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UniProtKB - O43432 (IF4G3_HUMAN)

Entry version 186 (17 Jun 2020)
Sequence version 2 (01 Mar 2001)
Previous versions | rss
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Protein

Eukaryotic translation initiation factor 4 gamma 3

Gene

EIF4G3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1169408 ISG15 antiviral mechanism

SIGNOR Signaling Network Open Resource

More...SIGNORi		O43432

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4 gamma 3
Short name:
eIF-4-gamma 3
Short name:
eIF-4G 3
Short name:
eIF4G 3
Alternative name(s):
eIF-4-gamma II
Short name:
eIF4GII
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF4G3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000075151.20

Human Gene Nomenclature Database

More...HGNCi		HGNC:3298 EIF4G3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603929 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43432

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi756R → D: Reduces binding to EIF4A; when associated with D-759 and D-764. 1 Publication1
Mutagenesisi759R → D: Reduces binding to EIF4A; when associated with D-756 and D-764. 1 Publication1
Mutagenesisi764K → D: Reduces binding to EIF4A; when associated with D-756 and D-759. 1 Publication1
Mutagenesisi814R → D: Reduces binding to EIF4A; when associated with D-820. 1 Publication1
Mutagenesisi820K → D: Reduces binding to EIF4A; when associated with D-814. 1 Publication1
Mutagenesisi834 – 835RK → DD: Reduces binding to IRES. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		8672

Open Targets

More...OpenTargetsi		ENSG00000075151

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27724

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43432 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EIF4G3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002133291 – 1585Eukaryotic translation initiation factor 4 gamma 3Add BLAST1585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei168PhosphothreonineBy similarity1
Modified residuei230PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Modified residuei441PhosphoserineBy similarity1
Modified residuei495PhosphoserineCombined sources1
Modified residuei1156Phosphoserine; by CaMK11 Publication1
Modified residuei1218PhosphoserineCombined sources1
Modified residuei1409PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei699 – 700Cleavage; by enterovirus/rhinovirus protease 2A2
Sitei700 – 701Cleavage; by foot-and-mouth disease virus leader protease2

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43432

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43432

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43432

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43432

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43432

PeptideAtlas

More...PeptideAtlasi		O43432

PRoteomics IDEntifications database

More...PRIDEi		O43432

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48943 [O43432-1]
48944 [O43432-2]
48945 [O43432-3]
62418

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43432

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O43432

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43432

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000075151 Expressed in sperm and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43432 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43432 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000075151 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EIF4A, EIF4E, eIF3 and PABPC1.

Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114220, 51 interactors

Database of interacting proteins

More...DIPi		DIP-33245N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		O43432

Protein interaction database and analysis system

More...IntActi		O43432, 32 interactors

Molecular INTeraction database

More...MINTi		O43432

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000383274

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43432 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11585
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43432

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O43432

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati745 – 783HEAT 1Add BLAST39
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini755 – 983MIF4GPROSITE-ProRule annotationAdd BLAST229
Repeati784 – 831HEAT 2Add BLAST48
Repeati832 – 905HEAT 3Add BLAST74
Repeati906 – 944HEAT 4Add BLAST39
Repeati945 – 984HEAT 5Add BLAST40
Domaini1221 – 1343MIPROSITE-ProRule annotationAdd BLAST123
Domaini1416 – 1585W2PROSITE-ProRule annotationAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni134 – 162PABPC1-bindingAdd BLAST29
Regioni619 – 630EIF4E-bindingBy similarityAdd BLAST12
Regioni699 – 1019eIF3/EIF4A-bindingBy similarityAdd BLAST321
Regioni1433 – 1585EIF4A-bindingBy similarityAdd BLAST153
Regioni1571 – 1585Necessary but not sufficient for MKNK1-bindingBy similarityAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili447 – 475Sequence analysisAdd BLAST29
Coiled coili994 – 1023Sequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic initiation factor 4G family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0401 Eukaryota
ENOG410XS4P LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156454

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001519_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43432

KEGG Orthology (KO)

More...KOi		K03260

Database of Orthologous Groups

More...OrthoDBi		594395at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43432

TreeFam database of animal gene trees

More...TreeFami		TF101527

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024 ARM-type_fold
IPR037585 EIF4G3
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain

The PANTHER Classification System

More...PANTHERi		PTHR23253:SF23 PTHR23253:SF23, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
PF02020 W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00515 eIF5C, 1 hit
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371 SSF48371, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51366 MI, 1 hit
PS51363 W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43432-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM 
        60         70         80         90        100
VNHLPMPYPV PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG 
       110        120        130        140        150
PGDFPNAYGT PFYPSQPVYQ SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG 
       160        170        180        190        200
GKDITEEIMS GGGSRNPTPP IGRPTSTPTP PQQLPSQVPE HSPVVYGTVE 
       210        220        230        240        250
SAHLAASTPV TAASDQKQEE KPKPDPVLKS PSPVLRLVLS GEKKEQEGQT 
       260        270        280        290        300
SETTAIVSIA ELPLPPSPTT VSSVARSTIA APTSSALSSQ PIFTTAIDDR 
       310        320        330        340        350
CELSSPREDT IPIPSLTSCT ETSDPLPTNE NDDDICKKPC SVAPNDIPLV 
       360        370        380        390        400
SSTNLINEIN GVSEKLSATE SIVEIVKQEV LPLTLELEIL ENPPEEMKLE 
       410        420        430        440        450
CIPAPITPST VPSFPPTPPT PPASPPHTPV IVPAAATTVS SPSAAITVQR 
       460        470        480        490        500
VLEEDESIRT CLSEDAKEIQ NKIEVEADGQ TEEILDSQNL NSRRSPVPAQ 
       510        520        530        540        550
IAITVPKTWK KPKDRTRTTE EMLEAELELK AEEELSIDKV LESEQDKMSQ 
       560        570        580        590        600
GFHPERDPSD LKKVKAVEEN GEEAEPVRNG AESVSEGEGI DANSGSTDSS 
       610        620        630        640        650
GDGVTFPFKP ESWKPTDTEG KKQYDREFLL DFQFMPACIQ KPEGLPPISD 
       660        670        680        690        700
VVLDKINQPK LPMRTLDPRI LPRGPDFTPA FADFGRQTPG GRGVPLLNVG 
       710        720        730        740        750
SRRSQPGQRR EPRKIITVSV KEDVHLKKAE NAWKPSQKRD SQADDPENIK 
       760        770        780        790        800
TQELFRKVRS ILNKLTPQMF NQLMKQVSGL TVDTEERLKG VIDLVFEKAI 
       810        820        830        840        850
DEPSFSVAYA NMCRCLVTLK VPMADKPGNT VNFRKLLLNR CQKEFEKDKA 
       860        870        880        890        900
DDDVFEKKQK ELEAASAPEE RTRLHDELEE AKDKARRRSI GNIKFIGELF 
       910        920        930        940        950
KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFEKAKPRMD 
       960        970        980        990       1000
QYFNQMEKIV KERKTSSRIR FMLQDVIDLR LCNWVSRRAD QGPKTIEQIH 
      1010       1020       1030       1040       1050
KEAKIEEQEE QRKVQQLMTK EKRRPGVQRV DEGGWNTVQG AKNSRVLDPS 
      1060       1070       1080       1090       1100
KFLKITKPTI DEKIQLVPKA QLGSWGKGSS GGAKASETDA LRSSASSLNR 
      1110       1120       1130       1140       1150
FSALQPPAPS GSTPSTPVEF DSRRTLTSRG SMGREKNDKP LPSATARPNT 
      1160       1170       1180       1190       1200
FMRGGSSKDL LDNQSQEEQR REMLETVKQL TGGVDVERNS TEAERNKTRE 
      1210       1220       1230       1240       1250
SAKPEISAMS AHDKAALSEE ELERKSKSII DEFLHINDFK EAMQCVEELN 
      1260       1270       1280       1290       1300
AQGLLHVFVR VGVESTLERS QITRDHMGQL LYQLVQSEKL SKQDFFKGFS 
      1310       1320       1330       1340       1350
ETLELADDMA IDIPHIWLYL AELVTPMLKE GGISMRELTI EFSKPLLPVG 
      1360       1370       1380       1390       1400
RAGVLLSEIL HLLCKQMSHK KVGALWREAD LSWKDFLPEG EDVHNFLLEQ 
      1410       1420       1430       1440       1450
KLDFIESDSP CSSEALSKKE LSAEELYKRL EKLIIEDKAN DEQIFDWVEA 
      1460       1470       1480       1490       1500
NLDEIQMSSP TFLRALMTAV CKAAIIADSS TFRVDTAVIK QRVPILLKYL 
      1510       1520       1530       1540       1550
DSDTEKELQA LYALQASIVK LDQPANLLRM FFDCLYDEEV ISEDAFYKWE 
      1560       1570       1580 
SSKDPAEQNG KGVALKSVTA FFTWLREAEE ESEDN
Length:1,585
Mass (Da):176,652
Last modified:March 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA483139373DCA5C
GO
Isoform 2 (identifier: O43432-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: F → FAAGPRPPHHQF
     499-504: AQIAIT → ETSNEC
     505-1585: Missing.

Show »
Length:515
Mass (Da):55,227
Checksum:i0B4E961F10F62EA0
GO
Isoform 3 (identifier: O43432-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-10: P → PGGFRPIQ
     182-182: Missing.

Show »
Length:1,591
Mass (Da):177,280
Checksum:iA6A4BEC78E05CC92
GO
Isoform 4 (identifier: O43432-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-498: Missing.

Show »
Length:1,305
Mass (Da):146,871
Checksum:iEDF74715CD55642D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSA7A0A0A0MSA7_HUMAN
Eukaryotic translation initiation f...
EIF4G3
1,621Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQK7A0A0U1RQK7_HUMAN
Eukaryotic translation initiation f...
EIF4G3
1,774Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AN91B1AN91_HUMAN
Eukaryotic translation initiation f...
EIF4G3
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AN92B1AN92_HUMAN
Eukaryotic translation initiation f...
EIF4G3
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159M → I in AAH30578 (PubMed:15489334).Curated1
Sequence conflicti333D → G in AAH30578 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048924378Q → R. Corresponds to variant dbSNP:rs35731992Ensembl.1
Natural variantiVAR_034009496P → A. Corresponds to variant dbSNP:rs35176330Ensembl.1
Natural variantiVAR_0489251185D → E. Corresponds to variant dbSNP:rs2230572Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04344710P → PGGFRPIQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_01048711F → FAAGPRPPHHQF in isoform 2. 1 Publication1
Alternative sequenceiVSP_043448182Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_054502219 – 498Missing in isoform 4. 1 PublicationAdd BLAST280
Alternative sequenceiVSP_010488499 – 504AQIAIT → ETSNEC in isoform 2. 1 Publication6
Alternative sequenceiVSP_010489505 – 1585Missing in isoform 2. 1 PublicationAdd BLAST1081

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF012072 mRNA Translation: AAC02903.2
AL031005 Genomic DNA No translation available.
AL358392 Genomic DNA No translation available.
AL606477 Genomic DNA No translation available.
AL627311 Genomic DNA No translation available.
AL672037 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94956.1
BC030578 mRNA Translation: AAH30578.1
BC094683 mRNA Translation: AAH94683.1
BC136643 mRNA Translation: AAI36644.1
Z34918 mRNA Translation: CAA84397.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS214.1 [O43432-1]
CCDS55580.1 [O43432-3]
CCDS59192.1 [O43432-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S49172

NCBI Reference Sequences

More...RefSeqi		NP_001185730.1, NM_001198801.1
NP_001185731.1, NM_001198802.1 [O43432-3]
NP_001185732.1, NM_001198803.2 [O43432-2]
NP_003751.2, NM_003760.4 [O43432-1]
XP_016858189.1, XM_017002700.1 [O43432-1]
XP_016858197.1, XM_017002708.1 [O43432-4]
XP_016858201.1, XM_017002712.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264211; ENSP00000264211; ENSG00000075151 [O43432-1]
ENST00000356916; ENSP00000349386; ENSG00000075151 [O43432-2]
ENST00000374935; ENSP00000364071; ENSG00000075151 [O43432-4]
ENST00000602326; ENSP00000473510; ENSG00000075151 [O43432-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8672

