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Entry version 155 (02 Dec 2020)
Sequence version 2 (03 Apr 2002)
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Protein

Protein Mis18-beta

Gene

OIP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi80ZincPROSITE-ProRule annotation1
Metal bindingi83ZincPROSITE-ProRule annotation1
Metal bindingi137ZincPROSITE-ProRule annotation1
Metal bindingi140ZincPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
O43482

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Mis18-beta
Alternative name(s):
Cancer/testis antigen 86
Short name:
CT86
Opa-interacting protein 51 Publication
Short name:
OIP-51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OIP51 Publication
Synonyms:MIS18B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000104147.8

Human Gene Nomenclature Database

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HGNCi
HGNC:20300, OIP5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606020, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O43482

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi77V → E: Abolishes interaction with MIS18A; when associated with D-172. 1 Publication1
Mutagenesisi172Y → D: Abolishes interaction with MIS18A; when associated with E-77. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
11339

Open Targets

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OpenTargetsi
ENSG00000104147

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134887641

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
O43482, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
OIP5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000580381 – 229Protein Mis18-betaAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphothreonineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei221PhosphothreonineCombined sources1
Modified residuei225PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O43482

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O43482

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O43482

MaxQB - The MaxQuant DataBase

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MaxQBi
O43482

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O43482

PeptideAtlas

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PeptideAtlasi
O43482

PRoteomics IDEntifications database

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PRIDEi
O43482

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
48965

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O43482

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O43482

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000104147, Expressed in oocyte and 141 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43482, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43482, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000104147, Tissue enhanced (lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, and heterodimer with MIS18A (PubMed:17199038, PubMed:26921242).

