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Protein

Zinc finger protein 749

Gene

ZNF749

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 174C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri584 – 606C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri612 – 634C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri640 – 662C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri668 – 690C2H2-type 17; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri696 – 718C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri751 – 773C2H2-type 19; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 749
Gene namesi
Name:ZNF749
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000186230.6
HGNCiHGNC:32783 ZNF749
neXtProtiNX_O43361

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiZNF749

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743971 – 778Zinc finger protein 749Add BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei466N6-acetyllysineCombined sources1
Modified residuei539N6-acetyllysineCombined sources1
Cross-linki761Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki768Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO43361
MaxQBiO43361
PaxDbiO43361
PeptideAtlasiO43361
PRIDEiO43361
ProteomicsDBi48910

PTM databases

iPTMnetiO43361
PhosphoSitePlusiO43361

Expressioni

Gene expression databases

BgeeiENSG00000186230 Expressed in 104 organ(s), highest expression level in liver
CleanExiHS_ZNF749
ExpressionAtlasiO43361 baseline and differential
GenevisibleiO43361 HS

Organism-specific databases

HPAiHPA042082
HPA042091
HPA056001

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333980

Structurei

3D structure databases

ProteinModelPortaliO43361
SMRiO43361
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 101KRABPROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 174C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri584 – 606C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri612 – 634C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri640 – 662C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri668 – 690C2H2-type 17; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri696 – 718C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri751 – 773C2H2-type 19; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO43361
KOiK09228
OMAiHTDAFSK
OrthoDBiEOG091G02KC
PhylomeDBiO43361
TreeFamiTF339848

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O43361-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLTEDCMVF EDVAIYFSQE EWGILNDAQR HLHSNVMLEN FALLSSVGCW
60 70 80 90 100
HGAKDEEVPS KQCVSVRVLQ VTIPKPALST LKAQPCKMCS SILKDILHLA
110 120 130 140 150
EHDGTHPEQG LYTCAAEHDL HQKEQIREKL TRSDEWRPSF VNHSAHVGER
160 170 180 190 200
NFTCTQGGKD FTASSDLLQQ QVLNSGWKLY RDTQDGEAFQ GEQNDFNSSQ
210 220 230 240 250
GGKDFCHQHG LFEHQKTHNG ERPYEFSECG ELFRYNSNLI KYQQNHAGER
260 270 280 290 300
PYEGTEYGKT FIRKSNLVQH QKIHSEGFLS KRSDPIEHQE ILSRPTPYEC
310 320 330 340 350
TQCGKAFLTQ AHLVGHQKTH TGEQPYECNK CGKFFMYNSK LIRHQKVHTG
360 370 380 390 400
ERRYECSECG KLFMDSFTLG RHQRVHTGER PFECSICGKF FSHRSTLNMH
410 420 430 440 450
QRVHAGKRLY KCSECGKAFS LKHNVVQHLK IHTGERPYEC TECEKAFVRK
460 470 480 490 500
SHLVQHQKIH TDAFSKRSDL IQHKRIDIRP RPYTCSECGK AFLTQAHLVG
510 520 530 540 550
HQKIHTGERP YECTQCAKAF VRKSHLVQHE KIHTDAFSKR SDLIQHKRID
560 570 580 590 600
LRPRPYVCSE CGKAFLTQAH LDGHQKIQTG ERRYECNECG KFFLDSYKLV
610 620 630 640 650
IHQRIHTGEK PYKCSKCGKF FRYRCTLSRH QKVHTGERPY ECSECGKFFR
660 670 680 690 700
DSYKLIIHQR VHTGEKPYEC SNCGKFLRYR STFIKHHKVC TGEKPHECSK
710 720 730 740 750
CRELFRTKSS LIIHQQSHTG ESPFKLRECG KDFNKCNTGQ RQKTHTGERS
760 770
YECGESSKVF KYNSSLIKHQ IIHTGKRP
Length:778
Mass (Da):90,364
Last modified:November 30, 2010 - v2
Checksum:iFB08226F2E47856B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J756C9J756_HUMAN
Zinc finger protein 749
ZNF749
66Annotation score:

Sequence cautioni

The sequence AAB97932 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177Missing in AK122794 (PubMed:14702039).Curated1
Sequence conflicti679Y → C in AK122794 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030278243Q → R. Corresponds to variant dbSNP:rs12986235Ensembl.1
Natural variantiVAR_030279405A → T. Corresponds to variant dbSNP:rs2240038Ensembl.1
Natural variantiVAR_030280771I → R. Corresponds to variant dbSNP:rs7246856Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004076 Genomic DNA Translation: AAB97932.1 Sequence problems.
AK122794 mRNA No translation available.
CCDSiCCDS33132.2
RefSeqiNP_001018855.2, NM_001023561.3
NP_001308882.1, NM_001321953.1
NP_001308883.1, NM_001321954.1
XP_016882291.1, XM_017026802.1
UniGeneiHs.467358

Genome annotation databases

EnsembliENST00000334181; ENSP00000333980; ENSG00000186230
GeneIDi388567
KEGGihsa:388567
UCSCiuc002qoq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004076 Genomic DNA Translation: AAB97932.1 Sequence problems.
AK122794 mRNA No translation available.
CCDSiCCDS33132.2
RefSeqiNP_001018855.2, NM_001023561.3
NP_001308882.1, NM_001321953.1
NP_001308883.1, NM_001321954.1
XP_016882291.1, XM_017026802.1
UniGeneiHs.467358

3D structure databases

ProteinModelPortaliO43361
SMRiO43361
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333980

PTM databases

iPTMnetiO43361
PhosphoSitePlusiO43361

Polymorphism and mutation databases

BioMutaiZNF749

Proteomic databases

EPDiO43361
MaxQBiO43361
PaxDbiO43361
PeptideAtlasiO43361
PRIDEiO43361
ProteomicsDBi48910

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334181; ENSP00000333980; ENSG00000186230
GeneIDi388567
KEGGihsa:388567
UCSCiuc002qoq.3 human

Organism-specific databases

CTDi388567
EuPathDBiHostDB:ENSG00000186230.6
GeneCardsiZNF749
HGNCiHGNC:32783 ZNF749
HPAiHPA042082
HPA042091
HPA056001
neXtProtiNX_O43361
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO43361
KOiK09228
OMAiHTDAFSK
OrthoDBiEOG091G02KC
PhylomeDBiO43361
TreeFamiTF339848

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii388567
PROiPR:O43361

Gene expression databases

BgeeiENSG00000186230 Expressed in 104 organ(s), highest expression level in liver
CleanExiHS_ZNF749
ExpressionAtlasiO43361 baseline and differential
GenevisibleiO43361 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN749_HUMAN
AccessioniPrimary (citable) accession number: O43361
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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