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Protein

Tumor protein D54

Gene

TPD52L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • regulation of cell proliferation Source: UniProtKB

Enzyme and pathway databases

SignaLinkiO43399

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein D54
Short name:
hD54
Alternative name(s):
Tumor protein D52-like 2
Gene namesi
Name:TPD52L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101150.17
HGNCiHGNC:12007 TPD52L2
MIMi603747 gene
neXtProtiNX_O43399

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi7165
OpenTargetsiENSG00000101150
PharmGKBiPA36688

Polymorphism and mutation databases

BioMutaiTPD52L2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857441 – 206Tumor protein D54Add BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei163PhosphothreonineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei173PhosphothreonineCombined sources1
Modified residuei192PhosphoserineBy similarity1
Modified residuei195PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO43399
PeptideAtlasiO43399
PRIDEiO43399
ProteomicsDBi48923
48924 [O43399-2]
48925 [O43399-3]
48926 [O43399-4]
48927 [O43399-5]
TopDownProteomicsiO43399-5 [O43399-5]

2D gel databases

OGPiO43399

PTM databases

iPTMnetiO43399
PhosphoSitePlusiO43399
SwissPalmiO43399

Expressioni

Gene expression databases

BgeeiENSG00000101150 Expressed in 230 organ(s), highest expression level in blood
CleanExiHS_TPD52L2
ExpressionAtlasiO43399 baseline and differential
GenevisibleiO43399 HS

Organism-specific databases

HPAiHPA047489

Interactioni

Subunit structurei

Forms a homodimer or heterodimer with other members of the family (By similarity). Interacts with MAL2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Tpd52Q623932EBI-782616,EBI-782591From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113018, 71 interactors
IntActiO43399, 12 interactors

Structurei

3D structure databases

ProteinModelPortaliO43399
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili38 – 82Sequence analysisAdd BLAST45

Sequence similaritiesi

Belongs to the TPD52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000015988
HOGENOMiHOG000231968
HOVERGENiHBG058643
InParanoidiO43399
OMAiRARPFSH
OrthoDBiEOG091G0MLN
PhylomeDBiO43399
TreeFamiTF317562

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR007327 TPD52
PANTHERiPTHR19307 PTHR19307, 1 hit
PfamiView protein in Pfam
PF04201 TPD52, 2 hits

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43399-1) [UniParc]FASTAAdd to basket
Also known as: HD54+ins2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSAGQDINL NSPNKGLLSD SMTDVPVDTG VAARTPAVEG LTEAEEEELR
60 70 80 90 100
AELTKVEEEI VTLRQVLAAK ERHCGELKRR LGLSTLGELK QNLSRSWHDV
110 120 130 140 150
QVSSAYVKTS EKLGEWNEKV TQSDLYKKTQ ETLSQAGQKT SAALSTVGSA
160 170 180 190 200
ISRKLGDMRN SATFKSFEDR VGTIKSKVVG DRENGSDNLP SSAGSGDKPL

SDPAPF
Length:206
Mass (Da):22,238
Last modified:January 23, 2002 - v2
Checksum:i58F01BC67B1E3DE9
GO
Isoform 2 (identifier: O43399-2) [UniParc]FASTAAdd to basket
Also known as: HD54-ins2

The sequence of this isoform differs from the canonical sequence as follows:
     106-125: Missing.

Show »
Length:186
Mass (Da):19,901
Checksum:i002CD68479D8250C
GO
Isoform 3 (identifier: O43399-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-125: Missing.
     159-159: R → RAHPFSHSFSSYSIRHSISMPAMR

Show »
Length:209
Mass (Da):22,517
Checksum:i5087B635B9155443
GO
Isoform 4 (identifier: O43399-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-125: Missing.
     157-157: D → DMSSYSIRHSISMPA

Show »
Length:200
Mass (Da):21,450
Checksum:i9BAD0A523C8F14DB
GO
Isoform 5 (identifier: O43399-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: D → DMSSYSIRHSISMPA

Note: No experimental confirmation available.
Show »
Length:220
Mass (Da):23,787
Checksum:i0A47C22C7C285FFF
GO
Isoform 6 (identifier: O43399-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-29: Missing.
     106-125: Missing.

Show »
Length:163
Mass (Da):17,473
Checksum:i1CF34D45DF97AABC
GO
Isoform 7 (identifier: O43399-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: D → DMRAHPFSHSFSSYSIRHSISMPA

Note: No experimental confirmation available.
Show »
Length:229
Mass (Da):24,854
Checksum:i0AF18A6C7059BE30
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYR3A0A087WYR3_HUMAN
Tumor protein D54
TPD52L2
222Annotation score:
A0A087WZ51A0A087WZ51_HUMAN
Tumor protein D54
TPD52L2
152Annotation score:

Sequence cautioni

The sequence BU165202 differs from that shown. Reason: Frameshift at positions 155, 157, 173 and 188.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72R → K in AAC98478 (PubMed:9838088).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451547 – 29Missing in isoform 6. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_006547106 – 125Missing in isoform 2, isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_038361157D → DMSSYSIRHSISMPA in isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_047409157D → DMRAHPFSHSFSSYSIRHSI SMPA in isoform 7. 1 Publication1
Alternative sequenceiVSP_036756159R → RAHPFSHSFSSYSIRHSISM PAMR in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004429 mRNA Translation: AAC98477.1
AF004430 mRNA Translation: AAC98478.1
AK055068 mRNA Translation: BAG51460.1
AK298366 mRNA Translation: BAG60608.1
BT019631 mRNA Translation: AAV38437.1
AL118506 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75195.1
CH471077 Genomic DNA Translation: EAW75197.1
CH471077 Genomic DNA Translation: EAW75198.1
CH471077 Genomic DNA Translation: EAW75199.1
CH471077 Genomic DNA Translation: EAW75201.1
BC006804 mRNA Translation: AAH06804.1
BU165202 mRNA No translation available.
CCDSiCCDS13540.1 [O43399-1]
CCDS13541.1 [O43399-2]
CCDS13542.1 [O43399-7]
CCDS13543.1 [O43399-3]
CCDS13544.1 [O43399-5]
CCDS13545.1 [O43399-4]
CCDS58785.1 [O43399-6]
RefSeqiNP_001230821.1, NM_001243892.1 [O43399-6]
NP_003279.2, NM_003288.3 [O43399-1]
NP_955392.1, NM_199360.2 [O43399-7]
NP_955393.1, NM_199361.2 [O43399-3]
NP_955394.1, NM_199362.2 [O43399-5]
NP_955395.1, NM_199363.2 [O43399-4]
UniGeneiHs.473296

