UniProtKB - O43448 (KCAB3_HUMAN)
Protein
Voltage-gated potassium channel subunit beta-3
Gene
KCNAB3
Organism
Homo sapiens (Human)
Status
Functioni
Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.1 Publication
GO - Molecular functioni
- aldo-keto reductase (NADP) activity Source: GO_Central
- ion channel binding Source: GO_Central
- potassium channel regulator activity Source: GO_Central
- voltage-gated potassium channel activity Source: InterPro
GO - Biological processi
- oxidation-reduction process Source: GO_Central
- potassium ion transport Source: ProtInc
- regulation of potassium ion transmembrane transport Source: GO_Central
Keywordsi
Molecular function | Ion channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
PathwayCommonsi | O43448 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-gated potassium channel subunit beta-3Alternative name(s): K(+) channel subunit beta-3 Kv-beta-3 |
Gene namesi | Name:KCNAB3 Synonyms:KCNA3B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170049.9 |
HGNCi | HGNC:6230, KCNAB3 |
MIMi | 604111, gene |
neXtProti | NX_O43448 |
Subcellular locationi
Other locations
- Cytoplasm Curated
Plasma Membrane
- plasma membrane Source: Reactome
- voltage-gated potassium channel complex Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 9196 |
OpenTargetsi | ENSG00000170049 |
PharmGKBi | PA30024 |
Miscellaneous databases
Pharosi | O43448, Tbio |
Polymorphism and mutation databases
BioMutai | KCNAB3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000148750 | 1 – 404 | Voltage-gated potassium channel subunit beta-3Add BLAST | 404 |
Proteomic databases
jPOSTi | O43448 |
MassIVEi | O43448 |
MaxQBi | O43448 |
PaxDbi | O43448 |
PeptideAtlasi | O43448 |
PRIDEi | O43448 |
ProteomicsDBi | 48954 |
PTM databases
iPTMneti | O43448 |
PhosphoSitePlusi | O43448 |
Expressioni
Tissue specificityi
Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000170049, Expressed in right hemisphere of cerebellum and 117 other tissues |
ExpressionAtlasi | O43448, baseline and differential |
Genevisiblei | O43448, HS |
Organism-specific databases
HPAi | ENSG00000170049, Tissue enhanced (brain, endometrium) |
Interactioni
Subunit structurei
Forms heteromultimeric complex with alpha subunits.
Binary interactionsi
Hide detailsGO - Molecular functioni
- ion channel binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114631, 10 interactors |
IntActi | O43448, 7 interactors |
STRINGi | 9606.ENSP00000302719 |
Miscellaneous databases
RNActi | O43448, protein |
Family & Domainsi
Domaini
Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated
Sequence similaritiesi
Belongs to the shaker potassium channel beta subunit family.Curated
Phylogenomic databases
eggNOGi | KOG1575, Eukaryota |
GeneTreei | ENSGT00940000159306 |
HOGENOMi | CLU_023205_2_0_1 |
InParanoidi | O43448 |
OMAi | SMFNRWI |
OrthoDBi | 1106773at2759 |
PhylomeDBi | O43448 |
TreeFami | TF324563 |
Family and domain databases
CDDi | cd06660, Aldo_ket_red, 1 hit |
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR005983, K_chnl_volt-dep_bsu_KCNAB IPR005399, K_chnl_volt-dep_bsu_KCNAB-rel IPR005402, K_chnl_volt-dep_bsu_KCNAB3 IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PRINTSi | PR01580, KCNAB3CHANEL PR01577, KCNABCHANNEL |
SUPFAMi | SSF51430, SSF51430, 1 hit |
TIGRFAMsi | TIGR01293, Kv_beta, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O43448-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPAGGGH GNPPGGGGSG
60 70 80 90 100
PKARAALVPR PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT
110 120 130 140 150
FGSQISDETA EDVLTVAYEH GVNLFDTAEV YAAGKAERTL GNILKSKGWR
160 170 180 190 200
RSSYVITTKI FWGGQAETER GLSRKHIIEG LRGSLERLQL GYVDIVFANR
210 220 230 240 250
SDPNCPMEEI VRAMTYVINQ GLALYWGTSR WGAAEIMEAY SMARQFNLIP
260 270 280 290 300
PVCEQAEHHL FQREKVEMQL PELYHKIGVG SVTWYPLACG LITSKYDGRV
310 320 330 340 350
PDTCRASIKG YQWLKDKVQS EDGKKQQAKV MDLLPVAHQL GCTVAQLAIA
360 370 380 390 400
WCLRSEGVSS VLLGVSSAEQ LIEHLGALQV LSQLTPQTVM EIDGLLGNKP
HSKK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L0P1 | I3L0P1_HUMAN | Voltage-gated potassium channel sub... | KCNAB3 | 42 | Annotation score: | ||
I3L4I8 | I3L4I8_HUMAN | Voltage-gated potassium channel sub... | KCNAB3 | 101 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 | L → V in AAB92499 (PubMed:9857044).Curated | 1 | |
Sequence conflicti | 60 | R → G in AAB92499 (PubMed:9857044).Curated | 1 | |
Sequence conflicti | 65 | A → G in AAB92499 (PubMed:9857044).Curated | 1 | |
Sequence conflicti | 68 | L → V in AAB92499 (PubMed:9857044).Curated | 1 | |
Sequence conflicti | 86 – 88 | SGL → CGV in AAB92499 (PubMed:9857044).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF016411 mRNA Translation: AAB92499.1 BC096232 mRNA Translation: AAH96232.1 BC096234 mRNA Translation: AAH96234.1 BC099634 mRNA Translation: AAH99634.1 |
CCDSi | CCDS11124.1 |
RefSeqi | NP_004723.2, NM_004732.3 |
Genome annotation databases
Ensembli | ENST00000303790; ENSP00000302719; ENSG00000170049 |
GeneIDi | 9196 |
KEGGi | hsa:9196 |
UCSCi | uc002gjm.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF016411 mRNA Translation: AAB92499.1 BC096232 mRNA Translation: AAH96232.1 BC096234 mRNA Translation: AAH96234.1 BC099634 mRNA Translation: AAH99634.1 |
CCDSi | CCDS11124.1 |
RefSeqi | NP_004723.2, NM_004732.3 |
3D structure databases
SMRi | O43448 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114631, 10 interactors |
IntActi | O43448, 7 interactors |
STRINGi | 9606.ENSP00000302719 |
PTM databases
iPTMneti | O43448 |
PhosphoSitePlusi | O43448 |
Polymorphism and mutation databases
BioMutai | KCNAB3 |
Proteomic databases
jPOSTi | O43448 |
MassIVEi | O43448 |
MaxQBi | O43448 |
PaxDbi | O43448 |
PeptideAtlasi | O43448 |
PRIDEi | O43448 |
ProteomicsDBi | 48954 |
Protocols and materials databases
ABCDi | O43448, 1 sequenced antibody |
Antibodypediai | 12312, 146 antibodies |
Genome annotation databases
Ensembli | ENST00000303790; ENSP00000302719; ENSG00000170049 |
GeneIDi | 9196 |
KEGGi | hsa:9196 |
UCSCi | uc002gjm.2, human |
Organism-specific databases
CTDi | 9196 |
DisGeNETi | 9196 |
EuPathDBi | HostDB:ENSG00000170049.9 |
GeneCardsi | KCNAB3 |
HGNCi | HGNC:6230, KCNAB3 |
HPAi | ENSG00000170049, Tissue enhanced (brain, endometrium) |
MIMi | 604111, gene |
neXtProti | NX_O43448 |
OpenTargetsi | ENSG00000170049 |
PharmGKBi | PA30024 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1575, Eukaryota |
GeneTreei | ENSGT00940000159306 |
HOGENOMi | CLU_023205_2_0_1 |
InParanoidi | O43448 |
OMAi | SMFNRWI |
OrthoDBi | 1106773at2759 |
PhylomeDBi | O43448 |
TreeFami | TF324563 |
Enzyme and pathway databases
PathwayCommonsi | O43448 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels |
Miscellaneous databases
BioGRID-ORCSi | 9196, 2 hits in 845 CRISPR screens |
ChiTaRSi | KCNAB3, human |
GeneWikii | KCNAB3 |
GenomeRNAii | 9196 |
Pharosi | O43448, Tbio |
PROi | PR:O43448 |
RNActi | O43448, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170049, Expressed in right hemisphere of cerebellum and 117 other tissues |
ExpressionAtlasi | O43448, baseline and differential |
Genevisiblei | O43448, HS |
Family and domain databases
CDDi | cd06660, Aldo_ket_red, 1 hit |
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR005983, K_chnl_volt-dep_bsu_KCNAB IPR005399, K_chnl_volt-dep_bsu_KCNAB-rel IPR005402, K_chnl_volt-dep_bsu_KCNAB3 IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PRINTSi | PR01580, KCNAB3CHANEL PR01577, KCNABCHANNEL |
SUPFAMi | SSF51430, SSF51430, 1 hit |
TIGRFAMsi | TIGR01293, Kv_beta, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCAB3_HUMAN | |
Accessioni | O43448Primary (citable) accession number: O43448 Secondary accession number(s): Q4VAW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | February 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM