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Entry version 160 (13 Feb 2019)
Sequence version 1 (01 Jun 1998)
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Protein

Mitogen-activated protein kinase kinase kinase 13

Gene

MAP3K13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by autophosphorylation and homodimerization.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei195ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei279Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi174 – 182ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • IkappaB kinase complex binding Source: UniProtKB
  • JUN kinase kinase kinase activity Source: ARUK-UCL
  • MAP kinase kinase kinase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein homodimerization activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O43283

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O43283

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 13 (EC:2.7.11.25)
Alternative name(s):
Leucine zipper-bearing kinase
Mixed lineage kinase
Short name:
MLK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP3K13Imported
Synonyms:LZKImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000073803.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6852 MAP3K13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604915 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43283

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi195K → A: Kinase inactive. Fails to activate NF-kappa-B. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9175

Open Targets

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OpenTargetsi
ENSG00000073803

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30596

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1163124

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2073

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAP3K13

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000862641 – 966Mitogen-activated protein kinase kinase kinase 13Add BLAST966

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated on serine and threonine residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43283

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43283

PeptideAtlas

More...
PeptideAtlasi
O43283

PRoteomics IDEntifications database

More...
PRIDEi
O43283

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48852
48853 [O43283-3]
48854 [O43283-4]
48855 [O43283-5]
48856 [O43283-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43283

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43283

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000073803 Expressed in 225 organ(s), highest expression level in corpus epididymis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43283 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43283 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA016497
HPA036691
HPA036692

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1 through the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1168480,EBI-1168480

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114614, 12 interactors

Protein interaction database and analysis system

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IntActi
O43283, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265026

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O43283

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O43283

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43283

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini168 – 409Protein kinasePROSITE-ProRule annotationAdd BLAST242

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni433 – 454Leucine-zipper 1Add BLAST22
Regioni486 – 507Leucine-zipper 2Add BLAST22
Regioni815 – 828AcidicCuratedAdd BLAST14

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4721 Eukaryota
ENOG410YKX2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158216

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052383

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43283

KEGG Orthology (KO)

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KOi
K04422

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAEERGY

Database of Orthologous Groups

More...
OrthoDBi
938929at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43283

TreeFam database of animal gene trees

More...
TreeFami
TF105119

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR017419 MAP3K12_MAP3K13
IPR027258 MAPKKK13
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714 Pkinase_Tyr, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038165 MAPKKK12_MAPKKK13, 1 hit
PIRSF500742 MAPKKK13, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANFQEHLSC SSSPHLPFSE SKTFNGLQDE LTAMGNHPSP KLLEDQQEKG
60 70 80 90 100
MVRTELIESV HSPVTTTVLT SVSEDSRDQF ENSVLQLREH DESETAVSQG
110 120 130 140 150
NSNTVDGEST SGTEDIKIQF SRSGSGSGGF LEGLFGCLRP VWNIIGKAYS
160 170 180 190 200
TDYKLQQQDT WEVPFEEISE LQWLGSGAQG AVFLGKFRAE EVAIKKVREQ
210 220 230 240 250
NETDIKHLRK LKHPNIIAFK GVCTQAPCYC IIMEYCAHGQ LYEVLRAGRK
260 270 280 290 300
ITPRLLVDWS TGIASGMNYL HLHKIIHRDL KSPNVLVTHT DAVKISDFGT
310 320 330 340 350
SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE
360 370 380 390 400
IPYKDVDSSA IIWGVGSNSL HLPVPSTCPD GFKILMKQTW QSKPRNRPSF
410 420 430 440 450
RQTLMHLDIA SADVLATPQE TYFKSQAEWR EEVKKHFEKI KSEGTCIHRL
460 470 480 490 500
DEELIRRRRE ELRHALDIRE HYERKLERAN NLYMELSAIM LQLEMREKEL
510 520 530 540 550
IKREQAVEKK YPGTYKRHPV RPIIHPNAME KLMKRKGVPH KSGMQTKRPD
560 570 580 590 600
LLRSEGIPTT EVAPTASPLS GSPKMSTSSS KSRYRSKPRH RRGNSRGSHS
610 620 630 640 650
DFAAILKNQP AQENSPHPTY LHQAQSQYPS LHHHNSLQQQ YQQPPPAMSQ
660 670 680 690 700
SHHPRLNMHG QDIATCANNL RYFGPAAALR SPLSNHAQRQ LPGSSPDLIS
710 720 730 740 750
TAMAADCWRS SEPDKGQAGP WGCCQADAYD PCLQCRPEQY GSLDIPSAEP
760 770 780 790 800
VGRSPDLSKS PAHNPLLENA QSSEKTEENE FSGCRSESSL GTSHLGTPPA
810 820 830 840 850
LPRKTRPLQK SGDDSSEEEE GEVDSEVEFP RRQRPHRCIS SCQSYSTFSS
860 870 880 890 900
ENFSVSDGEE GNTSDHSNSP DELADKLEDR LAEKLDDLLS QTPEIPIDIS
910 920 930 940 950
SHSDGLSDKE CAVRRVKTQM SLGKLCVEER GYENPMQFEE SDCDSSDGEC
960
SDATVRTNKH YSSATW
Length:966
Mass (Da):108,296
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9687F38C8AB20AB1
GO
Isoform 2 (identifier: O43283-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-160: DT → VF
     161-966: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:160
Mass (Da):17,575
Checksum:i95152C01C501AEFC
GO
Isoform 3 (identifier: O43283-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.
     145-159: IGKAYSTDYKLQQQD → MSYVECKCLQLENKN

Show »
Length:822
Mass (Da):92,654
Checksum:i22B40649EEF108AB
GO
Isoform 4 (identifier: O43283-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-207: Missing.
     208-220: LRKLKHPNIIAFK → MYCGIQILALWER

Show »
Length:759
Mass (Da):85,404
Checksum:i6E1DCE6581A1A2DC
GO
Isoform 5 (identifier: O43283-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-128: RSGSGSG → RYLGSAI
     129-966: Missing.

Show »
Length:128
Mass (Da):14,073
Checksum:i9000EE02899AC48D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C459H7C459_HUMAN
Mitogen-activated protein kinase ki...
MAP3K13
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4W2C9J4W2_HUMAN
Mitogen-activated protein kinase ki...
MAP3K13
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JP65C9JP65_HUMAN
Mitogen-activated protein kinase ki...
MAP3K13
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF41F8WF41_HUMAN
Mitogen-activated protein kinase ki...
MAP3K13
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYH2C9IYH2_HUMAN
Mitogen-activated protein kinase ki...
MAP3K13
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI11727 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAG59505 differs from that shown. Reason: Erroneous termination at position 740. Translated as Tyr.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106D → G in BAG59505 (PubMed:14702039).Curated1
Sequence conflicti230 – 232CII → YLY in CAA80915 (PubMed:8274451).Curated3
Sequence conflicti268N → D in BAG59505 (PubMed:14702039).Curated1
Sequence conflicti339 – 340FG → MV in CAA80915 (PubMed:8274451).Curated2
Sequence conflicti508E → G in BAG64106 (PubMed:14702039).Curated1
Sequence conflicti821G → R in BAG60014 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05164044E → K. Corresponds to variant dbSNP:rs35266179Ensembl.1
Natural variantiVAR_040708517R → G1 PublicationCorresponds to variant dbSNP:rs56408536Ensembl.1
Natural variantiVAR_040709712E → K1 PublicationCorresponds to variant dbSNP:rs56309231Ensembl.1
Natural variantiVAR_040710746P → L in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_030577915R → H. Corresponds to variant dbSNP:rs3732576Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0365621 – 207Missing in isoform 4. 1 PublicationAdd BLAST207
Alternative sequenceiVSP_0365631 – 144Missing in isoform 3. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_036564122 – 128RSGSGSG → RYLGSAI in isoform 5. 1 Publication7
Alternative sequenceiVSP_036565129 – 966Missing in isoform 5. 1 PublicationAdd BLAST838
Alternative sequenceiVSP_036566145 – 159IGKAY…LQQQD → MSYVECKCLQLENKN in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_036567159 – 160DT → VF in isoform 2. 1 Publication2
Alternative sequenceiVSP_036568161 – 966Missing in isoform 2. 1 PublicationAdd BLAST806
Alternative sequenceiVSP_036569208 – 220LRKLK…IIAFK → MYCGIQILALWER in isoform 4. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB001872 mRNA Translation: BAA24817.1
AK296961 mRNA Translation: BAG59505.1 Sequence problems.
AK297646 mRNA Translation: BAG60014.1
AK302951 mRNA Translation: BAG64106.1
AK312714 mRNA Translation: BAG35589.1
AC099661 Genomic DNA No translation available.
AC128680 Genomic DNA No translation available.
AC132516 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78224.1
CH471052 Genomic DNA Translation: EAW78225.1
BC031677 mRNA Translation: AAH31677.1
BC111726 mRNA Translation: AAI11727.1 Sequence problems.
Z25428 mRNA Translation: CAA80915.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3270.1 [O43283-1]
CCDS56298.1 [O43283-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
I38218

