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Protein

Fibroblast growth factor 16

Gene

FGF16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 16
Short name:
FGF-16
Gene namesi
Name:FGF16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000196468.7
HGNCiHGNC:3672 FGF16
MIMi300827 gene
neXtProtiNX_O43320

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Metacarpal 4-5 fusion (MF4)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital malformation of the hand characterized by the partial or complete fusion of the fourth and fifth metacarpals. The anomaly occurs as an isolated trait or part of a syndrome.
See also OMIM:309630
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07239668R → L in MF4. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi8823
MalaCardsiFGF16
MIMi309630 phenotype
OpenTargetsiENSG00000196468
Orphaneti2498 Syndactyly type 8
PharmGKBiPA28111

Polymorphism and mutation databases

BioMutaiFGF16

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476131 – 207Fibroblast growth factor 16Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei111PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO43320
PRIDEiO43320
ProteomicsDBi48902

PTM databases

iPTMnetiO43320
PhosphoSitePlusiO43320

Expressioni

Gene expression databases

BgeeiENSG00000196468 Expressed in 30 organ(s), highest expression level in esophagus
CleanExiHS_FGF16
GenevisibleiO43320 HS

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114350, 1 interactor
IntActiO43320, 7 interactors
STRINGi9606.ENSP00000399324

Structurei

3D structure databases

ProteinModelPortaliO43320
SMRiO43320
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000118859
HOVERGENiHBG007580
InParanoidiO43320
KOiK04358
OMAiMDSERHY
OrthoDBiEOG091G0NAY
PhylomeDBiO43320

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028285 FGF16
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF27 PTHR11486:SF27, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

O43320-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP
60 70 80 90 100
TDFAHLKGIL RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA
110 120 130 140 150
VGLISIRGVD SGLYLGMNER GELYGSKKLT RECVFREQFE ENWYNTYAST
160 170 180 190 200
LYKHSDSERQ YYVALNKDGS PREGYRTKRH QKFTHFLPRP VDPSKLPSMS

RDLFHYR
Length:207
Mass (Da):23,759
Last modified:June 1, 1998 - v1
Checksum:iD8AD160BDABDB5F8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07239668R → L in MF4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009391 mRNA Translation: BAA24956.1
BX682239 Genomic DNA No translation available.
CCDSiCCDS75996.1
PIRiJC5941
RefSeqiNP_003859.1, NM_003868.2
UniGeneiHs.666364

Genome annotation databases

EnsembliENST00000439435; ENSP00000399324; ENSG00000196468
GeneIDi8823
KEGGihsa:8823
UCSCiuc033ejs.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009391 mRNA Translation: BAA24956.1
BX682239 Genomic DNA No translation available.
CCDSiCCDS75996.1
PIRiJC5941
RefSeqiNP_003859.1, NM_003868.2
UniGeneiHs.666364

3D structure databases

ProteinModelPortaliO43320
SMRiO43320
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114350, 1 interactor
IntActiO43320, 7 interactors
STRINGi9606.ENSP00000399324

PTM databases

iPTMnetiO43320
PhosphoSitePlusiO43320

Polymorphism and mutation databases

BioMutaiFGF16

Proteomic databases

PaxDbiO43320
PRIDEiO43320
ProteomicsDBi48902

Protocols and materials databases

DNASUi8823
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439435; ENSP00000399324; ENSG00000196468
GeneIDi8823
KEGGihsa:8823
UCSCiuc033ejs.2 human

Organism-specific databases

CTDi8823
DisGeNETi8823
EuPathDBiHostDB:ENSG00000196468.7
GeneCardsiFGF16
HGNCiHGNC:3672 FGF16
MalaCardsiFGF16
MIMi300827 gene
309630 phenotype
neXtProtiNX_O43320
OpenTargetsiENSG00000196468
Orphaneti2498 Syndactyly type 8
PharmGKBiPA28111
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118859
HOVERGENiHBG007580
InParanoidiO43320
KOiK04358
OMAiMDSERHY
OrthoDBiEOG091G0NAY
PhylomeDBiO43320

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer

Miscellaneous databases

GenomeRNAii8823
PROiPR:O43320
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196468 Expressed in 30 organ(s), highest expression level in esophagus
CleanExiHS_FGF16
GenevisibleiO43320 HS

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028285 FGF16
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF27 PTHR11486:SF27, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGF16_HUMAN
AccessioniPrimary (citable) accession number: O43320
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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