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Protein

Heat shock 70 kDa protein 12A

Gene

HSPA12A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 12A
Gene namesi
Name:HSPA12A
Synonyms:KIAA0417
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165868.12
HGNCiHGNC:19022 HSPA12A
MIMi610701 gene
neXtProtiNX_O43301

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi259217
OpenTargetsiENSG00000165868
PharmGKBiPA38779

Polymorphism and mutation databases

BioMutaiHSPA12A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000782922 – 675Heat shock 70 kDa protein 12AAdd BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43301
MaxQBiO43301
PaxDbiO43301
PeptideAtlasiO43301
PRIDEiO43301
ProteomicsDBi48876

PTM databases

iPTMnetiO43301
PhosphoSitePlusiO43301

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain, kidney and muscle.1 Publication

Gene expression databases

BgeeiENSG00000165868 Expressed in 192 organ(s), highest expression level in dorsal root ganglion
CleanExiHS_HSPA12A
ExpressionAtlasiO43301 baseline and differential
GenevisibleiO43301 HS

Organism-specific databases

HPAiHPA011273
HPA073244

Interactioni

Protein-protein interaction databases

BioGridi129226, 27 interactors
IntActiO43301, 7 interactors
MINTiO43301
STRINGi9606.ENSP00000358211

Structurei

3D structure databases

ProteinModelPortaliO43301
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000014360
HOGENOMiHOG000231707
HOVERGENiHBG051928
InParanoidiO43301
OrthoDBiEOG091G03BF
PhylomeDBiO43301
TreeFamiTF329492

Family and domain databases

InterProiView protein in InterPro
IPR026685 HSPA12A
PANTHERiPTHR14187:SF46 PTHR14187:SF46, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

O43301-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADKEAGGSD GPRETAPTSA YSSPARSLGD TGITPLSPSH IVNDTDSNVS
60 70 80 90 100
EQQSFLVVVA VDFGTTSSGY AYSFTKEPEC IHVMRRWEGG DPGVSNQKTP
110 120 130 140 150
TTILLTPERK FHSFGYAARD FYHDLDPNEA KQWLYLEKFK MKLHTTGDLT
160 170 180 190 200
MDTDLTAANG KKVKALEIFA YALQYFKEQA LKELSDQAGS EFENSDVRWV
210 220 230 240 250
ITVPAIWKQP AKQFMRQAAY QAGLASPENS EQLIIALEPE AASIYCRKLR
260 270 280 290 300
LHQMIELSSK AAVNGYSGSD TVGAGFTQAK EHIRRNRQSR TFLVENVIGE
310 320 330 340 350
IWSELEEGDK YVVVDSGGGT VDLTVHQIRL PEGHLKELYK ATGGPYGSLG
360 370 380 390 400
VDYEFEKLLY KIFGEDFIEQ FKIKRPAAWV DLMIAFESRK RAAAPDRTNP
410 420 430 440 450
LNITLPFSFI DYYKKFRGHS VEHALRKSNV DFVKWSSQGM LRMSPDAMNA
460 470 480 490 500
LFKPTIDSII EHLRDLFQKP EVSTVKFLFL VGGFAEAPLL QQAVQAAFGD
510 520 530 540 550
QCRIIIPQDV GLTILKGAVL FGLDPAVIKV RRSPLTYGVG VLNRYVEGKH
560 570 580 590 600
PPEKLLVKDG TRWCTDVFDK FISADQSVAL GELVKRSYTP AKPSQLVIVI
610 620 630 640 650
NIYSSEHDNV SFITDPGVKK CGTLRLDLTG TSGTAVPARR EIQTLMQFGD
660 670
TEIKATAIDI ATSKSVKVGI DFLNY
Length:675
Mass (Da):74,978
Last modified:July 19, 2003 - v2
Checksum:i5DF35D68F9D76437
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GTF3A0A1B0GTF3_HUMAN
Heat shock 70 kDa protein 12A
HSPA12A
692Annotation score:
K7ENF6K7ENF6_HUMAN
Heat shock 70 kDa protein 12A
HSPA12A
136Annotation score:
K7ELE6K7ELE6_HUMAN
Heat shock 70 kDa protein 12A
HSPA12A
119Annotation score:

Sequence cautioni

The sequence BAA24847 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007877 mRNA Translation: BAA24847.1 Different initiation.
CCDSiCCDS41569.1
PIRiT00055
RefSeqiNP_079291.2, NM_025015.2
UniGeneiHs.648448

Genome annotation databases

EnsembliENST00000369209; ENSP00000358211; ENSG00000165868
GeneIDi259217
KEGGihsa:259217
UCSCiuc001lct.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007877 mRNA Translation: BAA24847.1 Different initiation.
CCDSiCCDS41569.1
PIRiT00055
RefSeqiNP_079291.2, NM_025015.2
UniGeneiHs.648448

3D structure databases

ProteinModelPortaliO43301
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129226, 27 interactors
IntActiO43301, 7 interactors
MINTiO43301
STRINGi9606.ENSP00000358211

PTM databases

iPTMnetiO43301
PhosphoSitePlusiO43301

Polymorphism and mutation databases

BioMutaiHSPA12A

Proteomic databases

EPDiO43301
MaxQBiO43301
PaxDbiO43301
PeptideAtlasiO43301
PRIDEiO43301
ProteomicsDBi48876

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369209; ENSP00000358211; ENSG00000165868
GeneIDi259217
KEGGihsa:259217
UCSCiuc001lct.3 human

Organism-specific databases

CTDi259217
DisGeNETi259217
EuPathDBiHostDB:ENSG00000165868.12
GeneCardsiHSPA12A
HGNCiHGNC:19022 HSPA12A
HPAiHPA011273
HPA073244
MIMi610701 gene
neXtProtiNX_O43301
OpenTargetsiENSG00000165868
PharmGKBiPA38779
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000014360
HOGENOMiHOG000231707
HOVERGENiHBG051928
InParanoidiO43301
OrthoDBiEOG091G03BF
PhylomeDBiO43301
TreeFamiTF329492

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Miscellaneous databases

ChiTaRSiHSPA12A human
GenomeRNAii259217
PROiPR:O43301
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165868 Expressed in 192 organ(s), highest expression level in dorsal root ganglion
CleanExiHS_HSPA12A
ExpressionAtlasiO43301 baseline and differential
GenevisibleiO43301 HS

Family and domain databases

InterProiView protein in InterPro
IPR026685 HSPA12A
PANTHERiPTHR14187:SF46 PTHR14187:SF46, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHS12A_HUMAN
AccessioniPrimary (citable) accession number: O43301
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 19, 2003
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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