SPINT2

Functionⁱ

Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	48 – 49	Reactive bondBy similarity		2
Siteⁱ	143 – 144	Reactive bondBy similarity		2

GO - Molecular functionⁱ

endopeptidase inhibitor activity
Source: ProtInc
Traceable author statementⁱ
- 9115294
serine-type endopeptidase inhibitor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19185281

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

basement membrane organization Source: Ensembl
cellular response to BMP stimulus Source: Ensembl
epithelial cell morphogenesis involved in placental branching Source: Ensembl
establishment or maintenance of cell polarity Source: Ensembl
negative regulation of cell-cell adhesion
Source: MGI
Inferred from direct assayⁱ
- 19592578
negative regulation of cell motility
Source: MGI
Inferred from direct assayⁱ
- 19592578
negative regulation of neural precursor cell proliferation Source: Ensembl
neural tube closure Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protease inhibitor, Serine protease inhibitor

Molecular function

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6806942 MET Receptor Activation R-HSA-8852405 Signaling by MST1

Reactomeⁱ

R-HSA-6806942 MET Receptor Activation
R-HSA-8852405 Signaling by MST1

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I02.009

MEROPSⁱ

I02.009

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kunitz-type protease inhibitor 2 Alternative name(s): Hepatocyte growth factor activator inhibitor type 2 Short name: HAI-2 Placental bikunin
Gene namesⁱ	Name:SPINT2 Synonyms:HAI2, KOP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167642.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11247 SPINT2
MIMⁱ	605124 gene
neXtProtⁱ	NX_O43291

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	28 – 197	ExtracellularSequence analysisAdd BLAST	170
Transmembraneⁱ	198 – 218	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	219 – 252	CytoplasmicSequence analysisAdd BLAST	34

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies (DIAR3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by life-threatening secretory diarrhea, severe metabolic acidosis and hyponatremia. Hyponatremia is secondary to extraordinarily high fecal sodium loss, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune and endocrine causes.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10653
MalaCards human disease database More...MalaCardsⁱ	SPINT2
MIMⁱ	270420 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000167642
Orphanetⁱ	103908 Congenital sodium diarrhea
PharmGKBⁱ	PA36077

Polymorphism and mutation databases

BioMutaⁱ	SPINT2

BioMutaⁱ

SPINT2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 27	2 PublicationsAdd BLAST		27
ChainⁱPRO_0000016885	28 – 252	Kunitz-type protease inhibitor 2Add BLAST		225

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	38 ↔ 88	PROSITE-ProRule annotation
Disulfide bondⁱ	47 ↔ 71	PROSITE-ProRule annotation
Glycosylationⁱ	57	N-linked (GlcNAc...) asparagine	1
Disulfide bondⁱ	63 ↔ 84	PROSITE-ProRule annotation
Glycosylationⁱ	94	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	133 ↔ 183	PROSITE-ProRule annotation
Disulfide bondⁱ	142 ↔ 166	PROSITE-ProRule annotation
Disulfide bondⁱ	158 ↔ 179	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	O43291
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43291
PaxDbⁱ	O43291
PeptideAtlas More...PeptideAtlasⁱ	O43291
PRIDEⁱ	O43291
ProteomicsDBⁱ	48859 48860 [O43291-2]

PTM databases

iPTMnetⁱ	O43291
PhosphoSitePlusⁱ	O43291

Expressionⁱ

Tissue specificityⁱ

Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.

Gene expression databases

Bgeeⁱ	ENSG00000167642 Expressed in 225 organ(s), highest expression level in pituitary gland
CleanExⁱ	HS_SPINT2
ExpressionAtlasⁱ	O43291 baseline and differential
Genevisibleⁱ	O43291 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB018969 HPA011101

HPAⁱ

CAB018969
HPA011101

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115896, 109 interactors
IntActⁱ	O43291, 1 interactor
Molecular INTeraction database More...MINTⁱ	O43291
STRINGⁱ	9606.ENSP00000301244

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	36 – 38	Combined sources	3
Beta strandⁱ	51 – 57	Combined sources	7
Turnⁱ	58 – 61	Combined sources	4
Beta strandⁱ	62 – 68	Combined sources	7
Beta strandⁱ	70 – 72	Combined sources	3
Beta strandⁱ	78 – 80	Combined sources	3
Helixⁱ	81 – 87	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	O43291
SMRⁱ	O43291
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	38 – 88	BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST		51
Domainⁱ	133 – 183	BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST		51

Domainⁱ

This inhibitor contains two inhibitory domains.