Genome annotation databases

EnsembliENST00000217121; ENSP00000217121; ENSG00000101150 [O43399-7]
ENST00000346249; ENSP00000343547; ENSG00000101150 [O43399-1]
ENST00000348257; ENSP00000343554; ENSG00000101150 [O43399-2]
ENST00000351424; ENSP00000340006; ENSG00000101150 [O43399-3]
ENST00000352482; ENSP00000344647; ENSG00000101150 [O43399-5]
ENST00000358548; ENSP00000351350; ENSG00000101150 [O43399-4]
ENST00000369927; ENSP00000358943; ENSG00000101150 [O43399-6]
GeneIDi7165
KEGGihsa:7165
UCSCiuc002ygy.4 human [O43399-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004429 mRNA Translation: AAC98477.1
AF004430 mRNA Translation: AAC98478.1
AK055068 mRNA Translation: BAG51460.1
AK298366 mRNA Translation: BAG60608.1
BT019631 mRNA Translation: AAV38437.1
AL118506 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75195.1
CH471077 Genomic DNA Translation: EAW75197.1
CH471077 Genomic DNA Translation: EAW75198.1
CH471077 Genomic DNA Translation: EAW75199.1
CH471077 Genomic DNA Translation: EAW75201.1
BC006804 mRNA Translation: AAH06804.1
BU165202 mRNA No translation available.
CCDSiCCDS13540.1 [O43399-1]
CCDS13541.1 [O43399-2]
CCDS13542.1 [O43399-7]
CCDS13543.1 [O43399-3]
CCDS13544.1 [O43399-5]
CCDS13545.1 [O43399-4]
CCDS58785.1 [O43399-6]
RefSeqiNP_001230821.1, NM_001243892.1 [O43399-6]
NP_003279.2, NM_003288.3 [O43399-1]
NP_955392.1, NM_199360.2 [O43399-7]
NP_955393.1, NM_199361.2 [O43399-3]
NP_955394.1, NM_199362.2 [O43399-5]
NP_955395.1, NM_199363.2 [O43399-4]
UniGeneiHs.473296

3D structure databases

ProteinModelPortaliO43399
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113018, 71 interactors
IntActiO43399, 12 interactors

PTM databases

iPTMnetiO43399
PhosphoSitePlusiO43399
SwissPalmiO43399

Polymorphism and mutation databases

BioMutaiTPD52L2

2D gel databases

OGPiO43399

Proteomic databases

EPDiO43399
PeptideAtlasiO43399
PRIDEiO43399
ProteomicsDBi48923
48924 [O43399-2]
48925 [O43399-3]
48926 [O43399-4]
48927 [O43399-5]
TopDownProteomicsiO43399-5 [O43399-5]

Protocols and materials databases

DNASUi7165
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217121; ENSP00000217121; ENSG00000101150 [O43399-7]
ENST00000346249; ENSP00000343547; ENSG00000101150 [O43399-1]
ENST00000348257; ENSP00000343554; ENSG00000101150 [O43399-2]
ENST00000351424; ENSP00000340006; ENSG00000101150 [O43399-3]
ENST00000352482; ENSP00000344647; ENSG00000101150 [O43399-5]
ENST00000358548; ENSP00000351350; ENSG00000101150 [O43399-4]
ENST00000369927; ENSP00000358943; ENSG00000101150 [O43399-6]
GeneIDi7165
KEGGihsa:7165
UCSCiuc002ygy.4 human [O43399-1]

Organism-specific databases

CTDi7165
DisGeNETi7165
EuPathDBiHostDB:ENSG00000101150.17
GeneCardsiTPD52L2
HGNCiHGNC:12007 TPD52L2
HPAiHPA047489
MIMi603747 gene
neXtProtiNX_O43399
OpenTargetsiENSG00000101150
PharmGKBiPA36688
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000015988
HOGENOMiHOG000231968
HOVERGENiHBG058643
InParanoidiO43399
OMAiRARPFSH
OrthoDBiEOG091G0MLN
PhylomeDBiO43399
TreeFamiTF317562

Enzyme and pathway databases

SignaLinkiO43399

Miscellaneous databases

ChiTaRSiTPD52L2 human
GeneWikiiTPD52L2
GenomeRNAii7165
PROiPR:O43399
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101150 Expressed in 230 organ(s), highest expression level in blood
CleanExiHS_TPD52L2
ExpressionAtlasiO43399 baseline and differential
GenevisibleiO43399 HS

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR007327 TPD52
PANTHERiPTHR19307 PTHR19307, 1 hit
PfamiView protein in Pfam
PF04201 TPD52, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTPD54_HUMAN
AccessioniPrimary (citable) accession number: O43399
Secondary accession number(s): B4DPJ6
, E1P5G7, O43398, Q5JWU5, Q5JWU6, Q5JWU8, Q5U0E0, Q9H3Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 23, 2002
Last modified: October 10, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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