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UniProtKB - O43448 (KCAB3_HUMAN)

Protein

Voltage-gated potassium channel subunit beta-3

Gene

KCNAB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • potassium channel regulator activity Source: ProtInc
  • voltage-gated potassium channel activity Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1296072 Voltage gated Potassium channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-3
Alternative name(s):
K(+) channel subunit beta-3
Kv-beta-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNAB3
Synonyms:KCNA3B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000170049.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:6230 KCNAB3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604111 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43448

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9196

Open Targets

More...OpenTargetsi		ENSG00000170049

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30024

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCNAB3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001487501 – 404Voltage-gated potassium channel subunit beta-3Add BLAST404

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43448

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43448

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43448

PeptideAtlas

More...PeptideAtlasi		O43448

PRoteomics IDEntifications database

More...PRIDEi		O43448

ProteomicsDB human proteome resource

More...ProteomicsDBi		48954

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43448

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43448

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170049 Expressed in 95 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...CleanExi		HS_KCNAB3

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43448 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43448 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA077993

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heteromultimeric complex with alpha subunits.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		114631, 7 interactors

Protein interaction database and analysis system

More...IntActi		O43448, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000302719

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O43448

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43448

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the shaker potassium channel beta subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1575 Eukaryota
COG0667 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159306

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000250283

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG052216

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43448

KEGG Orthology (KO)

More...KOi		K04884

Identification of Orthologs from Complete Genome Data

More...OMAi		AYLPWSP

Database of Orthologous Groups

More...OrthoDBi		1106773at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43448

TreeFam database of animal gene trees

More...TreeFami		TF324563

Family and domain databases

Conserved Domains Database

More...CDDi		cd06660 Aldo_ket_red, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.20.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR005402 K_chnl_volt-dep_bsu_KCNAB3
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00248 Aldo_ket_red, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01580 KCNAB3CHANEL
PR01577 KCNABCHANNEL

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51430 SSF51430, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01293 Kv_beta, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O43448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPAGGGH GNPPGGGGSG 
        60         70         80         90        100
PKARAALVPR PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT 
       110        120        130        140        150
FGSQISDETA EDVLTVAYEH GVNLFDTAEV YAAGKAERTL GNILKSKGWR 
       160        170        180        190        200
RSSYVITTKI FWGGQAETER GLSRKHIIEG LRGSLERLQL GYVDIVFANR 
       210        220        230        240        250
SDPNCPMEEI VRAMTYVINQ GLALYWGTSR WGAAEIMEAY SMARQFNLIP 
       260        270        280        290        300
PVCEQAEHHL FQREKVEMQL PELYHKIGVG SVTWYPLACG LITSKYDGRV 
       310        320        330        340        350
PDTCRASIKG YQWLKDKVQS EDGKKQQAKV MDLLPVAHQL GCTVAQLAIA 
       360        370        380        390        400
WCLRSEGVSS VLLGVSSAEQ LIEHLGALQV LSQLTPQTVM EIDGLLGNKP 

HSKK
Length:404
Mass (Da):43,670
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57C4FAD8D19D9EBB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L4I8I3L4I8_HUMAN
Voltage-gated potassium channel sub...
KCNAB3
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0P1I3L0P1_HUMAN
Voltage-gated potassium channel sub...
KCNAB3
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57L → V in AAB92499 (PubMed:9857044).Curated1
Sequence conflicti60R → G in AAB92499 (PubMed:9857044).Curated1
Sequence conflicti65A → G in AAB92499 (PubMed:9857044).Curated1
Sequence conflicti68L → V in AAB92499 (PubMed:9857044).Curated1
Sequence conflicti86 – 88SGL → CGV in AAB92499 (PubMed:9857044).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF016411 mRNA Translation: AAB92499.1
BC096232 mRNA Translation: AAH96232.1
BC096234 mRNA Translation: AAH96234.1
BC099634 mRNA Translation: AAH99634.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11124.1

NCBI Reference Sequences

More...RefSeqi		NP_004723.2, NM_004732.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.435074

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000303790; ENSP00000302719; ENSG00000170049

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9196

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9196

UCSC genome browser

More...UCSCi		uc002gjm.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016411 mRNA Translation: AAB92499.1
BC096232 mRNA Translation: AAH96232.1
BC096234 mRNA Translation: AAH96234.1
BC099634 mRNA Translation: AAH99634.1
CCDSiCCDS11124.1
RefSeqiNP_004723.2, NM_004732.3
UniGeneiHs.435074

3D structure databases

ProteinModelPortaliO43448
SMRiO43448
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114631, 7 interactors
IntActiO43448, 2 interactors
STRINGi9606.ENSP00000302719

PTM databases

iPTMnetiO43448
PhosphoSitePlusiO43448

Polymorphism and mutation databases

BioMutaiKCNAB3

Proteomic databases

jPOSTiO43448
MaxQBiO43448
PaxDbiO43448
PeptideAtlasiO43448
PRIDEiO43448
ProteomicsDBi48954

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303790; ENSP00000302719; ENSG00000170049
GeneIDi9196
KEGGihsa:9196
UCSCiuc002gjm.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9196
DisGeNETi9196
EuPathDBiHostDB:ENSG00000170049.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCNAB3

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0173736
HGNCiHGNC:6230 KCNAB3
HPAiHPA077993
MIMi604111 gene
neXtProtiNX_O43448
OpenTargetsiENSG00000170049
PharmGKBiPA30024

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1575 Eukaryota
COG0667 LUCA
GeneTreeiENSGT00940000159306
HOGENOMiHOG000250283
HOVERGENiHBG052216
InParanoidiO43448
KOiK04884
OMAiAYLPWSP
OrthoDBi1106773at2759
PhylomeDBiO43448
TreeFamiTF324563

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KCNAB3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9196

Protein Ontology

More...PROi		PR:O43448

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170049 Expressed in 95 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_KCNAB3
ExpressionAtlasiO43448 baseline and differential
GenevisibleiO43448 HS

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR005402 K_chnl_volt-dep_bsu_KCNAB3
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PRINTSiPR01580 KCNAB3CHANEL
PR01577 KCNABCHANNEL
SUPFAMiSSF51430 SSF51430, 1 hit
TIGRFAMsiTIGR01293 Kv_beta, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCAB3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43448
Secondary accession number(s): Q4VAW0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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