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Protein

Zinc finger protein 208

Gene

ZNF208

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri777 – 799C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri805 – 827C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri833 – 855C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri861 – 883C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri889 – 911C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri917 – 939C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri945 – 967C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri973 – 995C2H2-type 29; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1001 – 1023C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1029 – 1051C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1057 – 1079C2H2-type 32PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1085 – 1107C2H2-type 33PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1113 – 1135C2H2-type 34PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1141 – 1163C2H2-type 35PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1169 – 1191C2H2-type 36PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1197 – 1219C2H2-type 37PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1225 – 1247C2H2-type 38PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1253 – 1275C2H2-type 39PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 208
Alternative name(s):
Zinc finger protein 91-like
Gene namesi
Name:ZNF208
Synonyms:ZNF91L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000160321.14
HGNCiHGNC:12999 ZNF208
MIMi603977 gene
neXtProtiNX_O43345

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7757
OpenTargetsiENSG00000160321

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474541 – 1280Zinc finger protein 208Add BLAST1280

Proteomic databases

EPDiO43345
PaxDbiO43345
PeptideAtlasiO43345
PRIDEiO43345
ProteomicsDBi48906

PTM databases

iPTMnetiO43345
PhosphoSitePlusiO43345

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000160321 Expressed in 109 organ(s), highest expression level in substantia nigra
CleanExiHS_ZNF208
ExpressionAtlasiO43345 baseline and differential
GenevisibleiO43345 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000380315

Structurei

3D structure databases

ProteinModelPortaliO43345
SMRiO43345
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri777 – 799C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri805 – 827C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri833 – 855C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri861 – 883C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri889 – 911C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri917 – 939C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri945 – 967C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri973 – 995C2H2-type 29; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1001 – 1023C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1029 – 1051C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1057 – 1079C2H2-type 32PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1085 – 1107C2H2-type 33PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1113 – 1135C2H2-type 34PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1141 – 1163C2H2-type 35PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1169 – 1191C2H2-type 36PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1197 – 1219C2H2-type 37PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1225 – 1247C2H2-type 38PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1253 – 1275C2H2-type 39PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150816
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO43345
KOiK09228
OMAiRWCARRF
OrthoDBiEOG091G02KC
PhylomeDBiO43345
TreeFamiTF350794

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 19 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 37 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 23 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 33 hits
PS50157 ZINC_FINGER_C2H2_2, 34 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43345-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSLTFRDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAFKP
60 70 80 90 100
DLIIFLEEGK ESWNMKRHEM VEESPVICSH FAQDLWPEQG IEDSFQKVIL
110 120 130 140 150
RRYEKCGHEN LHLKIGYTNV DECKVHKEGY NKLNQSLTTT QSKVFQRGKY
160 170 180 190 200
ANVFHKCSNS NRHKIRHTGK KHLQCKEYVR SFCMLSHLSQ HKRIYTRENS
210 220 230 240 250
YKCEEGGKAF NWSSTLTYYK SAHTGEKPYR CKECGKAFSK FSILTKHKVI
260 270 280 290 300
HTGEKSYKCE ECGKAFNQSA ILTKHKIIHT GEKPNKCEEC GKAFSKVSTL
310 320 330 340 350
TTHKAIHAGE KPYKCKECGK AFSKVSTLIT HKAIHAGEKP YKCKECGKAF
360 370 380 390 400
SKFSILTKHK VIHTGEKPYK CEECGKAYKW PSTLSYHKKI HTGEKPYKCE
410 420 430 440 450
ECGKGFSMFS ILTKHEVIHT GEKPYKCEEC GKAFNWSSNL MEHKKIHTGE
460 470 480 490 500
TPYKCEECGK GFSMFSILTK HKVIHNGEKP YKCEECDKAT HAGEKPYKCE
510 520 530 540 550
ECGKAFNWSS NLMEHKRIHT GEKPYKCEEC GKSFSTFSIL TKHKVIHTGE
560 570 580 590 600
KPYKCEECGK AYKWSSTLSY HKKIHTVEKP YKCEECGKAF NQSAILIKHK
610 620 630 640 650
RIHTGEKPYK CEECGKTFSK VSTLTTHKAI HAGEKPYKCK ECGKTFIKVS
660 670 680 690 700
TLTTHKAIHA GEKPYKCKEC GKAFSKFSIL TKHKVIHTGE KPYKCEECGK
710 720 730 740 750
AFNWSSNLME HKRIHTGEKP YKCEECGKSF STFSVLTKHK VIHTGEKPYK
760 770 780 790 800
CEECGKAYKW SSTLSYHKKI HTVEKPYKCE ECGKAFNRSA ILIKHKRIHT
810 820 830 840 850
DEKPYKCEEC GKTFSKVSTL TTHKAIHAGE KPYKCKECGK AFSKFSILTK
860 870 880 890 900
HKVIHTGEKP YKCEECGKAY KWPSTLSYHK KIHTGEKPYK CEECGKGFSM
910 920 930 940 950
FSILTKHEVI HTGEKPYKCE ECGKAFSWLS VFSKHKKTHA GEKFYKCEAC
960 970 980 990 1000
GKAYKSSSTL SYHKKIHTEE KPYKYEECGK GFSTFSILTK HKVIHTGEKP
1010 1020 1030 1040 1050
YKCEECGKAF NWSSNLMEHK KIHTGETPYK CEECDKAFSW PSSLTEHKAT
1060 1070 1080 1090 1100
HAGEKPYKCE ECGKAFSWPS RLTEHKATHA GEEPYKCEEC GKAFNWSSNL
1110 1120 1130 1140 1150
MEHKRIHTGE KPYKCEECGK SFSTFSILTK HKVIHTGEKP YKCEECGKAY
1160 1170 1180 1190 1200
KWSSTLSYHK KIHTVEKPYK CEECGKGFVM FSILAKHKVI HTGEKLYKCE
1210 1220 1230 1240 1250
ECGKAYKWPS TLRYHKKIHT GEKPYKCEEC GKAFSTFSIL TKHKVIHTGE
1260 1270 1280
KPYKCEECGK AFSWLSVFSK HKKIHTGEKL
Note: No experimental confirmation available.
Length:1,280
Mass (Da):147,487
Last modified:March 19, 2014 - v2
Checksum:i296AEB9EF588A8DB
GO
Isoform 2 (identifier: O43345-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     464-563: Missing.
     955-983: KSSSTLSYHKKIHTEEKPYKYEECGKGFS → N
     1277-1280: GEKL → GVPNPPTHKKIHAGEKLYK

Note: No experimental confirmation available.
Show »
Length:1,167
Mass (Da):134,353
Checksum:iE2184DF23B0D35E9
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B7G2A0A075B7G2_HUMAN
Zinc finger protein 208
ZNF208
1,167Annotation score:
M0QYK4M0QYK4_HUMAN
Zinc finger protein 208
ZNF208
112Annotation score:
M0QXL7M0QXL7_HUMAN
Zinc finger protein 208
ZNF208
127Annotation score:
M0R370M0R370_HUMAN
Zinc finger protein 208
ZNF208
76Annotation score:
M0R1F2M0R1F2_HUMAN
Zinc finger protein 208
ZNF208
38Annotation score:
M0R293M0R293_HUMAN
Zinc finger protein 208
ZNF208
51Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052791282E → K. Corresponds to variant dbSNP:rs2007506Ensembl.1
Natural variantiVAR_052792298S → L. Corresponds to variant dbSNP:rs12462668Ensembl.1
Natural variantiVAR_052793456E → Q. Corresponds to variant dbSNP:rs7255075Ensembl.1
Natural variantiVAR_059903640K → E. Corresponds to variant dbSNP:rs10425763Ensembl.1
Natural variantiVAR_0599041035D → G. Corresponds to variant dbSNP:rs8108957Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053780464 – 563Missing in isoform 2. CuratedAdd BLAST100
Alternative sequenceiVSP_053781955 – 983KSSST…GKGFS → N in isoform 2. CuratedAdd BLAST29
Alternative sequenceiVSP_0537821277 – 1280GEKL → GVPNPPTHKKIHAGEKLYK in isoform 2. Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003973 Genomic DNA Translation: AAB94784.1
CCDSiCCDS54240.1 [O43345-1]
RefSeqiNP_009084.2, NM_007153.3 [O43345-1]
UniGeneiHs.732975

Genome annotation databases

EnsembliENST00000397126; ENSP00000380315; ENSG00000160321 [O43345-1]
GeneIDi7757
KEGGihsa:7757
UCSCiuc021urr.2 human [O43345-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003973 Genomic DNA Translation: AAB94784.1
CCDSiCCDS54240.1 [O43345-1]
RefSeqiNP_009084.2, NM_007153.3 [O43345-1]
UniGeneiHs.732975

3D structure databases

ProteinModelPortaliO43345
SMRiO43345
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000380315

PTM databases

iPTMnetiO43345
PhosphoSitePlusiO43345

Proteomic databases

EPDiO43345
PaxDbiO43345
PeptideAtlasiO43345
PRIDEiO43345
ProteomicsDBi48906

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397126; ENSP00000380315; ENSG00000160321 [O43345-1]
GeneIDi7757
KEGGihsa:7757
UCSCiuc021urr.2 human [O43345-1]

Organism-specific databases

CTDi7757
DisGeNETi7757
EuPathDBiHostDB:ENSG00000160321.14
GeneCardsiZNF208
HGNCiHGNC:12999 ZNF208
MIMi603977 gene
neXtProtiNX_O43345
OpenTargetsiENSG00000160321
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150816
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO43345
KOiK09228
OMAiRWCARRF
OrthoDBiEOG091G02KC
PhylomeDBiO43345
TreeFamiTF350794

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF208 human
GenomeRNAii7757
PROiPR:O43345
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160321 Expressed in 109 organ(s), highest expression level in substantia nigra
CleanExiHS_ZNF208
ExpressionAtlasiO43345 baseline and differential
GenevisibleiO43345 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 19 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 37 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 23 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 33 hits
PS50157 ZINC_FINGER_C2H2_2, 34 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN208_HUMAN
AccessioniPrimary (citable) accession number: O43345
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 19, 2014
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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