UniProtKB - O43314 (VIP2_HUMAN)
Protein
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
Gene
PPIP5K2
Organism
Homo sapiens (Human)
Status
Functioni
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114).4 Publications
Catalytic activityi
- 1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP1 PublicationEC:2.7.4.211 Publication
- 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H+ = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP1 PublicationEC:2.7.4.211 Publication
- 1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP2 PublicationsEC:2.7.4.242 Publications
- 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H+ = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP2 PublicationsEC:2.7.4.242 Publications
Kineticsi
- KM=0.13 µM for InsP61 Publication
- KM=0.19 µM for InsP71 Publication
- Vmax=0.39 nmol/min/mg enzyme with InsP6 as substrate1 Publication
- Vmax=1.38 nmol/min/mg enzyme with InsP7 as substrate1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 134 | ATPCombined sources1 Publication | 1 | |
Binding sitei | 187 | ATPCombined sources1 Publication | 1 | |
Binding sitei | 194 | ATPCombined sources1 Publication | 1 | |
Binding sitei | 213 | ATPCombined sources1 Publication | 1 | |
Binding sitei | 248 | SubstrateCombined sources1 Publication | 1 | |
Binding sitei | 262 | SubstrateCombined sources1 Publication | 1 | |
Binding sitei | 264 | ATPCombined sources1 Publication | 1 | |
Binding sitei | 309 | ATPCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 237 – 240 | ATPCombined sources1 Publication | 4 | |
Nucleotide bindingi | 246 – 248 | ATPCombined sources1 Publication | 3 | |
Nucleotide bindingi | 321 – 323 | ATPCombined sources1 Publication | 3 |
GO - Molecular functioni
- 5-diphosphoinositol pentakisphosphate 3-kinase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB
- diphosphoinositol-pentakisphosphate kinase activity Source: MGI
- inositol-1,3,4,5,6-pentakisphosphate kinase activity Source: UniProtKB
- inositol heptakisphosphate kinase activity Source: GO_Central
- inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
- inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
- inositol hexakisphosphate 5-kinase activity Source: UniProtKB
- inositol hexakisphosphate kinase activity Source: MGI
GO - Biological processi
- inositol metabolic process Source: UniProtKB
- inositol phosphate biosynthetic process Source: GO_Central
- inositol phosphate metabolic process Source: Reactome
- sensory perception of sound Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Hearing |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.4.21, 2681 2.7.4.24, 2681 |
PathwayCommonsi | O43314 |
Reactomei | R-HSA-1855167, Synthesis of pyrophosphates in the cytosol |
SABIO-RKi | O43314 |
Names & Taxonomyi
Protein namesi | Recommended name: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC:2.7.4.211 Publication, EC:2.7.4.241 Publication)Alternative name(s): Diphosphoinositol pentakisphosphate kinase 2 Histidine acid phosphatase domain-containing protein 1 InsP6 and PP-IP5 kinase 2 VIP1 homolog 2 Short name: hsVIP2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29035, PPIP5K2 |
MIMi | 611648, gene |
neXtProti | NX_O43314 |