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8672

UCSC genome browser

More...UCSCi		uc001bee.4 human [O43432-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012072 mRNA Translation: AAC02903.2
AL031005 Genomic DNA No translation available.
AL358392 Genomic DNA No translation available.
AL606477 Genomic DNA No translation available.
AL627311 Genomic DNA No translation available.
AL672037 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94956.1
BC030578 mRNA Translation: AAH30578.1
BC094683 mRNA Translation: AAH94683.1
BC136643 mRNA Translation: AAI36644.1
Z34918 mRNA Translation: CAA84397.1
CCDSiCCDS214.1 [O43432-1]
CCDS55580.1 [O43432-3]
CCDS59192.1 [O43432-2]
PIRiS49172
RefSeqiNP_001185730.1, NM_001198801.1
NP_001185731.1, NM_001198802.1 [O43432-3]
NP_001185732.1, NM_001198803.2 [O43432-2]
NP_003751.2, NM_003760.4 [O43432-1]
XP_016858189.1, XM_017002700.1 [O43432-1]
XP_016858197.1, XM_017002708.1 [O43432-4]
XP_016858201.1, XM_017002712.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HU3X-ray2.37A745-1003[»]
SMRiO43432
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114220, 51 interactors
DIPiDIP-33245N
ELMiO43432
IntActiO43432, 32 interactors
MINTiO43432
STRINGi9606.ENSP00000383274

PTM databases

iPTMnetiO43432
MetOSiteiO43432
PhosphoSitePlusiO43432

Polymorphism and mutation databases

BioMutaiEIF4G3

Proteomic databases

EPDiO43432
jPOSTiO43432
MassIVEiO43432
MaxQBiO43432
PaxDbiO43432
PeptideAtlasiO43432
PRIDEiO43432
ProteomicsDBi48943 [O43432-1]
48944 [O43432-2]
48945 [O43432-3]
62418

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15146 140 antibodies

Genome annotation databases

EnsembliENST00000264211; ENSP00000264211; ENSG00000075151 [O43432-1]
ENST00000356916; ENSP00000349386; ENSG00000075151 [O43432-2]
ENST00000374935; ENSP00000364071; ENSG00000075151 [O43432-4]
ENST00000602326; ENSP00000473510; ENSG00000075151 [O43432-3]
GeneIDi8672
KEGGihsa:8672
UCSCiuc001bee.4 human [O43432-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8672
DisGeNETi8672
EuPathDBiHostDB:ENSG00000075151.20

GeneCards: human genes, protein and diseases

More...GeneCardsi		EIF4G3
HGNCiHGNC:3298 EIF4G3
HPAiENSG00000075151 Low tissue specificity
MIMi603929 gene
neXtProtiNX_O43432
OpenTargetsiENSG00000075151
PharmGKBiPA27724

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0401 Eukaryota
ENOG410XS4P LUCA
GeneTreeiENSGT00940000156454
HOGENOMiCLU_001519_2_0_1
InParanoidiO43432
KOiK03260
OrthoDBi594395at2759
PhylomeDBiO43432
TreeFamiTF101527

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
SIGNORiO43432

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8672 0 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		EIF4G3 human
EvolutionaryTraceiO43432

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		EIF4G3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8672
PharosiO43432 Tbio

Protein Ontology

More...PROi		PR:O43432
RNActiO43432 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000075151 Expressed in sperm and 227 other tissues
ExpressionAtlasiO43432 baseline and differential
GenevisibleiO43432 HS

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037585 EIF4G3
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain
PANTHERiPTHR23253:SF23 PTHR23253:SF23, 1 hit
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit
PS51363 W2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF4G3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43432
Secondary accession number(s): B9EGQ7
, Q15597, Q504Z1, Q5SWC3, Q8NEN1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2001
Last modified: June 17, 2020
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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