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Protein

Zinc finger protein 208

Gene

ZNF208

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri173 – 195C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri777 – 799C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri805 – 827C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri833 – 855C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri861 – 883C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri889 – 911C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri917 – 939C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri945 – 967C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri973 – 995C2H2-type 29; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1001 – 1023C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1029 – 1051C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1057 – 1079C2H2-type 32PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1085 – 1107C2H2-type 33PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1113 – 1135C2H2-type 34PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1141 – 1163C2H2-type 35PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1169 – 1191C2H2-type 36PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1197 – 1219C2H2-type 37PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1225 – 1247C2H2-type 38PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1253 – 1275C2H2-type 39PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 208
Alternative name(s):
Zinc finger protein 91-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF208
Synonyms:ZNF91L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160321.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12999 ZNF208

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603977 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43345

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7757

Open Targets

More...
OpenTargetsi
ENSG00000160321

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF208

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474541 – 1280Zinc finger protein 208Add BLAST1280

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43345

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43345

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43345

PeptideAtlas

More...
PeptideAtlasi
O43345

PRoteomics IDEntifications database

More...
PRIDEi
O43345

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48906

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43345

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43345

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160321 Expressed in 109 organ(s), highest expression level in substantia nigra

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZNF208

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O43345 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43345 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380315

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O43345

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43345

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri777 – 799C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri805 – 827C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri833 – 855C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri861 – 883C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri889 – 911C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri917 – 939C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri945 – 967C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri973 – 995C2H2-type 29; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1001 – 1023C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1029 – 1051C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1057 – 1079C2H2-type 32PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1085 – 1107C2H2-type 33PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1113 – 1135C2H2-type 34PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1141 – 1163C2H2-type 35PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1169 – 1191C2H2-type 36PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1197 – 1219C2H2-type 37PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1225 – 1247C2H2-type 38PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1253 – 1275C2H2-type 39PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000165698

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018163

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43345

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
RWCARRF

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43345

TreeFam database of animal gene trees

More...
TreeFami
TF350794

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 37 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 23 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 33 hits
PS50157 ZINC_FINGER_C2H2_2, 34 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43345-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSLTFRDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAFKP
60 70 80 90 100
DLIIFLEEGK ESWNMKRHEM VEESPVICSH FAQDLWPEQG IEDSFQKVIL
110 120 130 140 150
RRYEKCGHEN LHLKIGYTNV DECKVHKEGY NKLNQSLTTT QSKVFQRGKY
160 170 180 190 200
ANVFHKCSNS NRHKIRHTGK KHLQCKEYVR SFCMLSHLSQ HKRIYTRENS
210 220 230 240 250
YKCEEGGKAF NWSSTLTYYK SAHTGEKPYR CKECGKAFSK FSILTKHKVI
260 270 280 290 300
HTGEKSYKCE ECGKAFNQSA ILTKHKIIHT GEKPNKCEEC GKAFSKVSTL
310 320 330 340 350
TTHKAIHAGE KPYKCKECGK AFSKVSTLIT HKAIHAGEKP YKCKECGKAF
360 370 380 390 400
SKFSILTKHK VIHTGEKPYK CEECGKAYKW PSTLSYHKKI HTGEKPYKCE
410 420 430 440 450
ECGKGFSMFS ILTKHEVIHT GEKPYKCEEC GKAFNWSSNL MEHKKIHTGE
460 470 480 490 500
TPYKCEECGK GFSMFSILTK HKVIHNGEKP YKCEECDKAT HAGEKPYKCE
510 520 530 540 550
ECGKAFNWSS NLMEHKRIHT GEKPYKCEEC GKSFSTFSIL TKHKVIHTGE
560 570 580 590 600
KPYKCEECGK AYKWSSTLSY HKKIHTVEKP YKCEECGKAF NQSAILIKHK
610 620 630 640 650
RIHTGEKPYK CEECGKTFSK VSTLTTHKAI HAGEKPYKCK ECGKTFIKVS
660 670 680 690 700
TLTTHKAIHA GEKPYKCKEC GKAFSKFSIL TKHKVIHTGE KPYKCEECGK
710 720 730 740 750
AFNWSSNLME HKRIHTGEKP YKCEECGKSF STFSVLTKHK VIHTGEKPYK
760 770 780 790 800
CEECGKAYKW SSTLSYHKKI HTVEKPYKCE ECGKAFNRSA ILIKHKRIHT
810 820 830 840 850
DEKPYKCEEC GKTFSKVSTL TTHKAIHAGE KPYKCKECGK AFSKFSILTK
860 870 880 890 900
HKVIHTGEKP YKCEECGKAY KWPSTLSYHK KIHTGEKPYK CEECGKGFSM
910 920 930 940 950
FSILTKHEVI HTGEKPYKCE ECGKAFSWLS VFSKHKKTHA GEKFYKCEAC
960 970 980 990 1000
GKAYKSSSTL SYHKKIHTEE KPYKYEECGK GFSTFSILTK HKVIHTGEKP
1010 1020 1030 1040 1050
YKCEECGKAF NWSSNLMEHK KIHTGETPYK CEECDKAFSW PSSLTEHKAT
1060 1070 1080 1090 1100
HAGEKPYKCE ECGKAFSWPS RLTEHKATHA GEEPYKCEEC GKAFNWSSNL
1110 1120 1130 1140 1150
MEHKRIHTGE KPYKCEECGK SFSTFSILTK HKVIHTGEKP YKCEECGKAY
1160 1170 1180 1190 1200
KWSSTLSYHK KIHTVEKPYK CEECGKGFVM FSILAKHKVI HTGEKLYKCE
1210 1220 1230 1240 1250
ECGKAYKWPS TLRYHKKIHT GEKPYKCEEC GKAFSTFSIL TKHKVIHTGE
1260 1270 1280
KPYKCEECGK AFSWLSVFSK HKKIHTGEKL
Note: No experimental confirmation available.
Length:1,280
Mass (Da):147,487
Last modified:March 19, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i296AEB9EF588A8DB
GO
Isoform 2 (identifier: O43345-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     464-563: Missing.
     955-983: KSSSTLSYHKKIHTEEKPYKYEECGKGFS → N
     1277-1280: GEKL → GVPNPPTHKKIHAGEKLYK

Note: No experimental confirmation available.
Show »
Length:1,167
Mass (Da):134,353
Checksum:iE2184DF23B0D35E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B7G2A0A075B7G2_HUMAN
Zinc finger protein 208
ZNF208
1,167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYK4M0QYK4_HUMAN
Zinc finger protein 208
ZNF208
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R370M0R370_HUMAN
Zinc finger protein 208
ZNF208
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXL7M0QXL7_HUMAN
Zinc finger protein 208
ZNF208
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1F2M0R1F2_HUMAN
Zinc finger protein 208
ZNF208
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R293M0R293_HUMAN
Zinc finger protein 208
ZNF208
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052791282E → K. Corresponds to variant dbSNP:rs2007506Ensembl.1
Natural variantiVAR_052792298S → L. Corresponds to variant dbSNP:rs12462668Ensembl.1
Natural variantiVAR_052793456E → Q. Corresponds to variant dbSNP:rs7255075Ensembl.1
Natural variantiVAR_059903640K → E. Corresponds to variant dbSNP:rs10425763Ensembl.1
Natural variantiVAR_0599041035D → G. Corresponds to variant dbSNP:rs8108957Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053780464 – 563Missing in isoform 2. CuratedAdd BLAST100
Alternative sequenceiVSP_053781955 – 983KSSST…GKGFS → N in isoform 2. CuratedAdd BLAST29
Alternative sequenceiVSP_0537821277 – 1280GEKL → GVPNPPTHKKIHAGEKLYK in isoform 2. Curated4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC003973 Genomic DNA Translation: AAB94784.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS54240.1 [O43345-1]

NCBI Reference Sequences

More...
RefSeqi
NP_009084.2, NM_007153.3 [O43345-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.732975

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397126; ENSP00000380315; ENSG00000160321 [O43345-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7757

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7757

UCSC genome browser

More...
UCSCi
uc021urr.2 human [O43345-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003973 Genomic DNA Translation: AAB94784.1
CCDSiCCDS54240.1 [O43345-1]
RefSeqiNP_009084.2, NM_007153.3 [O43345-1]
UniGeneiHs.732975

3D structure databases

ProteinModelPortaliO43345
SMRiO43345
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000380315

PTM databases

iPTMnetiO43345
PhosphoSitePlusiO43345

Polymorphism and mutation databases

BioMutaiZNF208

Proteomic databases

EPDiO43345
jPOSTiO43345
PaxDbiO43345
PeptideAtlasiO43345
PRIDEiO43345
ProteomicsDBi48906

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397126; ENSP00000380315; ENSG00000160321 [O43345-1]
GeneIDi7757
KEGGihsa:7757
UCSCiuc021urr.2 human [O43345-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7757
DisGeNETi7757
EuPathDBiHostDB:ENSG00000160321.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF208
HGNCiHGNC:12999 ZNF208
MIMi603977 gene
neXtProtiNX_O43345
OpenTargetsiENSG00000160321

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000165698
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO43345
KOiK09228
OMAiRWCARRF
OrthoDBi1318335at2759
PhylomeDBiO43345
TreeFamiTF350794

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF208 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7757

Protein Ontology

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PROi
PR:O43345

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160321 Expressed in 109 organ(s), highest expression level in substantia nigra
CleanExiHS_ZNF208
ExpressionAtlasiO43345 baseline and differential
GenevisibleiO43345 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 37 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 23 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 33 hits
PS50157 ZINC_FINGER_C2H2_2, 34 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN208_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43345
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 19, 2014
Last modified: January 16, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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