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4295 Eukaryota ENOG410XQNP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00740000114929
HOGENOMⁱ	HOG000013109
HOVERGENⁱ	HBG079207
InParanoidⁱ	O43291
OMAⁱ	CDNFIYG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09P2
PhylomeDBⁱ	O43291
TreeFamⁱ	TF326553

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00109 KU, 2 hits
Gene3Dⁱ	4.10.410.10, 2 hits
InterProⁱ	View protein in InterPro IPR002223 Kunitz_BPTI IPR036880 Kunitz_BPTI_sf IPR020901 Prtase_inh_Kunz-CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00014 Kunitz_BPTI, 2 hits
PRINTSⁱ	PR00759 BASICPTASE
SMARTⁱ	View protein in SMART SM00131 KU, 2 hits
SUPFAMⁱ	SSF57362 SSF57362, 2 hits
PROSITEⁱ	View protein in PROSITE PS00280 BPTI_KUNITZ_1, 2 hits PS50279 BPTI_KUNITZ_2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O43291-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQLCGLRRS RAFLALLGSL LLSGVLAADR ERSIHDFCLV SKVVGRCRAS 
        60         70         80         90        100
MPRWWYNVTD GSCQLFVYGG CDGNSNNYLT KEECLKKCAT VTENATGDLA 
       110        120        130        140        150
TSRNAADSSV PSAPRRQDSE DHSSDMFNYE EYCTANAVTG PCRASFPRWY 
       160        170        180        190        200
FDVERNSCNN FIYGGCRGNK NSYRSEEACM LRCFRQQENP PLPLGSKVVV 
       210        220        230        240        250
LAGLFVMVLI LFLGASMVYL IRVARRNQER ALRTVWSSGD DKEQLVKNTY 

VL

Length:252

Mass (Da):28,228

Last modified:February 21, 2001 - v2

Checksum:ⁱA7D3360C0EECAB2B

GO

Isoform 2 (identifier: O43291-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
36-92: Missing.

« Hide

        10         20         30         40         50
MAQLCGLRRS RAFLALLGSL LLSGVLAADR ERSIHENATG DLATSRNAAD 
        60         70         80         90        100
SSVPSAPRRQ DSEDHSSDMF NYEEYCTANA VTGPCRASFP RWYFDVERNS 
       110        120        130        140        150
CNNFIYGGCR GNKNSYRSEE ACMLRCFRQQ ENPPLPLGSK VVVLAGLFVM 
       160        170        180        190 
VLILFLGASM VYLIRVARRN QERALRTVWS SGDDKEQLVK NTYVL

Note: No experimental confirmation available.

Show »

Length:195

Mass (Da):21,828

Checksum:ⁱ7E046F218A22319B

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EM91	K7EM91_HUMAN	Kunitz-type protease inhibitor 2 Kunitz-type protease inhibitor 2	SPINT2	202	Annotation score:
K7EKQ0	K7EKQ0_HUMAN	Kunitz-type protease inhibitor 2 Kunitz-type protease inhibitor 2	SPINT2	174	Annotation score:
K7ES27	K7ES27_HUMAN	Kunitz-type protease inhibitor 2 Kunitz-type protease inhibitor 2	SPINT2	106	Annotation score:
K7EKC8	K7EKC8_HUMAN	Kunitz-type protease inhibitor 2 Kunitz-type protease inhibitor 2	SPINT2	62	Annotation score:
K7EJS4	K7EJS4_HUMAN	Kunitz-type protease inhibitor 2 Kunitz-type protease inhibitor 2	SPINT2	52	Annotation score:
K7ESI5	K7ESI5_HUMAN	Kunitz-type protease inhibitor 2 Kunitz-type protease inhibitor 2	SPINT2	130	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	3	Q → H in AAB84031 (PubMed:9434156).Curated	1
Sequence conflictⁱ	11	R → P in BAA25024 (PubMed:9346890).Curated	1
Sequence conflictⁱ	53	R → K in AAB84031 (PubMed:9434156).Curated	1
Sequence conflictⁱ	240	D → H in AAB84031 (PubMed:9434156).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_058718	163	Y → C in DIAR3; has a significantly reduced ability to inhibit trypsin compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs121908403EnsemblClinVar.		1
Natural variantⁱVAR_012482	200	V → L1 PublicationCorresponds to variant dbSNP:rs11548457Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043680	36 – 92	Missing in isoform 2. 1 PublicationAdd BLAST		57

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB006534 mRNA Translation: BAA25024.1 U78095 mRNA Translation: AAC02781.1 AF027205 mRNA Translation: AAB84031.1 AK291532 mRNA Translation: BAF84221.1 AK297154 mRNA Translation: BAG59653.1 BT020115 mRNA Translation: AAV38918.1 BT020116 mRNA Translation: AAV38919.1 BT020117 mRNA Translation: AAV38920.1 AC011479 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW56766.1 CH471126 Genomic DNA Translation: EAW56767.1 BC001668 mRNA Translation: AAH01668.1 BC007705 mRNA Translation: AAH07705.1 BC011951 mRNA Translation: AAH11951.1 BC011955 mRNA Translation: AAH11955.1 BC012868 mRNA Translation: AAH12868.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12510.1 [O43291-1] CCDS54261.1 [O43291-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001159575.1, NM_001166103.1 [O43291-2] NP_066925.1, NM_021102.3 [O43291-1]
UniGeneⁱ	Hs.31439

Genome annotation databases

Ensemblⁱ	ENST00000301244; ENSP00000301244; ENSG00000167642 [O43291-1] ENST00000454580; ENSP00000389788; ENSG00000167642 [O43291-2]
GeneIDⁱ	10653
KEGGⁱ	hsa:10653
UCSC genome browser More...UCSCⁱ	uc002ohr.2 human [O43291-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43291	Kunitz-type protease inhibitor 2 (Fragment)		HUMAN		62	UniRef100_O43291
Kunitz-type protease inhibitor 2		HUMAN		202
Kunitz-type protease inhibitor 2 (Fragment)		HUMAN		52
O43291-2	Testicular tissue protein Li 183		HUMAN		195	UniRef100_A0A140VJV6

Protein	Similar proteins		Species	Score	Length	Source
O43291	Kunitz-type protease inhibitor 2 (Fragment)		HUMAN		62	UniRef90_O43291
Uncharacterized protein		RHIRO		260
Uncharacterized protein		RHIBE		252
Serine peptidase inhibitor, Kunitz type 2		PANTR		252
Uncharacterized protein		PANPA		252
+31
O43291-2	Uncharacterized protein		NOMLE		195	UniRef90_A0A2I3HHB4
Testicular tissue protein Li 183		HUMAN		195
Uncharacterized protein		MACMU		195
Uncharacterized protein		MANLE		195
Uncharacterized protein		MACNE		195
+10

Protein	Similar proteins		Species	Score	Length	Source
O43291	Kunitz-type protease inhibitor 2 (Fragment)		HUMAN		62	UniRef50_O43291
Uncharacterized protein		RHIRO		260
Uncharacterized protein		RHIBE		252
Hepatocyte growth factor activator inhibitor type 2		MACMU		252
Uncharacterized protein		CHLSB		252
+65
O43291-2	Serine peptidase inhibitor, Kunitz type 2		LOXAF		206	UniRef50_G3T8L8
kunitz-type protease inhibitor 2		ERIEU		252
Uncharacterized protein		COLAP		203
Uncharacterized protein		SARHA		224
Serine peptidase inhibitor, Kunitz type 2		PANTR		195
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB006534 mRNA Translation: BAA25024.1 U78095 mRNA Translation: AAC02781.1 AF027205 mRNA Translation: AAB84031.1 AK291532 mRNA Translation: BAF84221.1 AK297154 mRNA Translation: BAG59653.1 BT020115 mRNA Translation: AAV38918.1 BT020116 mRNA Translation: AAV38919.1 BT020117 mRNA Translation: AAV38920.1 AC011479 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW56766.1 CH471126 Genomic DNA Translation: EAW56767.1 BC001668 mRNA Translation: AAH01668.1 BC007705 mRNA Translation: AAH07705.1 BC011951 mRNA Translation: AAH11951.1 BC011955 mRNA Translation: AAH11955.1 BC012868 mRNA Translation: AAH12868.1
CCDSⁱ	CCDS12510.1 [O43291-1] CCDS54261.1 [O43291-2]
RefSeqⁱ	NP_001159575.1, NM_001166103.1 [O43291-2] NP_066925.1, NM_021102.3 [O43291-1]
UniGeneⁱ	Hs.31439

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4U32	X-ray	1.65	X	34-88	[»]
ProteinModelPortalⁱ	O43291
SMRⁱ	O43291
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115896, 109 interactors
IntActⁱ	O43291, 1 interactor
MINTⁱ	O43291
STRINGⁱ	9606.ENSP00000301244

Protein family/group databases

MEROPSⁱ	I02.009

MEROPSⁱ

I02.009

PTM databases

iPTMnetⁱ	O43291
PhosphoSitePlusⁱ	O43291

Polymorphism and mutation databases

BioMutaⁱ	SPINT2

BioMutaⁱ

SPINT2

Proteomic databases

EPDⁱ	O43291
MaxQBⁱ	O43291
PaxDbⁱ	O43291
PeptideAtlasⁱ	O43291
PRIDEⁱ	O43291
ProteomicsDBⁱ	48859 48860 [O43291-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10653
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000301244; ENSP00000301244; ENSG00000167642 [O43291-1] ENST00000454580; ENSP00000389788; ENSG00000167642 [O43291-2]
GeneIDⁱ	10653
KEGGⁱ	hsa:10653
UCSCⁱ	uc002ohr.2 human [O43291-1]

Organism-specific databases

CTDⁱ	10653
DisGeNETⁱ	10653
EuPathDBⁱ	HostDB:ENSG00000167642.12
GeneCardsⁱ	SPINT2
HGNCⁱ	HGNC:11247 SPINT2
HPAⁱ	CAB018969 HPA011101
MalaCardsⁱ	SPINT2
MIMⁱ	270420 phenotype 605124 gene
neXtProtⁱ	NX_O43291
OpenTargetsⁱ	ENSG00000167642
Orphanetⁱ	103908 Congenital sodium diarrhea
PharmGKBⁱ	PA36077
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4295 Eukaryota ENOG410XQNP LUCA
GeneTreeⁱ	ENSGT00740000114929
HOGENOMⁱ	HOG000013109
HOVERGENⁱ	HBG079207
InParanoidⁱ	O43291
OMAⁱ	CDNFIYG
OrthoDBⁱ	EOG091G09P2
PhylomeDBⁱ	O43291
TreeFamⁱ	TF326553

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6806942 MET Receptor Activation R-HSA-8852405 Signaling by MST1

Reactomeⁱ

R-HSA-6806942 MET Receptor Activation
R-HSA-8852405 Signaling by MST1

Miscellaneous databases

ChiTaRSⁱ	SPINT2 human
GeneWikiⁱ	SPINT2
GenomeRNAiⁱ	10653
Protein Ontology More...PROⁱ	PR:O43291
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167642 Expressed in 225 organ(s), highest expression level in pituitary gland
CleanExⁱ	HS_SPINT2
ExpressionAtlasⁱ	O43291 baseline and differential
Genevisibleⁱ	O43291 HS

Family and domain databases

CDDⁱ	cd00109 KU, 2 hits
Gene3Dⁱ	4.10.410.10, 2 hits
InterProⁱ	View protein in InterPro IPR002223 Kunitz_BPTI IPR036880 Kunitz_BPTI_sf IPR020901 Prtase_inh_Kunz-CS
Pfamⁱ	View protein in Pfam PF00014 Kunitz_BPTI, 2 hits
PRINTSⁱ	PR00759 BASICPTASE
SMARTⁱ	View protein in SMART SM00131 KU, 2 hits
SUPFAMⁱ	SSF57362 SSF57362, 2 hits
PROSITEⁱ	View protein in PROSITE PS00280 BPTI_KUNITZ_1, 2 hits PS50279 BPTI_KUNITZ_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPIT2_HUMAN
Accessionⁱ	O43291Primary (citable) accession number: O43291 Secondary accession number(s): A8K667 , B4DLU1, O00271, O14895, Q5TZQ3, Q969E0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	February 21, 2001
	Last modified:	September 12, 2018
	This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O43291 (SPIT2_HUMAN)

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Kunitz-type protease inhibitor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