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Protein

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

Gene

PPIP5K2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.13 µM for InsP61 Publication
  2. KM=0.19 µM for InsP71 Publication
  1. Vmax=0.39 nmol/min/mg enzyme with InsP6 as substrate1 Publication
  2. Vmax=1.38 nmol/min/mg enzyme with InsP7 as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei134ATPCombined sources1 Publication1
Binding sitei187ATPCombined sources1 Publication1
Binding sitei194ATPCombined sources1 Publication1
Binding sitei213ATPCombined sources1 Publication1
Binding sitei248SubstrateCombined sources1 Publication1
Binding sitei262SubstrateCombined sources1 Publication1
Binding sitei264ATPCombined sources1 Publication1
Binding sitei309ATPCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi237 – 240ATPCombined sources1 Publication4
Nucleotide bindingi246 – 248ATPCombined sources1 Publication3
Nucleotide bindingi321 – 323ATPCombined sources1 Publication3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.4.21 2681
2.7.4.24 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O43314

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC:2.7.4.211 Publication, EC:2.7.4.241 Publication)
Alternative name(s):
Diphosphoinositol pentakisphosphate kinase 2
Histidine acid phosphatase domain-containing protein 1
InsP6 and PP-IP5 kinase 2
VIP1 homolog 2
Short name:
hsVIP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPIP5K2
Synonyms:HISPPD1, KIAA0433, VIP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145725.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29035 PPIP5K2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611648 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43314

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi213R → A or K: Reduces enzyme activity by about 99%. 1 Publication1
Mutagenesisi248K → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi262R → A: Reduces enzyme activity by about 99%. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23262

Open Targets

More...
OpenTargetsi
ENSG00000145725

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165660454

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPIP5K2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003156921 – 1243Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2Add BLAST1243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei38PhosphoserineCombined sources1
Modified residuei223PhosphoserineCombined sources1
Modified residuei1006PhosphoserineCombined sources1
Modified residuei1016PhosphoserineCombined sources1
Modified residuei1074PhosphoserineCombined sources1
Modified residuei1091PhosphoserineCombined sources1
Modified residuei1165PhosphoserineCombined sources1
Modified residuei1172PhosphoserineCombined sources1
Modified residuei1180PhosphoserineCombined sources1
Modified residuei1220PhosphoserineCombined sources1
Modified residuei1221PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43314

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43314

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43314

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43314

PeptideAtlas

More...
PeptideAtlasi
O43314

PRoteomics IDEntifications database

More...
PRIDEi
O43314

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48892
48893 [O43314-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43314

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43314

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000145725 Expressed in 225 organ(s), highest expression level in intestine

CleanEx database of gene expression profiles

More...
CleanExi
HS_HISPPD1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43314 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43314 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037895
HPA038442

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116864, 24 interactors

Protein interaction database and analysis system

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IntActi
O43314, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000313070

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11243
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T54X-ray1.90A37-366[»]
3T7AX-ray1.70A41-366[»]
3T99X-ray2.10A37-366[»]
3T9AX-ray1.80A41-366[»]
3T9BX-ray1.85A41-366[»]
3T9CX-ray1.90A41-366[»]
3T9DX-ray1.85A41-366[»]
3T9EX-ray1.90A41-366[»]
3T9FX-ray2.00A41-366[»]
4HN2X-ray1.90A41-366[»]
4NZMX-ray2.00A41-366[»]
4NZNX-ray1.75A41-366[»]
4NZOX-ray1.90A41-366[»]
4Q4CX-ray1.90A41-366[»]
4Q4DX-ray1.85A41-366[»]
5BYAX-ray1.90A41-366[»]
5BYBX-ray2.30A41-366[»]
5DGHX-ray2.10A41-366[»]
5DGIX-ray1.85A41-366[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O43314

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O43314

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 54Substrate bindingCombined sources1 Publication2
Regioni213 – 214Substrate bindingCombined sources1 Publication2
Regioni326 – 329Substrate bindingCombined sources1 Publication4
Regioni371 – 442Polyphosphoinositide-binding domain1 PublicationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal acid phosphatase-like domain binds PtdIns(3,4,5)P3 and InsP6. Despite its similarity with the phosphatase domain of histidine acid phosphatases, it has no phosphatase activity.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1057 Eukaryota
ENOG410XNSN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009048

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000177917

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108657

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43314

KEGG Orthology (KO)

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KOi
K13024

Database of Orthologous Groups

More...
OrthoDBi
93740at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43314

TreeFam database of animal gene trees

More...
TreeFami
TF313594

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07061 HP_HAP_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR037446 His_Pase_VIP1
IPR029033 His_PPase_superfam

