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Protein

Leucine-rich repeat transmembrane neuronal protein 2

Gene

LRRTM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 2
Alternative name(s):
Leucine-rich repeat neuronal 2 protein
Gene namesi
Name:LRRTM2
Synonyms:KIAA0416, LRRN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000146006.7
HGNCiHGNC:19409 LRRTM2
MIMi610868 gene
neXtProtiNX_O43300

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 422ExtracellularSequence analysisAdd BLAST389
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 516CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi26045
OpenTargetsiENSG00000146006
PharmGKBiPA134993038

Polymorphism and mutation databases

BioMutaiLRRTM2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000001835334 – 516Leucine-rich repeat transmembrane neuronal protein 2Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO43300
PeptideAtlasiO43300
PRIDEiO43300
ProteomicsDBi48875

PTM databases

iPTMnetiO43300
PhosphoSitePlusiO43300

Expressioni

Tissue specificityi

Expressed in neuronal tissues.1 Publication

Gene expression databases

BgeeiENSG00000146006 Expressed in 138 organ(s), highest expression level in frontal cortex
CleanExiHS_LRRN2
HS_LRRTM2
ExpressionAtlasiO43300 baseline and differential
GenevisibleiO43300 HS

Interactioni

Subunit structurei

Interacts with DLG4 and NRXN1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117508, 12 interactors
IntActiO43300, 1 interactor
STRINGi9606.ENSP00000274711

Structurei

3D structure databases

ProteinModelPortaliO43300
SMRiO43300
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 61LRRNTAdd BLAST28
Repeati63 – 83LRR 1Add BLAST21
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 131LRR 3Add BLAST22
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 179LRR 5Add BLAST22
Repeati182 – 203LRR 6Add BLAST22
Repeati206 – 227LRR 7Add BLAST22
Repeati230 – 251LRR 8Add BLAST22
Repeati254 – 275LRR 9Add BLAST22
Repeati278 – 299LRR 10Add BLAST22
Domaini311 – 362LRRCTAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi513 – 516Involved in DLG4-bindingBy similarity4

Domaini

Synaptogenic effects are mediated by the extracellular LRR region.By similarity

Sequence similaritiesi

Belongs to the LRRTM family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148957
HOGENOMiHOG000290681
HOVERGENiHBG052362
InParanoidiO43300
KOiK16665
OMAiAMATTYR
OrthoDBiEOG091G03BI
PhylomeDBiO43300
TreeFamiTF332659

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O43300-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLHFKWPLG APMLAAIYAM SMVLKMLPAL GMACPPKCRC EKLLFYCDSQ
60 70 80 90 100
GFHSVPNATD KGSLGLSLRH NHITELERDQ FASFSQLTWL HLDHNQISTV
110 120 130 140 150
KEDAFQGLYK LKELILSSNK IFYLPNTTFT QLINLQNLDL SFNQLSSLHP
160 170 180 190 200
ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC RSLEFLDLST NRLRSLARNG
210 220 230 240 250
FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK ISNLTCGMEW
260 270 280 290 300
TWGTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL
310 320 330 340 350
RSLTTVGLSG NLWECSARIC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI
360 370 380 390 400
LDAVHGFQLC WNLSTTVTVM ATTYRDPTTE YTKRISSSSY HVGDKEIPTT
410 420 430 440 450
AGIAVTTEEH FPEPDNAIFT QRVITGTMAL LFSFFFIIFI VFISRKCCPP
460 470 480 490 500
TLRRIRQCSM VQNHRQLRSQ TRLHMSNMSD QGPYNEYEPT HEGPFIIING
510
YGQCKCQQLP YKECEV
Length:516
Mass (Da):59,076
Last modified:July 19, 2004 - v3
Checksum:iF2EDD45C854BC3A6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHE5E5RHE5_HUMAN
Leucine-rich repeat transmembrane n...
LRRTM2
77Annotation score:
E5RIQ2E5RIQ2_HUMAN
Leucine-rich repeat transmembrane n...
LRRTM2
38Annotation score:

Sequence cautioni

The sequence BAA24846 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti334E → G in BAF83753 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182026 mRNA Translation: AAO67547.1
AB007876 mRNA Translation: BAA24846.2 Different initiation.
AK291064 mRNA Translation: BAF83753.1
BC126408 mRNA Translation: AAI26409.1
BC126410 mRNA Translation: AAI26411.1
BC143926 mRNA Translation: AAI43927.1
CCDSiCCDS47272.1
RefSeqiNP_056379.1, NM_015564.2
UniGeneiHs.656653

Genome annotation databases

EnsembliENST00000274711; ENSP00000274711; ENSG00000146006
GeneIDi26045
KEGGihsa:26045
UCSCiuc011cyz.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182026 mRNA Translation: AAO67547.1
AB007876 mRNA Translation: BAA24846.2 Different initiation.
AK291064 mRNA Translation: BAF83753.1
BC126408 mRNA Translation: AAI26409.1
BC126410 mRNA Translation: AAI26411.1
BC143926 mRNA Translation: AAI43927.1
CCDSiCCDS47272.1
RefSeqiNP_056379.1, NM_015564.2
UniGeneiHs.656653

3D structure databases

ProteinModelPortaliO43300
SMRiO43300
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117508, 12 interactors
IntActiO43300, 1 interactor
STRINGi9606.ENSP00000274711

PTM databases

iPTMnetiO43300
PhosphoSitePlusiO43300

Polymorphism and mutation databases

BioMutaiLRRTM2

Proteomic databases

PaxDbiO43300
PeptideAtlasiO43300
PRIDEiO43300
ProteomicsDBi48875

Protocols and materials databases

DNASUi26045
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274711; ENSP00000274711; ENSG00000146006
GeneIDi26045
KEGGihsa:26045
UCSCiuc011cyz.2 human

Organism-specific databases

CTDi26045
DisGeNETi26045
EuPathDBiHostDB:ENSG00000146006.7
GeneCardsiLRRTM2
HGNCiHGNC:19409 LRRTM2
MIMi610868 gene
neXtProtiNX_O43300
OpenTargetsiENSG00000146006
PharmGKBiPA134993038
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148957
HOGENOMiHOG000290681
HOVERGENiHBG052362
InParanoidiO43300
KOiK16665
OMAiAMATTYR
OrthoDBiEOG091G03BI
PhylomeDBiO43300
TreeFamiTF332659

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

GenomeRNAii26045
PROiPR:O43300
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146006 Expressed in 138 organ(s), highest expression level in frontal cortex
CleanExiHS_LRRN2
HS_LRRTM2
ExpressionAtlasiO43300 baseline and differential
GenevisibleiO43300 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRRT2_HUMAN
AccessioniPrimary (citable) accession number: O43300
Secondary accession number(s): A0AVL3
, A8K4U9, B7ZLN8, Q7L770
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 10, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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