UniProtKB - O43301 (HS12A_HUMAN)
Protein
Heat shock 70 kDa protein 12A
Gene
HSPA12A
Organism
Homo sapiens (Human)
Status
Functioni
Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization.1 Publication
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O43301 |
Reactomei | R-HSA-3371453, Regulation of HSF1-mediated heat shock response |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock 70 kDa protein 12A |
Gene namesi | Name:HSPA12A Synonyms:KIAA0417 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19022, HSPA12A |
MIMi | 610701, gene |
neXtProti | NX_O43301 |
VEuPathDBi | HostDB:ENSG00000165868.12 |
Subcellular locationi
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 259217 |
OpenTargetsi | ENSG00000165868 |
PharmGKBi | PA38779 |
Miscellaneous databases
Pharosi | O43301, Tbio |
Genetic variation databases
BioMutai | HSPA12A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000078292 | 2 – 675 | Heat shock 70 kDa protein 12AAdd BLAST | 674 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O43301 |
jPOSTi | O43301 |
MassIVEi | O43301 |
MaxQBi | O43301 |
PaxDbi | O43301 |
PeptideAtlasi | O43301 |
PRIDEi | O43301 |
ProteomicsDBi | 48876 |
PTM databases
iPTMneti | O43301 |
PhosphoSitePlusi | O43301 |
Expressioni
Tissue specificityi
Widely expressed with highest levels in brain, kidney and muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000165868, Expressed in dorsal root ganglion and 206 other tissues |
ExpressionAtlasi | O43301, baseline and differential |
Genevisiblei | O43301, HS |
Organism-specific databases
HPAi | ENSG00000165868, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with SORL1 (via cytosolic C-terminus); this interaction affects SORL1 internalization and subcellular localization.
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 129226, 33 interactors |
IntActi | O43301, 26 interactors |
MINTi | O43301 |
STRINGi | 9606.ENSP00000358211 |
Miscellaneous databases
RNActi | O43301, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the heat shock protein 70 family.Curated
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
GeneTreei | ENSGT00940000154551 |
HOGENOMi | CLU_009958_5_3_1 |
InParanoidi | O43301 |
PhylomeDBi | O43301 |
TreeFami | TF329492 |
Family and domain databases
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR026685, HSPA12A |
PANTHERi | PTHR14187:SF46, PTHR14187:SF46, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All
O43301-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADKEAGGSD GPRETAPTSA YSSPARSLGD TGITPLSPSH IVNDTDSNVS
60 70 80 90 100
EQQSFLVVVA VDFGTTSSGY AYSFTKEPEC IHVMRRWEGG DPGVSNQKTP
110 120 130 140 150
TTILLTPERK FHSFGYAARD FYHDLDPNEA KQWLYLEKFK MKLHTTGDLT
160 170 180 190 200
MDTDLTAANG KKVKALEIFA YALQYFKEQA LKELSDQAGS EFENSDVRWV
210 220 230 240 250
ITVPAIWKQP AKQFMRQAAY QAGLASPENS EQLIIALEPE AASIYCRKLR
260 270 280 290 300
LHQMIELSSK AAVNGYSGSD TVGAGFTQAK EHIRRNRQSR TFLVENVIGE
310 320 330 340 350
IWSELEEGDK YVVVDSGGGT VDLTVHQIRL PEGHLKELYK ATGGPYGSLG
360 370 380 390 400
VDYEFEKLLY KIFGEDFIEQ FKIKRPAAWV DLMIAFESRK RAAAPDRTNP
410 420 430 440 450
LNITLPFSFI DYYKKFRGHS VEHALRKSNV DFVKWSSQGM LRMSPDAMNA
460 470 480 490 500
LFKPTIDSII EHLRDLFQKP EVSTVKFLFL VGGFAEAPLL QQAVQAAFGD
510 520 530 540 550
QCRIIIPQDV GLTILKGAVL FGLDPAVIKV RRSPLTYGVG VLNRYVEGKH
560 570 580 590 600
PPEKLLVKDG TRWCTDVFDK FISADQSVAL GELVKRSYTP AKPSQLVIVI
610 620 630 640 650
NIYSSEHDNV SFITDPGVKK CGTLRLDLTG TSGTAVPARR EIQTLMQFGD
660 670
TEIKATAIDI ATSKSVKVGI DFLNY
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8PIU5 | A0A6I8PIU5_HUMAN | Heat shock 70 kDa protein 12A | HSPA12A | 227 | Annotation score: | ||
A0A6I8PIW1 | A0A6I8PIW1_HUMAN | Heat shock 70 kDa protein 12A | HSPA12A | 646 | Annotation score: | ||
A0A6I8PIX2 | A0A6I8PIX2_HUMAN | Heat shock 70 kDa protein 12A | HSPA12A | 86 | Annotation score: | ||
A0A6I8PII9 | A0A6I8PII9_HUMAN | Heat shock 70 kDa protein 12A | HSPA12A | 34 | Annotation score: | ||
A0A6I8PRZ9 | A0A6I8PRZ9_HUMAN | Heat shock 70 kDa protein 12A | HSPA12A | 46 | Annotation score: | ||
A0A1B0GTF3 | A0A1B0GTF3_HUMAN | Heat shock 70 kDa protein 12A | HSPA12A | 692 | Annotation score: | ||
K7ELE6 | K7ELE6_HUMAN | Heat shock 70 kDa protein 12A | HSPA12A | 119 | Annotation score: | ||
A0A6I8PIT5 | A0A6I8PIT5_HUMAN | Heat shock 70 kDa protein 12A | HSPA12A | 592 | Annotation score: | ||
A0A6I8PLB1 | A0A6I8PLB1_HUMAN | Heat shock 70 kDa protein 12A | HSPA12A | 691 | Annotation score: | ||
A0A6I8PL32 | A0A6I8PL32_HUMAN | Heat shock 70 kDa protein 12A | HSPA12A | 461 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence BAA24847 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007877 mRNA Translation: BAA24847.1 Different initiation. |
CCDSi | CCDS41569.1 |
PIRi | T00055 |
RefSeqi | NP_079291.2, NM_025015.2 |
Genome annotation databases
Ensembli | ENST00000369209; ENSP00000358211; ENSG00000165868 |
GeneIDi | 259217 |
KEGGi | hsa:259217 |
UCSCi | uc001lct.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007877 mRNA Translation: BAA24847.1 Different initiation. |
CCDSi | CCDS41569.1 |
PIRi | T00055 |
RefSeqi | NP_079291.2, NM_025015.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 129226, 33 interactors |
IntActi | O43301, 26 interactors |
MINTi | O43301 |
STRINGi | 9606.ENSP00000358211 |
PTM databases
iPTMneti | O43301 |
PhosphoSitePlusi | O43301 |
Genetic variation databases
BioMutai | HSPA12A |
Proteomic databases
EPDi | O43301 |
jPOSTi | O43301 |
MassIVEi | O43301 |
MaxQBi | O43301 |
PaxDbi | O43301 |
PeptideAtlasi | O43301 |
PRIDEi | O43301 |
ProteomicsDBi | 48876 |
Protocols and materials databases
Antibodypediai | 2201, 97 antibodies |
Genome annotation databases
Ensembli | ENST00000369209; ENSP00000358211; ENSG00000165868 |
GeneIDi | 259217 |
KEGGi | hsa:259217 |
UCSCi | uc001lct.3, human |
Organism-specific databases
CTDi | 259217 |
DisGeNETi | 259217 |
GeneCardsi | HSPA12A |
HGNCi | HGNC:19022, HSPA12A |
HPAi | ENSG00000165868, Tissue enhanced (brain) |
MIMi | 610701, gene |
neXtProti | NX_O43301 |
OpenTargetsi | ENSG00000165868 |
PharmGKBi | PA38779 |
VEuPathDBi | HostDB:ENSG00000165868.12 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
GeneTreei | ENSGT00940000154551 |
HOGENOMi | CLU_009958_5_3_1 |
InParanoidi | O43301 |
PhylomeDBi | O43301 |
TreeFami | TF329492 |
Enzyme and pathway databases
PathwayCommonsi | O43301 |
Reactomei | R-HSA-3371453, Regulation of HSF1-mediated heat shock response |
Miscellaneous databases
BioGRID-ORCSi | 259217, 1 hit in 875 CRISPR screens |
ChiTaRSi | HSPA12A, human |
GenomeRNAii | 259217 |
Pharosi | O43301, Tbio |
PROi | PR:O43301 |
RNActi | O43301, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165868, Expressed in dorsal root ganglion and 206 other tissues |
ExpressionAtlasi | O43301, baseline and differential |
Genevisiblei | O43301, HS |
Family and domain databases
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR026685, HSPA12A |
PANTHERi | PTHR14187:SF46, PTHR14187:SF46, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HS12A_HUMAN | |
Accessioni | O43301Primary (citable) accession number: O43301 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | July 19, 2003 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families