The PANTHER Classification System

More...
PANTHERi
PTHR12750 PTHR12750, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00328 His_Phos_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53254 SSF53254, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43314-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEAPRFFVG PEDTEINPGN YRHFFHHADE DDEEEDDSPP ERQIVVGICS
60 70 80 90 100
MAKKSKSKPM KEILERISLF KYITVVVFEE EVILNEPVEN WPLCDCLISF
110 120 130 140 150
HSKGFPLDKA VAYAKLRNPF VINDLNMQYL IQDRREVYSI LQAEGILLPR
160 170 180 190 200
YAILNRDPNN PKECNLIEGE DHVEVNGEVF QKPFVEKPVS AEDHNVYIYY
210 220 230 240 250
PTSAGGGSQR LFRKIGSRSS VYSPESNVRK TGSYIYEEFM PTDGTDVKVY
260 270 280 290 300
TVGPDYAHAE ARKSPALDGK VERDSEGKEV RYPVILNARE KLIAWKVCLA
310 320 330 340 350
FKQTVCGFDL LRANGQSYVC DVNGFSFVKN SMKYYDDCAK ILGNIVMREL
360 370 380 390 400
APQFHIPWSI PLEAEDIPIV PTTSGTMMEL RCVIAVIRHG DRTPKQKMKM
410 420 430 440 450
EVRHQKFFDL FEKCDGYKSG KLKLKKPKQL QEVLDIARQL LMELGQNNDS
460 470 480 490 500
EIEENKPKLE QLKTVLEMYG HFSGINRKVQ LTYLPHGCPK TSSEEEDSRR
510 520 530 540 550
EEPSLLLVLK WGGELTPAGR VQAEELGRAF RCMYPGGQGD YAGFPGCGLL
560 570 580 590 600
RLHSTYRHDL KIYASDEGRV QMTAAAFAKG LLALEGELTP ILVQMVKSAN
610 620 630 640 650
MNGLLDSDSD SLSSCQQRVK ARLHEILQKD RDFTAEDYEK LTPSGSISLI
660 670 680 690 700
KSMHLIKNPV KTCDKVYSLI QSLTSQIRHR MEDPKSSDIQ LYHSETLELM
710 720 730 740 750
LRRWSKLEKD FKTKNGRYDI SKIPDIYDCI KYDVQHNGSL KLENTMELYR
760 770 780 790 800
LSKALADIVI PQEYGITKAE KLEIAKGYCT PLVRKIRSDL QRTQDDDTVN
810 820 830 840 850
KLHPVYSRGV LSPERHVRTR LYFTSESHVH SLLSILRYGA LCNESKDEQW
860 870 880 890 900
KRAMDYLNVV NELNYMTQIV IMLYEDPNKD LSSEERFHVE LHFSPGAKGC
910 920 930 940 950
EEDKNLPSGY GYRPASRENE GRRPFKIDND DEPHTSKRDE VDRAVILFKP
960 970 980 990 1000
MVSEPIHIHR KSPLPRSRKT ATNDEESPLS VSSPEGTGTW LHYTSGVGTG
1010 1020 1030 1040 1050
RRRRRSGEQI TSSPVSPKSL AFTSSIFGSW QQVVSENANY LRTPRTLVEQ
1060 1070 1080 1090 1100
KQNPTVGSHC AGLFSTSVLG GSSSAPNLQD YARTHRKKLT SSGCIDDATR
1110 1120 1130 1140 1150
GSAVKRFSIS FARHPTNGFE LYSMVPSICP LETLHNALSL KQVDEFLASI
1160 1170 1180 1190 1200
ASPSSDVPRK TAEISSTALR SSPIMRKKVS LNTYTPAKIL PTPPATLKST
1210 1220 1230 1240
KASSKPATSG PSSAVVPNTS SRKKNITSKT ETHEHKKNTG KKK
Length:1,243
Mass (Da):140,407
Last modified:January 15, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8831DDDAB9B2E6E
GO
Isoform 2 (identifier: O43314-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1097-1117: Missing.

Note: No experimental confirmation available.
Show »
Length:1,222
Mass (Da):138,106
Checksum:iC61F832FE77F87F3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZV0A0A087WZV0_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K2
1,278Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBU4D6RBU4_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K2
452Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9S9H0Y9S9_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K2
398Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9M0H0Y9M0_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K2
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFG4D6RFG4_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K2
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPT7K7EPT7_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K2
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWN8A0A087WWN8_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K2
357Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENU7K7ENU7_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K2
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJG8K7EJG8_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K2
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA24863 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW49076 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038276944A → G. Corresponds to variant dbSNP:rs17155115Ensembl.1
Natural variantiVAR_038277985E → K. Corresponds to variant dbSNP:rs12519525Ensembl.1
Natural variantiVAR_0382781003R → K. Corresponds to variant dbSNP:rs12520040Ensembl.1
Natural variantiVAR_0382791206P → Q. Corresponds to variant dbSNP:rs17155138Ensembl.1
Natural variantiVAR_0382801232T → M. Corresponds to variant dbSNP:rs17155147Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0306361097 – 1117Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007893 mRNA Translation: BAA24863.2 Different initiation.
AC011362 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW49076.1 Sequence problems.
BC024591 mRNA Translation: AAH24591.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34207.1 [O43314-2]
CCDS64212.1 [O43314-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001263206.1, NM_001276277.2 [O43314-1]
NP_001268400.1, NM_001281471.2
NP_056031.2, NM_015216.4 [O43314-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.212046

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000321521; ENSP00000313070; ENSG00000145725 [O43314-2]
ENST00000358359; ENSP00000351126; ENSG00000145725 [O43314-1]
ENST00000414217; ENSP00000416016; ENSG00000145725 [O43314-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23262

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23262

UCSC genome browser

More...
UCSCi
uc003kod.6 human [O43314-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007893 mRNA Translation: BAA24863.2 Different initiation.
AC011362 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW49076.1 Sequence problems.
BC024591 mRNA Translation: AAH24591.1
CCDSiCCDS34207.1 [O43314-2]
CCDS64212.1 [O43314-1]
RefSeqiNP_001263206.1, NM_001276277.2 [O43314-1]
NP_001268400.1, NM_001281471.2
NP_056031.2, NM_015216.4 [O43314-2]
UniGeneiHs.212046

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T54X-ray1.90A37-366[»]
3T7AX-ray1.70A41-366[»]
3T99X-ray2.10A37-366[»]
3T9AX-ray1.80A41-366[»]
3T9BX-ray1.85A41-366[»]
3T9CX-ray1.90A41-366[»]
3T9DX-ray1.85A41-366[»]
3T9EX-ray1.90A41-366[»]
3T9FX-ray2.00A41-366[»]
4HN2X-ray1.90A41-366[»]
4NZMX-ray2.00A41-366[»]
4NZNX-ray1.75A41-366[»]
4NZOX-ray1.90A41-366[»]
4Q4CX-ray1.90A41-366[»]
4Q4DX-ray1.85A41-366[»]
5BYAX-ray1.90A41-366[»]
5BYBX-ray2.30A41-366[»]
5DGHX-ray2.10A41-366[»]
5DGIX-ray1.85A41-366[»]
ProteinModelPortaliO43314
SMRiO43314
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116864, 24 interactors
IntActiO43314, 5 interactors
STRINGi9606.ENSP00000313070

PTM databases

iPTMnetiO43314
PhosphoSitePlusiO43314

Polymorphism and mutation databases

BioMutaiPPIP5K2

Proteomic databases

EPDiO43314
jPOSTiO43314
MaxQBiO43314
PaxDbiO43314
PeptideAtlasiO43314
PRIDEiO43314
ProteomicsDBi48892
48893 [O43314-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321521; ENSP00000313070; ENSG00000145725 [O43314-2]
ENST00000358359; ENSP00000351126; ENSG00000145725 [O43314-1]
ENST00000414217; ENSP00000416016; ENSG00000145725 [O43314-2]
GeneIDi23262
KEGGihsa:23262
UCSCiuc003kod.6 human [O43314-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23262
DisGeNETi23262
EuPathDBiHostDB:ENSG00000145725.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPIP5K2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0005068
HIX0029534
HGNCiHGNC:29035 PPIP5K2
HPAiHPA037895
HPA038442
MIMi611648 gene
neXtProtiNX_O43314
OpenTargetsiENSG00000145725
PharmGKBiPA165660454

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1057 Eukaryota
ENOG410XNSN LUCA
GeneTreeiENSGT00390000009048
HOGENOMiHOG000177917
HOVERGENiHBG108657
InParanoidiO43314
KOiK13024
OrthoDBi93740at2759
PhylomeDBiO43314
TreeFamiTF313594

Enzyme and pathway databases

BRENDAi2.7.4.21 2681
2.7.4.24 2681
ReactomeiR-HSA-1855167 Synthesis of pyrophosphates in the cytosol
SABIO-RKiO43314

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPIP5K2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23262

Protein Ontology

More...
PROi
PR:O43314

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145725 Expressed in 225 organ(s), highest expression level in intestine
CleanExiHS_HISPPD1
ExpressionAtlasiO43314 baseline and differential
GenevisibleiO43314 HS

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR037446 His_Pase_VIP1
IPR029033 His_PPase_superfam
PANTHERiPTHR12750 PTHR12750, 1 hit
PfamiView protein in Pfam
PF00328 His_Phos_2, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVIP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43314
Secondary accession number(s): A1NI53, A6NGS8, Q8TB50
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: January 16, 2019
This is version 144 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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