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UniProtKB - O43294 (TGFI1_HUMAN)

Entry version 161 (12 Aug 2020)
Sequence version 2 (26 Jun 2007)
Previous versions | rss
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Protein

Transforming growth factor beta-1-induced transcript 1 protein

Gene

TGFB1I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.15 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processDifferentiation, Wnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43294

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O43294

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transforming growth factor beta-1-induced transcript 1 protein
Alternative name(s):
Androgen receptor coactivator 55 kDa protein
Androgen receptor-associated protein of 55 kDa
Hydrogen peroxide-inducible clone 5 protein
Short name:
Hic-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TGFB1I1
Synonyms:ARA55
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000140682.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:11767, TGFB1I1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602353, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43294

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi60Y → F: Prevents phosphorylation by FAK2 and FYN. Prevents interaction with CSK. 1 Publication1
Mutagenesisi287C → A: Abolishes interaction with CBLC and enhancement of CBLC E3 ubiquitin-protein ligase activity. 1 Publication1
Mutagenesisi313C → A: No effect on interaction with CBLC. 1 Publication1
Mutagenesisi338 – 342FLQLF → ALQAA: Loss of interaction with AR; when associated with 456-A--A-460. 1 Publication5
Mutagenesisi369C → S: Loss of AR coactivation; when associated with S-372. 1 Publication1
Mutagenesisi372C → S: Loss of AR coactivation; when associated with S-369. 1 Publication1
Mutagenesisi428H → S: Loss of AR coactivation; when associated with S-431. 1 Publication1
Mutagenesisi431C → S: Loss of AR coactivation; when associated with S-428. 1 Publication1
Mutagenesisi456 – 460FLKLF → ALKAA: Loss of interaction with AR; when associated with 338-A--A-342. 1 Publication5

Organism-specific databases

DisGeNET

More...DisGeNETi		7041

Open Targets

More...OpenTargetsi		ENSG00000140682

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36481

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43294, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TGFB1I1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002915821 – 461Transforming growth factor beta-1-induced transcript 1 proteinAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei33PhosphothreonineCombined sources1
Modified residuei38PhosphotyrosineBy similarity1
Modified residuei60Phosphotyrosine; by FAK2 and FYN2 Publications1
Modified residuei68PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei186PhosphoserineBy similarity1
Modified residuei188PhosphothreonineBy similarity1
Modified residuei192PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei407PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by gonadotropin-releasing hormone-activated SRC.5 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43294

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43294

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43294

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43294

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43294

PeptideAtlas

More...PeptideAtlasi		O43294

PRoteomics IDEntifications database

More...PRIDEi		O43294

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48865 [O43294-1]
48866 [O43294-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43294

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O43294

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43294

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in platelets, smooth muscle and prostate stromal cells (at protein level).9 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by TNF and hydrogen peroxide.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140682, Expressed in myometrium and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43294, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43294, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140682, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer.

Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL.

Forms a complex with GIT1 and ARHGEF7.

Interacts with AR/androgen receptor in a ligand-dependent manner.

Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin.

Interacts (via LIM zinc-binding domain 2) with CBLC (via RING-type zinc finger); the interaction is direct and enhances CBLC E3 ubiquitin-protein ligase activity.

20 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112899, 35 interactors

Database of interacting proteins

More...DIPi		DIP-5931N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		O43294

Protein interaction database and analysis system

More...IntActi		O43294, 31 interactors

Molecular INTeraction database

More...MINTi		O43294

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000378332

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43294, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43294

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini226 – 285LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini286 – 343LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST58
Domaini344 – 403LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini404 – 461LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 240Interaction with PTK2B/PYK2Add BLAST240
Regioni1 – 200Transcription activationBy similarityAdd BLAST200
Regioni83 – 136Interaction with PTK2/FAK1By similarityAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi3 – 15LD motif 1Add BLAST13
Motifi92 – 104LD motif 2Add BLAST13
Motifi157 – 168LD motif 3Add BLAST12
Motifi203 – 215LD motif 4Add BLAST13

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12.
The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paxillin family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1703, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160447

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001357_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43294

