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UniProtKB - O43451 (MGA_HUMAN)

Entry version 185 (23 Feb 2022)
Sequence version 6 (23 Feb 2022)
Previous versions | rss
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Protein

Maltase-glucoamylase

Gene

MGAM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alpha-(1,4) exo-glucosidase involved in breakdown of dietary starch oligosaccharides in small intestine. Cleaves the non-reducing alpha-(1,4)-linked glucose residue in linear dextrins with retention of anomeric center stereochemistry (PubMed:12547908, PubMed:18356321, PubMed:27480812, PubMed:18036614, PubMed:22058037).

Mainly hydrolyzes short length oligomaltoses having two to seven glucose residues (PubMed:12547908, PubMed:18356321, PubMed:27480812, PubMed:18036614, PubMed:22058037).

Can cleave alpha-(1,2), alpha-(1,3) and alpha-(1,6) glycosidic linkages with lower efficiency, whereas beta glycosidic linkages are usually not hydrolyzed (PubMed:27480812).

5 Publications

Miscellaneous

The displayed isoform 2 sequence is inferred based on alignments, homology, conservation, expression and longest protein. RNA-seq transcriptomic analysis supports all introns in a single sample. No single full-size mRNA sequence supports this isoform yet, however it is clearly identified by mass spectrometry analysis.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Down-regulated at high oligomaltose concentration as it occurs during the mealtime (PubMed:18356321). Down-regulated by anti-diabetic drug acarbose (PubMed:18036614, PubMed:22058037).3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=8.7 mM for maltose (with ntMGAM)1 Publication
  2. KM=27.1 mM for nigerose (with ntMGAM)1 Publication
  3. KM=11.6 mM for kojibiose (with ntMGAM)1 Publication
  4. KM=6.40 mM for maltose (with ntMGAM)1 Publication
  5. KM=4.44 mM for maltotriose (with ntMGAM)1 Publication
  6. KM=3.39 mM for maltotetraose (with ntMGAM)1 Publication
  7. KM=9.14 mM for maltopentaose (with ntMGAM)1 Publication
  8. KM=9.76 mM for maltohexaose (with ntMGAM)1 Publication
  9. KM=13.12 mM for maltoheptaose (with ntMGAM)1 Publication
  10. KM=5.67 mM for maltose (with ctMGAM)1 Publication
  11. KM=0.91 mM for maltotriose (with ctMGAM)1 Publication
  12. KM=0.96 mM for maltotetraose (with ctMGAM)1 Publication
  13. KM=0.61 mM for maltopentaose (with ctMGAM)1 Publication
  14. KM=1.05 mM for maltohexaose (with ctMGAM)1 Publication
  15. KM=2.27 mM for maltoheptaose (with ctMGAM)1 Publication
  16. KM=4.34 mM for maltopentaose (with ntMGAM)1 Publication
  17. KM=7 mM for maltopentaose (with ntMGAM)1 Publication
  1. Vmax=8.2 µmol/min/mg enzyme toward maltose (with ntMGAM)1 Publication
  2. Vmax=9.58 µmol/min/mg enzyme toward maltotriose (with ntMGAM)1 Publication
  3. Vmax=7.65 µmol/min/mg enzyme toward maltotetraose (with ntMGAM)1 Publication
  4. Vmax=6.97 µmol/min/mg enzyme toward maltopentaose (with ntMGAM)1 Publication
  5. Vmax=7.51 µmol/min/mg enzyme toward maltodextrin (with ntMGAM)1 Publication
  6. Vmax=11 µmol/min/mg enzyme toward alpha-limit dextrin (with ntMGAM)1 Publication

pH dependencei

Optimum pH is 7. Has substantial activity at acidic pH.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Carbohydrate degradation

This protein is involved in Carbohydrate degradation.3 Publications
View all proteins of this organism that are known to be involved in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei289Acarbose1 Publication1
Binding sitei413Acarbose1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei529NucleophilePROSITE-ProRule annotation1
Active sitei532By similarity1
Binding sitei612Acarbose1 Publication1
Binding sitei628Acarbose1 Publication1
Binding sitei686Acarbose1 Publication1
Active sitei1420NucleophilePROSITE-ProRule annotation1
Active sitei1423By similarity1
Active sitei1526Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase, Multifunctional enzyme

