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Protein

RNA-binding protein Musashi homolog 1

Gene

MSI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U1-3AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • nervous system development Source: ProtInc

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-9010553 Regulation of expression of SLITs and ROBOs
SIGNORiO43347

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Musashi homolog 1
Short name:
Musashi-1
Gene namesi
Name:MSI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135097.6
HGNCiHGNC:7330 MSI1
MIMi603328 gene
neXtProtiNX_O43347

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4440
OpenTargetsiENSG00000135097
PharmGKBiPA31137

Polymorphism and mutation databases

BioMutaiMSI1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816491 – 362RNA-binding protein Musashi homolog 1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei191PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO43347
MaxQBiO43347
PaxDbiO43347
PeptideAtlasiO43347
PRIDEiO43347
ProteomicsDBi48907

PTM databases

iPTMnetiO43347
PhosphoSitePlusiO43347

Expressioni

Tissue specificityi

Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.2 Publications

Gene expression databases

BgeeiENSG00000135097
CleanExiHS_MSI1
ExpressionAtlasiO43347 baseline and differential
GenevisibleiO43347 HS

Organism-specific databases

HPAiHPA064401

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPH2P557954EBI-726515,EBI-352823

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110577, 4 interactors
IntActiO43347, 6 interactors
MINTiO43347
STRINGi9606.ENSP00000257552

Structurei

3D structure databases

ProteinModelPortaliO43347
SMRiO43347
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 110RRM 1PROSITE-ProRule annotationAdd BLAST91
Domaini109 – 186RRM 2PROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi274 – 281Poly-Ala8

Domaini

The first RNA recognition motif binds more strongly to RNA compared to the second one.By similarity

Sequence similaritiesi

Belongs to the Musashi family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4205 Eukaryota
ENOG410YA8Z LUCA
GeneTreeiENSGT00900000140835
HOGENOMiHOG000234441
HOVERGENiHBG002295
InParanoidiO43347
KOiK14411
OMAiHYFEQFG
OrthoDBiEOG091G1CPI
PhylomeDBiO43347
TreeFamiTF325419

Family and domain databases

CDDicd12576 RRM1_MSI, 1 hit
cd12323 RRM2_MSI, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034130 MSI_RRM1
IPR034126 MSI_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequencei

Sequence statusi: Complete.

O43347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METDAPQPGL ASPDSPHDPC KMFIGGLSWQ TTQEGLREYF GQFGEVKECL
60 70 80 90 100
VMRDPLTKRS RGFGFVTFMD QAGVDKVLAQ SRHELDSKTI DPKVAFPRRA
110 120 130 140 150
QPKMVTRTKK IFVGGLSVNT TVEDVKQYFE QFGKVDDAML MFDKTTNRHR
160 170 180 190 200
GFGFVTFESE DIVEKVCEIH FHEINNKMVE CKKAQPKEVM SPTGSARGRS
210 220 230 240 250
RVMPYGMDAF MLGIGMLGYP GFQATTYASR SYTGLAPGYT YQFPEFRVER
260 270 280 290 300
TPLPSAPVLP ELTAIPLTAY GPMAAAAAAA AVVRGTGSHP WTMAPPPGST
310 320 330 340 350
PSRTGGFLGT TSPGPMAELY GAANQDSGVS SYISAASPAP STGFGHSLGG
360
PLIATAFTNG YH
Length:362
Mass (Da):39,125
Last modified:June 1, 1998 - v1
Checksum:i26487B0A32CF1F40
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197R → W in BAB70469 (PubMed:12054577).Curated1
Sequence conflicti225T → S in BAB69769 (PubMed:12054577).Curated1
Sequence conflicti232Y → C in BAB69769 (PubMed:12054577).Curated1
Sequence conflicti236A → P in BAB69767 (PubMed:12054577).Curated1
Sequence conflicti245E → K in BAB70469 (PubMed:12054577).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035485160E → Q in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012851 mRNA Translation: BAA33962.1
AC003982 Genomic DNA Translation: AAB95636.1
AB072590 mRNA Translation: BAB69767.1
AB072591 mRNA Translation: BAB69768.1
AB072592 mRNA Translation: BAB69769.1
AB073212 mRNA Translation: BAB70469.1
CCDSiCCDS9196.1
RefSeqiNP_002433.1, NM_002442.3
XP_011536663.1, XM_011538361.2
UniGeneiHs.158311

Genome annotation databases

EnsembliENST00000257552; ENSP00000257552; ENSG00000135097
GeneIDi4440
KEGGihsa:4440
UCSCiuc001tye.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMSI1H_HUMAN
AccessioniPrimary (citable) accession number: O43347
Secondary accession number(s): Q96PU0
, Q96PU1, Q96PU2, Q96PU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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