Identification of Orthologs from Complete Genome Data

More...OMAi		PEHFICG

Database of Orthologous Groups

More...OrthoDBi		1593918at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43294

TreeFam database of animal gene trees

More...TreeFami		TF314113

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017305, Tgfb1i1/Leupaxin/TGFB1I1
IPR001781, Znf_LIM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00412, LIM, 4 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037881, Leupaxin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00132, LIM, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00478, LIM_DOMAIN_1, 4 hits
PS50023, LIM_DOMAIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43294-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDLDALLSD LETTTSHMPR SGAPKERPAE PLTPPPSYGH QPQTGSGESS 
        60         70         80         90        100
GASGDKDHLY STVCKPRSPK PAAPAAPPFS SSSGVLGTGL CELDRLLQEL 
       110        120        130        140        150
NATQFNITDE IMSQFPSSKV ASGEQKEDQS EDKKRPSLPS SPSPGLPKAS 
       160        170        180        190        200
ATSATLELDR LMASLSDFRV QNHLPASGPT QPPVVSSTNE GSPSPPEPTG 
       210        220        230        240        250
KGSLDTMLGL LQSDLSRRGV PTQAKGLCGS CNKPIAGQVV TALGRAWHPE 
       260        270        280        290        300
HFVCGGCSTA LGGSSFFEKD GAPFCPECYF ERFSPRCGFC NQPIRHKMVT 
       310        320        330        340        350
ALGTHWHPEH FCCVSCGEPF GDEGFHEREG RPYCRRDFLQ LFAPRCQGCQ 
       360        370        380        390        400
GPILDNYISA LSALWHPDCF VCRECFAPFS GGSFFEHEGR PLCENHFHAR 
       410        420        430        440        450
RGSLCATCGL PVTGRCVSAL GRRFHPDHFT CTFCLRPLTK GSFQERAGKP 
       460 
YCQPCFLKLF G
Length:461
Mass (Da):49,814
Last modified:June 26, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2C7C32C3FD2C496
GO
Isoform 2 (identifier: O43294-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Show »
Length:444
Mass (Da):47,941
Checksum:iEC9E92DADE7156B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQC4H3BQC4_HUMAN
Transforming growth factor beta-1-i...
TGFB1I1
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS04H3BS04_HUMAN
Transforming growth factor beta-1-i...
TGFB1I1
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSN4H3BSN4_HUMAN
Transforming growth factor beta-1-i...
TGFB1I1
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L209I3L209_HUMAN
Transforming growth factor beta-1-i...
TGFB1I1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN49H3BN49_HUMAN
Transforming growth factor beta-1-i...
TGFB1I1
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRP2H3BRP2_HUMAN
Transforming growth factor beta-1-i...
TGFB1I1
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH32545 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti166S → P in AAD22552 (PubMed:10075738).Curated1
Sequence conflicti200G → A in AAD22552 (PubMed:10075738).Curated1
Sequence conflicti363A → L in AAD22552 (PubMed:10075738).Curated1
Sequence conflicti405 – 406CA → WP in AAD22552 (PubMed:10075738).Curated2
Sequence conflicti430T → A in AAD22552 (PubMed:10075738).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032831129Q → H1 PublicationCorresponds to variant dbSNP:rs45475699Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0261831 – 17Missing in isoform 2. 3 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF116343 mRNA Translation: AAD22552.1
DQ309025 Genomic DNA Translation: ABB96286.1
AK313327 mRNA Translation: BAG36132.1
CH471192 Genomic DNA Translation: EAW52126.1
BC001507 mRNA Translation: AAH01507.2
BC001830 mRNA Translation: AAH01830.1
BC017288 mRNA Translation: AAH17288.1
BC032545 mRNA Translation: AAH32545.1 Different initiation.
AB007836 mRNA Translation: BAA24799.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10713.1 [O43294-2]
CCDS42156.1 [O43294-1]

