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Protein

Thioredoxin-like protein 1

Gene

TXNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Active thioredoxin with a redox potential of about -250 mV.1 Publication

GO - Molecular functioni

  • disulfide oxidoreductase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 1
Alternative name(s):
32 kDa thioredoxin-related protein
Gene namesi
Name:TXNL1
Synonyms:TRP32, TXL, TXNL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000091164.12
HGNCiHGNC:12436 TXNL1
MIMi603049 gene
neXtProtiNX_O43396

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Organism-specific databases

DisGeNETi9352
OpenTargetsiENSG00000091164
PharmGKBiPA134967488

Polymorphism and mutation databases

BioMutaiTXNL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001200162 – 289Thioredoxin-like protein 1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 37Redox-active1 Publication
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiO43396
PaxDbiO43396
PeptideAtlasiO43396
PRIDEiO43396
ProteomicsDBi48922
TopDownProteomicsiO43396

2D gel databases

OGPiO43396
REPRODUCTION-2DPAGEiIPI00305692

PTM databases

iPTMnetiO43396
PhosphoSitePlusiO43396

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000091164 Expressed in 239 organ(s), highest expression level in thyroid gland
CleanExiHS_TXNL1
ExpressionAtlasiO43396 baseline and differential
GenevisibleiO43396 HS

Organism-specific databases

HPAiCAB016446
HPA002828
HPA002829

Interactioni

Subunit structurei

Component of the 19S regulatory cap of the 26S proteasome. Interacts with PSMD14/RPN11. Interacts with, and reduces EEF1A1.1 Publication

Protein-protein interaction databases

BioGridi114755, 64 interactors
IntActiO43396, 11 interactors
MINTiO43396
STRINGi9606.ENSP00000217515

Structurei

Secondary structure

1289
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43396
SMRiO43396
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43396

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 109ThioredoxinAdd BLAST108
Domaini115 – 285PITHPROSITE-ProRule annotationAdd BLAST171

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0908 Eukaryota
ENOG410YQ2G LUCA
GeneTreeiENSGT00530000063008
HOGENOMiHOG000189802
HOVERGENiHBG055982
InParanoidiO43396
OMAiPIFEMFP
OrthoDBiEOG091G0G71
PhylomeDBiO43396
TreeFamiTF314399

Family and domain databases

Gene3Di2.60.120.470, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR010400 PITH_dom
IPR037047 PITH_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF06201 PITH, 1 hit
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51532 PITH, 1 hit
PS00194 THIOREDOXIN_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O43396-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGVKPVGSD PDFQPELSGA GSRLAVVKFT MRGCGPCLRI APAFSSMSNK
60 70 80 90 100
YPQAVFLEVD VHQCQGTAAT NNISATPTFL FFRNKVRIDQ YQGADAVGLE
110 120 130 140 150
EKIKQHLEND PGSNEDTDIP KGYMDLMPFI NKAGCECLNE SDEHGFDNCL
160 170 180 190 200
RKDTTFLESD CDEQLLITVA FNQPVKLYSM KFQGPDNGQG PKYVKIFINL
210 220 230 240 250
PRSMDFEEAE RSEPTQALEL TEDDIKEDGI VPLRYVKFQN VNSVTIFVQS
260 270 280
NQGEEETTRI SYFTFIGTPV QATNMNDFKR VVGKKGESH
Length:289
Mass (Da):32,251
Last modified:January 23, 2007 - v3
Checksum:iB2CC0BD8042225C2
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EML9K7EML9_HUMAN
Thioredoxin-like protein 1
TXNL1
138Annotation score:
K7EPB7K7EPB7_HUMAN
Thioredoxin-like protein 1
TXNL1
69Annotation score:
K7ER96K7ER96_HUMAN
Thioredoxin-like protein 1
TXNL1
281Annotation score:
K7EME7K7EME7_HUMAN
Thioredoxin-like protein 1
TXNL1
103Annotation score:
K7EKG2K7EKG2_HUMAN
Thioredoxin-like protein 1
TXNL1
27Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003938 mRNA Translation: AAC39599.1
AF052659 mRNA Translation: AAC39898.1
AF143897
, AF143890, AF143891, AF143892, AF143893, AF143894, AF143895, AF143896 Genomic DNA Translation: AAF66676.1
AF051896 mRNA Translation: AAC05830.1
BC001156 mRNA Translation: AAH01156.1
CCDSiCCDS11961.1
PIRiJC5938
RefSeqiNP_004777.1, NM_004786.2
XP_016881582.1, XM_017026093.1
UniGeneiHs.114412

Genome annotation databases

EnsembliENST00000217515; ENSP00000217515; ENSG00000091164
ENST00000590954; ENSP00000464918; ENSG00000091164
GeneIDi9352
KEGGihsa:9352

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003938 mRNA Translation: AAC39599.1
AF052659 mRNA Translation: AAC39898.1
AF143897
, AF143890, AF143891, AF143892, AF143893, AF143894, AF143895, AF143896 Genomic DNA Translation: AAF66676.1
AF051896 mRNA Translation: AAC05830.1
BC001156 mRNA Translation: AAH01156.1
CCDSiCCDS11961.1
PIRiJC5938
RefSeqiNP_004777.1, NM_004786.2
XP_016881582.1, XM_017026093.1
UniGeneiHs.114412

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GH2X-ray2.22A2-108[»]
1WWYNMR-A122-279[»]
ProteinModelPortaliO43396
SMRiO43396
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114755, 64 interactors
IntActiO43396, 11 interactors
MINTiO43396
STRINGi9606.ENSP00000217515

PTM databases

iPTMnetiO43396
PhosphoSitePlusiO43396

Polymorphism and mutation databases

BioMutaiTXNL1

2D gel databases

OGPiO43396
REPRODUCTION-2DPAGEiIPI00305692

Proteomic databases

EPDiO43396
PaxDbiO43396
PeptideAtlasiO43396
PRIDEiO43396
ProteomicsDBi48922
TopDownProteomicsiO43396

Protocols and materials databases

DNASUi9352
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217515; ENSP00000217515; ENSG00000091164
ENST00000590954; ENSP00000464918; ENSG00000091164
GeneIDi9352
KEGGihsa:9352

Organism-specific databases

CTDi9352
DisGeNETi9352
EuPathDBiHostDB:ENSG00000091164.12
GeneCardsiTXNL1
HGNCiHGNC:12436 TXNL1
HPAiCAB016446
HPA002828
HPA002829
MIMi603049 gene
neXtProtiNX_O43396
OpenTargetsiENSG00000091164
PharmGKBiPA134967488
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0908 Eukaryota
ENOG410YQ2G LUCA
GeneTreeiENSGT00530000063008
HOGENOMiHOG000189802
HOVERGENiHBG055982
InParanoidiO43396
OMAiPIFEMFP
OrthoDBiEOG091G0G71
PhylomeDBiO43396
TreeFamiTF314399

Miscellaneous databases

ChiTaRSiTXNL1 human
EvolutionaryTraceiO43396
GeneWikiiTXNL1
GenomeRNAii9352
PROiPR:O43396
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091164 Expressed in 239 organ(s), highest expression level in thyroid gland
CleanExiHS_TXNL1
ExpressionAtlasiO43396 baseline and differential
GenevisibleiO43396 HS

Family and domain databases

Gene3Di2.60.120.470, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR010400 PITH_dom
IPR037047 PITH_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF06201 PITH, 1 hit
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51532 PITH, 1 hit
PS00194 THIOREDOXIN_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTXNL1_HUMAN
AccessioniPrimary (citable) accession number: O43396
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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