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.2.1.20, 2681
3.2.1.3, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43451

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-189085, Digestion of dietary carbohydrate
R-HSA-6798695, Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O43451

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH31, Glycoside Hydrolase Family 31

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Maltase-glucoamylase1 Publication
Alternative name(s):
Alpha-1,4-glucosidase (EC:3.2.1.204 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MGAM1 PublicationImported
Synonyms:MGA, MGAML
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7043, MGAM

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		154360, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43451

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000257335

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini35 – 2753LumenalSequence analysisAdd BLAST2719

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi385Y → W: Decreases alpha-1,4-glucosidase activity toward maltose. 1 Publication1
Mutagenesisi529D → A: Loss of alpha-1,4-glucosidase activity toward maltose. 1 Publication1
Mutagenesisi1251Y → W: Decreases alpha-1,4-glucosidase activity toward maltose. 1 Publication1
Mutagenesisi1357 – 1377Missing : Decreases alpha-1,4-glucosidase activity toward long oligomaltose substrates having four to seven D-glucose residues. 1 PublicationAdd BLAST21

Organism-specific databases

DisGeNET

More...DisGeNETi		8972

Open Targets

More...OpenTargetsi		ENSG00000257335

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30778

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43451, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2074

Drug and drug target database

More...DrugBanki		DB00284, Acarbose
DB00491, Miglitol
DB04878, Voglibose

DrugCentral

More...DrugCentrali		O43451

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2627

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MGAM

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001853631 – 2753Maltase-glucoamylaseAdd BLAST2753

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi90 ↔ 118PROSITE-ProRule annotation
Disulfide bondi101 ↔ 117PROSITE-ProRule annotation1 Publication
Disulfide bondi112 ↔ 130PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei416SulfotyrosineSequence analysis1
Modified residuei425SulfotyrosineSequence analysis1
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi479N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi659 ↔ 670PROSITE-ProRule annotation1 Publication
Glycosylationi707N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi749N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi827N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi885N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi912N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi966 ↔ 983PROSITE-ProRule annotation
Glycosylationi977N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi978 ↔ 996PROSITE-ProRule annotation
Glycosylationi989N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1255N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1282SulfotyrosineSequence analysis1
Glycosylationi1323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1388N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1862 ↔ 1879PROSITE-ProRule annotation
Disulfide bondi1874 ↔ 1892PROSITE-ProRule annotation
Glycosylationi2499N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2568N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2738N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2743N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated.2 Publications
Does not undergo intracellular or extracellular proteolytic cleavage.1 Publication
Sulfated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43451

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43451

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43451

PeptideAtlas

More...PeptideAtlasi		O43451

PRoteomics IDEntifications database

More...PRIDEi		O43451

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48955

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1958, 24 N-Linked glycans (6 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O43451, 24 sites, 24 N-linked glycans (6 sites), 4 O-linked glycans (4 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43451

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43451

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed. Highly expressed in small intestine. Expressed in granulocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000257335, Expressed in jejunal mucosa and 144 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43451, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43451, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000257335, Tissue enhanced (epididymis, intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114462, 9 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O43451

Protein interaction database and analysis system

More...IntActi		O43451, 11 interactors

Molecular INTeraction database

More...MINTi		O43451

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000447378

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O43451

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43451, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12753
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43451

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O43451

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini88 – 134P-type 1PROSITE-ProRule annotationAdd BLAST47
Domaini954 – 1000P-type 2PROSITE-ProRule annotationAdd BLAST47
Domaini1850 – 1896P-type 3PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 87DisorderedSequence analysisAdd BLAST47
Regioni356 – 737Maltase1 PublicationAdd BLAST382
Regioni1221 – 1632Glucoamylase1 PublicationAdd BLAST412

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 87Polar residuesSequence analysisAdd BLAST46

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal maltase domain (ntMGAM) mainly hydrolyzes short length oligomaltoses having two to four glucose residues.4 Publications
The C-terminal glucoamylase domain (ctMGAM) acts on longer maltoside substrates having four to seven glucose residues.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1065, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161540

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000631_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43451

Identification of Orthologs from Complete Genome Data

More...OMAi		TPISAEC

Database of Orthologous Groups

More...OrthoDBi		151244at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43451

TreeFam database of animal gene trees

More...TreeFami		TF314577

Family and domain databases

Conserved Domains Database

More...CDDi		cd00111, Trefoil, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.1180, 4 hits
4.10.110.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031727, Gal_mutarotase_N
IPR011013, Gal_mutarotase_sf_dom
IPR000322, Glyco_hydro_31
IPR030458, Glyco_hydro_31_AS
IPR030459, Glyco_hydro_31_CS
IPR013780, Glyco_hydro_b
IPR017853, Glycoside_hydrolase_SF
IPR017957, P_trefoil_CS
IPR000519, P_trefoil_dom
IPR044913, P_trefoil_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01055, Glyco_hydro_31, 2 hits
PF16863, NtCtMGAM_N, 2 hits
PF00088, Trefoil, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00018, PD, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51445, SSF51445, 2 hits
SSF74650, SSF74650, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00129, GLYCOSYL_HYDROL_F31_1, 2 hits
PS00707, GLYCOSYL_HYDROL_F31_2, 1 hit
PS00025, P_TREFOIL_1, 1 hit
PS51448, P_TREFOIL_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: O43451-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARKKLKKFT TLEIVLSVLL LVLFIISIVL IVLLAKESLK STAPDPGTTG 
        60         70         80         90        100
TPDPGTTGTP DPGTTGTTHA RTTGPPDPGT TGTTPVSAEC PVVNELERIN 
       110        120        130        140        150
CIPDQPPTKA TCDQRGCCWN PQGAVSVPWC YYSKNHSYHV EGNLVNTNAG 
       160        170        180        190        200
FTARLKNLPS SPVFGSNVDN VLLTAEYQTS NRFHFKLTDQ TNNRFEVPHE 
       210        220        230        240        250
HVQSFSGNAA ASLTYQVEIS RQPFSIKVTR RSNNRVLFDS SIGPLLFADQ 
       260        270        280        290        300
FLQLSTRLPS TNVYGLGEHV HQQYRHDMNW KTWPIFNRDT TPNGNGTNLY 
       310        320        330        340        350
GAQTFFLCLE DASGLSFGVF LMNSNAMEVV LQPAPAITYR TIGGILDFYV 
       360        370        380        390        400
FLGNTPEQVV QEYLELIGRP ALPSYWALGF HLSRYEYGTL DNMREVVERN 
       410        420        430        440        450
RAAQLPYDVQ HADIDYMDER RDFTYDSVDF KGFPEFVNEL HNNGQKLVII 
       460        470        480        490        500
VDPAISNNSS SSKPYGPYDR GSDMKIWVNS SDGVTPLIGE VWPGQTVFPD 
       510        520        530        540        550
YTNPNCAVWW TKEFELFHNQ VEFDGIWIDM NEVSNFVDGS VSGCSTNNLN 
       560        570        580        590        600
NPPFTPRILD GYLFCKTLCM DAVQHWGKQY DIHNLYGYSM AVATAEAAKT 
       610        620        630        640        650
VFPNKRSFIL TRSTFAGSGK FAAHWLGDNT ATWDDLRWSI PGVLEFNLFG 
       660        670        680        690        700
IPMVGPDICG FALDTPEELC RRWMQLGAFY PFSRNHNGQG YKDQDPASFG 
       710        720        730        740        750
ADSLLLNSSR HYLNIRYTLL PYLYTLFFRA HSRGDTVARP LLHEFYEDNS 
       760        770        780        790        800
TWDVHQQFLW GPGLLITPVL DEGAEKVMAY VPDAVWYDYE TGSQVRWRKQ 
       810        820        830        840        850
KVEMELPGDK IGLHLRGGYI FPTQQPNTTT LASRKNPLGL IIALDENKEA 
       860        870        880        890        900
KGELFWDNGE TKDTVANKVY LLCEFSVTQN RLEVNISQST YKDPNNLAFN 
       910        920        930        940        950
EIKILGTEEP SNVTVKHNGV PSQTSPTVTY DSNLKVAIIT DIDLLLGEAY 
       960        970        980        990       1000
TVEWSIKIRD EEKIDCYPDE NGASAENCTA RGCIWEASNS SGVPFCYFVN 
      1010       1020       1030       1040       1050
DLYSVSDVQY NSHGATADIS LKSSVYANAF PSTPVNPLRL DVTYHKNEML 
      1060       1070       1080       1090       1100
QFKIYDPNKN RYEVPVPLNI PSMPSSTPEG QLYDVLIKKN PFGIEIRRKS 
      1110       1120       1130       1140       1150
TGTIIWDSQL LGFTFSDMFI RISTRLPSKY LYGFGETEHR SYRRDLEWHT 
      1160       1170       1180       1190       1200
WGMFSRDQPP GYKKNSYGVH PYYMGLEEDG SAHGVLLLNS NAMDVTFQPL 
      1210       1220       1230       1240       1250
PALTYRTTGG VLDFYVFLGP TPELVTQQYT ELIGRPVMVP YWSLGFQLCR 
      1260       1270       1280       1290       1300
YGYQNDSEIA SLYDEMVAAQ IPYDVQYSDI DYMERQLDFT LSPKFAGFPA 
      1310       1320       1330       1340       1350
LINRMKADGM RVILILDPAI SGNETQPYPA FTRGVEDDVF IKYPNDGDIV 
      1360       1370       1380       1390       1400
WGKVWPDFPD VVVNGSLDWD SQVELYRAYV AFPDFFRNST AKWWKREIEE 
      1410       1420       1430       1440       1450
LYNNPQNPER SLKFDGMWID MNEPSSFVNG AVSPGCRDAS LNHPPYMPHL 
      1460       1470       1480       1490       1500
ESRDRGLSSK TLCMESQQIL PDGSLVQHYN VHNLYGWSQT RPTYEAVQEV 
      1510       1520       1530       1540       1550
TGQRGVVITR STFPSSGRWA GHWLGDNTAA WDQLKKSIIG MMEFSLFGIS 
      1560       1570       1580       1590       1600
YTGADICGFF QDAEYEMCVR WMQLGAFYPF SRNHNTIGTR RQDPVSWDAA 
      1610       1620       1630       1640       1650
FVNISRNVLQ TRYTLLPYLY TLMQKAHTEG VTVVRPLLHE FVSDQVTWDI 
      1660       1670       1680       1690       1700
DSQFLLGPAF LVSPVLERNA RNVTAYFPRA RWYDYYTGVD INARGEWKTL 
      1710       1720       1730       1740       1750
PAPLDHINLH VRGGYILPWQ EPALNTHLSR KNPLGLIIAL DENKEAKGEL 
      1760       1770       1780       1790       1800
FWDDGQTKDT VAKKVYLLCE FSVTQNHLEV TISQSTYKDP NNLAFNEIKI 
      1810       1820       1830       1840       1850
LGMEEPSNVT VKHNGVPSQT SPTVTYDSNL KVAIITDINL FLGEAYTVEW 
      1860       1870       1880       1890       1900
SIKIRDEEKI DCYPDENGDS AENCTARGCI WEASNSSGVP FCYFVNDLYS 
      1910       1920       1930       1940       1950
VSDVQYNSHG ATADISLKSS VHANAFPSTP VNPLRLDVTY HKNEMLQFKI 
      1960       1970       1980       1990       2000
YDPNNNRYEV PVPLNIPSVP SSTPEGQLYD VLIKKNPFGI EIRRKSTGTI 
      2010       2020       2030       2040       2050
IWDSQLLGFT FNDMFIRIST RLPSKYLYGF GETEHTSYRR DLEWHTWGMF 
      2060       2070       2080       2090       2100
SRDQPPGYKK NSYGVHPYYM GLEEDGSAHG VLLLNSNAMD VTFQPLPALT 
      2110       2120       2130       2140       2150
YRTTGGVLDF YVFLGPTPEL VTQQYTELIG RPVMVPYWSL GFQLCRYGYQ 
      2160       2170       2180       2190       2200
NDSEISSLYD EMVAAQIPYD VQYSDIDYME RQLDFTLSPK FAGFPALINR 
      2210       2220       2230       2240       2250
MKADGMRVIL ILDPAISGNE TQPYPAFTRG VEDDVFIKYP NDGDIVWGKV 
      2260       2270       2280       2290       2300
WPDFPDVVVN GSLDWDSQVE LYRAYVAFPD FFRNSTAKWW KREIEELYNN 
      2310       2320       2330       2340       2350
PQNPERSLKF DGMWIDMNEP SSFVNGAVSP GCRDASLNHP PYMPYLESRD 
      2360       2370       2380       2390       2400
RGLSSKTLCM ESQQILPDGS PVQHYNVHNL YGWSQTRPTY EAVQEVTGQR 
      2410       2420       2430       2440       2450
GVVITRSTFP SSGRWAGHWL GDNTAAWDQL KKSIIGMMEF SLFGISYTGA 
      2460       2470       2480       2490       2500
DICGFFQDAE YEMCVRWMQL GAFYPFSRNH NTIGTRRQDP VSWDVAFVNI 
      2510       2520       2530       2540       2550
SRTVLQTRYT LLPYLYTLMH KAHTEGVTVV RPLLHEFVSD QVTWDIDSQF 
      2560       2570       2580       2590       2600
LLGPAFLVSP VLERNARNVT AYFPRARWYD YYTGVDINAR GEWKTLPAPL 
      2610       2620       2630       2640       2650
DHINLHVRGG YILPWQEPAL NTHLSRQKFM GFKIALDDEG TAGGWLFWDD 
      2660       2670       2680       2690       2700
GQSIDTYGKG LYYLASFSAS QNTMQSHIIF NNYITGTNPL KLGYIEIWGV 
      2710       2720       2730       2740       2750
GSVPVTSVSI SVSGMVITPS FNNDPTTQVL SIDVTDRNIS LHNFTSLTWI 

STL
Length:2,753
Mass (Da):312,022
Last modified:February 23, 2022 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i148327B7C5E264EF
GO
Isoform 1 (identifier: O43451-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1594-2489: Missing.

Show »
Length:1,857
Mass (Da):209,852
Checksum:i166EEC045C2031F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EW87E7EW87_HUMAN
Maltase-glucoamylase, intestinal
MGAM
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVZ3A0A0J9YVZ3_HUMAN
Maltase-glucoamylase, intestinal
MGAM
2,012Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YX77A0A0J9YX77_HUMAN
Maltase-glucoamylase, intestinal
MGAM
1,114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PEQ5E9PEQ5_HUMAN
Maltase-glucoamylase, intestinal
MGAM
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti854L → P in AAI20873 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047350404Q → H. Corresponds to variant dbSNP:rs2272330Ensembl.1
Natural variantiVAR_047351542S → L. Corresponds to variant dbSNP:rs10266732Ensembl.1
Natural variantiVAR_047352858N → D2 PublicationsCorresponds to variant dbSNP:rs2960746Ensembl.1
Natural variantiVAR_0473532534L → I. Corresponds to variant dbSNP:rs9655651Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0613641594 – 2489Missing in isoform 1. 1 PublicationAdd BLAST896

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF016833 mRNA Translation: AAC39568.2
AC091684 Genomic DNA Translation: AAP21875.1
AC073647 Genomic DNA Translation: AAS07445.1
AC091742 Genomic DNA No translation available.
BC120872 mRNA Translation: AAI20873.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47727.1

NCBI Reference Sequences

More...RefSeqi		NP_004659.2, NM_004668.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000549489; ENSP00000447378; ENSG00000257335
ENST00000620571; ENSP00000482292; ENSG00000257335

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8972

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8972

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000475668.6; ENSP00000417515.2; NM_001365693.1; NP_001352622.1

UCSC genome browser

More...UCSCi		uc003vwy.4, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016833 mRNA Translation: AAC39568.2
AC091684 Genomic DNA Translation: AAP21875.1
AC073647 Genomic DNA Translation: AAS07445.1
AC091742 Genomic DNA No translation available.
BC120872 mRNA Translation: AAI20873.1
CCDSiCCDS47727.1
RefSeqiNP_004659.2, NM_004668.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QLYX-ray2.00A87-954[»]
2QMJX-ray1.90A87-954[»]
3CTTX-ray2.10A87-954[»]
3L4TX-ray1.90A87-954[»]
3L4UX-ray1.90A87-954[»]
3L4VX-ray2.10A87-954[»]
3L4WX-ray2.00A87-954[»]
3L4XX-ray1.90A87-954[»]
3L4YX-ray1.80A87-954[»]
3L4ZX-ray2.00A87-954[»]
3TONX-ray2.95A/B960-1853[»]
3TOPX-ray2.88A/B960-1853[»]
SMRiO43451
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114462, 9 interactors
CORUMiO43451
IntActiO43451, 11 interactors
MINTiO43451
STRINGi9606.ENSP00000447378

Chemistry databases

BindingDBiO43451
ChEMBLiCHEMBL2074
DrugBankiDB00284, Acarbose
DB00491, Miglitol
DB04878, Voglibose
DrugCentraliO43451
GuidetoPHARMACOLOGYi2627

Protein family/group databases

CAZyiGH31, Glycoside Hydrolase Family 31

PTM databases

GlyConnecti1958, 24 N-Linked glycans (6 sites)
GlyGeniO43451, 24 sites, 24 N-linked glycans (6 sites), 4 O-linked glycans (4 sites)
iPTMnetiO43451
PhosphoSitePlusiO43451

Genetic variation databases

BioMutaiMGAM

Proteomic databases

jPOSTiO43451
MassIVEiO43451
PaxDbiO43451
PeptideAtlasiO43451
PRIDEiO43451
ProteomicsDBi48955

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		50132, 38 antibodies from 14 providers

The DNASU plasmid repository

More...DNASUi		8972

Genome annotation databases

EnsembliENST00000549489; ENSP00000447378; ENSG00000257335
ENST00000620571; ENSP00000482292; ENSG00000257335
GeneIDi8972
KEGGihsa:8972
MANE-SelectiENST00000475668.6; ENSP00000417515.2; NM_001365693.1; NP_001352622.1
UCSCiuc003vwy.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8972
DisGeNETi8972

GeneCards: human genes, protein and diseases

More...GeneCardsi		MGAM
HGNCiHGNC:7043, MGAM
HPAiENSG00000257335, Tissue enhanced (epididymis, intestine)
MIMi154360, gene
neXtProtiNX_O43451
OpenTargetsiENSG00000257335
PharmGKBiPA30778
VEuPathDBiHostDB:ENSG00000257335

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1065, Eukaryota
GeneTreeiENSGT00940000161540
HOGENOMiCLU_000631_3_0_1
InParanoidiO43451
OMAiTPISAEC
OrthoDBi151244at2759
PhylomeDBiO43451
TreeFamiTF314577

Enzyme and pathway databases

BRENDAi3.2.1.20, 2681
3.2.1.3, 2681
PathwayCommonsiO43451
ReactomeiR-HSA-189085, Digestion of dietary carbohydrate
R-HSA-6798695, Neutrophil degranulation
SignaLinkiO43451

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8972, 7 hits in 1038 CRISPR screens
EvolutionaryTraceiO43451

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Maltase-glucoamylase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8972
PharosiO43451, Tclin

Protein Ontology

More...PROi		PR:O43451
RNActiO43451, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000257335, Expressed in jejunal mucosa and 144 other tissues
ExpressionAtlasiO43451, baseline and differential
GenevisibleiO43451, HS

Family and domain databases

CDDicd00111, Trefoil, 2 hits
Gene3Di2.60.40.1180, 4 hits
4.10.110.10, 2 hits
InterProiView protein in InterPro
IPR031727, Gal_mutarotase_N
IPR011013, Gal_mutarotase_sf_dom
IPR000322, Glyco_hydro_31
IPR030458, Glyco_hydro_31_AS
IPR030459, Glyco_hydro_31_CS
IPR013780, Glyco_hydro_b
IPR017853, Glycoside_hydrolase_SF
IPR017957, P_trefoil_CS
IPR000519, P_trefoil_dom
IPR044913, P_trefoil_dom_sf
PfamiView protein in Pfam
PF01055, Glyco_hydro_31, 2 hits
PF16863, NtCtMGAM_N, 2 hits
PF00088, Trefoil, 2 hits
SMARTiView protein in SMART
SM00018, PD, 2 hits
SUPFAMiSSF51445, SSF51445, 2 hits
SSF74650, SSF74650, 2 hits
PROSITEiView protein in PROSITE
PS00129, GLYCOSYL_HYDROL_F31_1, 2 hits
PS00707, GLYCOSYL_HYDROL_F31_2, 1 hit
PS00025, P_TREFOIL_1, 1 hit
PS51448, P_TREFOIL_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43451
Secondary accession number(s): E7ER45
, Q0VAX6, Q75ME7, Q86UM5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 23, 2022
Last modified: February 23, 2022
This is version 185 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families
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