UniProtKB - O43448 (KCAB3_HUMAN)

BLAST

>sp|O43448|KCAB3_HUMAN Voltage-gated potassium channel subunit beta-3 OS=Homo sapiens OX=9606 GN=KCNAB3 PE=2 SV=2
MQVSIACTEQNLRSRSSEDRLCGPRPGPGGGNGGPAGGGHGNPPGGGGSGPKARAALVPR
PPAPAGALRESTGRGTGMKYRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDVLTVAYEH
GVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEG
LRGSLERLQLGYVDIVFANRSDPNCPMEEIVRAMTYVINQGLALYWGTSRWGAAEIMEAY
SMARQFNLIPPVCEQAEHHLFQREKVEMQLPELYHKIGVGSVTWYPLACGLITSKYDGRV
PDTCRASIKGYQWLKDKVQSEDGKKQQAKVMDLLPVAHQLGCTVAQLAIAWCLRSEGVSS
VLLGVSSAEQLIEHLGALQVLSQLTPQTVMEIDGLLGNKPHSKK

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History
Entry version 143 (12 Sep 2018)
Sequence version 2 (20 Feb 2007)
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Protein

Voltage-gated potassium channel subunit beta-3

Gene

KCNAB3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.1 Publication

GO - Molecular functionⁱ

potassium channel regulator activity
Source: ProtInc
Traceable author statementⁱ
- 9857044
voltage-gated potassium channel activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

potassium ion transport
Source: ProtInc
Traceable author statementⁱ
- 9857044
regulation of ion transmembrane transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Voltage-gated channel
Biological process	Ion transport, Potassium transport, Transport
Ligand	Potassium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1296072 Voltage gated Potassium channels

Reactomeⁱ

R-HSA-1296072 Voltage gated Potassium channels

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Voltage-gated potassium channel subunit beta-3 Alternative name(s): K(+) channel subunit beta-3 Kv-beta-3
Gene namesⁱ	Name:KCNAB3 Synonyms:KCNA3B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170049.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6230 KCNAB3
MIMⁱ	604111 gene
neXtProtⁱ	NX_O43448

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9196
Open Targets More...OpenTargetsⁱ	ENSG00000170049
PharmGKBⁱ	PA30024

Polymorphism and mutation databases

BioMutaⁱ	KCNAB3

BioMutaⁱ

KCNAB3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000148750	1 – 404	Voltage-gated potassium channel subunit beta-3Add BLAST		404

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43448
PaxDbⁱ	O43448
PeptideAtlas More...PeptideAtlasⁱ	O43448
PRIDEⁱ	O43448
ProteomicsDBⁱ	48954

PTM databases

iPTMnetⁱ	O43448
PhosphoSitePlusⁱ	O43448

Expressionⁱ

Tissue specificityⁱ

Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000170049 Expressed in 95 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_KCNAB3
ExpressionAtlasⁱ	O43448 baseline and differential
Genevisibleⁱ	O43448 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA077993

HPAⁱ

HPA077993

Interactionⁱ

Subunit structureⁱ

Forms heteromultimeric complex with alpha subunits.

Protein-protein interaction databases

BioGridⁱ	114631, 7 interactors
IntActⁱ	O43448, 2 interactors
STRINGⁱ	9606.ENSP00000302719

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43448
SMRⁱ	O43448
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

Sequence similaritiesⁱ

Belongs to the shaker potassium channel beta subunit family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1575 Eukaryota COG0667 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074567
HOGENOMⁱ	HOG000250283
HOVERGENⁱ	HBG052216
InParanoidⁱ	O43448
KEGG Orthology (KO) More...KOⁱ	K04884
OMAⁱ	QMALAWT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KDN
PhylomeDBⁱ	O43448
TreeFamⁱ	TF324563