VEuPathDBi | HostDB:ENSG00000145725.19 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Deafness, autosomal recessive, 100 (DFNB100)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic, sensorineural deafness characterized by prelingual hearing impairment. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_082201 | 837 | R → H in DFNB100; Impaired diphosphoinositol-pentakisphosphate kinase activity. 1 PublicationCorresponds to variant dbSNP:rs548137246EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 213 | R → A or K: Reduces enzyme activity by about 99%. 1 Publication | 1 | |
Mutagenesisi | 248 | K → A: Loss of enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 262 | R → A: Reduces enzyme activity by about 99%. 1 Publication | 1 |
Keywords - Diseasei
Deafness, Disease variant, Non-syndromic deafnessOrganism-specific databases
DisGeNETi | 23262 |
MalaCardsi | PPIP5K2 |
MIMi | 618422, phenotype |
OpenTargetsi | ENSG00000145725 |
Orphaneti | 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB |
PharmGKBi | PA165660454 |
Miscellaneous databases
Pharosi | O43314, Tbio |
Genetic variation databases
BioMutai | PPIP5K2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315692 | 1 – 1243 | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2Add BLAST | 1243 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | PhosphoserineCombined sources | 1 | |
Modified residuei | 223 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1006 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1016 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1074 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1091 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1165 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1172 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1180 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1220 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1221 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O43314 |
jPOSTi | O43314 |
MassIVEi | O43314 |
MaxQBi | O43314 |
PaxDbi | O43314 |
PeptideAtlasi | O43314 |
PRIDEi | O43314 |
ProteomicsDBi | 48892 [O43314-1] 48893 [O43314-2] |
PTM databases
DEPODi | PPIP5K2 |
iPTMneti | O43314 |
PhosphoSitePlusi | O43314 |
Expressioni
Gene expression databases
Bgeei | ENSG00000145725, Expressed in intestine and 233 other tissues |
ExpressionAtlasi | O43314, baseline and differential |
Genevisiblei | O43314, HS |
Organism-specific databases
HPAi | ENSG00000145725, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsIsoform 2 [O43314-2]
With | #Exp. | IntAct |
---|---|---|
POU2F1 - isoform 6 [P14859-6] | 3 | EBI-12906508,EBI-11526590 |
POU6F2 [P78424] | 3 | EBI-12906508,EBI-12029004 |
SMARCC1 [Q92922] | 3 | EBI-12906508,EBI-355653 |
Protein-protein interaction databases
BioGRIDi | 116864, 33 interactors |
IntActi | O43314, 16 interactors |
STRINGi | 9606.ENSP00000482907 |
Miscellaneous databases
RNActi | O43314, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O43314 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 53 – 54 | Substrate bindingCombined sources1 Publication | 2 | |
Regioni | 213 – 214 | Substrate bindingCombined sources1 Publication | 2 | |
Regioni | 326 – 329 | Substrate bindingCombined sources1 Publication | 4 | |
