UniProtKB - O43313 (ATMIN_HUMAN)
Protein
ATM interactor
Gene
ATMIN
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.3 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 84 – 109 | C2H2-type 1Add BLAST | 26 | |
Zinc fingeri | 165 – 184 | C2H2-type 2; degenerateAdd BLAST | 20 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: ARUK-UCL
- dynein complex binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- transcription regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB-KW
- motile cilium assembly Source: Ensembl
- positive regulation of non-motile cilium assembly Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: ARUK-UCL
Keywordsi
Molecular function | Activator |
Biological process | DNA damage, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O43313 |
Names & Taxonomyi
Protein namesi | Recommended name: ATM interactorAlternative name(s): ATM/ATR-substrate CHK2-interacting zinc finger protein Short name: ASCIZ Zinc finger protein 822 |
Gene namesi | Name:ATMIN Synonyms:KIAA0431, ZNF822 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166454.9 |
HGNCi | HGNC:29034, ATMIN |
MIMi | 614693, gene |
neXtProti | NX_O43313 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Note: Nuclear, in discrete foci during G1 phase.
Nucleus
- nuclear body Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 23300 |
OpenTargetsi | ENSG00000166454 |
PharmGKBi | PA162377191 |
Miscellaneous databases
Pharosi | O43313, Tbio |
Polymorphism and mutation databases
BioMutai | ATMIN |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050756 | 1 – 823 | ATM interactorAdd BLAST | 823 |
Proteomic databases
EPDi | O43313 |
jPOSTi | O43313 |
MassIVEi | O43313 |
MaxQBi | O43313 |
PaxDbi | O43313 |
PeptideAtlasi | O43313 |
PRIDEi | O43313 |
ProteomicsDBi | 48890 [O43313-1] 48891 [O43313-2] |
PTM databases
iPTMneti | O43313 |
PhosphoSitePlusi | O43313 |
Expressioni
Tissue specificityi
Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000166454, Expressed in sperm and 251 other tissues |
ExpressionAtlasi | O43313, baseline and differential |
Genevisiblei | O43313, HS |
Organism-specific databases
HPAi | ENSG00000166454, Low tissue specificity |
Interactioni
Subunit structurei
Interacts via its C-terminus with ATM.
Interacts with DYNLL1; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN.
2 PublicationsBinary interactionsi
O43313
With | #Exp. | IntAct |
---|---|---|
ATM [Q13315] | 5 | EBI-7422202,EBI-495465 |
Protein-protein interaction databases
BioGRIDi | 116892, 8 interactors |
IntActi | O43313, 4 interactors |
MINTi | O43313 |
STRINGi | 9606.ENSP00000299575 |
Miscellaneous databases
RNActi | O43313, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 223 – 442 | Required for formation of RAD51 fociAdd BLAST | 220 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 2 – 33 | Ala-richAdd BLAST | 32 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 84 – 109 | C2H2-type 1Add BLAST | 26 | |
Zinc fingeri | 165 – 184 | C2H2-type 2; degenerateAdd BLAST | 20 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00390000013091 |
HOGENOMi | CLU_023902_0_0_1 |
InParanoidi | O43313 |
OMAi | DIQTQTD |
OrthoDBi | 583153at2759 |
PhylomeDBi | O43313 |
TreeFami | TF331171 |
Family and domain databases
DisProti | DP01288 |
InterProi | View protein in InterPro IPR013087, Znf_C2H2_type |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O43313-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAASEAAAAA GSAALAAGAR AVPAATTGAA AAASGPWVPP GPRLRGSRPR
60 70 80 90 100
PAGATQQPAV PAPPAGELIQ PSVSELSRAV RTNILCTVRG CGKILPNSPA
110 120 130 140 150
LNMHLVKSHR LQDGIVNPTI RKDLKTGPKF YCCPIEGCPR GPERPFSQFS
160 170 180 190 200
LVKQHFMKMH AEKKHKCSKC SNSYGTEWDL KRHAEDCGKT FRCTCGCPYA
210 220 230 240 250
SRTALQSHIY RTGHEIPAEH RDPPSKKRKM ENCAQNQKLS NKTIESLNNQ
260 270 280 290 300
PIPRPDTQEL EASEIKLEPS FEDSCGSNTD KQTLTTPPRY PQKLLLPKPK
310 320 330 340 350
VALVKLPVMQ FSVMPVFVPT ADSSAQPVVL GVDQGSATGA VHLMPLSVGT
360 370 380 390 400
LILGLDSEAC SLKESLPLFK IANPIAGEPI STGVQVNFGK SPSNPLQELG
410 420 430 440 450
NTCQKNSISS INVQTDLSYA SQNFIPSAQW ATADSSVSSC SQTDLSFDSQ
460 470 480 490 500
VSLPISVHTQ TFLPSSKVTS SIAAQTDAFM DTCFQSGGVS RETQTSGIES
510 520 530 540 550
PTDDHVQMDQ AGMCGDIFES VHSSYNVATG NIISNSLVAE TVTHSLLPQN
560 570 580 590 600
EPKTLNQDIE KSAPIINFSA QNSMLPSQNM TDNQTQTIDL LSDLENILSS
610 620 630 640 650
NLPAQTLDHR SLLSDTNPGP DTQLPSGPAQ NPGIDFDIEE FFSASNIQTQ
660 670 680 690 700
TEESELSTMT TEPVLESLDI ETQTDFLLAD TSAQSYGCRG NSNFLGLEMF
710 720 730 740 750
DTQTQTDLNF FLDSSPHLPL GSILKHSSFS VSTDSSDTET QTEGVSTAKN
760 770 780 790 800
IPALESKVQL NSTETQTMSS GFETLGSLFF TSNETQTAMD DFLLADLAWN
810 820
TMESQFSSVE TQTSAEPHTV SNF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketJ3QRX7 | J3QRX7_HUMAN | ATM interactor | ATMIN | 54 | Annotation score: |
Sequence cautioni
The sequence BAA24861 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAF83632 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 174 | Y → C in CAH18291 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 309 | M → V in BAF83632 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 338 | T → A in CAH18291 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 433 | A → T in CAH18291 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 474 | A → P in CAH18291 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 525 | Y → H in CAH18291 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 703 | Q → R in BAF83632 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 814 | S → P in CAH18291 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050681 | 240 | S → P. Corresponds to variant dbSNP:rs2278022Ensembl. | 1 | |
Natural variantiVAR_050682 | 305 | K → E. Corresponds to variant dbSNP:rs2278023Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035820 | 1 – 156 | Missing in isoform 2. 2 PublicationsAdd BLAST | 156 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007891 mRNA Translation: BAA24861.2 Different initiation. CR749457 mRNA Translation: CAH18291.1 AC092718 Genomic DNA No translation available. BC002701 mRNA Translation: AAH02701.2 AK290943 mRNA Translation: BAF83632.1 Different initiation. |
CCDSi | CCDS32494.1 [O43313-1] CCDS73917.1 [O43313-2] |
PIRi | T00061 |
RefSeqi | NP_001287657.1, NM_001300728.1 [O43313-2] NP_056066.2, NM_015251.2 [O43313-1] |
Genome annotation databases
Ensembli | ENST00000299575; ENSP00000299575; ENSG00000166454 [O43313-1] ENST00000564241; ENSP00000463478; ENSG00000166454 [O43313-2] ENST00000566488; ENSP00000455497; ENSG00000166454 [O43313-2] |
GeneIDi | 23300 |
KEGGi | hsa:23300 |
UCSCi | uc002ffz.2, human [O43313-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007891 mRNA Translation: BAA24861.2 Different initiation. CR749457 mRNA Translation: CAH18291.1 AC092718 Genomic DNA No translation available. BC002701 mRNA Translation: AAH02701.2 AK290943 mRNA Translation: BAF83632.1 Different initiation. |
CCDSi | CCDS32494.1 [O43313-1] CCDS73917.1 [O43313-2] |
PIRi | T00061 |
RefSeqi | NP_001287657.1, NM_001300728.1 [O43313-2] NP_056066.2, NM_015251.2 [O43313-1] |
3D structure databases
SMRi | O43313 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116892, 8 interactors |
IntActi | O43313, 4 interactors |
MINTi | O43313 |
STRINGi | 9606.ENSP00000299575 |
PTM databases
iPTMneti | O43313 |
PhosphoSitePlusi | O43313 |
Polymorphism and mutation databases
BioMutai | ATMIN |
Proteomic databases
EPDi | O43313 |
jPOSTi | O43313 |
MassIVEi | O43313 |
MaxQBi | O43313 |
PaxDbi | O43313 |
PeptideAtlasi | O43313 |
PRIDEi | O43313 |
ProteomicsDBi | 48890 [O43313-1] 48891 [O43313-2] |
Protocols and materials databases
Antibodypediai | 30434, 129 antibodies |
Genome annotation databases
Ensembli | ENST00000299575; ENSP00000299575; ENSG00000166454 [O43313-1] ENST00000564241; ENSP00000463478; ENSG00000166454 [O43313-2] ENST00000566488; ENSP00000455497; ENSG00000166454 [O43313-2] |
GeneIDi | 23300 |
KEGGi | hsa:23300 |
UCSCi | uc002ffz.2, human [O43313-1] |
Organism-specific databases
CTDi | 23300 |
DisGeNETi | 23300 |
EuPathDBi | HostDB:ENSG00000166454.9 |
GeneCardsi | ATMIN |
HGNCi | HGNC:29034, ATMIN |
HPAi | ENSG00000166454, Low tissue specificity |
MIMi | 614693, gene |
neXtProti | NX_O43313 |
OpenTargetsi | ENSG00000166454 |
PharmGKBi | PA162377191 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00390000013091 |
HOGENOMi | CLU_023902_0_0_1 |
InParanoidi | O43313 |
OMAi | DIQTQTD |
OrthoDBi | 583153at2759 |
PhylomeDBi | O43313 |
TreeFami | TF331171 |
Enzyme and pathway databases
PathwayCommonsi | O43313 |
Miscellaneous databases
BioGRID-ORCSi | 23300, 114 hits in 856 CRISPR screens |
ChiTaRSi | ATMIN, human |
GenomeRNAii | 23300 |
Pharosi | O43313, Tbio |
PROi | PR:O43313 |
RNActi | O43313, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166454, Expressed in sperm and 251 other tissues |
ExpressionAtlasi | O43313, baseline and differential |
Genevisiblei | O43313, HS |
Family and domain databases
DisProti | DP01288 |
InterProi | View protein in InterPro IPR013087, Znf_C2H2_type |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATMIN_HUMAN | |
Accessioni | O43313Primary (citable) accession number: O43313 Secondary accession number(s): A8K4H8, Q68DC9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | November 25, 2008 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations