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Protein

Heterogeneous nuclear ribonucleoprotein R

Gene

HNRNPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein R
Short name:
hnRNP R
Gene namesi
Name:HNRNPR
Synonyms:HNRPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000125944.18
HGNCiHGNC:5047 HNRNPR
MIMi607201 gene
neXtProtiNX_O43390

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi10236
OpenTargetsiENSG00000125944
PharmGKBiPA162391459

Polymorphism and mutation databases

BioMutaiHNRNPR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000818702 – 633Heterogeneous nuclear ribonucleoprotein RAdd BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Cross-linki13Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki359Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei366N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO43390
MaxQBiO43390
PaxDbiO43390
PeptideAtlasiO43390
PRIDEiO43390
ProteomicsDBi48919
48920 [O43390-2]
TopDownProteomicsiO43390-1 [O43390-1]

PTM databases

iPTMnetiO43390
PhosphoSitePlusiO43390
SwissPalmiO43390

Miscellaneous databases

PMAP-CutDBiO43390

Expressioni

Gene expression databases

BgeeiENSG00000125944 Expressed in 241 organ(s), highest expression level in female gonad
CleanExiHS_HNRNPR
ExpressionAtlasiO43390 baseline and differential
GenevisibleiO43390 HS

Organism-specific databases

HPAiCAB011687
HPA026092

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with GTPBP1.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115530, 291 interactors
CORUMiO43390
IntActiO43390, 63 interactors
MINTiO43390
STRINGi9606.ENSP00000363745

Structurei

Secondary structure

1633
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43390
SMRiO43390
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43390

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 244RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini246 – 328RRM 2PROSITE-ProRule annotationAdd BLAST83
Domaini341 – 411RRM 3PROSITE-ProRule annotationAdd BLAST71
Repeati462 – 4711; approximate10
Repeati472 – 4822Add BLAST11
Repeati488 – 4973; approximate10

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni447 – 567RNA-binding RGG-boxAdd BLAST121
Regioni462 – 4973 X 11 AA approximate repeats of D-D-Y-Y-G-Y-D-Y-H-D-YAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi412 – 418Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 153Asp/Glu-rich (acidic)Add BLAST152
Compositional biasi579 – 633Asn/Gln-richAdd BLAST55

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0117 Eukaryota
ENOG410XTJ5 LUCA
GeneTreeiENSGT00550000074366
HOGENOMiHOG000186082
HOVERGENiHBG051917
InParanoidiO43390
KOiK13161
OMAiRKADVFN
OrthoDBiEOG091G0EUB
PhylomeDBiO43390
TreeFamiTF314932

Family and domain databases

CDDicd12482 RRM1_hnRNPR, 1 hit
cd12488 RRM2_hnRNPR, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006535 HnRNP_R/Q_splicing_fac
IPR034410 hnRNPR_RRM1
IPR034411 hnRNPR_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01648 hnRNP-R-Q, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43390-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF
60 70 80 90 100
QTGLVAYVDL DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG
110 120 130 140 150
VMKTYRQREK QGSKVQESTK GPDEAKIKAL LERTGYTLDV TTGQRKYGGP
160 170 180 190 200
PPDSVYSGVQ PGIGTEVFVG KIPRDLYEDE LVPLFEKAGP IWDLRLMMDP
210 220 230 240 250
LSGQNRGYAF ITFCGKEAAQ EAVKLCDSYE IRPGKHLGVC ISVANNRLFV
260 270 280 290 300
GSIPKNKTKE NILEEFSKVT EGLVDVILYH QPDDKKKNRG FCFLEYEDHK
310 320 330 340 350
SAAQARRRLM SGKVKVWGNV VTVEWADPVE EPDPEVMAKV KVLFVRNLAT
360 370 380 390 400
TVTEEILEKS FSEFGKLERV KKLKDYAFVH FEDRGAAVKA MDEMNGKEIE
410 420 430 440 450
GEEIEIVLAK PPDKKRKERQ AARQASRSTA YEDYYYHPPP RMPPPIRGRG
460 470 480 490 500
RGGGRGGYGY PPDYYGYEDY YDDYYGYDYH DYRGGYEDPY YGYDDGYAVR
510 520 530 540 550
GRGGGRGGRG APPPPRGRGA PPPRGRAGYS QRGAPLGPPR GSRGGRGGPA
560 570 580 590 600
QQQRGRGSRG SRGNRGGNVG GKRKADGYNQ PDSKRRQTNN QQNWGSQPIA
610 620 630
QQPLQQGGDY SGNYGYNNDN QEFYQDTYGQ QWK
Length:633
Mass (Da):70,943
Last modified:June 1, 1998 - v1
Checksum:i088341F6465ED46F
GO
Isoform 2 (identifier: O43390-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-269: V → VTGL

Show »
Length:636
Mass (Da):71,214
Checksum:i4319EA79A1A6DED2
GO
Isoform 3 (identifier: O43390-3) [UniParc]FASTAAdd to basket
Also known as: hnRNP-R2

The sequence of this isoform differs from the canonical sequence as follows:
     129-166: Missing.

Note: Expression is low and neural-specific.
Show »
Length:595
Mass (Da):66,980
Checksum:iC9C67D917E7BCC44
GO
Isoform 4 (identifier: O43390-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     269-269: V → VTGL

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:535
Mass (Da):59,953
Checksum:iEDEE799FB18DE444
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DT28B4DT28_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPR HNRPR, hCG_38907
494Annotation score:
A0A286YEZ8A0A286YEZ8_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPR
141Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547031 – 101Missing in isoform 4. CuratedAdd BLAST101
Alternative sequenceiVSP_047647129 – 166Missing in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_038360269V → VTGL in isoform 2 and isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000364 mRNA Translation: AAC39540.1
DQ351905 mRNA Translation: ABC73063.1
AL109936 Genomic DNA No translation available.
BC001449 mRNA Translation: AAH01449.1
CCDSiCCDS232.1 [O43390-1]
CCDS44085.1 [O43390-2]
CCDS60020.1 [O43390-4]
CCDS72727.1 [O43390-3]
PIRiT02673
RefSeqiNP_001095868.1, NM_001102398.2 [O43390-2]
NP_001284549.1, NM_001297620.1 [O43390-3]
NP_005817.1, NM_005826.4 [O43390-1]
XP_005245768.1, XM_005245711.4 [O43390-1]
XP_011538773.1, XM_011540471.2 [O43390-2]
XP_016855497.1, XM_017000008.1 [O43390-3]
UniGeneiHs.373763

Genome annotation databases

EnsembliENST00000302271; ENSP00000304405; ENSG00000125944 [O43390-1]
ENST00000374612; ENSP00000363741; ENSG00000125944 [O43390-1]
ENST00000374616; ENSP00000363745; ENSG00000125944 [O43390-2]
ENST00000427764; ENSP00000392799; ENSG00000125944 [O43390-3]
ENST00000478691; ENSP00000474437; ENSG00000125944 [O43390-4]
ENST00000634263; ENSP00000489371; ENSG00000282958 [O43390-1]
ENST00000634634; ENSP00000488941; ENSG00000282958 [O43390-3]
ENST00000634713; ENSP00000488945; ENSG00000282958 [O43390-2]
ENST00000634766; ENSP00000489252; ENSG00000282958 [O43390-1]
ENST00000635150; ENSP00000489275; ENSG00000282958 [O43390-4]
GeneIDi10236
KEGGihsa:10236
UCSCiuc001bgp.5 human [O43390-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000364 mRNA Translation: AAC39540.1
DQ351905 mRNA Translation: ABC73063.1
AL109936 Genomic DNA No translation available.
BC001449 mRNA Translation: AAH01449.1
CCDSiCCDS232.1 [O43390-1]
CCDS44085.1 [O43390-2]
CCDS60020.1 [O43390-4]
CCDS72727.1 [O43390-3]
PIRiT02673
RefSeqiNP_001095868.1, NM_001102398.2 [O43390-2]
NP_001284549.1, NM_001297620.1 [O43390-3]
NP_005817.1, NM_005826.4 [O43390-1]
XP_005245768.1, XM_005245711.4 [O43390-1]
XP_011538773.1, XM_011540471.2 [O43390-2]
XP_016855497.1, XM_017000008.1 [O43390-3]
UniGeneiHs.373763

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DK2NMR-A333-416[»]
ProteinModelPortaliO43390
SMRiO43390
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115530, 291 interactors
CORUMiO43390
IntActiO43390, 63 interactors
MINTiO43390
STRINGi9606.ENSP00000363745

PTM databases

iPTMnetiO43390
PhosphoSitePlusiO43390
SwissPalmiO43390

Polymorphism and mutation databases

BioMutaiHNRNPR

Proteomic databases

EPDiO43390
MaxQBiO43390
PaxDbiO43390
PeptideAtlasiO43390
PRIDEiO43390
ProteomicsDBi48919
48920 [O43390-2]
TopDownProteomicsiO43390-1 [O43390-1]

Protocols and materials databases

DNASUi10236
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302271; ENSP00000304405; ENSG00000125944 [O43390-1]
ENST00000374612; ENSP00000363741; ENSG00000125944 [O43390-1]
ENST00000374616; ENSP00000363745; ENSG00000125944 [O43390-2]
ENST00000427764; ENSP00000392799; ENSG00000125944 [O43390-3]
ENST00000478691; ENSP00000474437; ENSG00000125944 [O43390-4]
ENST00000634263; ENSP00000489371; ENSG00000282958 [O43390-1]
ENST00000634634; ENSP00000488941; ENSG00000282958 [O43390-3]
ENST00000634713; ENSP00000488945; ENSG00000282958 [O43390-2]
ENST00000634766; ENSP00000489252; ENSG00000282958 [O43390-1]
ENST00000635150; ENSP00000489275; ENSG00000282958 [O43390-4]
GeneIDi10236
KEGGihsa:10236
UCSCiuc001bgp.5 human [O43390-1]

Organism-specific databases

CTDi10236
DisGeNETi10236
EuPathDBiHostDB:ENSG00000125944.18
GeneCardsiHNRNPR
HGNCiHGNC:5047 HNRNPR
HPAiCAB011687
HPA026092
MIMi607201 gene
neXtProtiNX_O43390
OpenTargetsiENSG00000125944
PharmGKBiPA162391459
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0117 Eukaryota
ENOG410XTJ5 LUCA
GeneTreeiENSGT00550000074366
HOGENOMiHOG000186082
HOVERGENiHBG051917
InParanoidiO43390
KOiK13161
OMAiRKADVFN
OrthoDBiEOG091G0EUB
PhylomeDBiO43390
TreeFamiTF314932

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Miscellaneous databases

ChiTaRSiHNRNPR human
EvolutionaryTraceiO43390
GeneWikiiHNRNPR
GenomeRNAii10236
PMAP-CutDBiO43390
PROiPR:O43390
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125944 Expressed in 241 organ(s), highest expression level in female gonad
CleanExiHS_HNRNPR
ExpressionAtlasiO43390 baseline and differential
GenevisibleiO43390 HS

Family and domain databases

CDDicd12482 RRM1_hnRNPR, 1 hit
cd12488 RRM2_hnRNPR, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006535 HnRNP_R/Q_splicing_fac
IPR034410 hnRNPR_RRM1
IPR034411 hnRNPR_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01648 hnRNP-R-Q, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHNRPR_HUMAN
AccessioniPrimary (citable) accession number: O43390
Secondary accession number(s): Q2L7G6
, Q5TEH1, Q9BV64, S4R3J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 193 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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