UniProtKB - O43432 (IF4G3_HUMAN)
Eukaryotic translation initiation factor 4 gamma 3
EIF4G3
Functioni
GO - Molecular functioni
- mRNA binding Source: GO_Central
- RNA binding Source: UniProtKB
- RNA cap binding Source: ProtInc
- translation factor activity, RNA binding Source: ProtInc
- translation initiation factor activity Source: GO_Central
GO - Biological processi
- regulation of translational initiation Source: ProtInc
Keywordsi
Molecular function | Initiation factor, RNA-binding |
Biological process | Protein biosynthesis, Translation regulation |
Enzyme and pathway databases
PathwayCommonsi | O43432 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism |
SIGNORi | O43432 |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic translation initiation factor 4 gamma 3Short name: eIF-4-gamma 3 Short name: eIF-4G 3 Short name: eIF4G 3 Alternative name(s): eIF-4-gamma II Short name: eIF4GII |
Gene namesi | Name:EIF4G3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000075151.20 |
HGNCi | HGNC:3298, EIF4G3 |
MIMi | 603929, gene |
neXtProti | NX_O43432 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Other locations
- eukaryotic translation initiation factor 4F complex Source: GO_Central
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 756 | R → D: Reduces binding to EIF4A; when associated with D-759 and D-764. 1 Publication | 1 | |
Mutagenesisi | 759 | R → D: Reduces binding to EIF4A; when associated with D-756 and D-764. 1 Publication | 1 | |
Mutagenesisi | 764 | K → D: Reduces binding to EIF4A; when associated with D-756 and D-759. 1 Publication | 1 | |
Mutagenesisi | 814 | R → D: Reduces binding to EIF4A; when associated with D-820. 1 Publication | 1 | |
Mutagenesisi | 820 | K → D: Reduces binding to EIF4A; when associated with D-814. 1 Publication | 1 | |
Mutagenesisi | 834 – 835 | RK → DD: Reduces binding to IRES. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 8672 |
OpenTargetsi | ENSG00000075151 |
PharmGKBi | PA27724 |
Miscellaneous databases
Pharosi | O43432, Tbio |
Polymorphism and mutation databases
BioMutai | EIF4G3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213329 | 1 – 1585 | Eukaryotic translation initiation factor 4 gamma 3Add BLAST | 1585 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 168 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 230 | PhosphoserineCombined sources | 1 | |
Modified residuei | 232 | PhosphoserineCombined sources | 1 | |
Modified residuei | 267 | PhosphoserineCombined sources | 1 | |
Modified residuei | 441 | PhosphoserineBy similarity | 1 | |
Modified residuei | 495 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1156 | Phosphoserine; by CaMK11 Publication | 1 | |
Modified residuei | 1218 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1409 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 699 – 700 | Cleavage; by enterovirus/rhinovirus protease 2A | 2 | |
Sitei | 700 – 701 | Cleavage; by foot-and-mouth disease virus leader protease | 2 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O43432 |
jPOSTi | O43432 |
MassIVEi | O43432 |
MaxQBi | O43432 |
PaxDbi | O43432 |
PeptideAtlasi | O43432 |
PRIDEi | O43432 |
ProteomicsDBi | 48943 [O43432-1] 48944 [O43432-2] 48945 [O43432-3] 62418 |
PTM databases
GlyGeni | O43432, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O43432 |
MetOSitei | O43432 |
PhosphoSitePlusi | O43432 |
Expressioni
Gene expression databases
Bgeei | ENSG00000075151, Expressed in sperm and 238 other tissues |
ExpressionAtlasi | O43432, baseline and differential |
Genevisiblei | O43432, HS |
Organism-specific databases
HPAi | ENSG00000075151, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with EIF4A, EIF4E, eIF3 and PABPC1.
Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA (By similarity).
