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Protein

Aquaporin-9

Gene

AQP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na+, K+, Cl-, and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-432030 Transport of glycerol from adipocytes to the liver by Aquaporins
R-HSA-432047 Passive transport by Aquaporins
SIGNORiO43315

Protein family/group databases

TCDBi1.A.8.9.14 the major intrinsic protein (mip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-9
Short name:
AQP-9
Alternative name(s):
Aquaglyceroporin-9
Small solute channel 1
Gene namesi
Name:AQP9
Synonyms:SSC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000103569.9
HGNCiHGNC:643 AQP9
MIMi602914 gene+phenotype
neXtProtiNX_O43315

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 54ExtracellularSequence analysis4
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 110CytoplasmicSequence analysisAdd BLAST35
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 158ExtracellularSequence analysisAdd BLAST27
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 189CytoplasmicSequence analysis10
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 245ExtracellularSequence analysisAdd BLAST35
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 295CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi366
MIMi602914 gene+phenotype
OpenTargetsiENSG00000103569
PharmGKBiPA24927

Polymorphism and mutation databases

BioMutaiAQP9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639641 – 295Aquaporin-9Add BLAST295

Proteomic databases

PaxDbiO43315
PeptideAtlasiO43315
PRIDEiO43315
ProteomicsDBi48894

PTM databases

iPTMnetiO43315
PhosphoSitePlusiO43315

Expressioni

Tissue specificityi

Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.

Gene expression databases

BgeeiENSG00000103569 Expressed in 121 organ(s), highest expression level in blood
CleanExiHS_AQP9
ExpressionAtlasiO43315 baseline and differential
GenevisibleiO43315 HS

Organism-specific databases

HPAiCAB075684
HPA074762

Interactioni

Protein-protein interaction databases

BioGridi106861, 3 interactors
IntActiO43315, 18 interactors
STRINGi9606.ENSP00000219919

Structurei

3D structure databases

ProteinModelPortaliO43315
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi84 – 86NPA 13
Motifi216 – 218NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0224 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00510000046311
HOGENOMiHOG000288287
HOVERGENiHBG106057
InParanoidiO43315
KOiK09877
OMAiFMTRTGM
OrthoDBiEOG091G0FMS
PhylomeDBiO43315
TreeFamiTF313173

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR015685 Aquaporin_9
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR43829:SF6 PTHR43829:SF6, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02021 AQUAPORIN9
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O43315-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPEGAEKGK SFKQRLVLKS SLAKETLSEF LGTFILIVLG CGCVAQAILS
60 70 80 90 100
RGRFGGVITI NVGFSMAVAM AIYVAGGVSG GHINPAVSLA MCLFGRMKWF
110 120 130 140 150
KLPFYVGAQF LGAFVGAATV FGIYYDGLMS FAGGKLLIVG ENATAHIFAT
160 170 180 190 200
YPAPYLSLAN AFADQVVATM ILLIIVFAIF DSRNLGAPRG LEPIAIGLLI
210 220 230 240 250
IVIASSLGLN SGCAMNPARD LSPRLFTALA GWGFEVFRAG NNFWWIPVVG
260 270 280 290
PLVGAVIGGL IYVLVIEIHH PEPDSVFKTE QSEDKPEKYE LSVIM
Length:295
Mass (Da):31,431
Last modified:January 11, 2011 - v2
Checksum:iB3B416CD9F1F9CAF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YK62H0YK62_HUMAN
Aquaporin-9
AQP9
230Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024538279T → A3 PublicationsCorresponds to variant dbSNP:rs1867380Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008775 mRNA Translation: BAA24864.1
AF016495 mRNA Translation: AAF16677.1
AF102870 Genomic DNA Translation: AAF27983.1
AC025431 Genomic DNA No translation available.
AC066616 Genomic DNA No translation available.
BC026258 mRNA Translation: AAH26258.1
CCDSiCCDS10165.1
PIRiJC5973
RefSeqiNP_066190.2, NM_020980.4
UniGeneiHs.104624

Genome annotation databases

EnsembliENST00000219919; ENSP00000219919; ENSG00000103569
ENST00000536493; ENSP00000441390; ENSG00000103569
GeneIDi366
KEGGihsa:366
UCSCiuc002aez.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008775 mRNA Translation: BAA24864.1
AF016495 mRNA Translation: AAF16677.1
AF102870 Genomic DNA Translation: AAF27983.1
AC025431 Genomic DNA No translation available.
AC066616 Genomic DNA No translation available.
BC026258 mRNA Translation: AAH26258.1
CCDSiCCDS10165.1
PIRiJC5973
RefSeqiNP_066190.2, NM_020980.4
UniGeneiHs.104624

3D structure databases

ProteinModelPortaliO43315
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106861, 3 interactors
IntActiO43315, 18 interactors
STRINGi9606.ENSP00000219919

Protein family/group databases

TCDBi1.A.8.9.14 the major intrinsic protein (mip) family

PTM databases

iPTMnetiO43315
PhosphoSitePlusiO43315

Polymorphism and mutation databases

BioMutaiAQP9

Proteomic databases

PaxDbiO43315
PeptideAtlasiO43315
PRIDEiO43315
ProteomicsDBi48894

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219919; ENSP00000219919; ENSG00000103569
ENST00000536493; ENSP00000441390; ENSG00000103569
GeneIDi366
KEGGihsa:366
UCSCiuc002aez.3 human

Organism-specific databases

CTDi366
DisGeNETi366
EuPathDBiHostDB:ENSG00000103569.9
GeneCardsiAQP9
H-InvDBiHIX0012281
HGNCiHGNC:643 AQP9
HPAiCAB075684
HPA074762
MIMi602914 gene+phenotype
neXtProtiNX_O43315
OpenTargetsiENSG00000103569
PharmGKBiPA24927
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0224 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00510000046311
HOGENOMiHOG000288287
HOVERGENiHBG106057
InParanoidiO43315
KOiK09877
OMAiFMTRTGM
OrthoDBiEOG091G0FMS
PhylomeDBiO43315
TreeFamiTF313173

Enzyme and pathway databases

ReactomeiR-HSA-432030 Transport of glycerol from adipocytes to the liver by Aquaporins
R-HSA-432047 Passive transport by Aquaporins
SIGNORiO43315

Miscellaneous databases

ChiTaRSiAQP9 human
GeneWikiiAQP9
GenomeRNAii366
PROiPR:O43315
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103569 Expressed in 121 organ(s), highest expression level in blood
CleanExiHS_AQP9
ExpressionAtlasiO43315 baseline and differential
GenevisibleiO43315 HS

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR015685 Aquaporin_9
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR43829:SF6 PTHR43829:SF6, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02021 AQUAPORIN9
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAQP9_HUMAN
AccessioniPrimary (citable) accession number: O43315
Secondary accession number(s): Q9NP32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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