UniProtKB - O43422 (P52K_HUMAN)
Protein
52 kDa repressor of the inhibitor of the protein kinase
Gene
THAP12
Organism
Homo sapiens (Human)
Status
Functioni
Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 86 | THAP-typePROSITE-ProRule annotationAdd BLAST | 86 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein dimerization activity Source: InterPro
GO - Biological processi
- negative regulation of cell population proliferation Source: ProtInc
- signal transduction Source: ProtInc
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O43422 |
SIGNORi | O43422 |
Names & Taxonomyi
Protein namesi | Recommended name: 52 kDa repressor of the inhibitor of the protein kinaseShort name: p52rIPK Alternative name(s): 58 kDa interferon-induced protein kinase-interacting protein Short name: p58IPK-interacting protein Death-associated protein 4 THAP domain-containing protein 0 THAP domain-containing protein 12Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137492.7 |
HGNCi | HGNC:9440, THAP12 |
MIMi | 607374, gene |
neXtProti | NX_O43422 |
Subcellular locationi
Nucleus
- nucleus Source: Ensembl
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 5612 |
OpenTargetsi | ENSG00000137492 |
PharmGKBi | PA33781 |
Miscellaneous databases
Pharosi | O43422, Tbio |
Polymorphism and mutation databases
BioMutai | THAP12 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068634 | 1 – 761 | 52 kDa repressor of the inhibitor of the protein kinaseAdd BLAST | 761 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 566 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O43422 |
jPOSTi | O43422 |
MassIVEi | O43422 |
MaxQBi | O43422 |
PaxDbi | O43422 |
PeptideAtlasi | O43422 |
PRIDEi | O43422 |
ProteomicsDBi | 48933 [O43422-1] 48934 [O43422-2] |
PTM databases
iPTMneti | O43422 |
PhosphoSitePlusi | O43422 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137492, Expressed in lung and 238 other tissues |
ExpressionAtlasi | O43422, baseline and differential |
Genevisiblei | O43422, HS |
Organism-specific databases
HPAi | ENSG00000137492, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with DNAJC3, probably sequestring it.
Binary interactionsi
Hide detailsO43422
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 111598, 38 interactors |
IntActi | O43422, 24 interactors |
STRINGi | 9606.ENSP00000260045 |
Miscellaneous databases
RNActi | O43422, protein |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 86 | THAP-typePROSITE-ProRule annotationAdd BLAST | 86 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QU3U, Eukaryota |
GeneTreei | ENSGT00530000063516 |
HOGENOMi | CLU_023409_0_0_1 |
InParanoidi | O43422 |
OMAi | FFPNVNA |
PhylomeDBi | O43422 |
TreeFami | TF330114 |
Family and domain databases
Gene3Di | 3.30.40.180, 1 hit |
InterProi | View protein in InterPro IPR025398, DUF4371 IPR008906, HATC_C_dom IPR012337, RNaseH-like_sf IPR006612, THAP_Znf IPR038441, THAP_Znf_sf |
Pfami | View protein in Pfam PF05699, Dimer_Tnp_hAT, 1 hit PF14291, DUF4371, 1 hit PF05485, THAP, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform Long (identifier: O43422-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPNFCAAPNC TRKSTQSDLA FFRFPRDPAR CQKWVENCRR ADLEDKTPDQ
60 70 80 90 100
LNKHYRLCAK HFETSMICRT SPYRTVLRDN AIPTIFDLTS HLNNPHSRHR
110 120 130 140 150
KRIKELSEDE IRTLKQKKID ETSEQEQKHK ETNNSNAQNP SEEEGEGQDE
160 170 180 190 200
DILPLTLEEK ENKEYLKSLF EILILMGKQN IPLDGHEADE IPEGLFTPDN
210 220 230 240 250
FQALLECRIN SGEEVLRKRF ETTAVNTLFC SKTQQRQMLE ICESCIREET
260 270 280 290 300
LREVRDSHFF SIITDDVVDI AGEEHLPVLV RFVDESHNLR EEFIGFLPYE
310 320 330 340 350
ADAEILAVKF HTMITEKWGL NMEYCRGQAY IVSSGFSSKM KVVASRLLEK
360 370 380 390 400
YPQAIYTLCS SCALNMWLAK SVPVMGVSVA LGTIEEVCSF FHRSPQLLLE
410 420 430 440 450
LDNVISVLFQ NSKERGKELK EICHSQWTGR HDAFEILVEL LQALVLCLDG
460 470 480 490 500
INSDTNIRWN NYIAGRAFVL CSAVSDFDFI VTIVVLKNVL SFTRAFGKNL
510 520 530 540 550
QGQTSDVFFA AGSLTAVLHS LNEVMENIEV YHEFWFEEAT NLATKLDIQM
560 570 580 590 600
KLPGKFRRAH QGNLESQLTS ESYYKETLSV PTVEHIIQEL KDIFSEQHLK
610 620 630 640 650
ALKCLSLVPS VMGQLKFNTS EEHHADMYRS DLPNPDTLSA ELHCWRIKWK
660 670 680 690 700
HRGKDIELPS TIYEALHLPD IKFFPNVYAL LKVLCILPVM KVENERYENG
710 720 730 740 750
RKRLKAYLRN TLTDQRSSNL ALLNINFDIK HDLDLMVDTY IKLYTSKSEL
760
PTDNSETVEN T
