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UniProtKB - O43451 (MGA_HUMAN)

Protein

Maltase-glucoamylase, intestinal

Gene

MGAM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei529NucleophilePROSITE-ProRule annotation1
Active sitei532By similarity1
Active sitei1420NucleophilePROSITE-ProRule annotation1
Active sitei1423By similarity1
Active sitei1526Proton donorBy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionGlycosidase, Hydrolase, Multifunctional enzyme

Enzyme and pathway databases

BRENDAi3.2.1.20 2681
3.2.1.3 2681
ReactomeiR-HSA-189085 Digestion of dietary carbohydrate
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

CAZyiGH31 Glycoside Hydrolase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
Maltase-glucoamylase, intestinal
Including the following 2 domains:
Maltase (EC:3.2.1.20)
Alternative name(s):
Alpha-glucosidase
Glucoamylase (EC:3.2.1.3)
Alternative name(s):
Glucan 1,4-alpha-glucosidase
Gene namesi
Name:MGAM
Synonyms:MGA, MGAML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000257335.8
HGNCiHGNC:7043 MGAM
MIMi154360 gene
neXtProtiNX_O43451

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini35 – 1857LumenalSequence analysisAdd BLAST1823

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8972
OpenTargetsiENSG00000257335
PharmGKBiPA30778

Chemistry databases

ChEMBLiCHEMBL2074
DrugBankiDB00284 Acarbose
DB00491 Miglitol
DB04878 Voglibose
GuidetoPHARMACOLOGYi2627

Polymorphism and mutation databases

BioMutaiMGAM

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001853631 – 1857Maltase-glucoamylase, intestinalAdd BLAST1857

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi90 ↔ 118PROSITE-ProRule annotation
Disulfide bondi101 ↔ 117PROSITE-ProRule annotation1 Publication
Disulfide bondi112 ↔ 130PROSITE-ProRule annotation1 Publication
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei416SulfotyrosineSequence analysis1
Modified residuei425SulfotyrosineSequence analysis1
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi479N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi659 ↔ 670PROSITE-ProRule annotation1 Publication
Glycosylationi707N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi749N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi827N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi885N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi912N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi966 ↔ 983PROSITE-ProRule annotation
Glycosylationi977N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi978 ↔ 996PROSITE-ProRule annotation
Glycosylationi989N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1255N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1282SulfotyrosineSequence analysis1
Glycosylationi1323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1388N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1603N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1672N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1842N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1847N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N- and O-glycosylated.1 Publication
Does not undergo intracellular or extracellular proteolytic cleavage.
Sulfated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PaxDbiO43451
PeptideAtlasiO43451
PRIDEiO43451
ProteomicsDBi48955

PTM databases

iPTMnetiO43451
PhosphoSitePlusiO43451

Expressioni

Tissue specificityi

Expressed in small intestine, granulocyte, and kidney but not in salivary gland or pancreas.

Gene expression databases

BgeeiENSG00000257335 Expressed in 122 organ(s), highest expression level in jejunal mucosa
CleanExiHS_MGA
HS_MGAM
ExpressionAtlasiO43451 baseline and differential
GenevisibleiO43451 HS

Organism-specific databases

HPAiHPA002270

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi114462, 1 interactor
CORUMiO43451
IntActiO43451, 8 interactors
STRINGi9606.ENSP00000447378

Chemistry databases

BindingDBiO43451

Structurei

Secondary structure

11857
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43451
SMRiO43451
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43451

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 134P-type 1PROSITE-ProRule annotationAdd BLAST47
Domaini954 – 1000P-type 2PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 915MaltaseAdd BLAST718
Regioni1067 – 1813GlucoamylaseAdd BLAST747

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 84Ser/Thr-richAdd BLAST47

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1065 Eukaryota
COG1501 LUCA
GeneTreeiENSGT00760000119229
HOGENOMiHOG000067936
HOVERGENiHBG080721
InParanoidiO43451
KOiK12047
PhylomeDBiO43451
TreeFamiTF314577