Identified in a complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4 (PubMed:17199038). Binds outer membrane protein OpaP from Neisseria gonorrhoeae (in vitro) (PubMed:9466265).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O43482
With#Exp.IntAct
A1CF [Q9NQ94]3EBI-536879,EBI-2809489
ABI2 - isoform 2 [Q9NYB9-2]3EBI-536879,EBI-11096309
ABI3 [Q9P2A4]3EBI-536879,EBI-742038
AGXT [P21549]3EBI-536879,EBI-727098
BCAS2 [O75934]3EBI-536879,EBI-1050106
BEX2 [Q9BXY8]3EBI-536879,EBI-745073
BFSP2 [Q13515]3EBI-536879,EBI-10229433
BLOC1S5 [Q8TDH9]3EBI-536879,EBI-465861
C1orf94 [Q6P1W5]6EBI-536879,EBI-946029
C20orf85 [Q9H1P6]3EBI-536879,EBI-12155483
C7orf31 [Q8N865]3EBI-536879,EBI-10174456
CBY2 - isoform 2 [Q8NA61-2]3EBI-536879,EBI-11524851
CCDC22 [O60826]3EBI-536879,EBI-3943153
CCDC24 [Q8N4L8]5EBI-536879,EBI-1104933
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-536879,EBI-10175300
CDR2L [Q86X02]3EBI-536879,EBI-11063830
CEP170P1 [Q96L14]3EBI-536879,EBI-743488
CEP57 - isoform 3 [Q86XR8-3]3EBI-536879,EBI-11752486
CERK [Q8TCT0]3EBI-536879,EBI-10274247
CHCHD2 [Q9Y6H1]3EBI-536879,EBI-2321769
COX5B [P10606]3EBI-536879,EBI-1053725
CRACR2A [Q9BSW2]3EBI-536879,EBI-739773
CTNNA3 - isoform 2 [Q9UI47-2]3EBI-536879,EBI-11962928
DMRT3 [Q9NQL9]3EBI-536879,EBI-9679045
DTNBP1 [Q96EV8]3EBI-536879,EBI-465804
DTX2 [Q86UW9]3EBI-536879,EBI-740376
DUSP21 [Q9H596]3EBI-536879,EBI-7357329
EFHC1 [Q5JVL4]3EBI-536879,EBI-743105
EIF4ENIF1 [Q9NRA8]3EBI-536879,EBI-301024
ESS2 [Q96DF8]3EBI-536879,EBI-3928124
EURL - isoform 3 [Q9NYK6-3]3EBI-536879,EBI-13371226
FAM161B [Q96MY7]4EBI-536879,EBI-7225287
FAM222B [Q8WU58]3EBI-536879,EBI-2807642
FSD2 [A1L4K1]3EBI-536879,EBI-5661036
GADD45GIP1 [Q8TAE8]3EBI-536879,EBI-372506
GCC1 [Q96CN9]3EBI-536879,EBI-746252
GEM [P55040]3EBI-536879,EBI-744104
GLIS2 [Q9BZE0]3EBI-536879,EBI-7251368
GPANK1 [O95872]3EBI-536879,EBI-751540
GPS2 [Q13227]5EBI-536879,EBI-713355
HAPLN2 [Q9GZV7]3EBI-536879,EBI-11956675
HGS [O14964]3EBI-536879,EBI-740220
HOXB5 [P09067]3EBI-536879,EBI-3893317
HOXB9 [P17482]3EBI-536879,EBI-745290
HOXC8 [P31273]3EBI-536879,EBI-1752118
HSF4 - isoform HSF4A [Q9ULV5-2]5EBI-536879,EBI-12056251
IL16 - isoform 2 [Q14005-2]3EBI-536879,EBI-17178971
KANK2 [Q63ZY3]3EBI-536879,EBI-2556193
KIF9 [Q9HAQ2]3EBI-536879,EBI-8472129
KLHL38 [Q2WGJ6]3EBI-536879,EBI-6426443
KLHL42 [Q9P2K6]3EBI-536879,EBI-739890
KNSTRN [Q9Y448]3EBI-536879,EBI-373334
KRT14 [P02533]3EBI-536879,EBI-702178
KRT15 [P19012]4EBI-536879,EBI-739566
KRT27 [Q7Z3Y8]3EBI-536879,EBI-3044087
KRT3 [P12035]3EBI-536879,EBI-2430095
KRT35 [Q92764]3EBI-536879,EBI-1058674
KRT37 [O76014]3EBI-536879,EBI-1045716
KRT40 [Q6A162]3EBI-536879,EBI-10171697
KRT6B [P04259]3EBI-536879,EBI-740907
KRT75 [O95678]5EBI-536879,EBI-2949715
KRT81 [Q14533]5EBI-536879,EBI-739648
KRT83 [P78385]3EBI-536879,EBI-10221390
KRT86 [O43790]3EBI-536879,EBI-9996498
KRTAP13-2 [Q52LG2]3EBI-536879,EBI-11953846
KRTAP19-5 [Q3LI72]3EBI-536879,EBI-1048945
KRTAP19-6 [Q3LI70]3EBI-536879,EBI-12805508
LENG1 [Q96BZ8]3EBI-536879,EBI-726510
MED4 [Q9NPJ6]3EBI-536879,EBI-394607
MEIS2 - isoform 4 [O14770-4]3EBI-536879,EBI-8025850
MIIP [Q5JXC2]3EBI-536879,EBI-2801965
MIS18A [Q9NYP9]23EBI-536879,EBI-1104552
MIS18BP1 [Q6P0N0]4EBI-536879,EBI-9870821
MISP [Q8IVT2]3EBI-536879,EBI-2555085
MORN3 [Q6PF18]3EBI-536879,EBI-9675802
MYEF2 - isoform 2 [Q9P2K5-2]5EBI-536879,EBI-10318831
MYRIP [Q8NFW9]3EBI-536879,EBI-1759414
NDUFAB1 [O14561]3EBI-536879,EBI-1246261
NECAB2 - isoform 2 [Q7Z6G3-2]6EBI-536879,EBI-10172876
NUP54 [Q7Z3B4]3EBI-536879,EBI-741048
NUP62 [P37198]6EBI-536879,EBI-347978
itself4EBI-536879,EBI-536879
P4HA3 [Q7Z4N8]3EBI-536879,EBI-10181968
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-536879,EBI-11022007
PHETA1 - isoform 4 [Q8N4B1-4]3EBI-536879,EBI-14131832
PITX2 - isoform PTX2C [Q99697-2]3EBI-536879,EBI-12138495
PLAGL2 [Q9UPG8]3EBI-536879,EBI-2876622
POLR2J [P52435]3EBI-536879,EBI-394753
POU6F2 [P78424]3EBI-536879,EBI-12029004
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-536879,EBI-12000762
PRR35 [P0CG20]3EBI-536879,EBI-11986293
PSMB1 [P20618]3EBI-536879,EBI-372273
RAB26 [Q9ULW5]3EBI-536879,EBI-958239
RABGEF1 - isoform 3 [Q9UJ41-4]3EBI-536879,EBI-14093916
RAF1 [P04049]4EBI-536879,EBI-365996
RIBC1 [Q8N443]3EBI-536879,EBI-10265323
RUNX1T1 - isoform MTG8A [Q06455-2]3EBI-536879,EBI-11984663
RUSC1 [Q9BVN2]3EBI-536879,EBI-6257312
S100Z [Q8WXG8]3EBI-536879,EBI-12198403
SAMD7 [Q7Z3H4]3EBI-536879,EBI-12148649
SAXO1 [Q8IYX7]3EBI-536879,EBI-3957636
SHISA6 [Q6ZSJ9]6EBI-536879,EBI-12037847
SKIL [P12757]3EBI-536879,EBI-2902468
SMARCE1 [Q969G3]3EBI-536879,EBI-455078
SNRNP25 [Q9BV90]3EBI-536879,EBI-9675976
SNRPB - isoform SM-B [P14678-2]3EBI-536879,EBI-372475
SOHLH1 [Q5JUK2]3EBI-536879,EBI-12288855
SORBS3 [O60504]3EBI-536879,EBI-741237
SPATA24 - isoform 2 [Q86W54-2]3EBI-536879,EBI-12041693
TEKT3 [Q9BXF9]5EBI-536879,EBI-8644516
TEX12 [Q9BXU0]3EBI-536879,EBI-12090309
TFAP2D [Q7Z6R9]5EBI-536879,EBI-11952651
TFIP11 [Q9UBB9]6EBI-536879,EBI-1105213
TIMM8A [O60220]3EBI-536879,EBI-1049822
TLX3 [O43711]3EBI-536879,EBI-3939165
TPM3 [P06753]12EBI-536879,EBI-355607
TPM3 [Q5VU62]5EBI-536879,EBI-10184033
TPRX1 - isoform 2 [Q8N7U7-2]5EBI-536879,EBI-14115717
TRIB3 [Q96RU7]3EBI-536879,EBI-492476
TRIM74 - isoform 2 [Q86UV6-2]3EBI-536879,EBI-10259086
TRIP6 [Q15654]4EBI-536879,EBI-742327
TROAP [Q12815]3EBI-536879,EBI-2349743
USHBP1 [Q8N6Y0]3EBI-536879,EBI-739895
USP2 [O75604]3EBI-536879,EBI-743272
USP54 - isoform 6 [Q70EL1-9]3EBI-536879,EBI-11975223
YTHDF1 [Q9BYJ9]3EBI-536879,EBI-1051237
ZIC1 [Q15915]5EBI-536879,EBI-11963196
ZNF417 [Q8TAU3]3EBI-536879,EBI-740727
ZNF655 [Q8N720]3EBI-536879,EBI-625509

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116467, 204 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3272, Mis18 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O43482

Protein interaction database and analysis system

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IntActi
O43482, 154 interactors

Molecular INTeraction database

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MINTi
O43482

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000220514

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O43482, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43482

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini75 – 174Mis18PROSITE-ProRule annotationAdd BLAST100

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mis18 family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502S5R3, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000154267

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43482

Identification of Orthologs from Complete Genome Data

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OMAi
KIMLTHT

Database of Orthologous Groups

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OrthoDBi
1253924at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O43482

TreeFam database of animal gene trees

More...
TreeFami
TF330739

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034752, Mis18
IPR004910, Yippee/Mis18/Cereblon

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03226, Yippee-Mis18, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51793, MIS18, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O43482-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQPLRHRS RCATPPRGDF CGGTERAIDQ ASFTTSMEWD TQVVKGSSPL
60 70 80 90 100
GPAGLGAEEP AAGPQLPSWL QPERCAVFQC AQCHAVLADS VHLAWDLSRS
110 120 130 140 150
LGAVVFSRVT NNVVLEAPFL VGIEGSLKGS TYNLLFCGSC GIPVGFHLYS
160 170 180 190 200
THAALAALRG HFCLSSDKMV CYLLKTKAIV NASEMDIQNV PLSEKIAELK
210 220
EKIVLTHNRL KSLMKILSEV TPDQSKPEN
Length:229
Mass (Da):24,691
Last modified:April 3, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EBD4006193A3106
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKL4H0YKL4_HUMAN
Protein yippee-like
OIP5 YPEL
162Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC39561 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF025441 mRNA Translation: AAC39561.1 Different initiation.
BC015050 mRNA Translation: AAH15050.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10074.1

NCBI Reference Sequences

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RefSeqi
NP_001304789.1, NM_001317860.1
NP_009211.1, NM_007280.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000220514; ENSP00000220514; ENSG00000104147

Database of genes from NCBI RefSeq genomes

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GeneIDi
11339

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11339

UCSC genome browser

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UCSCi
uc001znp.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025441 mRNA Translation: AAC39561.1 Different initiation.
BC015050 mRNA Translation: AAH15050.1
CCDSiCCDS10074.1
RefSeqiNP_001304789.1, NM_001317860.1
NP_009211.1, NM_007280.1

3D structure databases

SMRiO43482
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116467, 204 interactors
ComplexPortaliCPX-3272, Mis18 complex
CORUMiO43482
IntActiO43482, 154 interactors
MINTiO43482
STRINGi9606.ENSP00000220514

PTM databases

iPTMnetiO43482
PhosphoSitePlusiO43482

Polymorphism and mutation databases

BioMutaiOIP5

Proteomic databases

EPDiO43482
jPOSTiO43482
MassIVEiO43482
MaxQBiO43482
PaxDbiO43482
PeptideAtlasiO43482
PRIDEiO43482
ProteomicsDBi48965

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23263, 122 antibodies

Genome annotation databases

EnsembliENST00000220514; ENSP00000220514; ENSG00000104147
GeneIDi11339
KEGGihsa:11339
UCSCiuc001znp.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11339
DisGeNETi11339
EuPathDBiHostDB:ENSG00000104147.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OIP5
HGNCiHGNC:20300, OIP5
HPAiENSG00000104147, Tissue enhanced (lymphoid tissue, testis)
MIMi606020, gene
neXtProtiNX_O43482
OpenTargetsiENSG00000104147
PharmGKBiPA134887641

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S5R3, Eukaryota
GeneTreeiENSGT00940000154267
InParanoidiO43482
OMAiKIMLTHT
OrthoDBi1253924at2759
PhylomeDBiO43482
TreeFamiTF330739

Enzyme and pathway databases

PathwayCommonsiO43482
ReactomeiR-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
11339, 571 hits in 852 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OIP5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11339
PharosiO43482, Tbio

Protein Ontology

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PROi
PR:O43482
RNActiO43482, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104147, Expressed in oocyte and 141 other tissues
ExpressionAtlasiO43482, baseline and differential
GenevisibleiO43482, HS

Family and domain databases

InterProiView protein in InterPro
IPR034752, Mis18
IPR004910, Yippee/Mis18/Cereblon
PfamiView protein in Pfam
PF03226, Yippee-Mis18, 1 hit
PROSITEiView protein in PROSITE
PS51793, MIS18, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMS18B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43482
Secondary accession number(s): Q96BX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: April 3, 2002
Last modified: December 2, 2020
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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