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06660 Aldo_ket_red, 1 hit
Gene3Dⁱ	3.20.20.100, 1 hit
InterProⁱ	View protein in InterPro IPR005983 K_chnl_volt-dep_bsu_KCNAB IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel IPR005402 K_chnl_volt-dep_bsu_KCNAB3 IPR023210 NADP_OxRdtase_dom IPR036812 NADP_OxRdtase_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00248 Aldo_ket_red, 1 hit
PRINTSⁱ	PR01580 KCNAB3CHANEL PR01577 KCNABCHANNEL
SUPFAMⁱ	SSF51430 SSF51430, 1 hit
TIGRFAMsⁱ	TIGR01293 Kv_beta, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

O43448-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPAGGGH GNPPGGGGSG 
        60         70         80         90        100
PKARAALVPR PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT 
       110        120        130        140        150
FGSQISDETA EDVLTVAYEH GVNLFDTAEV YAAGKAERTL GNILKSKGWR 
       160        170        180        190        200
RSSYVITTKI FWGGQAETER GLSRKHIIEG LRGSLERLQL GYVDIVFANR 
       210        220        230        240        250
SDPNCPMEEI VRAMTYVINQ GLALYWGTSR WGAAEIMEAY SMARQFNLIP 
       260        270        280        290        300
PVCEQAEHHL FQREKVEMQL PELYHKIGVG SVTWYPLACG LITSKYDGRV 
       310        320        330        340        350
PDTCRASIKG YQWLKDKVQS EDGKKQQAKV MDLLPVAHQL GCTVAQLAIA 
       360        370        380        390        400
WCLRSEGVSS VLLGVSSAEQ LIEHLGALQV LSQLTPQTVM EIDGLLGNKP 

HSKK

Length:404

Mass (Da):43,670

Last modified:February 20, 2007 - v2

Checksum:ⁱ57C4FAD8D19D9EBB

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

I3L4I8	I3L4I8_HUMAN	Voltage-gated potassium channel sub... Voltage-gated potassium channel subunit beta-3	KCNAB3	101	Annotation score:
I3L0P1	I3L0P1_HUMAN	Voltage-gated potassium channel sub... Voltage-gated potassium channel subunit beta-3	KCNAB3	42	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	57	L → V in AAB92499 (PubMed:9857044).Curated	1
Sequence conflictⁱ	60	R → G in AAB92499 (PubMed:9857044).Curated	1
Sequence conflictⁱ	65	A → G in AAB92499 (PubMed:9857044).Curated	1
Sequence conflictⁱ	68	L → V in AAB92499 (PubMed:9857044).Curated	1
Sequence conflictⁱ	86 – 88	SGL → CGV in AAB92499 (PubMed:9857044).Curated	3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF016411 mRNA Translation: AAB92499.1 BC096232 mRNA Translation: AAH96232.1 BC096234 mRNA Translation: AAH96234.1 BC099634 mRNA Translation: AAH99634.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11124.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004723.2, NM_004732.3
UniGeneⁱ	Hs.435074

Genome annotation databases

Ensemblⁱ	ENST00000303790; ENSP00000302719; ENSG00000170049
GeneIDⁱ	9196
KEGGⁱ	hsa:9196
UCSC genome browser More...UCSCⁱ	uc002gjm.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43448	Uncharacterized protein		NOMLE		404	UniRef100_O43448

Protein	Similar proteins		Species	Score	Length	Source
O43448	Uncharacterized protein		NOMLE		404	UniRef90_O43448
voltage-gated potassium channel subunit beta-3 isoform X3		DELLE		412
voltage-gated potassium channel subunit beta-3 isoform X1		NEOSC		406
Potassium voltage-gated channel subfamily A regulatory beta subunit 3		AILME		406
Potassium voltage-gated channel subfamily A regulatory beta subunit 3		PONAB		405
+82

Protein	Similar proteins		Species	Score	Length	Source
O43448	Uncharacterized protein		NOMLE		404	UniRef50_O43448
voltage-gated potassium channel subunit beta-3 isoform X3		DELLE		412
Potassium voltage-gated channel subfamily A regulatory beta subunit 3		AILME		406
voltage-gated potassium channel subunit beta-3 isoform X1		NEOSC		406
Uncharacterized protein		MUSPF		405
+121

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF016411 mRNA Translation: AAB92499.1 BC096232 mRNA Translation: AAH96232.1 BC096234 mRNA Translation: AAH96234.1 BC099634 mRNA Translation: AAH99634.1
CCDSⁱ	CCDS11124.1
RefSeqⁱ	NP_004723.2, NM_004732.3
UniGeneⁱ	Hs.435074

3D structure databases

ProteinModelPortalⁱ	O43448
SMRⁱ	O43448
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114631, 7 interactors
IntActⁱ	O43448, 2 interactors
STRINGⁱ	9606.ENSP00000302719

PTM databases

iPTMnetⁱ	O43448
PhosphoSitePlusⁱ	O43448

Polymorphism and mutation databases

BioMutaⁱ	KCNAB3

BioMutaⁱ

KCNAB3

Proteomic databases

MaxQBⁱ	O43448
PaxDbⁱ	O43448
PeptideAtlasⁱ	O43448
PRIDEⁱ	O43448
ProteomicsDBⁱ	48954

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000303790; ENSP00000302719; ENSG00000170049
GeneIDⁱ	9196
KEGGⁱ	hsa:9196
UCSCⁱ	uc002gjm.2 human

Organism-specific databases

CTDⁱ	9196
DisGeNETⁱ	9196
EuPathDBⁱ	HostDB:ENSG00000170049.9
GeneCardsⁱ	KCNAB3
H-InvDBⁱ	HIX0173736
HGNCⁱ	HGNC:6230 KCNAB3
HPAⁱ	HPA077993
MIMⁱ	604111 gene
neXtProtⁱ	NX_O43448
OpenTargetsⁱ	ENSG00000170049
PharmGKBⁱ	PA30024
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1575 Eukaryota COG0667 LUCA
GeneTreeⁱ	ENSGT00550000074567
HOGENOMⁱ	HOG000250283
HOVERGENⁱ	HBG052216
InParanoidⁱ	O43448
KOⁱ	K04884
OMAⁱ	QMALAWT
OrthoDBⁱ	EOG091G0KDN
PhylomeDBⁱ	O43448
TreeFamⁱ	TF324563

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1296072 Voltage gated Potassium channels

Reactomeⁱ

R-HSA-1296072 Voltage gated Potassium channels

Miscellaneous databases

GeneWikiⁱ	KCNAB3
GenomeRNAiⁱ	9196
Protein Ontology More...PROⁱ	PR:O43448
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170049 Expressed in 95 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_KCNAB3
ExpressionAtlasⁱ	O43448 baseline and differential
Genevisibleⁱ	O43448 HS

Family and domain databases

CDDⁱ	cd06660 Aldo_ket_red, 1 hit
Gene3Dⁱ	3.20.20.100, 1 hit
InterProⁱ	View protein in InterPro IPR005983 K_chnl_volt-dep_bsu_KCNAB IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel IPR005402 K_chnl_volt-dep_bsu_KCNAB3 IPR023210 NADP_OxRdtase_dom IPR036812 NADP_OxRdtase_dom_sf
Pfamⁱ	View protein in Pfam PF00248 Aldo_ket_red, 1 hit
PRINTSⁱ	PR01580 KCNAB3CHANEL PR01577 KCNABCHANNEL
SUPFAMⁱ	SSF51430 SSF51430, 1 hit
TIGRFAMsⁱ	TIGR01293 Kv_beta, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCAB3_HUMAN
Accessionⁱ	O43448Primary (citable) accession number: O43448 Secondary accession number(s): Q4VAW0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
	Last sequence update:	February 20, 2007
	Last modified:	September 12, 2018
	This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - O43448 (KCAB3_HUMAN)

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Voltage-gated potassium channel subunit beta-3

KCNAB3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