Family and domain databases

CDDicd00111 Trefoil, 2 hits
Gene3Di2.60.40.1180, 4 hits
InterProiView protein in InterPro
IPR031727 Gal_mutarotase_N
IPR011013 Gal_mutarotase_sf_dom
IPR000322 Glyco_hydro_31
IPR030458 Glyco_hydro_31_AS
IPR030459 Glyco_hydro_31_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
PfamiView protein in Pfam
PF01055 Glyco_hydro_31, 2 hits
PF16863 NtCtMGAM_N, 2 hits
PF00088 Trefoil, 2 hits
SMARTiView protein in SMART
SM00018 PD, 2 hits
SUPFAMiSSF51445 SSF51445, 2 hits
SSF74650 SSF74650, 2 hits
PROSITEiView protein in PROSITE
PS00129 GLYCOSYL_HYDROL_F31_1, 2 hits
PS00707 GLYCOSYL_HYDROL_F31_2, 1 hit
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O43451-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARKKLKKFT TLEIVLSVLL LVLFIISIVL IVLLAKESLK STAPDPGTTG 
        60         70         80         90        100
TPDPGTTGTP DPGTTGTTHA RTTGPPDPGT TGTTPVSAEC PVVNELERIN 
       110        120        130        140        150
CIPDQPPTKA TCDQRGCCWN PQGAVSVPWC YYSKNHSYHV EGNLVNTNAG 
       160        170        180        190        200
FTARLKNLPS SPVFGSNVDN VLLTAEYQTS NRFHFKLTDQ TNNRFEVPHE 
       210        220        230        240        250
HVQSFSGNAA ASLTYQVEIS RQPFSIKVTR RSNNRVLFDS SIGPLLFADQ 
       260        270        280        290        300
FLQLSTRLPS TNVYGLGEHV HQQYRHDMNW KTWPIFNRDT TPNGNGTNLY 
       310        320        330        340        350
GAQTFFLCLE DASGLSFGVF LMNSNAMEVV LQPAPAITYR TIGGILDFYV 
       360        370        380        390        400
FLGNTPEQVV QEYLELIGRP ALPSYWALGF HLSRYEYGTL DNMREVVERN 
       410        420        430        440        450
RAAQLPYDVQ HADIDYMDER RDFTYDSVDF KGFPEFVNEL HNNGQKLVII 
       460        470        480        490        500
VDPAISNNSS SSKPYGPYDR GSDMKIWVNS SDGVTPLIGE VWPGQTVFPD 
       510        520        530        540        550
YTNPNCAVWW TKEFELFHNQ VEFDGIWIDM NEVSNFVDGS VSGCSTNNLN 
       560        570        580        590        600
NPPFTPRILD GYLFCKTLCM DAVQHWGKQY DIHNLYGYSM AVATAEAAKT 
       610        620        630        640        650
VFPNKRSFIL TRSTFAGSGK FAAHWLGDNT ATWDDLRWSI PGVLEFNLFG 
       660        670        680        690        700
IPMVGPDICG FALDTPEELC RRWMQLGAFY PFSRNHNGQG YKDQDPASFG 
       710        720        730        740        750
ADSLLLNSSR HYLNIRYTLL PYLYTLFFRA HSRGDTVARP LLHEFYEDNS 
       760        770        780        790        800
TWDVHQQFLW GPGLLITPVL DEGAEKVMAY VPDAVWYDYE TGSQVRWRKQ 
       810        820        830        840        850
KVEMELPGDK IGLHLRGGYI FPTQQPNTTT LASRKNPLGL IIALDENKEA 
       860        870        880        890        900
KGELFWDNGE TKDTVANKVY LLCEFSVTQN RLEVNISQST YKDPNNLAFN 
       910        920        930        940        950
EIKILGTEEP SNVTVKHNGV PSQTSPTVTY DSNLKVAIIT DIDLLLGEAY 
       960        970        980        990       1000
TVEWSIKIRD EEKIDCYPDE NGASAENCTA RGCIWEASNS SGVPFCYFVN 
      1010       1020       1030       1040       1050
DLYSVSDVQY NSHGATADIS LKSSVYANAF PSTPVNPLRL DVTYHKNEML 
      1060       1070       1080       1090       1100
QFKIYDPNKN RYEVPVPLNI PSMPSSTPEG QLYDVLIKKN PFGIEIRRKS 
      1110       1120       1130       1140       1150
TGTIIWDSQL LGFTFSDMFI RISTRLPSKY LYGFGETEHR SYRRDLEWHT 
      1160       1170       1180       1190       1200
WGMFSRDQPP GYKKNSYGVH PYYMGLEEDG SAHGVLLLNS NAMDVTFQPL 
      1210       1220       1230       1240       1250
PALTYRTTGG VLDFYVFLGP TPELVTQQYT ELIGRPVMVP YWSLGFQLCR 
      1260       1270       1280       1290       1300
YGYQNDSEIA SLYDEMVAAQ IPYDVQYSDI DYMERQLDFT LSPKFAGFPA 
      1310       1320       1330       1340       1350
LINRMKADGM RVILILDPAI SGNETQPYPA FTRGVEDDVF IKYPNDGDIV 
      1360       1370       1380       1390       1400
WGKVWPDFPD VVVNGSLDWD SQVELYRAYV AFPDFFRNST AKWWKREIEE 
      1410       1420       1430       1440       1450
LYNNPQNPER SLKFDGMWID MNEPSSFVNG AVSPGCRDAS LNHPPYMPHL 
      1460       1470       1480       1490       1500
ESRDRGLSSK TLCMESQQIL PDGSLVQHYN VHNLYGWSQT RPTYEAVQEV 
      1510       1520       1530       1540       1550
TGQRGVVITR STFPSSGRWA GHWLGDNTAA WDQLKKSIIG MMEFSLFGIS 
      1560       1570       1580       1590       1600
YTGADICGFF QDAEYEMCVR WMQLGAFYPF SRNHNTIGTR RQDPVSWDVA 
      1610       1620       1630       1640       1650
FVNISRTVLQ TRYTLLPYLY TLMHKAHTEG VTVVRPLLHE FVSDQVTWDI 
      1660       1670       1680       1690       1700
DSQFLLGPAF LVSPVLERNA RNVTAYFPRA RWYDYYTGVD INARGEWKTL 
      1710       1720       1730       1740       1750
PAPLDHINLH VRGGYILPWQ EPALNTHLSR QKFMGFKIAL DDEGTAGGWL 
      1760       1770       1780       1790       1800
FWDDGQSIDT YGKGLYYLAS FSASQNTMQS HIIFNNYITG TNPLKLGYIE 
      1810       1820       1830       1840       1850
IWGVGSVPVT SVSISVSGMV ITPSFNNDPT TQVLSIDVTD RNISLHNFTS 

LTWISTL
Length:1,857
Mass (Da):209,852
Last modified:November 25, 2008 - v5
Checksum:i166EEC045C2031F7
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ER45E7ER45_HUMAN
Maltase-glucoamylase, intestinal
MGAM
2,753Annotation score:
A0A0J9YVZ3A0A0J9YVZ3_HUMAN
Maltase-glucoamylase, intestinal
MGAM
2,012Annotation score:
A0A0J9YX77A0A0J9YX77_HUMAN
Maltase-glucoamylase, intestinal
MGAM
1,114Annotation score:
E7EW87E7EW87_HUMAN
Maltase-glucoamylase, intestinal
MGAM
185Annotation score:
E9PEQ5E9PEQ5_HUMAN
Maltase-glucoamylase, intestinal
MGAM
143Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti854L → P in AAI20873 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047350404Q → H. Corresponds to variant dbSNP:rs2272330Ensembl.1
Natural variantiVAR_047351542S → L. Corresponds to variant dbSNP:rs10266732Ensembl.1
Natural variantiVAR_047352858N → D2 PublicationsCorresponds to variant dbSNP:rs2960746Ensembl.1
Natural variantiVAR_0473531638L → I. Corresponds to variant dbSNP:rs9655651Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016833 mRNA Translation: AAC39568.2
AC091684 Genomic DNA Translation: AAP21875.1
AC073647 Genomic DNA Translation: AAS07445.1
AC091742 Genomic DNA No translation available.
BC120872 mRNA Translation: AAI20873.1
CCDSiCCDS47727.1
RefSeqiNP_004659.2, NM_004668.2
UniGeneiHs.122785

Genome annotation databases

EnsembliENST00000549489; ENSP00000447378; ENSG00000257335
ENST00000620571; ENSP00000482292; ENSG00000257335
GeneIDi8972
KEGGihsa:8972
UCSCiuc003vwy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016833 mRNA Translation: AAC39568.2
AC091684 Genomic DNA Translation: AAP21875.1
AC073647 Genomic DNA Translation: AAS07445.1
AC091742 Genomic DNA No translation available.
BC120872 mRNA Translation: AAI20873.1
CCDSiCCDS47727.1
RefSeqiNP_004659.2, NM_004668.2
UniGeneiHs.122785

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QLYX-ray2.00A87-954[»]
2QMJX-ray1.90A87-954[»]
3CTTX-ray2.10A87-954[»]
3L4TX-ray1.90A87-954[»]
3L4UX-ray1.90A87-954[»]
3L4VX-ray2.10A87-954[»]
3L4WX-ray2.00A87-954[»]
3L4XX-ray1.90A87-954[»]
3L4YX-ray1.80A87-954[»]
3L4ZX-ray2.00A87-954[»]
3TONX-ray2.95A/B960-1853[»]
3TOPX-ray2.88A/B960-1853[»]
ProteinModelPortaliO43451
SMRiO43451
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114462, 1 interactor
CORUMiO43451
IntActiO43451, 8 interactors
STRINGi9606.ENSP00000447378

Chemistry databases

BindingDBiO43451
ChEMBLiCHEMBL2074
DrugBankiDB00284 Acarbose
DB00491 Miglitol
DB04878 Voglibose
GuidetoPHARMACOLOGYi2627

Protein family/group databases

CAZyiGH31 Glycoside Hydrolase Family 31

PTM databases

iPTMnetiO43451
PhosphoSitePlusiO43451

Polymorphism and mutation databases

BioMutaiMGAM

Proteomic databases

PaxDbiO43451
PeptideAtlasiO43451
PRIDEiO43451
ProteomicsDBi48955

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000549489; ENSP00000447378; ENSG00000257335
ENST00000620571; ENSP00000482292; ENSG00000257335
GeneIDi8972
KEGGihsa:8972
UCSCiuc003vwy.4 human

Organism-specific databases

CTDi8972
DisGeNETi8972
EuPathDBiHostDB:ENSG00000257335.8
GeneCardsiMGAM
H-InvDBiHIX0025263
HGNCiHGNC:7043 MGAM
HPAiHPA002270
MIMi154360 gene
neXtProtiNX_O43451
OpenTargetsiENSG00000257335
PharmGKBiPA30778
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1065 Eukaryota
COG1501 LUCA
GeneTreeiENSGT00760000119229
HOGENOMiHOG000067936
HOVERGENiHBG080721
InParanoidiO43451
KOiK12047
PhylomeDBiO43451
TreeFamiTF314577

Enzyme and pathway databases

BRENDAi3.2.1.20 2681
3.2.1.3 2681
ReactomeiR-HSA-189085 Digestion of dietary carbohydrate
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

EvolutionaryTraceiO43451
GeneWikiiMaltase-glucoamylase
GenomeRNAii8972
PROiPR:O43451
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000257335 Expressed in 122 organ(s), highest expression level in jejunal mucosa
CleanExiHS_MGA
HS_MGAM
ExpressionAtlasiO43451 baseline and differential
GenevisibleiO43451 HS

Family and domain databases

CDDicd00111 Trefoil, 2 hits
Gene3Di2.60.40.1180, 4 hits
InterProiView protein in InterPro
IPR031727 Gal_mutarotase_N
IPR011013 Gal_mutarotase_sf_dom
IPR000322 Glyco_hydro_31
IPR030458 Glyco_hydro_31_AS
IPR030459 Glyco_hydro_31_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
PfamiView protein in Pfam
PF01055 Glyco_hydro_31, 2 hits
PF16863 NtCtMGAM_N, 2 hits
PF00088 Trefoil, 2 hits
SMARTiView protein in SMART
SM00018 PD, 2 hits
SUPFAMiSSF51445 SSF51445, 2 hits
SSF74650 SSF74650, 2 hits
PROSITEiView protein in PROSITE
PS00129 GLYCOSYL_HYDROL_F31_1, 2 hits
PS00707 GLYCOSYL_HYDROL_F31_2, 1 hit
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMGA_HUMAN
AccessioniPrimary (citable) accession number: O43451
Secondary accession number(s): Q0VAX6, Q75ME7, Q86UM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 165 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  7. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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