NCBI Reference Sequences

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RefSeqi
NP_001229243.1, NM_001242314.1 [O43283-1]
NP_001229246.1, NM_001242317.1 [O43283-5]
NP_004712.1, NM_004721.4 [O43283-1]
XP_011511612.1, XM_011513310.2 [O43283-1]
XP_016862945.1, XM_017007456.1 [O43283-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.591306
Hs.634586

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000265026; ENSP00000265026; ENSG00000073803 [O43283-1]
ENST00000424227; ENSP00000399910; ENSG00000073803 [O43283-1]
ENST00000433092; ENSP00000389798; ENSG00000073803 [O43283-6]
ENST00000438053; ENSP00000403561; ENSG00000073803 [O43283-3]
ENST00000443863; ENSP00000409325; ENSG00000073803 [O43283-4]
ENST00000446828; ENSP00000411483; ENSG00000073803 [O43283-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9175

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9175

UCSC genome browser

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UCSCi
uc003fph.5 human [O43283-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001872 mRNA Translation: BAA24817.1
AK296961 mRNA Translation: BAG59505.1 Sequence problems.
AK297646 mRNA Translation: BAG60014.1
AK302951 mRNA Translation: BAG64106.1
AK312714 mRNA Translation: BAG35589.1
AC099661 Genomic DNA No translation available.
AC128680 Genomic DNA No translation available.
AC132516 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78224.1
CH471052 Genomic DNA Translation: EAW78225.1
BC031677 mRNA Translation: AAH31677.1
BC111726 mRNA Translation: AAI11727.1 Sequence problems.
Z25428 mRNA Translation: CAA80915.1
CCDSiCCDS3270.1 [O43283-1]
CCDS56298.1 [O43283-5]
PIRiI38218
RefSeqiNP_001229243.1, NM_001242314.1 [O43283-1]
NP_001229246.1, NM_001242317.1 [O43283-5]
NP_004712.1, NM_004721.4 [O43283-1]
XP_011511612.1, XM_011513310.2 [O43283-1]
XP_016862945.1, XM_017007456.1 [O43283-1]
UniGeneiHs.591306
Hs.634586

3D structure databases

ProteinModelPortaliO43283
SMRiO43283
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114614, 12 interactors
IntActiO43283, 3 interactors
STRINGi9606.ENSP00000265026

Chemistry databases

BindingDBiO43283
ChEMBLiCHEMBL1163124
GuidetoPHARMACOLOGYi2073

PTM databases

iPTMnetiO43283
PhosphoSitePlusiO43283

Polymorphism and mutation databases

BioMutaiMAP3K13

Proteomic databases

jPOSTiO43283
PaxDbiO43283
PeptideAtlasiO43283
PRIDEiO43283
ProteomicsDBi48852
48853 [O43283-3]
48854 [O43283-4]
48855 [O43283-5]
48856 [O43283-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265026; ENSP00000265026; ENSG00000073803 [O43283-1]
ENST00000424227; ENSP00000399910; ENSG00000073803 [O43283-1]
ENST00000433092; ENSP00000389798; ENSG00000073803 [O43283-6]
ENST00000438053; ENSP00000403561; ENSG00000073803 [O43283-3]
ENST00000443863; ENSP00000409325; ENSG00000073803 [O43283-4]
ENST00000446828; ENSP00000411483; ENSG00000073803 [O43283-5]
GeneIDi9175
KEGGihsa:9175
UCSCiuc003fph.5 human [O43283-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9175
DisGeNETi9175
EuPathDBiHostDB:ENSG00000073803.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAP3K13
HGNCiHGNC:6852 MAP3K13
HPAiHPA016497
HPA036691
HPA036692
MIMi604915 gene
neXtProtiNX_O43283
OpenTargetsiENSG00000073803
PharmGKBiPA30596

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4721 Eukaryota
ENOG410YKX2 LUCA
GeneTreeiENSGT00940000158216
HOVERGENiHBG052383
InParanoidiO43283
KOiK04422
OMAiCAEERGY
OrthoDBi938929at2759
PhylomeDBiO43283
TreeFamiTF105119

Enzyme and pathway databases

SignaLinkiO43283
SIGNORiO43283

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAP3K13 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MAP3K13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9175

Protein Ontology

More...
PROi
PR:O43283

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000073803 Expressed in 225 organ(s), highest expression level in corpus epididymis
ExpressionAtlasiO43283 baseline and differential
GenevisibleiO43283 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR017419 MAP3K12_MAP3K13
IPR027258 MAPKKK13
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF038165 MAPKKK12_MAPKKK13, 1 hit
PIRSF500742 MAPKKK13, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3K13_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43283
Secondary accession number(s): B2R6U2
, B4DLE3, B4DMV2, B4DZJ4, D3DNU1, Q05BY6, Q15450, Q2NKN3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 1998
Last modified: February 13, 2019
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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