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Protein

52 kDa repressor of the inhibitor of the protein kinase

Gene

THAP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 86THAP-typePROSITE-ProRule annotationAdd BLAST86

GO - Molecular functioni

GO - Biological processi

  • negative regulation of cell proliferation Source: ProtInc
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiO43422

Names & Taxonomyi

Protein namesi
Recommended name:
52 kDa repressor of the inhibitor of the protein kinase
Short name:
p52rIPK
Alternative name(s):
58 kDa interferon-induced protein kinase-interacting protein
Short name:
p58IPK-interacting protein
Death-associated protein 4
THAP domain-containing protein 0
THAP domain-containing protein 12Imported
Gene namesi
Name:THAP12Imported
Synonyms:DAP4, P52RIPK, PRKRIR, THAP0
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137492.7
HGNCiHGNC:9440 THAP12
MIMi607374 gene
neXtProtiNX_O43422

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5612
OpenTargetsiENSG00000137492
PharmGKBiPA33781

Polymorphism and mutation databases

BioMutaiPRKRIR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686341 – 76152 kDa repressor of the inhibitor of the protein kinaseAdd BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei566PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO43422
MaxQBiO43422
PaxDbiO43422
PeptideAtlasiO43422
PRIDEiO43422
ProteomicsDBi48933
48934 [O43422-2]

PTM databases

iPTMnetiO43422
PhosphoSitePlusiO43422

Expressioni

Gene expression databases

BgeeiENSG00000137492
CleanExiHS_PRKRIR
ExpressionAtlasiO43422 baseline and differential
GenevisibleiO43422 HS

Organism-specific databases

HPAiHPA008758

Interactioni

Subunit structurei

Interacts with DNAJC3, probably sequestring it.

Binary interactionsi

WithEntry#Exp.IntActNotes
TACC1O754103EBI-2828217,EBI-624237

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111598, 34 interactors
IntActiO43422, 8 interactors
STRINGi9606.ENSP00000260045

Structurei

3D structure databases

ProteinModelPortaliO43422
SMRiO43422
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 86THAP-typePROSITE-ProRule annotationAdd BLAST86

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHFF Eukaryota
ENOG4110ZMY LUCA
GeneTreeiENSGT00530000063516
HOGENOMiHOG000013127
HOVERGENiHBG007908
InParanoidiO43422
OMAiTRAFGRN
OrthoDBiEOG091G04DA
PhylomeDBiO43422
TreeFamiTF330114

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR025398 DUF4371
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PfamiView protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF14291 DUF4371, 1 hit
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
SUPFAMiSSF53098 SSF53098, 2 hits
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: O43422-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNFCAAPNC TRKSTQSDLA FFRFPRDPAR CQKWVENCRR ADLEDKTPDQ
60 70 80 90 100
LNKHYRLCAK HFETSMICRT SPYRTVLRDN AIPTIFDLTS HLNNPHSRHR
110 120 130 140 150
KRIKELSEDE IRTLKQKKID ETSEQEQKHK ETNNSNAQNP SEEEGEGQDE
160 170 180 190 200
DILPLTLEEK ENKEYLKSLF EILILMGKQN IPLDGHEADE IPEGLFTPDN
210 220 230 240 250
FQALLECRIN SGEEVLRKRF ETTAVNTLFC SKTQQRQMLE ICESCIREET
260 270 280 290 300
LREVRDSHFF SIITDDVVDI AGEEHLPVLV RFVDESHNLR EEFIGFLPYE
310 320 330 340 350
ADAEILAVKF HTMITEKWGL NMEYCRGQAY IVSSGFSSKM KVVASRLLEK
360 370 380 390 400
YPQAIYTLCS SCALNMWLAK SVPVMGVSVA LGTIEEVCSF FHRSPQLLLE
410 420 430 440 450
LDNVISVLFQ NSKERGKELK EICHSQWTGR HDAFEILVEL LQALVLCLDG
460 470 480 490 500
INSDTNIRWN NYIAGRAFVL CSAVSDFDFI VTIVVLKNVL SFTRAFGKNL
510 520 530 540 550
QGQTSDVFFA AGSLTAVLHS LNEVMENIEV YHEFWFEEAT NLATKLDIQM
560 570 580 590 600
KLPGKFRRAH QGNLESQLTS ESYYKETLSV PTVEHIIQEL KDIFSEQHLK
610 620 630 640 650
ALKCLSLVPS VMGQLKFNTS EEHHADMYRS DLPNPDTLSA ELHCWRIKWK
660 670 680 690 700
HRGKDIELPS TIYEALHLPD IKFFPNVYAL LKVLCILPVM KVENERYENG
710 720 730 740 750
RKRLKAYLRN TLTDQRSSNL ALLNINFDIK HDLDLMVDTY IKLYTSKSEL
760
PTDNSETVEN T
Length:761
Mass (Da):87,704
Last modified:January 11, 2001 - v2
Checksum:i88809CFE52399C13
GO
Isoform Short (identifier: O43422-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     489-492: VLSF → EIKI
     493-761: Missing.

Note: No experimental confirmation available.
Show »
Length:492
Mass (Da):56,656
Checksum:iE0CC8E2C5DD93215
GO

Sequence cautioni

The sequence AAH21992 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43226 differs from that shown. Reason: Frameshift at position 471.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157L → W (PubMed:17974005).Curated1
Sequence conflicti738D → V (PubMed:17974005).Curated1
Sequence conflicti754N → K (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004355489 – 492VLSF → EIKI in isoform Short. 1 Publication4
Alternative sequenceiVSP_004356493 – 761Missing in isoform Short. 1 PublicationAdd BLAST269

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007393 mRNA Translation: AAC39564.1
AF081567 mRNA Translation: AAG01570.1
AK291843 mRNA Translation: BAF84532.1
CH471076 Genomic DNA Translation: EAW74993.1
BC021992 mRNA Translation: AAH21992.1 Different initiation.
BC117138 mRNA Translation: AAI17139.1
BC117140 mRNA Translation: AAI17141.1
AL049970 mRNA Translation: CAB43226.1 Frameshift.
CCDSiCCDS8243.1 [O43422-1]
RefSeqiNP_004696.2, NM_004705.3 [O43422-1]
UniGeneiHs.503315

Genome annotation databases

EnsembliENST00000260045; ENSP00000260045; ENSG00000137492 [O43422-1]
GeneIDi5612
KEGGihsa:5612
UCSCiuc001oxh.2 human [O43422-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiP52K_HUMAN
AccessioniPrimary (citable) accession number: O43422
Secondary accession number(s): A8K728
, Q17RY9, Q8WTW1, Q9Y3Z4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: June 20, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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