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UniProtKB - O43291 (SPIT2_HUMAN)

Protein

Kunitz-type protease inhibitor 2

Gene

SPINT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei48 – 49Reactive bondBy similarity2
Sitei143 – 144Reactive bondBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • endopeptidase inhibitor activity Source: ProtInc
  • serine-type endopeptidase inhibitor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6806942 MET Receptor Activation
R-HSA-8852405 Signaling by MST1

Protein family/group databases

MEROPS protease database

More...MEROPSi		I02.009

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kunitz-type protease inhibitor 2
Alternative name(s):
Hepatocyte growth factor activator inhibitor type 2
Short name:
HAI-2
Placental bikunin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPINT2
Synonyms:HAI2, KOP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000167642.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:11247 SPINT2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605124 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43291

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 197ExtracellularSequence analysisAdd BLAST170
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 252CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies (DIAR3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by life-threatening secretory diarrhea, severe metabolic acidosis and hyponatremia. Hyponatremia is secondary to extraordinarily high fecal sodium loss, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune and endocrine causes.
See also OMIM:270420
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058718163Y → C in DIAR3; has a significantly reduced ability to inhibit trypsin compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs121908403EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		10653

MalaCards human disease database

More...MalaCardsi		SPINT2
MIMi270420 phenotype

Open Targets

More...OpenTargetsi		ENSG00000167642

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		103908 Congenital sodium diarrhea

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36077

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPINT2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 272 PublicationsAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001688528 – 252Kunitz-type protease inhibitor 2Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi38 ↔ 88PROSITE-ProRule annotation
Disulfide bondi47 ↔ 71PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagine1
Disulfide bondi63 ↔ 84PROSITE-ProRule annotation
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 183PROSITE-ProRule annotation
Disulfide bondi142 ↔ 166PROSITE-ProRule annotation
Disulfide bondi158 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43291

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43291

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43291

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43291

PeptideAtlas

More...PeptideAtlasi		O43291

PRoteomics IDEntifications database

More...PRIDEi		O43291

ProteomicsDB human proteome resource

More...ProteomicsDBi		48859
48860 [O43291-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43291

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43291

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167642 Expressed in 225 organ(s), highest expression level in pituitary gland

CleanEx database of gene expression profiles

More...CleanExi		HS_SPINT2

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43291 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43291 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB018969
HPA011101

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		115896, 109 interactors

Protein interaction database and analysis system

More...IntActi		O43291, 1 interactor

Molecular INTeraction database

More...MINTi		O43291

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000301244

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1252
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4U32X-ray1.65X34-88[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O43291

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43291

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 88BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini133 – 183BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

This inhibitor contains two inhibitory domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4295 Eukaryota
ENOG410XQNP LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160348

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000013109

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG079207

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43291

Identification of Orthologs from Complete Genome Data

More...OMAi		CDNFIYG

Database of Orthologous Groups

More...OrthoDBi		1282068at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43291

TreeFam database of animal gene trees

More...TreeFami		TF326553

Family and domain databases

Conserved Domains Database

More...CDDi		cd00109 KU, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.410.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00014 Kunitz_BPTI, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00759 BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00131 KU, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57362 SSF57362, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00280 BPTI_KUNITZ_1, 2 hits
PS50279 BPTI_KUNITZ_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43291-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQLCGLRRS RAFLALLGSL LLSGVLAADR ERSIHDFCLV SKVVGRCRAS 
        60         70         80         90        100
MPRWWYNVTD GSCQLFVYGG CDGNSNNYLT KEECLKKCAT VTENATGDLA 
       110        120        130        140        150
TSRNAADSSV PSAPRRQDSE DHSSDMFNYE EYCTANAVTG PCRASFPRWY 
       160        170        180        190        200
FDVERNSCNN FIYGGCRGNK NSYRSEEACM LRCFRQQENP PLPLGSKVVV 
       210        220        230        240        250
LAGLFVMVLI LFLGASMVYL IRVARRNQER ALRTVWSSGD DKEQLVKNTY 

VL
Length:252
Mass (Da):28,228
Last modified:February 21, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7D3360C0EECAB2B
GO
Isoform 2 (identifier: O43291-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-92: Missing.

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):21,828
Checksum:i7E046F218A22319B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EM91K7EM91_HUMAN
Kunitz-type protease inhibitor 2
SPINT2
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKQ0K7EKQ0_HUMAN
Kunitz-type protease inhibitor 2
SPINT2
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES27K7ES27_HUMAN
Kunitz-type protease inhibitor 2
SPINT2
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKC8K7EKC8_HUMAN
Kunitz-type protease inhibitor 2
SPINT2
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESI5K7ESI5_HUMAN
Kunitz-type protease inhibitor 2
SPINT2
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJS4K7EJS4_HUMAN
Kunitz-type protease inhibitor 2
SPINT2
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3Q → H in AAB84031 (PubMed:9434156).Curated1
Sequence conflicti11R → P in BAA25024 (PubMed:9346890).Curated1
Sequence conflicti53R → K in AAB84031 (PubMed:9434156).Curated1
Sequence conflicti240D → H in AAB84031 (PubMed:9434156).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058718163Y → C in DIAR3; has a significantly reduced ability to inhibit trypsin compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs121908403EnsemblClinVar.1
Natural variantiVAR_012482200V → L1 PublicationCorresponds to variant dbSNP:rs11548457Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04368036 – 92Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB006534 mRNA Translation: BAA25024.1
U78095 mRNA Translation: AAC02781.1
AF027205 mRNA Translation: AAB84031.1
AK291532 mRNA Translation: BAF84221.1
AK297154 mRNA Translation: BAG59653.1
BT020115 mRNA Translation: AAV38918.1
BT020116 mRNA Translation: AAV38919.1
BT020117 mRNA Translation: AAV38920.1
AC011479 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW56766.1
CH471126 Genomic DNA Translation: EAW56767.1
BC001668 mRNA Translation: AAH01668.1
BC007705 mRNA Translation: AAH07705.1
BC011951 mRNA Translation: AAH11951.1
BC011955 mRNA Translation: AAH11955.1
BC012868 mRNA Translation: AAH12868.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12510.1 [O43291-1]
CCDS54261.1 [O43291-2]

NCBI Reference Sequences

More...RefSeqi		NP_001159575.1, NM_001166103.1 [O43291-2]
NP_066925.1, NM_021102.3 [O43291-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.31439

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000301244; ENSP00000301244; ENSG00000167642 [O43291-1]
ENST00000454580; ENSP00000389788; ENSG00000167642 [O43291-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10653

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10653

UCSC genome browser

More...UCSCi		uc002ohr.2 human [O43291-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006534 mRNA Translation: BAA25024.1
U78095 mRNA Translation: AAC02781.1
AF027205 mRNA Translation: AAB84031.1
AK291532 mRNA Translation: BAF84221.1
AK297154 mRNA Translation: BAG59653.1
BT020115 mRNA Translation: AAV38918.1
BT020116 mRNA Translation: AAV38919.1
BT020117 mRNA Translation: AAV38920.1
AC011479 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW56766.1
CH471126 Genomic DNA Translation: EAW56767.1
BC001668 mRNA Translation: AAH01668.1
BC007705 mRNA Translation: AAH07705.1
BC011951 mRNA Translation: AAH11951.1
BC011955 mRNA Translation: AAH11955.1
BC012868 mRNA Translation: AAH12868.1
CCDSiCCDS12510.1 [O43291-1]
CCDS54261.1 [O43291-2]
RefSeqiNP_001159575.1, NM_001166103.1 [O43291-2]
NP_066925.1, NM_021102.3 [O43291-1]
UniGeneiHs.31439

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4U32X-ray1.65X34-88[»]
ProteinModelPortaliO43291
SMRiO43291
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115896, 109 interactors
IntActiO43291, 1 interactor
MINTiO43291
STRINGi9606.ENSP00000301244

Protein family/group databases

MEROPSiI02.009

PTM databases

iPTMnetiO43291
PhosphoSitePlusiO43291

Polymorphism and mutation databases

BioMutaiSPINT2

Proteomic databases

EPDiO43291
jPOSTiO43291
MaxQBiO43291
PaxDbiO43291
PeptideAtlasiO43291
PRIDEiO43291
ProteomicsDBi48859
48860 [O43291-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		10653
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301244; ENSP00000301244; ENSG00000167642 [O43291-1]
ENST00000454580; ENSP00000389788; ENSG00000167642 [O43291-2]
GeneIDi10653
KEGGihsa:10653
UCSCiuc002ohr.2 human [O43291-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10653
DisGeNETi10653
EuPathDBiHostDB:ENSG00000167642.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPINT2
HGNCiHGNC:11247 SPINT2
HPAiCAB018969
HPA011101
MalaCardsiSPINT2
MIMi270420 phenotype
605124 gene
neXtProtiNX_O43291
OpenTargetsiENSG00000167642
Orphaneti103908 Congenital sodium diarrhea
PharmGKBiPA36077

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4295 Eukaryota
ENOG410XQNP LUCA
GeneTreeiENSGT00940000160348
HOGENOMiHOG000013109
HOVERGENiHBG079207
InParanoidiO43291
OMAiCDNFIYG
OrthoDBi1282068at2759
PhylomeDBiO43291
TreeFamiTF326553

Enzyme and pathway databases

ReactomeiR-HSA-6806942 MET Receptor Activation
R-HSA-8852405 Signaling by MST1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPINT2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SPINT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10653

Protein Ontology

More...PROi		PR:O43291

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000167642 Expressed in 225 organ(s), highest expression level in pituitary gland
CleanExiHS_SPINT2
ExpressionAtlasiO43291 baseline and differential
GenevisibleiO43291 HS

Family and domain databases

CDDicd00109 KU, 2 hits
Gene3Di4.10.410.10, 2 hits
InterProiView protein in InterPro
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 2 hits
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 2 hits
SUPFAMiSSF57362 SSF57362, 2 hits
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 2 hits
PS50279 BPTI_KUNITZ_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43291
Secondary accession number(s): A8K667
, B4DLU1, O00271, O14895, Q5TZQ3, Q969E0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: January 16, 2019
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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