A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5H7H7C5H7_HUMAN
Aflatoxin B1 aldehyde reductase mem...
AKR7A2
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLU7H3BLU7_HUMAN
Aflatoxin B1 aldehyde reductase mem...
AKR7A2
314Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4Q7H7C4Q7_HUMAN
Aflatoxin B1 aldehyde reductase mem...
AKR7A2
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC52104 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH04111 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH10852 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH11586 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH12171 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH13996 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP36011 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA76347 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048209135V → M. Corresponds to variant dbSNP:rs6670759Ensembl.1
Natural variantiVAR_017413142A → T2 PublicationsCorresponds to variant dbSNP:rs1043657Ensembl.1
Natural variantiVAR_017414157Q → H1 PublicationCorresponds to variant dbSNP:rs859208Ensembl.1
Natural variantiVAR_060222180E → K. Corresponds to variant dbSNP:rs859210EnsemblClinVar.1
Natural variantiVAR_048210198G → S. Corresponds to variant dbSNP:rs2231200Ensembl.1
Natural variantiVAR_017415214C → Y. Corresponds to variant dbSNP:rs2235794Ensembl.1
Natural variantiVAR_048211255S → N. Corresponds to variant dbSNP:rs2231203Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL035413 Genomic DNA No translation available.
BC004111 mRNA Translation: AAH04111.3 Different initiation.
BC007352 mRNA Translation: AAH07352.2
BC010852 mRNA Translation: AAH10852.1 Different initiation.
BC011586 mRNA Translation: AAH11586.1 Different initiation.
BC012171 mRNA Translation: AAH12171.1 Different initiation.
BC013996 mRNA Translation: AAH13996.1 Different initiation.
AF026947 mRNA Translation: AAC52104.1 Different initiation.
Y16675 mRNA Translation: CAA76347.1 Different initiation.
BT007347 mRNA Translation: AAP36011.1 Different initiation.
BK000395 mRNA Translation: DAA00088.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS194.1

NCBI Reference Sequences

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RefSeqi
NP_003680.2, NM_003689.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000235835; ENSP00000235835; ENSG00000053371

Database of genes from NCBI RefSeq genomes

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GeneIDi
8574

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8574

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035413 Genomic DNA No translation available.
BC004111 mRNA Translation: AAH04111.3 Different initiation.
BC007352 mRNA Translation: AAH07352.2
BC010852 mRNA Translation: AAH10852.1 Different initiation.
BC011586 mRNA Translation: AAH11586.1 Different initiation.
BC012171 mRNA Translation: AAH12171.1 Different initiation.
BC013996 mRNA Translation: AAH13996.1 Different initiation.
AF026947 mRNA Translation: AAC52104.1 Different initiation.
Y16675 mRNA Translation: CAA76347.1 Different initiation.
BT007347 mRNA Translation: AAP36011.1 Different initiation.
BK000395 mRNA Translation: DAA00088.1
CCDSiCCDS194.1
RefSeqiNP_003680.2, NM_003689.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BP1X-ray2.40A/B/C/D1-359[»]
SMRiO43488
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114142, 50 interactors
IntActiO43488, 46 interactors
STRINGi9606.ENSP00000235835

PTM databases

iPTMnetiO43488
MetOSiteiO43488
PhosphoSitePlusiO43488
SwissPalmiO43488

Genetic variation databases

BioMutaiAKR7A2

2D gel databases

REPRODUCTION-2DPAGEiIPI00305978
O43488
UCD-2DPAGEiO43488

Proteomic databases

EPDiO43488
jPOSTiO43488
MassIVEiO43488
PaxDbiO43488
PeptideAtlasiO43488
PRIDEiO43488
ProteomicsDBi48966

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29614, 277 antibodies

The DNASU plasmid repository

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DNASUi
8574

Genome annotation databases

EnsembliENST00000235835; ENSP00000235835; ENSG00000053371
GeneIDi8574
KEGGihsa:8574

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8574
DisGeNETi8574

GeneCards: human genes, protein and diseases

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GeneCardsi
AKR7A2
HGNCiHGNC:389, AKR7A2
HPAiENSG00000053371, Low tissue specificity
MIMi603418, gene
neXtProtiNX_O43488
OpenTargetsiENSG00000053371
PharmGKBiPA24682
VEuPathDBiHostDB:ENSG00000053371

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QU2T, Eukaryota
GeneTreeiENSGT00940000164191
HOGENOMiCLU_023205_1_1_1
InParanoidiO43488
OMAiTCKYNGW
OrthoDBi1226539at2759
PhylomeDBiO43488
TreeFamiTF329173

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000053371-MONOMER
PathwayCommonsiO43488
ReactomeiR-HSA-5423646, Aflatoxin activation and detoxification
SABIO-RKiO43488

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8574, 4 hits in 1024 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AKR7A2, human
EvolutionaryTraceiO43488

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AKR7A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8574
PharosiO43488, Tbio

Protein Ontology

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PROi
PR:O43488
RNActiO43488, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000053371, Expressed in nephron tubule and 236 other tissues
ExpressionAtlasiO43488, baseline and differential
GenevisibleiO43488, HS

Family and domain databases

Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR023210, NADP_OxRdtase_dom
IPR036812, NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248, Aldo_ket_red, 1 hit
SUPFAMiSSF51430, SSF51430, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARK72_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43488
Secondary accession number(s): O75749, Q5TG63
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 14, 2003
Last modified: September 29, 2021
This is version 198 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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