Regioni | 371 – 442 | Polyphosphoinositide-binding domain1 PublicationAdd BLAST | 72 |
Domaini
The C-terminal acid phosphatase-like domain binds PtdIns(3,4,5)P3 and InsP6. Despite its similarity with the phosphatase domain of histidine acid phosphatases, it has no phosphatase activity.1 Publication
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1057, Eukaryota |
GeneTreei | ENSGT00390000009048 |
HOGENOMi | CLU_000914_0_0_1 |
InParanoidi | O43314 |
OrthoDBi | 93740at2759 |
PhylomeDBi | O43314 |
TreeFami | TF313594 |
Family and domain databases
CDDi | cd07061, HP_HAP_like, 1 hit |
InterProi | View protein in InterPro IPR033379, Acid_Pase_AS IPR000560, His_Pase_clade-2 IPR037446, His_Pase_VIP1 IPR029033, His_PPase_superfam IPR040557, VIP1_N |
PANTHERi | PTHR12750, PTHR12750, 1 hit |
Pfami | View protein in Pfam PF00328, His_Phos_2, 1 hit PF18086, PPIP5K2_N, 1 hit |
SUPFAMi | SSF53254, SSF53254, 1 hit |
PROSITEi | View protein in PROSITE PS00616, HIS_ACID_PHOSPHAT_1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O43314-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSEAPRFFVG PEDTEINPGN YRHFFHHADE DDEEEDDSPP ERQIVVGICS
60 70 80 90 100
MAKKSKSKPM KEILERISLF KYITVVVFEE EVILNEPVEN WPLCDCLISF
110 120 130 140 150
HSKGFPLDKA VAYAKLRNPF VINDLNMQYL IQDRREVYSI LQAEGILLPR
160 170 180 190 200
YAILNRDPNN PKECNLIEGE DHVEVNGEVF QKPFVEKPVS AEDHNVYIYY
210 220 230 240 250
PTSAGGGSQR LFRKIGSRSS VYSPESNVRK TGSYIYEEFM PTDGTDVKVY
260 270 280 290 300
TVGPDYAHAE ARKSPALDGK VERDSEGKEV RYPVILNARE KLIAWKVCLA
310 320 330 340 350
FKQTVCGFDL LRANGQSYVC DVNGFSFVKN SMKYYDDCAK ILGNIVMREL
360 370 380 390 400
APQFHIPWSI PLEAEDIPIV PTTSGTMMEL RCVIAVIRHG DRTPKQKMKM
410 420 430 440 450
EVRHQKFFDL FEKCDGYKSG KLKLKKPKQL QEVLDIARQL LMELGQNNDS
460 470 480 490 500
EIEENKPKLE QLKTVLEMYG HFSGINRKVQ LTYLPHGCPK TSSEEEDSRR
510 520 530 540 550
EEPSLLLVLK WGGELTPAGR VQAEELGRAF RCMYPGGQGD YAGFPGCGLL
560 570 580 590 600
RLHSTYRHDL KIYASDEGRV QMTAAAFAKG LLALEGELTP ILVQMVKSAN
610 620 630 640 650
MNGLLDSDSD SLSSCQQRVK ARLHEILQKD RDFTAEDYEK LTPSGSISLI
660 670 680 690 700
KSMHLIKNPV KTCDKVYSLI QSLTSQIRHR MEDPKSSDIQ LYHSETLELM
710 720 730 740 750
LRRWSKLEKD FKTKNGRYDI SKIPDIYDCI KYDVQHNGSL KLENTMELYR
760 770 780 790 800
LSKALADIVI PQEYGITKAE KLEIAKGYCT PLVRKIRSDL QRTQDDDTVN
810 820 830 840 850
KLHPVYSRGV LSPERHVRTR LYFTSESHVH SLLSILRYGA LCNESKDEQW
860 870 880 890 900
KRAMDYLNVV NELNYMTQIV IMLYEDPNKD LSSEERFHVE LHFSPGAKGC
910 920 930 940 950
EEDKNLPSGY GYRPASRENE GRRPFKIDND DEPHTSKRDE VDRAVILFKP
960 970 980 990 1000
MVSEPIHIHR KSPLPRSRKT ATNDEESPLS VSSPEGTGTW LHYTSGVGTG
1010 1020 1030 1040 1050
RRRRRSGEQI TSSPVSPKSL AFTSSIFGSW QQVVSENANY LRTPRTLVEQ
1060 1070 1080 1090 1100
KQNPTVGSHC AGLFSTSVLG GSSSAPNLQD YARTHRKKLT SSGCIDDATR
1110 1120 1130 1140 1150
GSAVKRFSIS FARHPTNGFE LYSMVPSICP LETLHNALSL KQVDEFLASI
1160 1170 1180 1190 1200
ASPSSDVPRK TAEISSTALR SSPIMRKKVS LNTYTPAKIL PTPPATLKST
1210 1220 1230 1240
KASSKPATSG PSSAVVPNTS SRKKNITSKT ETHEHKKNTG KKK
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZV0 | A0A087WZV0_HUMAN | Inositol hexakisphosphate and dipho... | PPIP5K2 | 1,278 | Annotation score: | ||
H0Y9S9 | H0Y9S9_HUMAN | Inositol hexakisphosphate and dipho... | PPIP5K2 | 398 | Annotation score: | ||
D6RBU4 | D6RBU4_HUMAN | Inositol hexakisphosphate and dipho... | PPIP5K2 | 452 | Annotation score: | ||
K7ENU7 | K7ENU7_HUMAN | Inositol hexakisphosphate and dipho... | PPIP5K2 | 255 | Annotation score: | ||
A0A087WWN8 | A0A087WWN8_HUMAN | Inositol hexakisphosphate and dipho... | PPIP5K2 | 357 | Annotation score: | ||
D6RFG4 | D6RFG4_HUMAN | Inositol hexakisphosphate and dipho... | PPIP5K2 | 58 | Annotation score: | ||
H0Y9M0 | H0Y9M0_HUMAN | Inositol hexakisphosphate and dipho... | PPIP5K2 | 209 | Annotation score: | ||
K7EPT7 | K7EPT7_HUMAN | Inositol hexakisphosphate and dipho... | PPIP5K2 | 58 | Annotation score: | ||
K7EJG8 | K7EJG8_HUMAN | Inositol hexakisphosphate and dipho... | PPIP5K2 | 51 | Annotation score: |
Sequence cautioni
The sequence BAA24863 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence EAW49076 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_082201 | 837 | R → H in DFNB100; Impaired diphosphoinositol-pentakisphosphate kinase activity. 1 PublicationCorresponds to variant dbSNP:rs548137246EnsemblClinVar. | 1 | |
Natural variantiVAR_038276 | 944 | A → G. Corresponds to variant dbSNP:rs17155115Ensembl. | 1 | |
Natural variantiVAR_038277 | 985 | E → K. Corresponds to variant dbSNP:rs12519525Ensembl. | 1 | |
Natural variantiVAR_038278 | 1003 | R → K. Corresponds to variant dbSNP:rs12520040Ensembl. | 1 | |
Natural variantiVAR_038279 | 1206 | P → Q. Corresponds to variant dbSNP:rs17155138Ensembl. | 1 | |
Natural variantiVAR_038280 | 1232 | T → M. Corresponds to variant dbSNP:rs17155147Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030636 | 1097 – 1117 | Missing in isoform 2. 1 PublicationAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007893 mRNA Translation: BAA24863.2 Different initiation. AC011362 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49076.1 Sequence problems. BC024591 mRNA Translation: AAH24591.1 |
CCDSi | CCDS34207.1 [O43314-2] CCDS64212.1 [O43314-1] |
RefSeqi | NP_001263206.1, NM_001276277.2 [O43314-1] NP_001268400.1, NM_001281471.2 NP_056031.2, NM_015216.4 [O43314-2] |
Genome annotation databases
Ensembli | ENST00000321521; ENSP00000313070; ENSG00000145725 [O43314-2] ENST00000358359; ENSP00000351126; ENSG00000145725 [O43314-1] ENST00000414217; ENSP00000416016; ENSG00000145725 [O43314-2] |
GeneIDi | 23262 |
KEGGi | hsa:23262 |
UCSCi | uc003kod.6, human [O43314-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007893 mRNA Translation: BAA24863.2 Different initiation. AC011362 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49076.1 Sequence problems. BC024591 mRNA Translation: AAH24591.1 |
CCDSi | CCDS34207.1 [O43314-2] CCDS64212.1 [O43314-1] |
RefSeqi | NP_001263206.1, NM_001276277.2 [O43314-1] NP_001268400.1, NM_001281471.2 NP_056031.2, NM_015216.4 [O43314-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3T54 | X-ray | 1.90 | A | 37-366 | [»] | |
3T7A | X-ray | 1.70 | A | 41-366 | [»] | |
3T99 | X-ray | 2.10 | A | 37-366 | [»] | |
3T9A | X-ray | 1.80 | A | 41-366 | [»] | |
3T9B | X-ray | 1.85 | A | 41-366 | [»] | |
3T9C | X-ray | 1.90 | A | 41-366 | [»] | |
3T9D | X-ray | 1.85 | A | 41-366 | [»] | |
3T9E | X-ray | 1.90 | A | 41-366 | [»] | |
3T9F | X-ray | 2.00 | A | 41-366 | [»] | |
4HN2 | X-ray | 1.90 | A | 41-366 | [»] | |
4NZM | X-ray | 2.00 | A | 41-366 | [»] | |
4NZN | X-ray | 1.75 | A | 41-366 | [»] | |
4NZO | X-ray | 1.90 | A | 41-366 | [»] | |
4Q4C | X-ray | 1.90 | A | 41-366 | [»] | |
4Q4D | X-ray | 1.85 | A | 41-366 | [»] | |
5BYA | X-ray | 1.90 | A | 41-366 | [»] | |
5BYB | X-ray | 2.30 | A | 41-366 | [»] | |
5DGH | X-ray | 2.10 | A | 41-366 | [»] | |
5DGI | X-ray | 1.85 | A | 41-366 | [»] | |
6N5C | X-ray | 1.95 | A | 41-366 | [»] | |
SMRi | O43314 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116864, 33 interactors |
IntActi | O43314, 16 interactors |
STRINGi | 9606.ENSP00000482907 |
PTM databases
DEPODi | PPIP5K2 |
iPTMneti | O43314 |
PhosphoSitePlusi | O43314 |
Genetic variation databases
BioMutai | PPIP5K2 |
Proteomic databases
EPDi | O43314 |
jPOSTi | O43314 |
MassIVEi | O43314 |
MaxQBi | O43314 |
PaxDbi | O43314 |
PeptideAtlasi | O43314 |
PRIDEi | O43314 |
ProteomicsDBi | 48892 [O43314-1] 48893 [O43314-2] |
Protocols and materials databases
Antibodypediai | 44750, 69 antibodies |
Genome annotation databases
Ensembli | ENST00000321521; ENSP00000313070; ENSG00000145725 [O43314-2] ENST00000358359; ENSP00000351126; ENSG00000145725 [O43314-1] ENST00000414217; ENSP00000416016; ENSG00000145725 [O43314-2] |
GeneIDi | 23262 |
KEGGi | hsa:23262 |
UCSCi | uc003kod.6, human [O43314-1] |
Organism-specific databases
CTDi | 23262 |
DisGeNETi | 23262 |
GeneCardsi | PPIP5K2 |
HGNCi | HGNC:29035, PPIP5K2 |
HPAi | ENSG00000145725, Low tissue specificity |
MalaCardsi | PPIP5K2 |
MIMi | 611648, gene 618422, phenotype |
neXtProti | NX_O43314 |
OpenTargetsi | ENSG00000145725 |
Orphaneti | 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB |
PharmGKBi | PA165660454 |
VEuPathDBi | HostDB:ENSG00000145725.19 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1057, Eukaryota |
GeneTreei | ENSGT00390000009048 |
HOGENOMi | CLU_000914_0_0_1 |
InParanoidi | O43314 |
OrthoDBi | 93740at2759 |
PhylomeDBi | O43314 |
TreeFami | TF313594 |
Enzyme and pathway databases
BRENDAi | 2.7.4.21, 2681 2.7.4.24, 2681 |
PathwayCommonsi | O43314 |
Reactomei | R-HSA-1855167, Synthesis of pyrophosphates in the cytosol |
SABIO-RKi | O43314 |
Miscellaneous databases
BioGRID-ORCSi | 23262, 16 hits in 874 CRISPR screens |
ChiTaRSi | PPIP5K2, human |
GenomeRNAii | 23262 |
Pharosi | O43314, Tbio |
PROi | PR:O43314 |
RNActi | O43314, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145725, Expressed in intestine and 233 other tissues |
ExpressionAtlasi | O43314, baseline and differential |
Genevisiblei | O43314, HS |
Family and domain databases
CDDi | cd07061, HP_HAP_like, 1 hit |
InterProi | View protein in InterPro IPR033379, Acid_Pase_AS IPR000560, His_Pase_clade-2 IPR037446, His_Pase_VIP1 IPR029033, His_PPase_superfam IPR040557, VIP1_N |
PANTHERi | PTHR12750, PTHR12750, 1 hit |
Pfami | View protein in Pfam PF00328, His_Phos_2, 1 hit PF18086, PPIP5K2_N, 1 hit |
SUPFAMi | SSF53254, SSF53254, 1 hit |
PROSITEi | View protein in PROSITE PS00616, HIS_ACID_PHOSPHAT_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VIP2_HUMAN | |
Accessioni | O43314Primary (citable) accession number: O43314 Secondary accession number(s): A1NI53, A6NGS8, Q8TB50 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | February 10, 2021 | |
This is version 159 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants