UniProtKB - O43303 (CP110_HUMAN)
Centriolar coiled-coil protein of 110 kDa
CCP110
Functioni
GO - Biological processi
- centriole replication Source: UniProtKB
- centrosome duplication Source: UniProtKB
- ciliary basal body organization Source: UniProtKB
- ciliary basal body-plasma membrane docking Source: Reactome
- G2/M transition of mitotic cell cycle Source: Reactome
- negative regulation of centriole elongation Source: GO_Central
- negative regulation of cilium assembly Source: UniProtKB
- positive regulation of cilium assembly Source: UniProtKB
- protein deubiquitination Source: Reactome
- regulation of cytokinesis Source: UniProtKB
- regulation of G2/M transition of mitotic cell cycle Source: Reactome
Keywordsi
Biological process | Cilium biogenesis/degradation |
Enzyme and pathway databases
PathwayCommonsi | O43303 |
Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-5689880, Ub-specific processing proteases R-HSA-8854518, AURKA Activation by TPX2 |
Names & Taxonomyi
Protein namesi | Recommended name: Centriolar coiled-coil protein of 110 kDaAlternative name(s): Centrosomal protein of 110 kDa Short name: CP110 Short name: Cep110 |
Gene namesi | Name:CCP110 Synonyms:CEP110, CP110, KIAA0419 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24342, CCP110 |
MIMi | 609544, gene |
neXtProti | NX_O43303 |
VEuPathDBi | HostDB:ENSG00000103540.16 |
Subcellular locationi
Cytoskeleton
- centriole 7 Publications
- centrosome By similarity
- cilium basal body By similarity
Note: Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells. In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact.By similarity1 Publication
Cytoskeleton
- centriole Source: UniProtKB
- centrosome Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Other locations
- cilium Source: UniProtKB-KW
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, CytoskeletonPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 170 | S → A: Loss of centrosome clustering and protection from anaphase catastrophe upon CDK2 inhibition in lung cancer cells. 1 Publication | 1 | |
Mutagenesisi | 194 | T → A: Loss of centrosome clustering and protection from anaphase catastrophe upon CDK2 inhibition in lung cancer cells. 1 Publication | 1 | |
Mutagenesisi | 586 – 588 | RRL → ARA: Abolishes interaction with CCNF. 1 Publication | 3 |
Organism-specific databases
DisGeNETi | 9738 |
OpenTargetsi | ENSG00000103540 |
Miscellaneous databases
Pharosi | O43303, Tbio |
Genetic variation databases
BioMutai | CCP110 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089460 | 1 – 1012 | Centriolar coiled-coil protein of 110 kDaAdd BLAST | 1012 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 170 | Phosphoserine1 Publication | 1 | |
Modified residuei | 194 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 366 | PhosphoserineBy similarity | 1 | |
Modified residuei | 372 | PhosphoserineCombined sources | 1 | |
Modified residuei | 400 | PhosphoserineBy similarity | 1 | |
Modified residuei | 551 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O43303 |
jPOSTi | O43303 |
MassIVEi | O43303 |
MaxQBi | O43303 |
PaxDbi | O43303 |
PeptideAtlasi | O43303 |
PRIDEi | O43303 |
ProteomicsDBi | 48877 [O43303-1] 48878 [O43303-2] |
PTM databases
iPTMneti | O43303 |
PhosphoSitePlusi | O43303 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000103540, Expressed in corpus callosum and 231 other tissues |
ExpressionAtlasi | O43303, baseline and differential |
Genevisiblei | O43303, HS |
Organism-specific databases
HPAi | ENSG00000103540, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with CALM1, CETN2, CEP76, CEP97, CEP104, CEP290, TALPID3. Seems to associate with discrete CETN2, CEP97 and CEP290-containing complexes.
Interacts with NEURL4 and CCNF; these interactions are not mutually exclusive and both lead to CCP110 ubiquitination and proteasome-dependent degradation. Via its interaction with NEURL4, may indirectly interact with HERC2.
Interacts with KIF24, leading to its recruitment to centrioles.
Interacts with USP20 and USP33.
11 PublicationsBinary interactionsi
Hide detailsO43303
Protein-protein interaction databases
BioGRIDi | 115087, 89 interactors |
CORUMi | O43303 |
DIPi | DIP-39892N |
IntActi | O43303, 72 interactors |
MINTi | O43303 |
STRINGi | 9606.ENSP00000370803 |
Miscellaneous databases
RNActi | O43303, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 223 | CEP97 bindingAdd BLAST | 223 | |
Regioni | 64 – 82 | Calmodulin-bindingAdd BLAST | 19 | |
Regioni | 67 – 82 | Required for interaction with CEP2901 PublicationAdd BLAST | 16 | |
Regioni | 350 – 565 | Interaction with CEP761 PublicationAdd BLAST | 216 | |
Regioni | 781 – 821 | Calmodulin-bindingAdd BLAST | 41 | |
Regioni | 909 – 924 | Calmodulin-bindingAdd BLAST | 16 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 49 – 90 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 640 – 709 | Sequence analysisAdd BLAST | 70 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QUVS, Eukaryota |
GeneTreei | ENSGT00390000004090 |
HOGENOMi | CLU_302049_0_0_1 |
InParanoidi | O43303 |
OMAi | YATSQCI |
OrthoDBi | 408678at2759 |
PhylomeDBi | O43303 |
TreeFami | TF332788 |
Family and domain databases
InterProi | View protein in InterPro IPR033207, CCP110 |
PANTHERi | PTHR13594, PTHR13594, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEYEKFCEK SLARIQEASL STESFLPAQS ESISLIRFHG VAILSPLLNI
60 70 80 90 100
EKRKEMQQEK QKALDVEARK QVNRKKALLT RVQEILDNVQ VRKAPNASDF
110 120 130 140 150
DQWEMETVYS NSEVRNLNVP ATFPNSFPSH TEHSTAAKLD KIAGILPLDN
160 170 180 190 200
EDQCKTDGID LARDSEGFNS PKQCDSSNIS HVENEAFPKT SSATPQETLI
210 220 230 240 250
SDGPFSVNEQ QDLPLLAEVI PDPYVMSLQN LMKKSKEYIE REQSRRSLRG
260 270 280 290 300
SINRIVNESH LDKEHDAVEV ADCVKEKGQL TGKHCVSVIP DKPSLNKSNV
310 320 330 340 350
LLQGASTQAS SMSMPVLASF SKVDIPIRTG HPTVLESNSD FKVIPTFVTE
360 370 380 390 400
NNVIKSLTGS YAKLPSPEPS MSPKMHRRRS RTSSACHILI NNPINACELS
410 420 430 440 450
PKGKEQAMDL IIQDTDENTN VPEIMPKLPT DLAGVCSSKV YVGKNTSEVK
460 470 480 490 500
EDVVLGKSNQ VCQSSGNHLE NKVTHGLVTV EGQLTSDERG AHIMNSTCAA
510 520 530 540 550
MPKLHEPYAS SQCIASPNFG TVSGLKPASM LEKNCSLQTE LNKSYDVKNP
560 570 580 590 600
SPLLMQNQNT RQQMDTPMVS CGNEQFLDNS FEKVKRRLDL DIDGLQKENC
610 620 630 640 650
PYVITSGITE QERQHLPEKR YPKGSGFVNK NKMLGTSSKE SEELLKSKML
660 670 680 690 700
AFEEMRKRLE EQHAQQLSLL IAEQEREQER LQKEIEEQEK MLKEKKAMTA
710 720 730 740 750
EASELDINNA VELEWRKISD SSLLETMLSQ ADSLHTSNSN SSGFTNSAMQ
760 770 780 790 800
YSFVSANEAP FYLWGSSTSG LTKLSVTRPF GRAKTRWSQV FSLEIQAKFN
810 820 830 840 850
KITAVAKGFL TRRLMQTDKL KQLRQTVKDT MEFIRSFQSE APLKRGIVSA
860 870 880 890 900
QDASLQERVL AQLRAALYGI HDIFFVMDAA ERMSILHHDR EVRKEKMLRQ
910 920 930 940 950
MDKMKSPRVA LSAATQKSLD RKKYMKAAEM GMPNKKFLVK QNPSETRVLQ
960 970 980 990 1000
PNQGQNAPVH RLLSRQGTPK TSVKGVVQNR QKPSQSRVPN RVPVSGVYAG
1010
KIQRKRPNVA TI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L262 | I3L262_HUMAN | Centriolar coiled-coil protein of 1... | CCP110 | 120 | Annotation score: | ||
H3BVH3 | H3BVH3_HUMAN | Centriolar coiled-coil protein of 1... | CCP110 | 52 | Annotation score: | ||
H3BMS1 | H3BMS1_HUMAN | Centriolar coiled-coil protein of 1... | CCP110 | 50 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 628 | V → F in AAH36654 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056788 | 69 | R → S. Corresponds to variant dbSNP:rs16972129Ensembl. | 1 | |
Natural variantiVAR_056789 | 171 | P → L. Corresponds to variant dbSNP:rs3751821EnsemblClinVar. | 1 | |
Natural variantiVAR_019823 | 252 | I → M4 PublicationsCorresponds to variant dbSNP:rs226891EnsemblClinVar. | 1 | |
Natural variantiVAR_056790 | 347 | F → I1 PublicationCorresponds to variant dbSNP:rs11645625Ensembl. | 1 | |
Natural variantiVAR_019824 | 375 | M → I. Corresponds to variant dbSNP:rs7190666EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011897 | 968 – 1012 | TPKTS…NVATI → SICRKNPKKAAKCCDNLRRQ HSLG in isoform 2. 2 PublicationsAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007879 mRNA Translation: BAA24849.2 Different initiation. CR749255 mRNA Translation: CAH18111.1 AC003108 Genomic DNA Translation: AAC05804.1 AC012621 Genomic DNA No translation available. BC036654 mRNA Translation: AAH36654.1 |
CCDSi | CCDS10579.1 [O43303-2] CCDS55992.1 [O43303-1] |
PIRi | T01372 |
RefSeqi | NP_001185951.2, NM_001199022.2 [O43303-1] NP_001310498.1, NM_001323569.1 [O43303-1] NP_001310499.1, NM_001323570.1 [O43303-2] NP_001310500.1, NM_001323571.1 [O43303-2] NP_001310501.1, NM_001323572.1 [O43303-2] NP_055526.4, NM_014711.5 [O43303-2] XP_011544293.1, XM_011545991.2 [O43303-1] XP_011544294.1, XM_011545992.2 [O43303-1] XP_016879397.1, XM_017023908.1 [O43303-1] |
Genome annotation databases
Ensembli | ENST00000381396; ENSP00000370803; ENSG00000103540 [O43303-1] ENST00000396208; ENSP00000379511; ENSG00000103540 [O43303-2] ENST00000396212; ENSP00000379515; ENSG00000103540 [O43303-2] |
GeneIDi | 9738 |
KEGGi | hsa:9738 |
UCSCi | uc002dgk.5, human [O43303-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007879 mRNA Translation: BAA24849.2 Different initiation. CR749255 mRNA Translation: CAH18111.1 AC003108 Genomic DNA Translation: AAC05804.1 AC012621 Genomic DNA No translation available. BC036654 mRNA Translation: AAH36654.1 |
CCDSi | CCDS10579.1 [O43303-2] CCDS55992.1 [O43303-1] |
PIRi | T01372 |
RefSeqi | NP_001185951.2, NM_001199022.2 [O43303-1] NP_001310498.1, NM_001323569.1 [O43303-1] NP_001310499.1, NM_001323570.1 [O43303-2] NP_001310500.1, NM_001323571.1 [O43303-2] NP_001310501.1, NM_001323572.1 [O43303-2] NP_055526.4, NM_014711.5 [O43303-2] XP_011544293.1, XM_011545991.2 [O43303-1] XP_011544294.1, XM_011545992.2 [O43303-1] XP_016879397.1, XM_017023908.1 [O43303-1] |
3D structure databases
SMRi | O43303 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115087, 89 interactors |
CORUMi | O43303 |
DIPi | DIP-39892N |
IntActi | O43303, 72 interactors |
MINTi | O43303 |
STRINGi | 9606.ENSP00000370803 |
PTM databases
iPTMneti | O43303 |
PhosphoSitePlusi | O43303 |
Genetic variation databases
BioMutai | CCP110 |
Proteomic databases
EPDi | O43303 |
jPOSTi | O43303 |
MassIVEi | O43303 |
MaxQBi | O43303 |
PaxDbi | O43303 |
PeptideAtlasi | O43303 |
PRIDEi | O43303 |
ProteomicsDBi | 48877 [O43303-1] 48878 [O43303-2] |
Protocols and materials databases
Antibodypediai | 42931, 170 antibodies |
DNASUi | 9738 |
Genome annotation databases
Ensembli | ENST00000381396; ENSP00000370803; ENSG00000103540 [O43303-1] ENST00000396208; ENSP00000379511; ENSG00000103540 [O43303-2] ENST00000396212; ENSP00000379515; ENSG00000103540 [O43303-2] |
GeneIDi | 9738 |
KEGGi | hsa:9738 |
UCSCi | uc002dgk.5, human [O43303-1] |
Organism-specific databases
CTDi | 9738 |
DisGeNETi | 9738 |
GeneCardsi | CCP110 |
HGNCi | HGNC:24342, CCP110 |
HPAi | ENSG00000103540, Tissue enhanced (brain) |
MIMi | 609544, gene |
neXtProti | NX_O43303 |
OpenTargetsi | ENSG00000103540 |
VEuPathDBi | HostDB:ENSG00000103540.16 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUVS, Eukaryota |
GeneTreei | ENSGT00390000004090 |
HOGENOMi | CLU_302049_0_0_1 |
InParanoidi | O43303 |
OMAi | YATSQCI |
OrthoDBi | 408678at2759 |
PhylomeDBi | O43303 |
TreeFami | TF332788 |
Enzyme and pathway databases
PathwayCommonsi | O43303 |
Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-5689880, Ub-specific processing proteases R-HSA-8854518, AURKA Activation by TPX2 |
Miscellaneous databases
BioGRID-ORCSi | 9738, 151 hits in 882 CRISPR screens |
ChiTaRSi | CCP110, human |
GeneWikii | CCP110 |
GenomeRNAii | 9738 |
Pharosi | O43303, Tbio |
PROi | PR:O43303 |
RNActi | O43303, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103540, Expressed in corpus callosum and 231 other tissues |
ExpressionAtlasi | O43303, baseline and differential |
Genevisiblei | O43303, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033207, CCP110 |
PANTHERi | PTHR13594, PTHR13594, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP110_HUMAN | |
Accessioni | O43303Primary (citable) accession number: O43303 Secondary accession number(s): B7WP23 Q8NE13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | October 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 176 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants