TGFB1I1

Functionⁱ

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.15 Publications

GO - Molecular functionⁱ

androgen receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10075738
I-SMAD binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18762808
metal ion binding Source: UniProtKB-KW
Roundabout binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19855388
transcription coactivator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10075738

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

androgen receptor signaling pathway
Source: UniProtKB
Non-traceable author statementⁱ
- 15572661
cell adhesion
Source: ProtInc
Traceable author statementⁱ
- 9422762
cell fate commitment Source: Ensembl
epithelial cell differentiation Source: Ensembl
morphogenesis of embryonic epithelium Source: Ensembl
negative regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 7929412
negative regulation of fat cell differentiation Source: Ensembl
negative regulation of transforming growth factor beta receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 18762808
positive regulation of epithelial to mesenchymal transition
Source: BHF-UCL
Inferred from direct assayⁱ
- 18762808
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 10075738
positive regulation of transforming growth factor beta receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 18762808
response to heat Source: Ensembl
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 10075738
ubiquitin-dependent SMAD protein catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 18762808
Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Differentiation, Wnt signaling pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkⁱ	O43294

SignaLinkⁱ

O43294

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transforming growth factor beta-1-induced transcript 1 protein Alternative name(s): Androgen receptor coactivator 55 kDa protein Androgen receptor-associated protein of 55 kDa Hydrogen peroxide-inducible clone 5 protein Short name: Hic-5
Gene namesⁱ	Name:TGFB1I1 Synonyms:ARA55
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140682.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11767 TGFB1I1
MIMⁱ	602353 gene
neXtProtⁱ	NX_O43294

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	60	Y → F: Prevents phosphorylation by FAK2 and FYN. Prevents interaction with CSK. 1 Publication	1
Mutagenesisⁱ	287	C → A: Abolishes interaction with CBLC and enhancement of CBLC E3 ubiquitin-protein ligase activity. 1 Publication	1
Mutagenesisⁱ	313	C → A: No effect on interaction with CBLC. 1 Publication	1
Mutagenesisⁱ	338 – 342	FLQLF → ALQAA: Loss of interaction with AR; when associated with 456-A--A-460. 1 Publication	5
Mutagenesisⁱ	369	C → S: Loss of AR coactivation; when associated with S-372. 1 Publication	1
Mutagenesisⁱ	372	C → S: Loss of AR coactivation; when associated with S-369. 1 Publication	1
Mutagenesisⁱ	428	H → S: Loss of AR coactivation; when associated with S-431. 1 Publication	1
Mutagenesisⁱ	431	C → S: Loss of AR coactivation; when associated with S-428. 1 Publication	1
Mutagenesisⁱ	456 – 460	FLKLF → ALKAA: Loss of interaction with AR; when associated with 338-A--A-342. 1 Publication	5

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7041
Open Targets More...OpenTargetsⁱ	ENSG00000140682
PharmGKBⁱ	PA36481

Polymorphism and mutation databases

BioMutaⁱ	TGFB1I1

BioMutaⁱ

TGFB1I1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000291582	1 – 461	Transforming growth factor beta-1-induced transcript 1 proteinAdd BLAST		461

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	33	PhosphothreonineCombined sources	1
Modified residueⁱ	38	PhosphotyrosineBy similarity	1
Modified residueⁱ	60	Phosphotyrosine; by FAK2 and FYN2 Publications	1
Modified residueⁱ	68	PhosphoserineCombined sources	1
Modified residueⁱ	137	PhosphoserineCombined sources	1
Modified residueⁱ	140	PhosphoserineCombined sources	1
Modified residueⁱ	141	PhosphoserineCombined sources	1
Modified residueⁱ	143	PhosphoserineCombined sources	1
Modified residueⁱ	164	PhosphoserineCombined sources	1
Modified residueⁱ	186	PhosphoserineBy similarity	1
Modified residueⁱ	188	PhosphothreonineBy similarity	1
Modified residueⁱ	192	PhosphoserineCombined sources	1
Modified residueⁱ	194	PhosphoserineCombined sources	1
Modified residueⁱ	403	PhosphoserineCombined sources	1
Modified residueⁱ	407	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by gonadotropin-releasing hormone-activated SRC.5 Publications

