UniProtKB - O43306 (ADCY6_HUMAN)
Protein
Adenylate cyclase type 6
Gene
ADCY6
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca2+ uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity).By similarity2 Publications
Catalytic activityi
- EC:4.6.1.12 Publications
Cofactori
Mg2+1 Publication, Mn2+1 PublicationNote: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).By similarity
Activity regulationi
Activated by forskolin (PubMed:17916776, PubMed:17110384). Inhibited by calcium ions, already at micromolar concentrations (By similarity). Inhibited by adenosine, AMP and their analogs (By similarity). Activated by GNAS (PubMed:17110384). Is further activated by the complex formed by GNB1 and GNG2 (PubMed:17110384). Phosphorylation by RAF1 results in its activation (By similarity).By similarity1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 384 | Magnesium 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 384 | Magnesium 2; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 385 | Magnesium 2; via carbonyl oxygen; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 428 | Magnesium 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 428 | Magnesium 2; catalyticPROSITE-ProRule annotation | 1 | |
Binding sitei | 472 | ATPBy similarity | 1 | |
Binding sitei | 1031 | ATPBy similarity | 1 | |
Binding sitei | 1152 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 384 – 389 | ATPBy similarity | 6 | |
Nucleotide bindingi | 426 – 428 | ATPBy similarity | 3 | |
Nucleotide bindingi | 1105 – 1107 | ATPBy similarity | 3 | |
Nucleotide bindingi | 1112 – 1116 | ATPBy similarity | 5 |
GO - Molecular functioni
- adenylate cyclase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein kinase binding Source: BHF-UCL
- protein kinase C binding Source: UniProtKB
GO - Biological processi
- activation of adenylate cyclase activity Source: Reactome
- activation of protein kinase A activity Source: Reactome
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: GO_Central
- blood vessel diameter maintenance Source: UniProtKB
- cAMP biosynthetic process Source: UniProtKB
- cellular response to catecholamine stimulus Source: BHF-UCL
- cellular response to forskolin Source: UniProtKB
- cellular response to glucagon stimulus Source: Reactome
- cellular response to prostaglandin E stimulus Source: BHF-UCL
- cellular response to vasopressin Source: UniProtKB
- dopamine receptor signaling pathway Source: BHF-UCL
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of inflammatory response to antigenic stimulus Source: Reactome
- negative regulation of neuron projection development Source: ParkinsonsUK-UCL
- negative regulation of urine volume Source: UniProtKB
- renal water homeostasis Source: UniProtKB
Keywordsi
Molecular function | Lyase |
Biological process | cAMP biosynthesis |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O43306 |
Reactomei | R-HSA-163359, Glucagon signaling in metabolic regulation R-HSA-163615, PKA activation R-HSA-164378, PKA activation in glucagon signalling R-HSA-170660, Adenylate cyclase activating pathway R-HSA-170670, Adenylate cyclase inhibitory pathway R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion R-HSA-418555, G alpha (s) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5610787, Hedgehog 'off' state R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9664323, FCGR3A-mediated IL10 synthesis |
SIGNORi | O43306 |
Names & Taxonomyi
Protein namesi | Recommended name: Adenylate cyclase type 6 (EC:4.6.1.12 Publications)Alternative name(s): ATP pyrophosphate-lyase 6 Adenylate cyclase type VI Adenylyl cyclase 61 Publication Ca(2+)-inhibitable adenylyl cyclase |
Gene namesi | Name:ADCY6 Synonyms:KIAA0422 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:237, ADCY6 |
MIMi | 600294, gene |
neXtProti | NX_O43306 |
VEuPathDBi | HostDB:ENSG00000174233.11 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Other locations
- cilium By similarity
- stereocilium By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- intrinsic component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- cilium Source: UniProtKB-SubCell
- membrane Source: BHF-UCL
- stereocilium Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 151 | CytoplasmicSequence analysisAdd BLAST | 151 | |
Transmembranei | 152 – 168 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 181 – 197 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 214 – 230 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 239 – 255 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 259 – 275 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 289 – 305 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 306 – 673 | CytoplasmicSequence analysisAdd BLAST | 368 | |
Transmembranei | 674 – 691 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 702 – 718 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 743 – 759 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 760 – 819 | ExtracellularSequence analysisAdd BLAST | 60 | |
Transmembranei | 820 – 836 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 839 – 855 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 897 – 913 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 914 – 1168 | CytoplasmicSequence analysisAdd BLAST | 255 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Cilium, MembranePathology & Biotechi
Involvement in diseasei
Lethal congenital contracture syndrome 8 (LCCS8)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS8 is an axoglial form of arthrogryposis multiplex congenita, characterized by congenital distal joint contractures, reduced fetal movements, and severe motor paralysis leading to death early in the neonatal period.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073434 | 1116 | R → C in LCCS8. 1 PublicationCorresponds to variant dbSNP:rs786204798EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 112 |
MalaCardsi | ADCY6 |
MIMi | 616287, phenotype |
OpenTargetsi | ENSG00000174233 |
Orphaneti | 2680, Hypomyelination neuropathy-arthrogryposis syndrome |
PharmGKBi | PA27 |
Miscellaneous databases
Pharosi | O43306, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2097167 |
GuidetoPHARMACOLOGYi | 1283 |
Genetic variation databases
BioMutai | ADCY6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000195699 | 1 – 1168 | Adenylate cyclase type 6Add BLAST | 1168 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 54 | PhosphoserineCombined sources | 1 | |
Modified residuei | 556 | PhosphoserineBy similarity | 1 | |
Modified residuei | 576 | PhosphoserineCombined sources | 1 | |
Modified residuei | 662 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 793 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 919 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Phosphorylation by RAF1 increases enzyme activity. Phosphorylation by PKA at Ser-662 inhibits the GNAS-mediated increase in catalytic activity. Phosphorylation by PKC at Ser-556, Ser-662 and Thr-919 inhibits catalytic activity.By similarity
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | O43306 |
MassIVEi | O43306 |
MaxQBi | O43306 |
PaxDbi | O43306 |
PeptideAtlasi | O43306 |
PRIDEi | O43306 |
ProteomicsDBi | 48880 [O43306-1] 48881 [O43306-2] |
PTM databases
GlyGeni | O43306, 1 site |
iPTMneti | O43306 |
PhosphoSitePlusi | O43306 |
SwissPalmi | O43306 |
Expressioni
Tissue specificityi
Detected in peripheral blood mononuclear leukocytes (at protein level) (PubMed:17916776). Detected in thyroid (PubMed:10978539).1 Publication
Gene expression databases
Bgeei | ENSG00000174233, Expressed in heart left ventricle and 185 other tissues |
ExpressionAtlasi | O43306, baseline and differential |
Genevisiblei | O43306, HS |
Organism-specific databases
HPAi | ENSG00000174233, Low tissue specificity |
Interactioni
Subunit structurei
GO - Molecular functioni
- protein kinase binding Source: BHF-UCL
- protein kinase C binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 106625, 32 interactors |
IntActi | O43306, 24 interactors |
MINTi | O43306 |
STRINGi | 9606.ENSP00000311405 |
Chemistry databases
BindingDBi | O43306 |
Miscellaneous databases
RNActi | O43306, protein |
Family & Domainsi
Domaini
The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.By similarity
Sequence similaritiesi
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3619, Eukaryota |
GeneTreei | ENSGT00940000155687 |
HOGENOMi | CLU_001072_2_0_1 |
InParanoidi | O43306 |
OMAi | PLCEGTM |
OrthoDBi | 215180at2759 |
PhylomeDBi | O43306 |
TreeFami | TF313845 |
Family and domain databases
CDDi | cd07302, CHD, 2 hits |
Gene3Di | 3.30.70.1230, 2 hits |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR032628, AC_N IPR030672, Adcy IPR009398, Adcy_conserved_dom IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF16214, AC_N, 1 hit PF06327, DUF1053, 1 hit PF00211, Guanylate_cyc, 2 hits |
PIRSFi | PIRSF039050, Ade_cyc, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 2 hits |
SUPFAMi | SSF55073, SSF55073, 2 hits |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 2 hits PS50125, GUANYLATE_CYCLASE_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O43306-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSWFSGLLVP KVDERKTAWG ERNGQKRSRR RGTRAGGFCT PRYMSCLRDA
60 70 80 90 100
EPPSPTPAGP PRCPWQDDAF IRRGGPGKGK ELGLRAVALG FEDTEVTTTA
110 120 130 140 150
GGTAEVAPDA VPRSGRSCWR RLVQVFQSKQ FRSAKLERLY QRYFFQMNQS
160 170 180 190 200
SLTLLMAVLV LLTAVLLAFH AAPARPQPAY VALLACAAAL FVGLMVVCNR
210 220 230 240 250
HSFRQDSMWV VSYVVLGILA AVQVGGALAA DPRSPSAGLW CPVFFVYIAY
260 270 280 290 300
TLLPIRMRAA VLSGLGLSTL HLILAWQLNR GDAFLWKQLG ANVLLFLCTN
310 320 330 340 350
VIGICTHYPA EVSQRQAFQE TRGYIQARLH LQHENRQQER LLLSVLPQHV
360 370 380 390 400
AMEMKEDINT KKEDMMFHKI YIQKHDNVSI LFADIEGFTS LASQCTAQEL
410 420 430 440 450
VMTLNELFAR FDKLAAENHC LRIKILGDCY YCVSGLPEAR ADHAHCCVEM
460 470 480 490 500
GVDMIEAISL VREVTGVNVN MRVGIHSGRV HCGVLGLRKW QFDVWSNDVT
510 520 530 540 550
LANHMEAGGR AGRIHITRAT LQYLNGDYEV EPGRGGERNA YLKEQHIETF
560 570 580 590 600
LILGASQKRK EEKAMLAKLQ RTRANSMEGL MPRWVPDRAF SRTKDSKAFR
610 620 630 640 650
QMGIDDSSKD NRGTQDALNP EDEVDEFLSR AIDARSIDQL RKDHVRRFLL
660 670 680 690 700
TFQREDLEKK YSRKVDPRFG AYVACALLVF CFICFIQLLI FPHSTLMLGI
710 720 730 740 750
YASIFLLLLI TVLICAVYSC GSLFPKALQR LSRSIVRSRA HSTAVGIFSV
760 770 780 790 800
LLVFTSAIAN MFTCNHTPIR SCAARMLNLT PADITACHLQ QLNYSLGLDA
810 820 830 840 850
PLCEGTMPTC SFPEYFIGNM LLSLLASSVF LHISSIGKLA MIFVLGLIYL
860 870 880 890 900
VLLLLGPPAT IFDNYDLLLG VHGLASSNET FDGLDCPAAG RVALKYMTPV
910 920 930 940 950
ILLVFALALY LHAQQVESTA RLDFLWKLQA TGEKEEMEEL QAYNRRLLHN
960 970 980 990 1000
ILPKDVAAHF LARERRNDEL YYQSCECVAV MFASIANFSE FYVELEANNE
1010 1020 1030 1040 1050
GVECLRLLNE IIADFDEIIS EERFRQLEKI KTIGSTYMAA SGLNASTYDQ
1060 1070 1080 1090 1100
VGRSHITALA DYAMRLMEQM KHINEHSFNN FQMKIGLNMG PVVAGVIGAR
1110 1120 1130 1140 1150
KPQYDIWGNT VNVSSRMDST GVPDRIQVTT DLYQVLAAKG YQLECRGVVK
1160
VKGKGEMTTY FLNGGPSS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8VZJ5 | F8VZJ5_HUMAN | Adenylate cyclase type 6 | ADCY6 | 82 | Annotation score: |
Sequence cautioni
The sequence BAA24852 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048249 | 674 | A → S No effect on basal enzyme activity, but increased enzyme activity upon activation via G-proteins or forskolin. Corresponds to variant dbSNP:rs3730071Ensembl. | 1 | |
Natural variantiVAR_073434 | 1116 | R → C in LCCS8. 1 PublicationCorresponds to variant dbSNP:rs786204798EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000244 | 762 – 814 | Missing in isoform 2. 1 PublicationAdd BLAST | 53 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF250226 mRNA Translation: AAF82478.1 AB007882 mRNA Translation: BAA24852.2 Different initiation. BC064923 mRNA No translation available. |
CCDSi | CCDS8767.1 [O43306-1] |
RefSeqi | NP_056085.1, NM_015270.4 [O43306-1] XP_006719273.1, XM_006719210.3 [O43306-1] |
Genome annotation databases
Ensembli | ENST00000307885; ENSP00000311405; ENSG00000174233 [O43306-1] ENST00000357869; ENSP00000350536; ENSG00000174233 [O43306-2] ENST00000550422; ENSP00000446730; ENSG00000174233 [O43306-2] |
GeneIDi | 112 |
KEGGi | hsa:112 |
UCSCi | uc001rsh.5, human [O43306-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF250226 mRNA Translation: AAF82478.1 AB007882 mRNA Translation: BAA24852.2 Different initiation. BC064923 mRNA No translation available. |
CCDSi | CCDS8767.1 [O43306-1] |
RefSeqi | NP_056085.1, NM_015270.4 [O43306-1] XP_006719273.1, XM_006719210.3 [O43306-1] |
3D structure databases
SMRi | O43306 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106625, 32 interactors |
IntActi | O43306, 24 interactors |
MINTi | O43306 |
STRINGi | 9606.ENSP00000311405 |
Chemistry databases
BindingDBi | O43306 |
ChEMBLi | CHEMBL2097167 |
GuidetoPHARMACOLOGYi | 1283 |
PTM databases
GlyGeni | O43306, 1 site |
iPTMneti | O43306 |
PhosphoSitePlusi | O43306 |
SwissPalmi | O43306 |
Genetic variation databases
BioMutai | ADCY6 |
Proteomic databases
jPOSTi | O43306 |
MassIVEi | O43306 |
MaxQBi | O43306 |
PaxDbi | O43306 |
PeptideAtlasi | O43306 |
PRIDEi | O43306 |
ProteomicsDBi | 48880 [O43306-1] 48881 [O43306-2] |
Protocols and materials databases
Antibodypediai | 4336, 177 antibodies |
Genome annotation databases
Ensembli | ENST00000307885; ENSP00000311405; ENSG00000174233 [O43306-1] ENST00000357869; ENSP00000350536; ENSG00000174233 [O43306-2] ENST00000550422; ENSP00000446730; ENSG00000174233 [O43306-2] |
GeneIDi | 112 |
KEGGi | hsa:112 |
UCSCi | uc001rsh.5, human [O43306-1] |
Organism-specific databases
CTDi | 112 |
DisGeNETi | 112 |
GeneCardsi | ADCY6 |
HGNCi | HGNC:237, ADCY6 |
HPAi | ENSG00000174233, Low tissue specificity |
MalaCardsi | ADCY6 |
MIMi | 600294, gene 616287, phenotype |
neXtProti | NX_O43306 |
OpenTargetsi | ENSG00000174233 |
Orphaneti | 2680, Hypomyelination neuropathy-arthrogryposis syndrome |
PharmGKBi | PA27 |
VEuPathDBi | HostDB:ENSG00000174233.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3619, Eukaryota |
GeneTreei | ENSGT00940000155687 |
HOGENOMi | CLU_001072_2_0_1 |
InParanoidi | O43306 |
OMAi | PLCEGTM |
OrthoDBi | 215180at2759 |
PhylomeDBi | O43306 |
TreeFami | TF313845 |
Enzyme and pathway databases
PathwayCommonsi | O43306 |
Reactomei | R-HSA-163359, Glucagon signaling in metabolic regulation R-HSA-163615, PKA activation R-HSA-164378, PKA activation in glucagon signalling R-HSA-170660, Adenylate cyclase activating pathway R-HSA-170670, Adenylate cyclase inhibitory pathway R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion R-HSA-418555, G alpha (s) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5610787, Hedgehog 'off' state R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9664323, FCGR3A-mediated IL10 synthesis |
SIGNORi | O43306 |
Miscellaneous databases
BioGRID-ORCSi | 112, 6 hits in 990 CRISPR screens |
ChiTaRSi | ADCY6, human |
GeneWikii | ADCY6 |
GenomeRNAii | 112 |
Pharosi | O43306, Tchem |
PROi | PR:O43306 |
RNActi | O43306, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174233, Expressed in heart left ventricle and 185 other tissues |
ExpressionAtlasi | O43306, baseline and differential |
Genevisiblei | O43306, HS |
Family and domain databases
CDDi | cd07302, CHD, 2 hits |
Gene3Di | 3.30.70.1230, 2 hits |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR032628, AC_N IPR030672, Adcy IPR009398, Adcy_conserved_dom IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF16214, AC_N, 1 hit PF06327, DUF1053, 1 hit PF00211, Guanylate_cyc, 2 hits |
PIRSFi | PIRSF039050, Ade_cyc, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 2 hits |
SUPFAMi | SSF55073, SSF55073, 2 hits |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 2 hits PS50125, GUANYLATE_CYCLASE_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADCY6_HUMAN | |
Accessioni | O43306Primary (citable) accession number: O43306 Secondary accession number(s): Q9NR75, Q9UDB0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | January 11, 2001 | |
Last modified: | April 7, 2021 | |
This is version 199 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families