Isoform Short (identifier: O43422-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
489-492: VLSF → EIKI
493-761: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PSI2 | E9PSI2_HUMAN | 52 kDa repressor of the inhibitor o... | THAP12 | 79 | Annotation score: |
Sequence cautioni
The sequence AAH21992 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43226 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 157 | L → W (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 738 | D → V (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 754 | N → K (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004355 | 489 – 492 | VLSF → EIKI in isoform Short. 1 Publication | 4 | |
Alternative sequenceiVSP_004356 | 493 – 761 | Missing in isoform Short. 1 PublicationAdd BLAST | 269 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007393 mRNA Translation: AAC39564.1 AF081567 mRNA Translation: AAG01570.1 AK291843 mRNA Translation: BAF84532.1 CH471076 Genomic DNA Translation: EAW74993.1 BC021992 mRNA Translation: AAH21992.1 Different initiation. BC117138 mRNA Translation: AAI17139.1 BC117140 mRNA Translation: AAI17141.1 AL049970 mRNA Translation: CAB43226.1 Frameshift. |
CCDSi | CCDS8243.1 [O43422-1] |
RefSeqi | NP_004696.2, NM_004705.3 [O43422-1] |
Genome annotation databases
Ensembli | ENST00000260045; ENSP00000260045; ENSG00000137492 [O43422-1] |
GeneIDi | 5612 |
KEGGi | hsa:5612 |
UCSCi | uc001oxh.2, human [O43422-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007393 mRNA Translation: AAC39564.1 AF081567 mRNA Translation: AAG01570.1 AK291843 mRNA Translation: BAF84532.1 CH471076 Genomic DNA Translation: EAW74993.1 BC021992 mRNA Translation: AAH21992.1 Different initiation. BC117138 mRNA Translation: AAI17139.1 BC117140 mRNA Translation: AAI17141.1 AL049970 mRNA Translation: CAB43226.1 Frameshift. |
CCDSi | CCDS8243.1 [O43422-1] |
RefSeqi | NP_004696.2, NM_004705.3 [O43422-1] |
3D structure databases
SMRi | O43422 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111598, 38 interactors |
IntActi | O43422, 24 interactors |
STRINGi | 9606.ENSP00000260045 |
PTM databases
iPTMneti | O43422 |
PhosphoSitePlusi | O43422 |
Polymorphism and mutation databases
BioMutai | THAP12 |
Proteomic databases
EPDi | O43422 |
jPOSTi | O43422 |
MassIVEi | O43422 |
MaxQBi | O43422 |
PaxDbi | O43422 |
PeptideAtlasi | O43422 |
PRIDEi | O43422 |
ProteomicsDBi | 48933 [O43422-1] 48934 [O43422-2] |
Protocols and materials databases
Antibodypediai | 2160, 155 antibodies |
DNASUi | 5612 |
Genome annotation databases
Ensembli | ENST00000260045; ENSP00000260045; ENSG00000137492 [O43422-1] |
GeneIDi | 5612 |
KEGGi | hsa:5612 |
UCSCi | uc001oxh.2, human [O43422-1] |
Organism-specific databases
CTDi | 5612 |
DisGeNETi | 5612 |
EuPathDBi | HostDB:ENSG00000137492.7 |
GeneCardsi | THAP12 |
HGNCi | HGNC:9440, THAP12 |
HPAi | ENSG00000137492, Low tissue specificity |
MIMi | 607374, gene |
neXtProti | NX_O43422 |
OpenTargetsi | ENSG00000137492 |
PharmGKBi | PA33781 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QU3U, Eukaryota |
GeneTreei | ENSGT00530000063516 |
HOGENOMi | CLU_023409_0_0_1 |
InParanoidi | O43422 |
OMAi | FFPNVNA |
PhylomeDBi | O43422 |
TreeFami | TF330114 |
Enzyme and pathway databases
PathwayCommonsi | O43422 |
SIGNORi | O43422 |
Miscellaneous databases
BioGRID-ORCSi | 5612, 302 hits in 874 CRISPR screens |
ChiTaRSi | THAP12, human |
GeneWikii | PRKRIR |
GenomeRNAii | 5612 |
Pharosi | O43422, Tbio |
PROi | PR:O43422 |
RNActi | O43422, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137492, Expressed in lung and 238 other tissues |
ExpressionAtlasi | O43422, baseline and differential |
Genevisiblei | O43422, HS |
Family and domain databases
Gene3Di | 3.30.40.180, 1 hit |
InterProi | View protein in InterPro IPR025398, DUF4371 IPR008906, HATC_C_dom IPR012337, RNaseH-like_sf IPR006612, THAP_Znf IPR038441, THAP_Znf_sf |
Pfami | View protein in Pfam PF05699, Dimer_Tnp_hAT, 1 hit PF14291, DUF4371, 1 hit PF05485, THAP, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P52K_HUMAN | |
Accessioni | O43422Primary (citable) accession number: O43422 Secondary accession number(s): A8K728 Q9Y3Z4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | January 11, 2001 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM