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Entry version 154 (13 Feb 2019)
Sequence version 2 (30 Nov 2010)
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Protein

Zinc finger protein 749

Gene

ZNF749

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri152 – 174C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri584 – 606C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri612 – 634C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri640 – 662C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri668 – 690C2H2-type 17; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri696 – 718C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri751 – 773C2H2-type 19; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 749
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF749
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000186230.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32783 ZNF749

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43361

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF749

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002743971 – 778Zinc finger protein 749Add BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei466N6-acetyllysineCombined sources1
Modified residuei539N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki761Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki768Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43361

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43361

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43361

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43361

PeptideAtlas

More...
PeptideAtlasi
O43361

PRoteomics IDEntifications database

More...
PRIDEi
O43361

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48910

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43361

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43361

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186230 Expressed in 104 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O43361 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43361 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042082
HPA042091
HPA056001

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000333980

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O43361

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O43361

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 101KRABPROSITE-ProRule annotationAdd BLAST94

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 174C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri584 – 606C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri612 – 634C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri640 – 662C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri668 – 690C2H2-type 17; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri696 – 718C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri751 – 773C2H2-type 19; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164862

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018163

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43361

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTDAFSK

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43361

TreeFam database of animal gene trees

More...
TreeFami
TF339848

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O43361-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLTEDCMVF EDVAIYFSQE EWGILNDAQR HLHSNVMLEN FALLSSVGCW
60 70 80 90 100
HGAKDEEVPS KQCVSVRVLQ VTIPKPALST LKAQPCKMCS SILKDILHLA
110 120 130 140 150
EHDGTHPEQG LYTCAAEHDL HQKEQIREKL TRSDEWRPSF VNHSAHVGER
160 170 180 190 200
NFTCTQGGKD FTASSDLLQQ QVLNSGWKLY RDTQDGEAFQ GEQNDFNSSQ
210 220 230 240 250
GGKDFCHQHG LFEHQKTHNG ERPYEFSECG ELFRYNSNLI KYQQNHAGER
260 270 280 290 300
PYEGTEYGKT FIRKSNLVQH QKIHSEGFLS KRSDPIEHQE ILSRPTPYEC
310 320 330 340 350
TQCGKAFLTQ AHLVGHQKTH TGEQPYECNK CGKFFMYNSK LIRHQKVHTG
360 370 380 390 400
ERRYECSECG KLFMDSFTLG RHQRVHTGER PFECSICGKF FSHRSTLNMH
410 420 430 440 450
QRVHAGKRLY KCSECGKAFS LKHNVVQHLK IHTGERPYEC TECEKAFVRK
460 470 480 490 500
SHLVQHQKIH TDAFSKRSDL IQHKRIDIRP RPYTCSECGK AFLTQAHLVG
510 520 530 540 550
HQKIHTGERP YECTQCAKAF VRKSHLVQHE KIHTDAFSKR SDLIQHKRID
560 570 580 590 600
LRPRPYVCSE CGKAFLTQAH LDGHQKIQTG ERRYECNECG KFFLDSYKLV
610 620 630 640 650
IHQRIHTGEK PYKCSKCGKF FRYRCTLSRH QKVHTGERPY ECSECGKFFR
660 670 680 690 700
DSYKLIIHQR VHTGEKPYEC SNCGKFLRYR STFIKHHKVC TGEKPHECSK
710 720 730 740 750
CRELFRTKSS LIIHQQSHTG ESPFKLRECG KDFNKCNTGQ RQKTHTGERS
760 770
YECGESSKVF KYNSSLIKHQ IIHTGKRP
Length:778
Mass (Da):90,364
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB08226F2E47856B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J756C9J756_HUMAN
Zinc finger protein 749
ZNF749
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB97932 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti177Missing in AK122794 (PubMed:14702039).Curated1
Sequence conflicti679Y → C in AK122794 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030278243Q → R. Corresponds to variant dbSNP:rs12986235Ensembl.1
Natural variantiVAR_030279405A → T. Corresponds to variant dbSNP:rs2240038Ensembl.1
Natural variantiVAR_030280771I → R. Corresponds to variant dbSNP:rs7246856Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004076 Genomic DNA Translation: AAB97932.1 Sequence problems.
AK122794 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33132.2

NCBI Reference Sequences

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RefSeqi
NP_001018855.2, NM_001023561.3
NP_001308882.1, NM_001321953.1
NP_001308883.1, NM_001321954.1
XP_016882291.1, XM_017026802.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.467358

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334181; ENSP00000333980; ENSG00000186230

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
388567

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:388567

UCSC genome browser

More...
UCSCi
uc002qoq.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004076 Genomic DNA Translation: AAB97932.1 Sequence problems.
AK122794 mRNA No translation available.
CCDSiCCDS33132.2
RefSeqiNP_001018855.2, NM_001023561.3
NP_001308882.1, NM_001321953.1
NP_001308883.1, NM_001321954.1
XP_016882291.1, XM_017026802.1
UniGeneiHs.467358

3D structure databases

ProteinModelPortaliO43361
SMRiO43361
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333980

PTM databases

iPTMnetiO43361
PhosphoSitePlusiO43361

Polymorphism and mutation databases

BioMutaiZNF749

Proteomic databases

EPDiO43361
jPOSTiO43361
MaxQBiO43361
PaxDbiO43361
PeptideAtlasiO43361
PRIDEiO43361
ProteomicsDBi48910

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334181; ENSP00000333980; ENSG00000186230
GeneIDi388567
KEGGihsa:388567
UCSCiuc002qoq.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
388567
EuPathDBiHostDB:ENSG00000186230.6

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF749
HGNCiHGNC:32783 ZNF749
HPAiHPA042082
HPA042091
HPA056001
neXtProtiNX_O43361

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000164862
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO43361
KOiK09228
OMAiHTDAFSK
OrthoDBi1318335at2759
PhylomeDBiO43361
TreeFamiTF339848

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
388567

Protein Ontology

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PROi
PR:O43361

Gene expression databases

BgeeiENSG00000186230 Expressed in 104 organ(s), highest expression level in liver
ExpressionAtlasiO43361 baseline and differential
GenevisibleiO43361 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN749_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43361
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 30, 2010
Last modified: February 13, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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