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Protein

Zinc finger protein 264

Gene

ZNF264

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri203 – 225C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 264
Gene namesi
Name:ZNF264
Synonyms:KIAA0412
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000083844.10
HGNCiHGNC:13057 ZNF264
MIMi604668 gene
neXtProtiNX_O43296

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000083844
PharmGKBiPA37635

Polymorphism and mutation databases

BioMutaiZNF264

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474921 – 627Zinc finger protein 264Add BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphoserineCombined sources1
Modified residuei343PhosphotyrosineCombined sources1
Cross-linki425Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei511PhosphotyrosineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43296
MaxQBiO43296
PaxDbiO43296
PeptideAtlasiO43296
PRIDEiO43296
ProteomicsDBi48870

PTM databases

iPTMnetiO43296
PhosphoSitePlusiO43296

Expressioni

Tissue specificityi

Relatively highly expressed in kidney, thymus, testis, ovary, brain, lung, placenta, and prostate, and relatively low expression in heart, liver, skeletal muscle, pancreas, spleen, and small intestine.

Gene expression databases

BgeeiENSG00000083844 Expressed in 221 organ(s), highest expression level in adrenal gland
CleanExiHS_ZNF264
ExpressionAtlasiO43296 baseline and differential
GenevisibleiO43296 HS

Organism-specific databases

HPAiHPA057665

Interactioni

Protein-protein interaction databases

BioGridi114815, 27 interactors
IntActiO43296, 15 interactors
STRINGi9606.ENSP00000263095

Structurei

3D structure databases

ProteinModelPortaliO43296
SMRiO43296
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri203 – 225C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00750000117699
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO43296
KOiK09228
OMAiCSRIGQE
OrthoDBiEOG091G02KC
PhylomeDBiO43296
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O43296-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAVLTDRA QVSVTFDDVA VTFTKEEWGQ LDLAQRTLYQ EVMLENCGLL
60 70 80 90 100
VSLGCPVPKA ELICHLEHGQ EPWTRKEDLS QDTCPGDKGK PKTTEPTTCE
110 120 130 140 150
PALSEGISLQ GQVTQGNSVD SQLGQAEDQD GLSEMQEGHF RPGIDPQEKS
160 170 180 190 200
PGKMSPECDG LGTADGVCSR IGQEQVSPGD RVRSHNSCES GKDPMIQEEE
210 220 230 240 250
NNFKCSECGK VFNKKHLLAG HEKIHSGVKP YECTECGKTF IKSTHLLQHH
260 270 280 290 300
MIHTGERPYE CMECGKAFNR KSYLTQHQRI HSGEKPYKCN ECGKAFTHRS
310 320 330 340 350
NFVLHNRRHT GEKSFVCTEC GQVFRHRPGF LRHYVVHSGE NPYECLECGK
360 370 380 390 400
VFKHRSYLMW HQQTHTGEKP YECSECGKVF LESAALIHHY VIHTGEKPFE
410 420 430 440 450
CLECGKAFNH RSYLKRHQRI HTGEKPFVCS ECGKAFTHCS TFILHKRAHT
460 470 480 490 500
GEKPFECKEC GKAFSNRKDL IRHFSIHTGE KPYECVECGK AFTRMSGLTR
510 520 530 540 550
HKRIHSGEKP YECVECGKSF CWSTNLIRHA IIHTGEKPYK CSECGKAFSR
560 570 580 590 600
SSSLTQHQRM HTGKNPISVT DVGRPFTSGQ TSVTLRELLL GKDFLNVTTE
610 620
ANILPEETSS SASDQPYQRE TPQVSSL
Length:627
Mass (Da):70,587
Last modified:June 1, 1998 - v1
Checksum:iBF0A6460AD07CECB
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZT5M0QZT5_HUMAN
Zinc finger protein 264
ZNF264
84Annotation score:
M0R146M0R146_HUMAN
Zinc finger protein 264
ZNF264
64Annotation score:
M0QZJ4M0QZJ4_HUMAN
Zinc finger protein 264
ZNF264
96Annotation score:
M0QXF3M0QXF3_HUMAN
Zinc finger protein 264
ZNF264
39Annotation score:

Sequence cautioni

The sequence BAA24842 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052803181R → T. Corresponds to variant dbSNP:rs2074858Ensembl.1
Natural variantiVAR_052804183R → H. Corresponds to variant dbSNP:rs917340Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007872 mRNA Translation: BAA24842.2 Different initiation.
AK292504 mRNA Translation: BAF85193.1
AC005261 Genomic DNA No translation available.
AC025588 Genomic DNA Translation: AAF42766.1
CCDSiCCDS33127.1
RefSeqiNP_003408.1, NM_003417.4
UniGeneiHs.515634

Genome annotation databases

EnsembliENST00000263095; ENSP00000263095; ENSG00000083844
ENST00000536056; ENSP00000440376; ENSG00000083844
GeneIDi9422
KEGGihsa:9422
UCSCiuc002qob.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007872 mRNA Translation: BAA24842.2 Different initiation.
AK292504 mRNA Translation: BAF85193.1
AC005261 Genomic DNA No translation available.
AC025588 Genomic DNA Translation: AAF42766.1
CCDSiCCDS33127.1
RefSeqiNP_003408.1, NM_003417.4
UniGeneiHs.515634

3D structure databases

ProteinModelPortaliO43296
SMRiO43296
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114815, 27 interactors
IntActiO43296, 15 interactors
STRINGi9606.ENSP00000263095

PTM databases

iPTMnetiO43296
PhosphoSitePlusiO43296

Polymorphism and mutation databases

BioMutaiZNF264

Proteomic databases

EPDiO43296
MaxQBiO43296
PaxDbiO43296
PeptideAtlasiO43296
PRIDEiO43296
ProteomicsDBi48870

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263095; ENSP00000263095; ENSG00000083844
ENST00000536056; ENSP00000440376; ENSG00000083844
GeneIDi9422
KEGGihsa:9422
UCSCiuc002qob.3 human

Organism-specific databases

CTDi9422
EuPathDBiHostDB:ENSG00000083844.10
GeneCardsiZNF264
HGNCiHGNC:13057 ZNF264
HPAiHPA057665
MIMi604668 gene
neXtProtiNX_O43296
OpenTargetsiENSG00000083844
PharmGKBiPA37635
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00750000117699
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO43296
KOiK09228
OMAiCSRIGQE
OrthoDBiEOG091G02KC
PhylomeDBiO43296
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GeneWikiiZNF264
GenomeRNAii9422
PROiPR:O43296
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000083844 Expressed in 221 organ(s), highest expression level in adrenal gland
CleanExiHS_ZNF264
ExpressionAtlasiO43296 baseline and differential
GenevisibleiO43296 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN264_HUMAN
AccessioniPrimary (citable) accession number: O43296
Secondary accession number(s): A8K8Y9, Q9P1V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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