NCBI Reference Sequences

More...RefSeqi		NP_001035919.1, NM_001042454.2 [O43294-1]
NP_001158191.1, NM_001164719.1 [O43294-2]
NP_057011.2, NM_015927.4 [O43294-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361773; ENSP00000355117; ENSG00000140682 [O43294-2]
ENST00000394858; ENSP00000378327; ENSG00000140682 [O43294-2]
ENST00000394863; ENSP00000378332; ENSG00000140682 [O43294-1]
ENST00000567607; ENSP00000457586; ENSG00000140682 [O43294-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7041

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7041

UCSC genome browser

More...UCSCi		uc002ecd.3, human [O43294-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116343 mRNA Translation: AAD22552.1
DQ309025 Genomic DNA Translation: ABB96286.1
AK313327 mRNA Translation: BAG36132.1
CH471192 Genomic DNA Translation: EAW52126.1
BC001507 mRNA Translation: AAH01507.2
BC001830 mRNA Translation: AAH01830.1
BC017288 mRNA Translation: AAH17288.1
BC032545 mRNA Translation: AAH32545.1 Different initiation.
AB007836 mRNA Translation: BAA24799.1
CCDSiCCDS10713.1 [O43294-2]
CCDS42156.1 [O43294-1]
RefSeqiNP_001035919.1, NM_001042454.2 [O43294-1]
NP_001158191.1, NM_001164719.1 [O43294-2]
NP_057011.2, NM_015927.4 [O43294-2]

3D structure databases

SMRiO43294
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112899, 35 interactors
DIPiDIP-5931N
ELMiO43294
IntActiO43294, 31 interactors
MINTiO43294
STRINGi9606.ENSP00000378332

PTM databases

iPTMnetiO43294
MetOSiteiO43294
PhosphoSitePlusiO43294

Polymorphism and mutation databases

BioMutaiTGFB1I1

Proteomic databases

EPDiO43294
jPOSTiO43294
MassIVEiO43294
MaxQBiO43294
PaxDbiO43294
PeptideAtlasiO43294
PRIDEiO43294
ProteomicsDBi48865 [O43294-1]
48866 [O43294-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1738, 235 antibodies

The DNASU plasmid repository

More...DNASUi		7041

Genome annotation databases

EnsembliENST00000361773; ENSP00000355117; ENSG00000140682 [O43294-2]
ENST00000394858; ENSP00000378327; ENSG00000140682 [O43294-2]
ENST00000394863; ENSP00000378332; ENSG00000140682 [O43294-1]
ENST00000567607; ENSP00000457586; ENSG00000140682 [O43294-2]
GeneIDi7041
KEGGihsa:7041
UCSCiuc002ecd.3, human [O43294-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7041
DisGeNETi7041
EuPathDBiHostDB:ENSG00000140682.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		TGFB1I1
HGNCiHGNC:11767, TGFB1I1
HPAiENSG00000140682, Low tissue specificity
MIMi602353, gene
neXtProtiNX_O43294
OpenTargetsiENSG00000140682
PharmGKBiPA36481

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1703, Eukaryota
GeneTreeiENSGT00940000160447
HOGENOMiCLU_001357_1_2_1
InParanoidiO43294
OMAiPEHFICG
OrthoDBi1593918at2759
PhylomeDBiO43294
TreeFamiTF314113

Enzyme and pathway databases

PathwayCommonsiO43294
SignaLinkiO43294

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7041, 84 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TGFB1I1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TGFB1I1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7041
PharosiO43294, Tbio

Protein Ontology

More...PROi		PR:O43294
RNActiO43294, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140682, Expressed in myometrium and 213 other tissues
ExpressionAtlasiO43294, baseline and differential
GenevisibleiO43294, HS

Family and domain databases

InterProiView protein in InterPro
IPR017305, Tgfb1i1/Leupaxin/TGFB1I1
IPR001781, Znf_LIM
PfamiView protein in Pfam
PF00412, LIM, 4 hits
PIRSFiPIRSF037881, Leupaxin, 1 hit
SMARTiView protein in SMART
SM00132, LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478, LIM_DOMAIN_1, 4 hits
PS50023, LIM_DOMAIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTGFI1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43294
Secondary accession number(s): B2R8D5, Q9BPW3, Q9Y2V5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: August 12, 2020
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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