By similarityBinary interactionsi
Isoform 1 [O43432-1]
With | #Exp. | IntAct |
---|---|---|
EIF4E [P06730] | 2 | EBI-15841003,EBI-73440 |
Protein-protein interaction databases
BioGRIDi | 114220, 54 interactors |
ComplexPortali | CPX-5635, Eukaryotic translation initiation factor 4F, EIF4A1 and EIF4G3 variant CPX-5636, Eukaryotic translation initiation factor 4F, EIF4A2 and EIF4G3 variant |
DIPi | DIP-33245N |
ELMi | O43432 |
IntActi | O43432, 32 interactors |
MINTi | O43432 |
STRINGi | 9606.ENSP00000383274 |
Miscellaneous databases
RNActi | O43432, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | O43432 |
SMRi | O43432 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O43432 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 745 – 783 | HEAT 1Add BLAST | 39 | |
Domaini | 755 – 983 | MIF4GPROSITE-ProRule annotationAdd BLAST | 229 | |
Repeati | 784 – 831 | HEAT 2Add BLAST | 48 | |
Repeati | 832 – 905 | HEAT 3Add BLAST | 74 | |
Repeati | 906 – 944 | HEAT 4Add BLAST | 39 | |
Repeati | 945 – 984 | HEAT 5Add BLAST | 40 | |
Domaini | 1221 – 1343 | MIPROSITE-ProRule annotationAdd BLAST | 123 | |
Domaini | 1416 – 1585 | W2PROSITE-ProRule annotationAdd BLAST | 170 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 134 – 162 | PABPC1-bindingAdd BLAST | 29 | |
Regioni | 619 – 630 | EIF4E-bindingBy similarityAdd BLAST | 12 | |
Regioni | 699 – 1019 | eIF3/EIF4A-bindingBy similarityAdd BLAST | 321 | |
Regioni | 1433 – 1585 | EIF4A-bindingBy similarityAdd BLAST | 153 | |
Regioni | 1571 – 1585 | Necessary but not sufficient for MKNK1-bindingBy similarityAdd BLAST | 15 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 447 – 475 | Sequence analysisAdd BLAST | 29 | |
Coiled coili | 994 – 1023 | Sequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0401, Eukaryota |
GeneTreei | ENSGT00940000156454 |
HOGENOMi | CLU_001519_2_0_1 |
InParanoidi | O43432 |
OrthoDBi | 594395at2759 |
PhylomeDBi | O43432 |
TreeFami | TF101527 |
Family and domain databases
Gene3Di | 1.25.40.180, 3 hits |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR037585, EIF4G3 IPR003891, Initiation_fac_eIF4g_MI IPR016021, MIF4-like_sf IPR003890, MIF4G-like_typ-3 IPR003307, W2_domain |
PANTHERi | PTHR23253:SF23, PTHR23253:SF23, 1 hit |
Pfami | View protein in Pfam PF02847, MA3, 1 hit PF02854, MIF4G, 1 hit PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00515, eIF5C, 1 hit SM00544, MA3, 1 hit SM00543, MIF4G, 1 hit |
SUPFAMi | SSF48371, SSF48371, 3 hits |
PROSITEi | View protein in PROSITE PS51366, MI, 1 hit PS51363, W2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM
60 70 80 90 100
VNHLPMPYPV PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG
110 120 130 140 150
PGDFPNAYGT PFYPSQPVYQ SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG
160 170 180 190 200
GKDITEEIMS GGGSRNPTPP IGRPTSTPTP PQQLPSQVPE HSPVVYGTVE
210 220 230 240 250
SAHLAASTPV TAASDQKQEE KPKPDPVLKS PSPVLRLVLS GEKKEQEGQT
260 270 280 290 300
SETTAIVSIA ELPLPPSPTT VSSVARSTIA APTSSALSSQ PIFTTAIDDR
310 320 330 340 350
CELSSPREDT IPIPSLTSCT ETSDPLPTNE NDDDICKKPC SVAPNDIPLV
360 370 380 390 400
SSTNLINEIN GVSEKLSATE SIVEIVKQEV LPLTLELEIL ENPPEEMKLE
410 420 430 440 450
CIPAPITPST VPSFPPTPPT PPASPPHTPV IVPAAATTVS SPSAAITVQR
460 470 480 490 500
VLEEDESIRT CLSEDAKEIQ NKIEVEADGQ TEEILDSQNL NSRRSPVPAQ
510 520 530 540 550
IAITVPKTWK KPKDRTRTTE EMLEAELELK AEEELSIDKV LESEQDKMSQ
560 570 580 590 600
GFHPERDPSD LKKVKAVEEN GEEAEPVRNG AESVSEGEGI DANSGSTDSS
610 620 630 640 650
GDGVTFPFKP ESWKPTDTEG KKQYDREFLL DFQFMPACIQ KPEGLPPISD
660 670 680 690 700
VVLDKINQPK LPMRTLDPRI LPRGPDFTPA FADFGRQTPG GRGVPLLNVG
710 720 730 740 750
SRRSQPGQRR EPRKIITVSV KEDVHLKKAE NAWKPSQKRD SQADDPENIK
760 770 780 790 800
TQELFRKVRS ILNKLTPQMF NQLMKQVSGL TVDTEERLKG VIDLVFEKAI
810 820 830 840 850
DEPSFSVAYA NMCRCLVTLK VPMADKPGNT VNFRKLLLNR CQKEFEKDKA
860 870 880 890 900
DDDVFEKKQK ELEAASAPEE RTRLHDELEE AKDKARRRSI GNIKFIGELF
910 920 930 940 950
KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFEKAKPRMD
960 970 980 990 1000
QYFNQMEKIV KERKTSSRIR FMLQDVIDLR LCNWVSRRAD QGPKTIEQIH
1010 1020 1030 1040 1050
KEAKIEEQEE QRKVQQLMTK EKRRPGVQRV DEGGWNTVQG AKNSRVLDPS
1060 1070 1080 1090 1100
KFLKITKPTI DEKIQLVPKA QLGSWGKGSS GGAKASETDA LRSSASSLNR
1110 1120 1130 1140 1150
FSALQPPAPS GSTPSTPVEF DSRRTLTSRG SMGREKNDKP LPSATARPNT
1160 1170 1180 1190 1200
FMRGGSSKDL LDNQSQEEQR REMLETVKQL TGGVDVERNS TEAERNKTRE
1210 1220 1230 1240 1250
SAKPEISAMS AHDKAALSEE ELERKSKSII DEFLHINDFK EAMQCVEELN
1260 1270 1280 1290 1300
AQGLLHVFVR VGVESTLERS QITRDHMGQL LYQLVQSEKL SKQDFFKGFS
1310 1320 1330 1340 1350
ETLELADDMA IDIPHIWLYL AELVTPMLKE GGISMRELTI EFSKPLLPVG
1360 1370 1380 1390 1400
RAGVLLSEIL HLLCKQMSHK KVGALWREAD LSWKDFLPEG EDVHNFLLEQ
1410 1420 1430 1440 1450
KLDFIESDSP CSSEALSKKE LSAEELYKRL EKLIIEDKAN DEQIFDWVEA
1460 1470 1480 1490 1500
NLDEIQMSSP TFLRALMTAV CKAAIIADSS TFRVDTAVIK QRVPILLKYL
1510 1520 1530 1540 1550
DSDTEKELQA LYALQASIVK LDQPANLLRM FFDCLYDEEV ISEDAFYKWE
1560 1570 1580
SSKDPAEQNG KGVALKSVTA FFTWLREAEE ESEDN
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSA7 | A0A0A0MSA7_HUMAN | Eukaryotic translation initiation f... | EIF4G3 | 1,621 | Annotation score: | ||
A0A0U1RQK7 | A0A0U1RQK7_HUMAN | Eukaryotic translation initiation f... | EIF4G3 | 1,774 | Annotation score: | ||
B1AN91 | B1AN91_HUMAN | Eukaryotic translation initiation f... | EIF4G3 | 217 | Annotation score: | ||
B1AN92 | B1AN92_HUMAN | Eukaryotic translation initiation f... | EIF4G3 | 220 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 159 | M → I in AAH30578 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 333 | D → G in AAH30578 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048924 | 378 | Q → R. Corresponds to variant dbSNP:rs35731992Ensembl. | 1 | |
Natural variantiVAR_034009 | 496 | P → A. Corresponds to variant dbSNP:rs35176330Ensembl. | 1 | |
