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Protein

Heterogeneous nuclear ribonucleoprotein R

Gene

HNRNPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein R
Short name:
hnRNP R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPR
Synonyms:HNRPR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000125944.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5047 HNRNPR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607201 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43390

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10236

Open Targets

More...
OpenTargetsi
ENSG00000125944

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162391459

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HNRNPR

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818702 – 633Heterogeneous nuclear ribonucleoprotein RAdd BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki13Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki359Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei366N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43390

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43390

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43390

PeptideAtlas

More...
PeptideAtlasi
O43390

PRoteomics IDEntifications database

More...
PRIDEi
O43390

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48919
48920 [O43390-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O43390-1 [O43390-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43390

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43390

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O43390

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
O43390

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000125944 Expressed in 241 organ(s), highest expression level in female gonad

CleanEx database of gene expression profiles

More...
CleanExi
HS_HNRNPR

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O43390 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43390 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB011687
HPA026092

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with GTPBP1.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115530, 291 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O43390

Protein interaction database and analysis system

More...
IntActi
O43390, 65 interactors

Molecular INTeraction database

More...
MINTi
O43390

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363745

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1633
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O43390

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43390

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O43390

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 244RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini246 – 328RRM 2PROSITE-ProRule annotationAdd BLAST83
Domaini341 – 411RRM 3PROSITE-ProRule annotationAdd BLAST71
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati462 – 4711; approximate10
Repeati472 – 4822Add BLAST11
Repeati488 – 4973; approximate10

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni447 – 567RNA-binding RGG-boxAdd BLAST121
Regioni462 – 4973 X 11 AA approximate repeats of D-D-Y-Y-G-Y-D-Y-H-D-YAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi412 – 418Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 153Asp/Glu-rich (acidic)Add BLAST152
Compositional biasi579 – 633Asn/Gln-richAdd BLAST55

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0117 Eukaryota
ENOG410XTJ5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153511

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000186082

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051917

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43390

KEGG Orthology (KO)

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KOi
K13161

Identification of Orthologs from Complete Genome Data

More...
OMAi
RKADVFN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0EUB

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43390

TreeFam database of animal gene trees

More...
TreeFami
TF314932

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12482 RRM1_hnRNPR, 1 hit
cd12488 RRM2_hnRNPR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006535 HnRNP_R/Q_splicing_fac
IPR034410 hnRNPR_RRM1
IPR034411 hnRNPR_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 3 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01648 hnRNP-R-Q, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43390-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF
60 70 80 90 100
QTGLVAYVDL DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG
110 120 130 140 150
VMKTYRQREK QGSKVQESTK GPDEAKIKAL LERTGYTLDV TTGQRKYGGP
160 170 180 190 200
PPDSVYSGVQ PGIGTEVFVG KIPRDLYEDE LVPLFEKAGP IWDLRLMMDP
210 220 230 240 250
LSGQNRGYAF ITFCGKEAAQ EAVKLCDSYE IRPGKHLGVC ISVANNRLFV
260 270 280 290 300
GSIPKNKTKE NILEEFSKVT EGLVDVILYH QPDDKKKNRG FCFLEYEDHK
310 320 330 340 350
SAAQARRRLM SGKVKVWGNV VTVEWADPVE EPDPEVMAKV KVLFVRNLAT
360 370 380 390 400
TVTEEILEKS FSEFGKLERV KKLKDYAFVH FEDRGAAVKA MDEMNGKEIE
410 420 430 440 450
GEEIEIVLAK PPDKKRKERQ AARQASRSTA YEDYYYHPPP RMPPPIRGRG
460 470 480 490 500
RGGGRGGYGY PPDYYGYEDY YDDYYGYDYH DYRGGYEDPY YGYDDGYAVR
510 520 530 540 550
GRGGGRGGRG APPPPRGRGA PPPRGRAGYS QRGAPLGPPR GSRGGRGGPA
560 570 580 590 600
QQQRGRGSRG SRGNRGGNVG GKRKADGYNQ PDSKRRQTNN QQNWGSQPIA
610 620 630
QQPLQQGGDY SGNYGYNNDN QEFYQDTYGQ QWK
Length:633
Mass (Da):70,943
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i088341F6465ED46F
GO
Isoform 2 (identifier: O43390-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-269: V → VTGL

Show »
Length:636
Mass (Da):71,214
Checksum:i4319EA79A1A6DED2
GO
Isoform 3 (identifier: O43390-3) [UniParc]FASTAAdd to basket
Also known as: hnRNP-R2

The sequence of this isoform differs from the canonical sequence as follows:
     129-166: Missing.

Note: Expression is low and neural-specific.
Show »
Length:595
Mass (Da):66,980
Checksum:iC9C67D917E7BCC44
GO
Isoform 4 (identifier: O43390-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     269-269: V → VTGL

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:535
Mass (Da):59,953
Checksum:iEDEE799FB18DE444
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DT28B4DT28_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPR HNRPR, hCG_38907
494Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YEZ8A0A286YEZ8_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPR
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547031 – 101Missing in isoform 4. CuratedAdd BLAST101
Alternative sequenceiVSP_047647129 – 166Missing in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_038360269V → VTGL in isoform 2 and isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF000364 mRNA Translation: AAC39540.1
DQ351905 mRNA Translation: ABC73063.1
AL109936 Genomic DNA No translation available.
BC001449 mRNA Translation: AAH01449.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS232.1 [O43390-1]
CCDS44085.1 [O43390-2]
CCDS60020.1 [O43390-4]
CCDS72727.1 [O43390-3]

Protein sequence database of the Protein Information Resource

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PIRi
T02673

NCBI Reference Sequences

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RefSeqi
NP_001095868.1, NM_001102398.2 [O43390-2]
NP_001284549.1, NM_001297620.1 [O43390-3]
NP_005817.1, NM_005826.4 [O43390-1]
XP_005245768.1, XM_005245711.4 [O43390-1]
XP_011538773.1, XM_011540471.2 [O43390-2]
XP_016855497.1, XM_017000008.1 [O43390-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.373763

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302271; ENSP00000304405; ENSG00000125944 [O43390-1]
ENST00000374612; ENSP00000363741; ENSG00000125944 [O43390-1]
ENST00000374616; ENSP00000363745; ENSG00000125944 [O43390-2]
ENST00000427764; ENSP00000392799; ENSG00000125944 [O43390-3]
ENST00000478691; ENSP00000474437; ENSG00000125944 [O43390-4]
ENST00000634263; ENSP00000489371; ENSG00000282958 [O43390-1]
ENST00000634634; ENSP00000488941; ENSG00000282958 [O43390-3]
ENST00000634713; ENSP00000488945; ENSG00000282958 [O43390-2]
ENST00000634766; ENSP00000489252; ENSG00000282958 [O43390-1]
ENST00000635150; ENSP00000489275; ENSG00000282958 [O43390-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10236

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10236

UCSC genome browser

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UCSCi
uc001bgp.5 human [O43390-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000364 mRNA Translation: AAC39540.1
DQ351905 mRNA Translation: ABC73063.1
AL109936 Genomic DNA No translation available.
BC001449 mRNA Translation: AAH01449.1
CCDSiCCDS232.1 [O43390-1]
CCDS44085.1 [O43390-2]
CCDS60020.1 [O43390-4]
CCDS72727.1 [O43390-3]
PIRiT02673
RefSeqiNP_001095868.1, NM_001102398.2 [O43390-2]
NP_001284549.1, NM_001297620.1 [O43390-3]
NP_005817.1, NM_005826.4 [O43390-1]
XP_005245768.1, XM_005245711.4 [O43390-1]
XP_011538773.1, XM_011540471.2 [O43390-2]
XP_016855497.1, XM_017000008.1 [O43390-3]
UniGeneiHs.373763

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DK2NMR-A333-416[»]
ProteinModelPortaliO43390
SMRiO43390
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115530, 291 interactors
CORUMiO43390
IntActiO43390, 65 interactors
MINTiO43390
STRINGi9606.ENSP00000363745

PTM databases

iPTMnetiO43390
PhosphoSitePlusiO43390
SwissPalmiO43390

Polymorphism and mutation databases

BioMutaiHNRNPR

Proteomic databases

EPDiO43390
MaxQBiO43390
PaxDbiO43390
PeptideAtlasiO43390
PRIDEiO43390
ProteomicsDBi48919
48920 [O43390-2]
TopDownProteomicsiO43390-1 [O43390-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10236
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302271; ENSP00000304405; ENSG00000125944 [O43390-1]
ENST00000374612; ENSP00000363741; ENSG00000125944 [O43390-1]
ENST00000374616; ENSP00000363745; ENSG00000125944 [O43390-2]
ENST00000427764; ENSP00000392799; ENSG00000125944 [O43390-3]
ENST00000478691; ENSP00000474437; ENSG00000125944 [O43390-4]
ENST00000634263; ENSP00000489371; ENSG00000282958 [O43390-1]
ENST00000634634; ENSP00000488941; ENSG00000282958 [O43390-3]
ENST00000634713; ENSP00000488945; ENSG00000282958 [O43390-2]
ENST00000634766; ENSP00000489252; ENSG00000282958 [O43390-1]
ENST00000635150; ENSP00000489275; ENSG00000282958 [O43390-4]
GeneIDi10236
KEGGihsa:10236
UCSCiuc001bgp.5 human [O43390-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10236
DisGeNETi10236
EuPathDBiHostDB:ENSG00000125944.18

GeneCards: human genes, protein and diseases

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GeneCardsi
HNRNPR
HGNCiHGNC:5047 HNRNPR
HPAiCAB011687
HPA026092
MIMi607201 gene
neXtProtiNX_O43390
OpenTargetsiENSG00000125944
PharmGKBiPA162391459

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0117 Eukaryota
ENOG410XTJ5 LUCA
GeneTreeiENSGT00940000153511
HOGENOMiHOG000186082
HOVERGENiHBG051917
InParanoidiO43390
KOiK13161
OMAiRKADVFN
OrthoDBiEOG091G0EUB
PhylomeDBiO43390
TreeFamiTF314932

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HNRNPR human
EvolutionaryTraceiO43390

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HNRNPR

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10236
PMAP-CutDBiO43390

Protein Ontology

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PROi
PR:O43390

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125944 Expressed in 241 organ(s), highest expression level in female gonad
CleanExiHS_HNRNPR
ExpressionAtlasiO43390 baseline and differential
GenevisibleiO43390 HS

Family and domain databases

CDDicd12482 RRM1_hnRNPR, 1 hit
cd12488 RRM2_hnRNPR, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006535 HnRNP_R/Q_splicing_fac
IPR034410 hnRNPR_RRM1
IPR034411 hnRNPR_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01648 hnRNP-R-Q, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRPR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43390
Secondary accession number(s): Q2L7G6
, Q5TEH1, Q9BV64, S4R3J4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: December 5, 2018
This is version 194 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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