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O43294
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43294
PaxDbⁱ	O43294
PeptideAtlas More...PeptideAtlasⁱ	O43294
PRIDEⁱ	O43294
ProteomicsDBⁱ	48865 48866 [O43294-2]

PTM databases

iPTMnetⁱ	O43294
PhosphoSitePlusⁱ	O43294

Expressionⁱ

Tissue specificityⁱ

Expressed in platelets, smooth muscle and prostate stromal cells (at protein level).9 Publications

Inductionⁱ

Up-regulated by TNF and hydrogen peroxide.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000140682 Expressed in 198 organ(s), highest expression level in myometrium
CleanExⁱ	HS_TGFB1I1
ExpressionAtlasⁱ	O43294 baseline and differential
Genevisibleⁱ	O43294 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB020844

HPAⁱ

CAB020844

Interactionⁱ

Subunit structureⁱ

Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin. Interacts (via LIM zinc-binding domain 2) with CBLC (via RING-type zinc finger); the interaction is direct and enhances CBLC E3 ubiquitin-protein ligase activity.20 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ITGA4	P13612	2	EBI-1051449,EBI-703044
PTK2	Q05397	2	EBI-1051449,EBI-702142

GO - Molecular functionⁱ

androgen receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10075738
I-SMAD binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18762808
Roundabout binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19855388

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112899, 32 interactors
Database of interacting proteins More...DIPⁱ	DIP-5931N
ELMⁱ	O43294
IntActⁱ	O43294, 23 interactors
Molecular INTeraction database More...MINTⁱ	O43294
STRINGⁱ	9606.ENSP00000378332

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43294
SMRⁱ	O43294
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	226 – 285	LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	286 – 343	LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST	58
Domainⁱ	344 – 403	LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	404 – 461	LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST	58

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 240	Interaction with PTK2B/PYK2Add BLAST	240
Regionⁱ	1 – 200	Transcription activationBy similarityAdd BLAST	200
Regionⁱ	83 – 136	Interaction with PTK2/FAK1By similarityAdd BLAST	54

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	3 – 15	LD motif 1Add BLAST	13
Motifⁱ	92 – 104	LD motif 2Add BLAST	13
Motifⁱ	157 – 168	LD motif 3Add BLAST	12
Motifⁱ	203 – 215	LD motif 4Add BLAST	13

Domainⁱ

The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12.

The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.

Sequence similaritiesⁱ

Belongs to the paxillin family.Curated

Keywords - Domainⁱ

LIM domain, Repeat

Phylogenomic databases

eggNOGⁱ	KOG1703 Eukaryota ENOG410XRD4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118910
HOGENOMⁱ	HOG000018764
HOVERGENⁱ	HBG001512
InParanoidⁱ	O43294
OMAⁱ	MVTALDK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05AW
PhylomeDBⁱ	O43294
TreeFamⁱ	TF314113

Family and domain databases

InterProⁱ	View protein in InterPro IPR017305 Tgfb1i1/Leupaxin/TGFB1I1 IPR001781 Znf_LIM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00412 LIM, 4 hits
PIRSFⁱ	PIRSF037881 Leupaxin, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 4 hits
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 4 hits PS50023 LIM_DOMAIN_2, 4 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: O43294-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDLDALLSD LETTTSHMPR SGAPKERPAE PLTPPPSYGH QPQTGSGESS 
        60         70         80         90        100
GASGDKDHLY STVCKPRSPK PAAPAAPPFS SSSGVLGTGL CELDRLLQEL 
       110        120        130        140        150
NATQFNITDE IMSQFPSSKV ASGEQKEDQS EDKKRPSLPS SPSPGLPKAS 
       160        170        180        190        200
ATSATLELDR LMASLSDFRV QNHLPASGPT QPPVVSSTNE GSPSPPEPTG 
       210        220        230        240        250
KGSLDTMLGL LQSDLSRRGV PTQAKGLCGS CNKPIAGQVV TALGRAWHPE 
       260        270        280        290        300
HFVCGGCSTA LGGSSFFEKD GAPFCPECYF ERFSPRCGFC NQPIRHKMVT 
       310        320        330        340        350
ALGTHWHPEH FCCVSCGEPF GDEGFHEREG RPYCRRDFLQ LFAPRCQGCQ 
       360        370        380        390        400
GPILDNYISA LSALWHPDCF VCRECFAPFS GGSFFEHEGR PLCENHFHAR 
       410        420        430        440        450
RGSLCATCGL PVTGRCVSAL GRRFHPDHFT CTFCLRPLTK GSFQERAGKP 
       460 
YCQPCFLKLF G

Length:461

Mass (Da):49,814

Last modified:June 26, 2007 - v2

Checksum:ⁱD2C7C32C3FD2C496

GO

Isoform 2 (identifier: O43294-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-17: Missing.

« Hide

        10         20         30         40         50
MPRSGAPKER PAEPLTPPPS YGHQPQTGSG ESSGASGDKD HLYSTVCKPR 
        60         70         80         90        100
SPKPAAPAAP PFSSSSGVLG TGLCELDRLL QELNATQFNI TDEIMSQFPS 
       110        120        130        140        150
SKVASGEQKE DQSEDKKRPS LPSSPSPGLP KASATSATLE LDRLMASLSD 
       160        170        180        190        200
FRVQNHLPAS GPTQPPVVSS TNEGSPSPPE PTGKGSLDTM LGLLQSDLSR 
       210        220        230        240        250
RGVPTQAKGL CGSCNKPIAG QVVTALGRAW HPEHFVCGGC STALGGSSFF 
       260        270        280        290        300
EKDGAPFCPE CYFERFSPRC GFCNQPIRHK MVTALGTHWH PEHFCCVSCG 
       310        320        330        340        350
EPFGDEGFHE REGRPYCRRD FLQLFAPRCQ GCQGPILDNY ISALSALWHP 
       360        370        380        390        400
DCFVCRECFA PFSGGSFFEH EGRPLCENHF HARRGSLCAT CGLPVTGRCV 
       410        420        430        440 
SALGRRFHPD HFTCTFCLRP LTKGSFQERA GKPYCQPCFL KLFG

Show »

Length:444

Mass (Da):47,941

Checksum:ⁱEC9E92DADE7156B4

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
H3BQC4	H3BQC4_HUMAN	Transforming growth factor beta-1-i... Transforming growth factor beta-1-induced transcript 1 protein	TGFB1I1	216	Annotation score:
H3BSN4	H3BSN4_HUMAN	Transforming growth factor beta-1-i... Transforming growth factor beta-1-induced transcript 1 protein	TGFB1I1	165	Annotation score:
H3BN49	H3BN49_HUMAN	Transforming growth factor beta-1-i... Transforming growth factor beta-1-induced transcript 1 protein	TGFB1I1	114	Annotation score:
H3BS04	H3BS04_HUMAN	Transforming growth factor beta-1-i... Transforming growth factor beta-1-induced transcript 1 protein	TGFB1I1	89	Annotation score:
I3L209	I3L209_HUMAN	Transforming growth factor beta-1-i... Transforming growth factor beta-1-induced transcript 1 protein	TGFB1I1	61	Annotation score:
H3BRP2	H3BRP2_HUMAN	Transforming growth factor beta-1-i... Transforming growth factor beta-1-induced transcript 1 protein	TGFB1I1	52	Annotation score:

Sequence cautionⁱ

The sequence AAH32545 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	166	S → P in AAD22552 (PubMed:10075738).Curated	1
Sequence conflictⁱ	200	G → A in AAD22552 (PubMed:10075738).Curated	1
Sequence conflictⁱ	363	A → L in AAD22552 (PubMed:10075738).Curated	1
Sequence conflictⁱ	405 – 406	CA → WP in AAD22552 (PubMed:10075738).Curated	2
Sequence conflictⁱ	430	T → A in AAD22552 (PubMed:10075738).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_032831	129	Q → H1 PublicationCorresponds to variant dbSNP:rs45475699Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_026183	1 – 17	Missing in isoform 2. 3 PublicationsAdd BLAST		17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF116343 mRNA Translation: AAD22552.1 DQ309025 Genomic DNA Translation: ABB96286.1 AK313327 mRNA Translation: BAG36132.1 CH471192 Genomic DNA Translation: EAW52126.1 BC001507 mRNA Translation: AAH01507.2 BC001830 mRNA Translation: AAH01830.1 BC017288 mRNA Translation: AAH17288.1 BC032545 mRNA Translation: AAH32545.1 Different initiation. AB007836 mRNA Translation: BAA24799.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10713.1 [O43294-2] CCDS42156.1 [O43294-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001035919.1, NM_001042454.2 [O43294-1] NP_001158191.1, NM_001164719.1 [O43294-2] NP_057011.2, NM_015927.4 [O43294-2]
UniGeneⁱ	Hs.513530

Genome annotation databases

Ensemblⁱ	ENST00000361773; ENSP00000355117; ENSG00000140682 [O43294-2] ENST00000394858; ENSP00000378327; ENSG00000140682 [O43294-2] ENST00000394863; ENSP00000378332; ENSG00000140682 [O43294-1] ENST00000567607; ENSP00000457586; ENSG00000140682 [O43294-2]
GeneIDⁱ	7041
KEGGⁱ	hsa:7041
UCSC genome browser More...UCSCⁱ	uc002ecd.3 human [O43294-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43294	TGFB1I1 isoform 3		PANTR		461	UniRef100_O43294
Transforming growth factor beta 1 induced transcript 1, isoform CRA_a		HUMAN		444
TGFB1I1 isoform 12		PANTR		444
Isoform 2 of Transforming growth factor beta-1-induced transcript 1 protein		HUMAN		444
Transforming growth factor beta-1-induced transcript 1 protein (Fragment)		HUMAN		165
+1

Protein	Similar proteins		Species	Score	Length	Source
O43294	Transforming growth factor beta-1-induced transcript 1 protein		MOUSE		461	UniRef90_O43294
Transforming growth factor beta-1-induced transcript 1 protein		RAT		461
Transforming growth factor beta-1-induced transcript 1 protein		BOVIN		456
TGFB1I1 isoform 3		PANTR		461
Transforming growth factor beta 1 induced transcript 1, isoform CRA_a		HUMAN		444
+168

Protein	Similar proteins		Species	Score	Length	Source
O43294	Transforming growth factor beta-1-induced transcript 1 protein		MOUSE		461	UniRef50_O43294
Transforming growth factor beta-1-induced transcript 1 protein		RAT		461
Transforming growth factor beta-1-induced transcript 1 protein		BOVIN		456
TGFB1I1 isoform 3		PANTR		461
Transforming growth factor beta 1 induced transcript 1, isoform CRA_a		HUMAN		444
+200

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF116343 mRNA Translation: AAD22552.1 DQ309025 Genomic DNA Translation: ABB96286.1 AK313327 mRNA Translation: BAG36132.1 CH471192 Genomic DNA Translation: EAW52126.1 BC001507 mRNA Translation: AAH01507.2 BC001830 mRNA Translation: AAH01830.1 BC017288 mRNA Translation: AAH17288.1 BC032545 mRNA Translation: AAH32545.1 Different initiation. AB007836 mRNA Translation: BAA24799.1
CCDSⁱ	CCDS10713.1 [O43294-2] CCDS42156.1 [O43294-1]
RefSeqⁱ	NP_001035919.1, NM_001042454.2 [O43294-1] NP_001158191.1, NM_001164719.1 [O43294-2] NP_057011.2, NM_015927.4 [O43294-2]
UniGeneⁱ	Hs.513530

3D structure databases

ProteinModelPortalⁱ	O43294
SMRⁱ	O43294
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112899, 32 interactors
DIPⁱ	DIP-5931N
ELMⁱ	O43294
IntActⁱ	O43294, 23 interactors
MINTⁱ	O43294
STRINGⁱ	9606.ENSP00000378332

PTM databases

iPTMnetⁱ	O43294
PhosphoSitePlusⁱ	O43294

Polymorphism and mutation databases

BioMutaⁱ	TGFB1I1

BioMutaⁱ

TGFB1I1

Proteomic databases

EPDⁱ	O43294
MaxQBⁱ	O43294
PaxDbⁱ	O43294
PeptideAtlasⁱ	O43294
PRIDEⁱ	O43294
ProteomicsDBⁱ	48865 48866 [O43294-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7041
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000361773; ENSP00000355117; ENSG00000140682 [O43294-2] ENST00000394858; ENSP00000378327; ENSG00000140682 [O43294-2] ENST00000394863; ENSP00000378332; ENSG00000140682 [O43294-1] ENST00000567607; ENSP00000457586; ENSG00000140682 [O43294-2]
GeneIDⁱ	7041
KEGGⁱ	hsa:7041
UCSCⁱ	uc002ecd.3 human [O43294-1]

Organism-specific databases

CTDⁱ	7041
DisGeNETⁱ	7041
EuPathDBⁱ	HostDB:ENSG00000140682.18
GeneCardsⁱ	TGFB1I1
HGNCⁱ	HGNC:11767 TGFB1I1
HPAⁱ	CAB020844
MIMⁱ	602353 gene
neXtProtⁱ	NX_O43294
OpenTargetsⁱ	ENSG00000140682
PharmGKBⁱ	PA36481
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1703 Eukaryota ENOG410XRD4 LUCA
GeneTreeⁱ	ENSGT00760000118910
HOGENOMⁱ	HOG000018764
HOVERGENⁱ	HBG001512
InParanoidⁱ	O43294
OMAⁱ	MVTALDK
OrthoDBⁱ	EOG091G05AW
PhylomeDBⁱ	O43294
TreeFamⁱ	TF314113

Enzyme and pathway databases

SignaLinkⁱ	O43294

SignaLinkⁱ

O43294

Miscellaneous databases

GeneWikiⁱ	TGFB1I1
GenomeRNAiⁱ	7041
Protein Ontology More...PROⁱ	PR:O43294
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000140682 Expressed in 198 organ(s), highest expression level in myometrium
CleanExⁱ	HS_TGFB1I1
ExpressionAtlasⁱ	O43294 baseline and differential
Genevisibleⁱ	O43294 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR017305 Tgfb1i1/Leupaxin/TGFB1I1 IPR001781 Znf_LIM
Pfamⁱ	View protein in Pfam PF00412 LIM, 4 hits
PIRSFⁱ	PIRSF037881 Leupaxin, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 4 hits
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 4 hits PS50023 LIM_DOMAIN_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TGFI1_HUMAN
Accessionⁱ	O43294Primary (citable) accession number: O43294 Secondary accession number(s): B2R8D5, Q9BPW3, Q9Y2V5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
	Last sequence update:	June 26, 2007
	Last modified:	September 12, 2018
	This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43294 (TGFI1_HUMAN)

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Transforming growth factor beta-1-induced transcript 1 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Other locations

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