Natural variantiVAR_048925 | 1185 | D → E. Corresponds to variant dbSNP:rs2230572Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043447 | 10 | P → PGGFRPIQ in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_010487 | 11 | F → FAAGPRPPHHQF in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_043448 | 182 | Missing in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_054502 | 219 – 498 | Missing in isoform 4. 1 PublicationAdd BLAST | 280 | |
Alternative sequenceiVSP_010488 | 499 – 504 | AQIAIT → ETSNEC in isoform 2. 1 Publication | 6 | |
Alternative sequenceiVSP_010489 | 505 – 1585 | Missing in isoform 2. 1 PublicationAdd BLAST | 1081 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF012072 mRNA Translation: AAC02903.2 AL031005 Genomic DNA No translation available. AL358392 Genomic DNA No translation available. AL606477 Genomic DNA No translation available. AL627311 Genomic DNA No translation available. AL672037 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94956.1 BC030578 mRNA Translation: AAH30578.1 BC094683 mRNA Translation: AAH94683.1 BC136643 mRNA Translation: AAI36644.1 Z34918 mRNA Translation: CAA84397.1 |
CCDSi | CCDS214.1 [O43432-1] CCDS55580.1 [O43432-3] CCDS59192.1 [O43432-2] |
PIRi | S49172 |
RefSeqi | NP_001185730.1, NM_001198801.1 NP_001185731.1, NM_001198802.1 [O43432-3] NP_001185732.1, NM_001198803.2 [O43432-2] NP_003751.2, NM_003760.4 [O43432-1] XP_016858189.1, XM_017002700.1 [O43432-1] XP_016858197.1, XM_017002708.1 [O43432-4] XP_016858201.1, XM_017002712.1 |
Genome annotation databases
Ensembli | ENST00000264211; ENSP00000264211; ENSG00000075151 [O43432-1] ENST00000356916; ENSP00000349386; ENSG00000075151 [O43432-2] ENST00000374935; ENSP00000364071; ENSG00000075151 [O43432-4] ENST00000602326; ENSP00000473510; ENSG00000075151 [O43432-3] |
GeneIDi | 8672 |
KEGGi | hsa:8672 |
UCSCi | uc001bee.4, human [O43432-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF012072 mRNA Translation: AAC02903.2 AL031005 Genomic DNA No translation available. AL358392 Genomic DNA No translation available. AL606477 Genomic DNA No translation available. AL627311 Genomic DNA No translation available. AL672037 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94956.1 BC030578 mRNA Translation: AAH30578.1 BC094683 mRNA Translation: AAH94683.1 BC136643 mRNA Translation: AAI36644.1 Z34918 mRNA Translation: CAA84397.1 |
CCDSi | CCDS214.1 [O43432-1] CCDS55580.1 [O43432-3] CCDS59192.1 [O43432-2] |
PIRi | S49172 |
RefSeqi | NP_001185730.1, NM_001198801.1 NP_001185731.1, NM_001198802.1 [O43432-3] NP_001185732.1, NM_001198803.2 [O43432-2] NP_003751.2, NM_003760.4 [O43432-1] XP_016858189.1, XM_017002700.1 [O43432-1] XP_016858197.1, XM_017002708.1 [O43432-4] XP_016858201.1, XM_017002712.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HU3 | X-ray | 2.37 | A | 745-1003 | [»] | |
BMRBi | O43432 | |||||
SMRi | O43432 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114220, 54 interactors |
ComplexPortali | CPX-5635, Eukaryotic translation initiation factor 4F, EIF4A1 and EIF4G3 variant CPX-5636, Eukaryotic translation initiation factor 4F, EIF4A2 and EIF4G3 variant |
DIPi | DIP-33245N |
ELMi | O43432 |
IntActi | O43432, 32 interactors |
MINTi | O43432 |
STRINGi | 9606.ENSP00000383274 |
PTM databases
GlyGeni | O43432, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O43432 |
MetOSitei | O43432 |
PhosphoSitePlusi | O43432 |
Polymorphism and mutation databases
BioMutai | EIF4G3 |
Proteomic databases
EPDi | O43432 |
jPOSTi | O43432 |
MassIVEi | O43432 |
MaxQBi | O43432 |
PaxDbi | O43432 |
PeptideAtlasi | O43432 |
PRIDEi | O43432 |
ProteomicsDBi | 48943 [O43432-1] 48944 [O43432-2] 48945 [O43432-3] 62418 |
Protocols and materials databases
Antibodypediai | 15146, 140 antibodies |
Genome annotation databases
Ensembli | ENST00000264211; ENSP00000264211; ENSG00000075151 [O43432-1] ENST00000356916; ENSP00000349386; ENSG00000075151 [O43432-2] ENST00000374935; ENSP00000364071; ENSG00000075151 [O43432-4] ENST00000602326; ENSP00000473510; ENSG00000075151 [O43432-3] |
GeneIDi | 8672 |
KEGGi | hsa:8672 |
UCSCi | uc001bee.4, human [O43432-1] |
Organism-specific databases
CTDi | 8672 |
DisGeNETi | 8672 |
EuPathDBi | HostDB:ENSG00000075151.20 |
GeneCardsi | EIF4G3 |
HGNCi | HGNC:3298, EIF4G3 |
HPAi | ENSG00000075151, Low tissue specificity |
MIMi | 603929, gene |
neXtProti | NX_O43432 |
OpenTargetsi | ENSG00000075151 |
PharmGKBi | PA27724 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0401, Eukaryota |
GeneTreei | ENSGT00940000156454 |
HOGENOMi | CLU_001519_2_0_1 |
InParanoidi | O43432 |
OrthoDBi | 594395at2759 |
PhylomeDBi | O43432 |
TreeFami | TF101527 |
Enzyme and pathway databases
PathwayCommonsi | O43432 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism |
SIGNORi | O43432 |
Miscellaneous databases
BioGRID-ORCSi | 8672, 3 hits in 850 CRISPR screens |
ChiTaRSi | EIF4G3, human |
EvolutionaryTracei | O43432 |
GeneWikii | EIF4G3 |
GenomeRNAii | 8672 |
Pharosi | O43432, Tbio |
PROi | PR:O43432 |
RNActi | O43432, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000075151, Expressed in sperm and 238 other tissues |
ExpressionAtlasi | O43432, baseline and differential |
Genevisiblei | O43432, HS |
Family and domain databases
Gene3Di | 1.25.40.180, 3 hits |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR037585, EIF4G3 IPR003891, Initiation_fac_eIF4g_MI IPR016021, MIF4-like_sf IPR003890, MIF4G-like_typ-3 IPR003307, W2_domain |
PANTHERi | PTHR23253:SF23, PTHR23253:SF23, 1 hit |
Pfami | View protein in Pfam PF02847, MA3, 1 hit PF02854, MIF4G, 1 hit PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00515, eIF5C, 1 hit SM00544, MA3, 1 hit SM00543, MIF4G, 1 hit |
SUPFAMi | SSF48371, SSF48371, 3 hits |
PROSITEi | View protein in PROSITE PS51366, MI, 1 hit PS51363, W2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IF4G3_HUMAN | |
Accessioni | O43432Primary (citable) accession number: O43432 Secondary accession number(s): B9EGQ7 Q8NEN1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 189 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations