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Protein

Voltage-gated potassium channel subunit beta-3

Gene

KCNAB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.1 Publication

GO - Molecular functioni

  • potassium channel regulator activity Source: ProtInc
  • voltage-gated potassium channel activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-3
Alternative name(s):
K(+) channel subunit beta-3
Kv-beta-3
Gene namesi
Name:KCNAB3
Synonyms:KCNA3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000170049.9
HGNCiHGNC:6230 KCNAB3
MIMi604111 gene
neXtProtiNX_O43448

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9196
OpenTargetsiENSG00000170049
PharmGKBiPA30024

Polymorphism and mutation databases

BioMutaiKCNAB3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001487501 – 404Voltage-gated potassium channel subunit beta-3Add BLAST404

Proteomic databases

MaxQBiO43448
PaxDbiO43448
PeptideAtlasiO43448
PRIDEiO43448
ProteomicsDBi48954

PTM databases

iPTMnetiO43448
PhosphoSitePlusiO43448

Expressioni

Tissue specificityi

Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000170049 Expressed in 95 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_KCNAB3
ExpressionAtlasiO43448 baseline and differential
GenevisibleiO43448 HS

Organism-specific databases

HPAiHPA077993

Interactioni

Subunit structurei

Forms heteromultimeric complex with alpha subunits.

Protein-protein interaction databases

BioGridi114631, 7 interactors
IntActiO43448, 2 interactors
STRINGi9606.ENSP00000302719

Structurei

3D structure databases

ProteinModelPortaliO43448
SMRiO43448
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1575 Eukaryota
COG0667 LUCA
GeneTreeiENSGT00550000074567
HOGENOMiHOG000250283
HOVERGENiHBG052216
InParanoidiO43448
KOiK04884
OMAiQMALAWT
OrthoDBiEOG091G0KDN
PhylomeDBiO43448
TreeFamiTF324563

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR005402 K_chnl_volt-dep_bsu_KCNAB3
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PRINTSiPR01580 KCNAB3CHANEL
PR01577 KCNABCHANNEL
SUPFAMiSSF51430 SSF51430, 1 hit
TIGRFAMsiTIGR01293 Kv_beta, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O43448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPAGGGH GNPPGGGGSG
60 70 80 90 100
PKARAALVPR PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT
110 120 130 140 150
FGSQISDETA EDVLTVAYEH GVNLFDTAEV YAAGKAERTL GNILKSKGWR
160 170 180 190 200
RSSYVITTKI FWGGQAETER GLSRKHIIEG LRGSLERLQL GYVDIVFANR
210 220 230 240 250
SDPNCPMEEI VRAMTYVINQ GLALYWGTSR WGAAEIMEAY SMARQFNLIP
260 270 280 290 300
PVCEQAEHHL FQREKVEMQL PELYHKIGVG SVTWYPLACG LITSKYDGRV
310 320 330 340 350
PDTCRASIKG YQWLKDKVQS EDGKKQQAKV MDLLPVAHQL GCTVAQLAIA
360 370 380 390 400
WCLRSEGVSS VLLGVSSAEQ LIEHLGALQV LSQLTPQTVM EIDGLLGNKP

HSKK
Length:404
Mass (Da):43,670
Last modified:February 20, 2007 - v2
Checksum:i57C4FAD8D19D9EBB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L4I8I3L4I8_HUMAN
Voltage-gated potassium channel sub...
KCNAB3
101Annotation score:
I3L0P1I3L0P1_HUMAN
Voltage-gated potassium channel sub...
KCNAB3
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57L → V in AAB92499 (PubMed:9857044).Curated1
Sequence conflicti60R → G in AAB92499 (PubMed:9857044).Curated1
Sequence conflicti65A → G in AAB92499 (PubMed:9857044).Curated1
Sequence conflicti68L → V in AAB92499 (PubMed:9857044).Curated1
Sequence conflicti86 – 88SGL → CGV in AAB92499 (PubMed:9857044).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016411 mRNA Translation: AAB92499.1
BC096232 mRNA Translation: AAH96232.1
BC096234 mRNA Translation: AAH96234.1
BC099634 mRNA Translation: AAH99634.1
CCDSiCCDS11124.1
RefSeqiNP_004723.2, NM_004732.3
UniGeneiHs.435074

Genome annotation databases

EnsembliENST00000303790; ENSP00000302719; ENSG00000170049
GeneIDi9196
KEGGihsa:9196
UCSCiuc002gjm.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016411 mRNA Translation: AAB92499.1
BC096232 mRNA Translation: AAH96232.1
BC096234 mRNA Translation: AAH96234.1
BC099634 mRNA Translation: AAH99634.1
CCDSiCCDS11124.1
RefSeqiNP_004723.2, NM_004732.3
UniGeneiHs.435074

3D structure databases

ProteinModelPortaliO43448
SMRiO43448
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114631, 7 interactors
IntActiO43448, 2 interactors
STRINGi9606.ENSP00000302719

PTM databases

iPTMnetiO43448
PhosphoSitePlusiO43448

Polymorphism and mutation databases

BioMutaiKCNAB3

Proteomic databases

MaxQBiO43448
PaxDbiO43448
PeptideAtlasiO43448
PRIDEiO43448
ProteomicsDBi48954

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303790; ENSP00000302719; ENSG00000170049
GeneIDi9196
KEGGihsa:9196
UCSCiuc002gjm.2 human

Organism-specific databases

CTDi9196
DisGeNETi9196
EuPathDBiHostDB:ENSG00000170049.9
GeneCardsiKCNAB3
H-InvDBiHIX0173736
HGNCiHGNC:6230 KCNAB3
HPAiHPA077993
MIMi604111 gene
neXtProtiNX_O43448
OpenTargetsiENSG00000170049
PharmGKBiPA30024
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1575 Eukaryota
COG0667 LUCA
GeneTreeiENSGT00550000074567
HOGENOMiHOG000250283
HOVERGENiHBG052216
InParanoidiO43448
KOiK04884
OMAiQMALAWT
OrthoDBiEOG091G0KDN
PhylomeDBiO43448
TreeFamiTF324563

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels

Miscellaneous databases

GeneWikiiKCNAB3
GenomeRNAii9196
PROiPR:O43448
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170049 Expressed in 95 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_KCNAB3
ExpressionAtlasiO43448 baseline and differential
GenevisibleiO43448 HS

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR005402 K_chnl_volt-dep_bsu_KCNAB3
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PRINTSiPR01580 KCNAB3CHANEL
PR01577 KCNABCHANNEL
SUPFAMiSSF51430 SSF51430, 1 hit
TIGRFAMsiTIGR01293 Kv_beta, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCAB3_HUMAN
AccessioniPrimary (citable) accession number: O43448
Secondary accession number(s): Q4VAW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: February 20, 2007
Last modified: September 12, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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