UniProtKB - O43296 (ZN264_HUMAN)
Protein
Zinc finger protein 264
Gene
ZNF264
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 203 – 225 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 231 – 253 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 259 – 281 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 287 – 309 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 315 – 337 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 343 – 365 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 371 – 393 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 399 – 421 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 427 – 449 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 455 – 477 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 483 – 505 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 511 – 533 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 539 – 561 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O43296 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 264 |
Gene namesi | Name:ZNF264 Synonyms:KIAA0412 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13057, ZNF264 |
MIMi | 604668, gene |
neXtProti | NX_O43296 |
VEuPathDBi | HostDB:ENSG00000083844.10 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9422 |
OpenTargetsi | ENSG00000083844 |
PharmGKBi | PA37635 |
Miscellaneous databases
Pharosi | O43296, Tdark |
Genetic variation databases
BioMutai | ZNF264 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047492 | 1 – 627 | Zinc finger protein 264Add BLAST | 627 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 80 | PhosphoserineCombined sources | 1 | |
Modified residuei | 343 | PhosphotyrosineCombined sources | 1 | |
Cross-linki | 425 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 511 | PhosphotyrosineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O43296 |
jPOSTi | O43296 |
MassIVEi | O43296 |
MaxQBi | O43296 |
PaxDbi | O43296 |
PeptideAtlasi | O43296 |
PRIDEi | O43296 |
ProteomicsDBi | 48870 |
PTM databases
iPTMneti | O43296 |
PhosphoSitePlusi | O43296 |
Expressioni
Tissue specificityi
Relatively highly expressed in kidney, thymus, testis, ovary, brain, lung, placenta, and prostate, and relatively low expression in heart, liver, skeletal muscle, pancreas, spleen, and small intestine.
Gene expression databases
Bgeei | ENSG00000083844, Expressed in buccal mucosa cell and 233 other tissues |
ExpressionAtlasi | O43296, baseline and differential |
Genevisiblei | O43296, HS |
Organism-specific databases
HPAi | ENSG00000083844, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsO43296
Protein-protein interaction databases
BioGRIDi | 114815, 40 interactors |
IntActi | O43296, 29 interactors |
STRINGi | 9606.ENSP00000263095 |
Miscellaneous databases
RNActi | O43296, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 85 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 203 – 225 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 231 – 253 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 259 – 281 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 287 – 309 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 315 – 337 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 343 – 365 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 371 – 393 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 399 – 421 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 427 – 449 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 455 – 477 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 483 – 505 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 511 – 533 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 539 – 561 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159953 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | O43296 |
OMAi | MHTGKNP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O43296 |
TreeFami | TF341817 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O43296-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAVLTDRA QVSVTFDDVA VTFTKEEWGQ LDLAQRTLYQ EVMLENCGLL
60 70 80 90 100
VSLGCPVPKA ELICHLEHGQ EPWTRKEDLS QDTCPGDKGK PKTTEPTTCE
110 120 130 140 150
PALSEGISLQ GQVTQGNSVD SQLGQAEDQD GLSEMQEGHF RPGIDPQEKS
160 170 180 190 200
PGKMSPECDG LGTADGVCSR IGQEQVSPGD RVRSHNSCES GKDPMIQEEE
210 220 230 240 250
NNFKCSECGK VFNKKHLLAG HEKIHSGVKP YECTECGKTF IKSTHLLQHH
260 270 280 290 300
MIHTGERPYE CMECGKAFNR KSYLTQHQRI HSGEKPYKCN ECGKAFTHRS
310 320 330 340 350
NFVLHNRRHT GEKSFVCTEC GQVFRHRPGF LRHYVVHSGE NPYECLECGK
360 370 380 390 400
VFKHRSYLMW HQQTHTGEKP YECSECGKVF LESAALIHHY VIHTGEKPFE
410 420 430 440 450
CLECGKAFNH RSYLKRHQRI HTGEKPFVCS ECGKAFTHCS TFILHKRAHT
460 470 480 490 500
GEKPFECKEC GKAFSNRKDL IRHFSIHTGE KPYECVECGK AFTRMSGLTR
510 520 530 540 550
HKRIHSGEKP YECVECGKSF CWSTNLIRHA IIHTGEKPYK CSECGKAFSR
560 570 580 590 600
SSSLTQHQRM HTGKNPISVT DVGRPFTSGQ TSVTLRELLL GKDFLNVTTE
610 620
ANILPEETSS SASDQPYQRE TPQVSSL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QZJ4 | M0QZJ4_HUMAN | Zinc finger protein 264 | ZNF264 | 96 | Annotation score: | ||
M0QZT5 | M0QZT5_HUMAN | Zinc finger protein 264 | ZNF264 | 84 | Annotation score: | ||
M0R146 | M0R146_HUMAN | Zinc finger protein 264 | ZNF264 | 64 | Annotation score: | ||
M0QXF3 | M0QXF3_HUMAN | Zinc finger protein 264 | ZNF264 | 39 | Annotation score: |
Sequence cautioni
The sequence BAA24842 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052803 | 181 | R → T. Corresponds to variant dbSNP:rs2074858Ensembl. | 1 | |
Natural variantiVAR_052804 | 183 | R → H. Corresponds to variant dbSNP:rs917340Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007872 mRNA Translation: BAA24842.2 Different initiation. AK292504 mRNA Translation: BAF85193.1 AC005261 Genomic DNA No translation available. AC025588 Genomic DNA Translation: AAF42766.1 |
CCDSi | CCDS33127.1 |
RefSeqi | NP_003408.1, NM_003417.4 |
Genome annotation databases
Ensembli | ENST00000263095; ENSP00000263095; ENSG00000083844 ENST00000536056; ENSP00000440376; ENSG00000083844 |
GeneIDi | 9422 |
KEGGi | hsa:9422 |
UCSCi | uc002qob.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007872 mRNA Translation: BAA24842.2 Different initiation. AK292504 mRNA Translation: BAF85193.1 AC005261 Genomic DNA No translation available. AC025588 Genomic DNA Translation: AAF42766.1 |
CCDSi | CCDS33127.1 |
RefSeqi | NP_003408.1, NM_003417.4 |
3D structure databases
SMRi | O43296 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114815, 40 interactors |
IntActi | O43296, 29 interactors |
STRINGi | 9606.ENSP00000263095 |
PTM databases
iPTMneti | O43296 |
PhosphoSitePlusi | O43296 |
Genetic variation databases
BioMutai | ZNF264 |
Proteomic databases
EPDi | O43296 |
jPOSTi | O43296 |
MassIVEi | O43296 |
MaxQBi | O43296 |
PaxDbi | O43296 |
PeptideAtlasi | O43296 |
PRIDEi | O43296 |
ProteomicsDBi | 48870 |
Protocols and materials databases
Antibodypediai | 19635, 131 antibodies |
Genome annotation databases
Ensembli | ENST00000263095; ENSP00000263095; ENSG00000083844 ENST00000536056; ENSP00000440376; ENSG00000083844 |
GeneIDi | 9422 |
KEGGi | hsa:9422 |
UCSCi | uc002qob.3, human |
Organism-specific databases
CTDi | 9422 |
DisGeNETi | 9422 |
GeneCardsi | ZNF264 |
HGNCi | HGNC:13057, ZNF264 |
HPAi | ENSG00000083844, Low tissue specificity |
MIMi | 604668, gene |
neXtProti | NX_O43296 |
OpenTargetsi | ENSG00000083844 |
PharmGKBi | PA37635 |
VEuPathDBi | HostDB:ENSG00000083844.10 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159953 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | O43296 |
OMAi | MHTGKNP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O43296 |
TreeFami | TF341817 |
Enzyme and pathway databases
PathwayCommonsi | O43296 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 9422, 3 hits in 1010 CRISPR screens |
ChiTaRSi | ZNF264, human |
GeneWikii | ZNF264 |
GenomeRNAii | 9422 |
Pharosi | O43296, Tdark |
PROi | PR:O43296 |
RNActi | O43296, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000083844, Expressed in buccal mucosa cell and 233 other tissues |
ExpressionAtlasi | O43296, baseline and differential |
Genevisiblei | O43296, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN264_HUMAN | |
Accessioni | O43296Primary (citable) accession number: O43296 Secondary accession number(s): A8K8Y9, Q9P1V0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | June 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families