Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acidic fibroblast growth factor intracellular-binding protein

Gene

FIBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).By similarity1 Publication

GO - Molecular functioni

  • fibroblast growth factor binding Source: MGI

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: ProtInc
  • platelet aggregation Source: UniProtKB

Enzyme and pathway databases

SignaLinkiO43427

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic fibroblast growth factor intracellular-binding protein
Short name:
aFGF intracellular-binding protein
Alternative name(s):
FGF-1 intracellular-binding protein
Gene namesi
Name:FIBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172500.12
HGNCiHGNC:3705 FIBP
MIMi608296 gene
neXtProtiNX_O43427

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Thauvin-Robinet-Faivre syndrome (TROFAS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive syndrome characterized by generalized overgrowth, developmental delay, learning disabilities, and variable congenital abnormalities including congenital heart defects, renal dysplasia, and skeletal defects.
See also OMIM:617107
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07716059H → LN in TROFAS. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi9158
MalaCardsiFIBP
MIMi617107 phenotype
OpenTargetsiENSG00000172500
Orphaneti500095 Tall stature-intellectual disability-renal anomalies syndrome
PharmGKBiPA28145

Polymorphism and mutation databases

BioMutaiFIBP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000872372 – 364Acidic fibroblast growth factor intracellular-binding proteinAdd BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43427
MaxQBiO43427
PaxDbiO43427
PeptideAtlasiO43427
PRIDEiO43427
ProteomicsDBi48941
48942 [O43427-2]

PTM databases

iPTMnetiO43427
PhosphoSitePlusiO43427

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney.

Gene expression databases

BgeeiENSG00000172500 Expressed in 228 organ(s), highest expression level in testis
CleanExiHS_FIBP
ExpressionAtlasiO43427 baseline and differential
GenevisibleiO43427 HS

Organism-specific databases

HPAiHPA011729

Interactioni

Subunit structurei

Binds to internalized FGF1; this interaction is increased in the presence of CSNKB, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114603, 21 interactors
IntActiO43427, 6 interactors
MINTiO43427
STRINGi9606.ENSP00000344572

Structurei

3D structure databases

ProteinModelPortaliO43427
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFMD Eukaryota
ENOG410ZCZH LUCA
GeneTreeiENSGT00390000015815
HOGENOMiHOG000234336
HOVERGENiHBG005728
InParanoidiO43427
OMAiIACLRFE
OrthoDBiEOG091G0EUD
PhylomeDBiO43427
TreeFamiTF323763

Family and domain databases

InterProiView protein in InterPro
IPR008614 FIBP
PANTHERiPTHR13223 PTHR13223, 1 hit
PfamiView protein in Pfam
PF05427 FIBP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: O43427-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSELDIFVG NTTLIDEDVY RLWLDGYSVT DAVALRVRSG ILEQTGATAA
60 70 80 90 100
VLQSDTMDHY RTFHMLERLL HAPPKLLHQL IFQIPPSRQA LLIERYYAFD
110 120 130 140 150
EAFVREVLGK KLSKGTKKDL DDISTKTGIT LKSCRRQFDN FKRVFKVVEE
160 170 180 190 200
MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA NNRFETGKKK LQYLSFGDFA
210 220 230 240 250
FCAELMIQNW TLGAVGEAPT DPDSQMDDMD MDLDKEFLQD LKELKVLVAD
260 270 280 290 300
KDLLDLHKSL VCTALRGKLG VFSEMEANFK NLSRGLVNVA AKLTHNKDVR
310 320 330 340 350
DLFVDLVEKF VEPCRSDHWP LSDVRFFLNQ YSASVHSLDG FRHQALWDRY
360
MGTLRGCLLR LYHD
Length:364
Mass (Da):41,878
Last modified:April 27, 2001 - v3
Checksum:i7E9A05908760FF45
GO
Isoform Short (identifier: O43427-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-222: Missing.

Show »
Length:357
Mass (Da):41,210
Checksum:i259F5181185CB0ED
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PSD3E9PSD3_HUMAN
Acidic fibroblast growth factor int...
FIBP
348Annotation score:
H0YCE7H0YCE7_HUMAN
Acidic fibroblast growth factor int...
FIBP
137Annotation score:
E9PJW6E9PJW6_HUMAN
Acidic fibroblast growth factor int...
FIBP
146Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07716059H → LN in TROFAS. 1 Publication1
Natural variantiVAR_050991152R → W. Corresponds to variant dbSNP:rs11559154Ensembl.1
Natural variantiVAR_050992351M → V1 PublicationCorresponds to variant dbSNP:rs2231893Ensembl.1
Natural variantiVAR_060711359L → R1 PublicationCorresponds to variant dbSNP:rs36080962Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004250216 – 222Missing in isoform Short. 5 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010187 mRNA Translation: AAC97140.2
AF171944 mRNA Translation: AAD51694.1
AF171945 mRNA Translation: AAD51695.1
AF171946 mRNA Translation: AAD51696.1
AF250391 mRNA Translation: AAG01396.1
AF250392 Genomic DNA Translation: AAG01397.1
CR456749 mRNA Translation: CAG33030.1
AK289562 mRNA Translation: BAF82251.1
DQ388430 Genomic DNA Translation: ABD48957.1
CH471076 Genomic DNA Translation: EAW74465.1
CH471076 Genomic DNA Translation: EAW74466.1
BC014388 mRNA Translation: AAH14388.1
BC017448 mRNA Translation: AAH17448.1
CCDSiCCDS8118.1 [O43427-2]
CCDS8119.1 [O43427-1]
RefSeqiNP_004205.2, NM_004214.4 [O43427-2]
NP_942600.1, NM_198897.1 [O43427-1]
UniGeneiHs.7768

Genome annotation databases

EnsembliENST00000338369; ENSP00000344572; ENSG00000172500 [O43427-1]
ENST00000357519; ENSP00000350124; ENSG00000172500 [O43427-2]
GeneIDi9158
KEGGihsa:9158
UCSCiuc001ogd.4 human [O43427-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010187 mRNA Translation: AAC97140.2
AF171944 mRNA Translation: AAD51694.1
AF171945 mRNA Translation: AAD51695.1
AF171946 mRNA Translation: AAD51696.1
AF250391 mRNA Translation: AAG01396.1
AF250392 Genomic DNA Translation: AAG01397.1
CR456749 mRNA Translation: CAG33030.1
AK289562 mRNA Translation: BAF82251.1
DQ388430 Genomic DNA Translation: ABD48957.1
CH471076 Genomic DNA Translation: EAW74465.1
CH471076 Genomic DNA Translation: EAW74466.1
BC014388 mRNA Translation: AAH14388.1
BC017448 mRNA Translation: AAH17448.1
CCDSiCCDS8118.1 [O43427-2]
CCDS8119.1 [O43427-1]
RefSeqiNP_004205.2, NM_004214.4 [O43427-2]
NP_942600.1, NM_198897.1 [O43427-1]
UniGeneiHs.7768

3D structure databases

ProteinModelPortaliO43427
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114603, 21 interactors
IntActiO43427, 6 interactors
MINTiO43427
STRINGi9606.ENSP00000344572

PTM databases

iPTMnetiO43427
PhosphoSitePlusiO43427

Polymorphism and mutation databases

BioMutaiFIBP

Proteomic databases

EPDiO43427
MaxQBiO43427
PaxDbiO43427
PeptideAtlasiO43427
PRIDEiO43427
ProteomicsDBi48941
48942 [O43427-2]

Protocols and materials databases

DNASUi9158
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338369; ENSP00000344572; ENSG00000172500 [O43427-1]
ENST00000357519; ENSP00000350124; ENSG00000172500 [O43427-2]
GeneIDi9158
KEGGihsa:9158
UCSCiuc001ogd.4 human [O43427-1]

Organism-specific databases

CTDi9158
DisGeNETi9158
EuPathDBiHostDB:ENSG00000172500.12
GeneCardsiFIBP
HGNCiHGNC:3705 FIBP
HPAiHPA011729
MalaCardsiFIBP
MIMi608296 gene
617107 phenotype
neXtProtiNX_O43427
OpenTargetsiENSG00000172500
Orphaneti500095 Tall stature-intellectual disability-renal anomalies syndrome
PharmGKBiPA28145
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFMD Eukaryota
ENOG410ZCZH LUCA
GeneTreeiENSGT00390000015815
HOGENOMiHOG000234336
HOVERGENiHBG005728
InParanoidiO43427
OMAiIACLRFE
OrthoDBiEOG091G0EUD
PhylomeDBiO43427
TreeFamiTF323763

Enzyme and pathway databases

SignaLinkiO43427

Miscellaneous databases

ChiTaRSiFIBP human
GeneWikiiFIBP
GenomeRNAii9158
PROiPR:O43427
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172500 Expressed in 228 organ(s), highest expression level in testis
CleanExiHS_FIBP
ExpressionAtlasiO43427 baseline and differential
GenevisibleiO43427 HS

Family and domain databases

InterProiView protein in InterPro
IPR008614 FIBP
PANTHERiPTHR13223 PTHR13223, 1 hit
PfamiView protein in Pfam
PF05427 FIBP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFIBP_HUMAN
AccessioniPrimary (citable) accession number: O43427
Secondary accession number(s): A8K0J7
, Q27Q85, Q6IBQ3, Q9HD65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again