UniProtKB - O43280 (TREA_HUMAN)

BLAST

>sp|O43280|TREA_HUMAN Trehalase OS=Homo sapiens OX=9606 GN=TREH PE=1 SV=2
MPGRTWELCLLLLLGLGLGSQEALPPPCESEIYCHGELLNQVQMAKLYQDDKQFVDMPLS
IAPEQVLQTFTELSRDHNHSIPREQLQAFVHEHFQAKGQELQPWTPADWKDSPQFLQKIS
DAKLRAWAGQLHQLWKKLGKKMKPEVLSHPERFSLIYSEHPFIVPGGRFVEFYYWDSYWV
MEGLLLSEMAETVKGMLQNFLDLVKTYGHVPNGGRVYYLQRSQPPLLTLMMDCYLTHTND
TAFLQENIETLALELDFWTKNRTVSVSLEGKNYLLNRYYVPYGGPRPESYSKDVELADTL
PEGDREALWAELKAGAESGWDFSSRWLIGGPNPNSLSGIRTSKLVPVDLNAFLCQAEELM
SNFYSRLGNDSQATKYRILRSQRLAALNTVLWDEQTGAWFDYDLEKKKKNREFYPSNLTP
LWAGCFSDPGVADKALKYLEDNRILTYQYGIPTSLQKTGQQWDFPNAWAPLQDLVIRGLA
KAPLRRAQEVAFQLAQNWIRTNFDVYSQKSAMYEKYDVSNGGQPGGGGEYEVQEGFGWTN
GVVLMLLDRYGDRLTSGAKLAFLEPHCLAATLLPSLLLSLLPW

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History
Entry version 153 (07 Nov 2018)
Sequence version 2 (23 Sep 2008)
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Protein

Trehalase

Gene

TREH

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.2 Publications

Catalytic activityⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	168	SubstrateBy similarity	1
Binding siteⁱ	212	SubstrateBy similarity	1
Binding siteⁱ	319	Substrate; via carbonyl oxygenBy similarity	1
Active siteⁱ	321	Proton donor/acceptorBy similarity	1
Active siteⁱ	514	Proton donor/acceptorBy similarity	1
Binding siteⁱ	529	SubstrateBy similarity	1

GO - Molecular functionⁱ

alpha,alpha-trehalase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8773341
- 9427547

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ morphogenesis Source: Ensembl
trehalose catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 9427547
trehalose metabolic process
Source: UniProtKB
Non-traceable author statementⁱ
- 8773341

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase

Molecular function

Glycosidase, Hydrolase

Enzyme and pathway databases

Reactomeⁱ	R-HSA-189085 Digestion of dietary carbohydrate

Reactomeⁱ

R-HSA-189085 Digestion of dietary carbohydrate

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH37 Glycoside Hydrolase Family 37

CAZyⁱ

GH37 Glycoside Hydrolase Family 37

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Trehalase1 Publication (EC:3.2.1.282 Publications) Alternative name(s): Alpha,alpha-trehalase Alpha,alpha-trehalose glucohydrolase
Gene namesⁱ	Name:TREHImported Synonyms:TREA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000118094.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12266 TREH
MIMⁱ	275360 gene
neXtProtⁱ	NX_O43280

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Trehalase deficiency (TREHD)1 Publication

The gene represented in this entry is involved in disease pathogenesis.

Disease descriptionAn autosomal recessive condition characterized by the inability to digest trehalose, a disaccharide found in mushrooms, products containing baker's yeast, and dried food. Individuals with trehalase deficiency suffer from abdominal pain, increased rectal flatulence, and diarrhea due to osmotic water flow into the colon.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11181
MalaCards human disease database More...MalaCardsⁱ	TREH
MIMⁱ	612119 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000118094
Orphanetⁱ	103909 Trehalase deficiency
PharmGKBⁱ	PA36946

Chemistry databases

ChEMBLⁱ	CHEMBL3087

ChEMBLⁱ

CHEMBL3087

Polymorphism and mutation databases

BioMutaⁱ	TREH

BioMutaⁱ

TREH

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST	23
ChainⁱPRO_0000012051	24 – 556	TrehalaseAdd BLAST	533
PropeptideⁱPRO_0000012052	557 – 583	Removed in mature formSequence analysisAdd BLAST	27

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	78	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	239	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	261	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	369	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Lipidationⁱ	556	GPI-anchor amidated serineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbⁱ	O43280
PeptideAtlas More...PeptideAtlasⁱ	O43280
PRIDEⁱ	O43280
ProteomicsDBⁱ	48848 48849 [O43280-2]

PTM databases

iPTMnetⁱ	O43280
PhosphoSitePlusⁱ	O43280

Expressionⁱ

Tissue specificityⁱ

Expressed in kidney, liver and small intestine. Also more weakly expressed in pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000118094 Expressed in 83 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_TREH
ExpressionAtlasⁱ	O43280 baseline and differential
Genevisibleⁱ	O43280 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039913 HPA042045

HPAⁱ

HPA039913
HPA042045

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridⁱ	116351, 1 interactor
STRINGⁱ	9606.ENSP00000264029

Chemistry databases

BindingDBⁱ

O43280

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43280
SMRⁱ	O43280
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	175 – 176	Substrate bindingBy similarity	2
Regionⁱ	221 – 223	Substrate bindingBy similarity	3
Regionⁱ	286 – 288	Substrate bindingBy similarity	3

Sequence similaritiesⁱ

Belongs to the glycosyl hydrolase 37 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG0602 Eukaryota COG1626 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006949
HOGENOMⁱ	HOG000215465
HOVERGENⁱ	HBG014956
InParanoidⁱ	O43280
KEGG Orthology (KO) More...KOⁱ	K01194
OMAⁱ	NRYWDAS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0341
PhylomeDBⁱ	O43280
TreeFamⁱ	TF314239

Family and domain databases

Gene3Dⁱ	1.50.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR008928 6-hairpin_glycosidase_sf IPR012341 6hp_glycosidase-like_sf IPR001661 Glyco_hydro_37 IPR018232 Glyco_hydro_37_CS
PANTHERⁱ	PTHR23403 PTHR23403, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01204 Trehalase, 1 hit
PRINTSⁱ	PR00744 GLHYDRLASE37
SUPFAMⁱ	SSF48208 SSF48208, 1 hit
PROSITEⁱ	View protein in PROSITE PS00927 TREHALASE_1, 1 hit PS00928 TREHALASE_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O43280-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGRTWELCL LLLLGLGLGS QEALPPPCES EIYCHGELLN QVQMAKLYQD 
        60         70         80         90        100
DKQFVDMPLS IAPEQVLQTF TELSRDHNHS IPREQLQAFV HEHFQAKGQE 
       110        120        130        140        150
LQPWTPADWK DSPQFLQKIS DAKLRAWAGQ LHQLWKKLGK KMKPEVLSHP 
       160        170        180        190        200
ERFSLIYSEH PFIVPGGRFV EFYYWDSYWV MEGLLLSEMA ETVKGMLQNF 
       210        220        230        240        250
LDLVKTYGHV PNGGRVYYLQ RSQPPLLTLM MDCYLTHTND TAFLQENIET 
       260        270        280        290        300
LALELDFWTK NRTVSVSLEG KNYLLNRYYV PYGGPRPESY SKDVELADTL 
       310        320        330        340        350
PEGDREALWA ELKAGAESGW DFSSRWLIGG PNPNSLSGIR TSKLVPVDLN 
       360        370        380        390        400
AFLCQAEELM SNFYSRLGND SQATKYRILR SQRLAALNTV LWDEQTGAWF 
       410        420        430        440        450
DYDLEKKKKN REFYPSNLTP LWAGCFSDPG VADKALKYLE DNRILTYQYG 
       460        470        480        490        500
IPTSLQKTGQ QWDFPNAWAP LQDLVIRGLA KAPLRRAQEV AFQLAQNWIR 
       510        520        530        540        550
TNFDVYSQKS AMYEKYDVSN GGQPGGGGEY EVQEGFGWTN GVVLMLLDRY 
       560        570        580 
GDRLTSGAKL AFLEPHCLAA TLLPSLLLSL LPW

Length:583

Mass (Da):66,568

Last modified:September 23, 2008 - v2

Checksum:ⁱ3EE4D312B82185F9

Isoform 2 (identifier: O43280-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
175-206: WDSYWVMEGLLLSEMAETVKGMLQNFLDLVKT → C

« Hide

        10         20         30         40         50
MPGRTWELCL LLLLGLGLGS QEALPPPCES EIYCHGELLN QVQMAKLYQD 
        60         70         80         90        100
DKQFVDMPLS IAPEQVLQTF TELSRDHNHS IPREQLQAFV HEHFQAKGQE 
       110        120        130        140        150
LQPWTPADWK DSPQFLQKIS DAKLRAWAGQ LHQLWKKLGK KMKPEVLSHP 
       160        170        180        190        200
ERFSLIYSEH PFIVPGGRFV EFYYCYGHVP NGGRVYYLQR SQPPLLTLMM 
       210        220        230        240        250
DCYLTHTNDT AFLQENIETL ALELDFWTKN RTVSVSLEGK NYLLNRYYVP 
       260        270        280        290        300
YGGPRPESYS KDVELADTLP EGDREALWAE LKAGAESGWD FSSRWLIGGP 
       310        320        330        340        350
NPNSLSGIRT SKLVPVDLNA FLCQAEELMS NFYSRLGNDS QATKYRILRS 
       360        370        380        390        400
QRLAALNTVL WDEQTGAWFD YDLEKKKKNR EFYPSNLTPL WAGCFSDPGV 
       410        420        430        440        450
ADKALKYLED NRILTYQYGI PTSLQKTGQQ WDFPNAWAPL QDLVIRGLAK 
       460        470        480        490        500
APLRRAQEVA FQLAQNWIRT NFDVYSQKSA MYEKYDVSNG GQPGGGGEYE 
       510        520        530        540        550
VQEGFGWTNG VVLMLLDRYG DRLTSGAKLA FLEPHCLAAT LLPSLLLSLL 

PW

Note: No experimental confirmation available.

Show »

Length:552

Mass (Da):62,941

Checksum:ⁱ09B87A62D49F49DF

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087WTJ4	A0A087WTJ4_HUMAN		Trehalase Trehalase	TREH	37	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	539 – 540	TN → DE in BAA24381 (PubMed:9427547).Curated		2

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049205	389	T → A. Corresponds to variant dbSNP:rs2276065Ensembl.	1
Natural variantⁱVAR_049206	449	Y → H. Corresponds to variant dbSNP:rs11827611EnsemblClinVar.	1
Natural variantⁱVAR_049207	486	R → W. Corresponds to variant dbSNP:rs2276064Ensembl.	1
Natural variantⁱVAR_049208	558	A → P. Corresponds to variant dbSNP:rs6589671Ensembl.	1
Natural variantⁱVAR_061191	561	A → P. Corresponds to variant dbSNP:rs6589670Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035440	175 – 206	WDSYW…DLVKT → C in isoform 2. 1 PublicationAdd BLAST		32

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000824 mRNA Translation: BAA24381.1 AK223140 mRNA Translation: BAD96860.1 AK223143 mRNA Translation: BAD96863.1 CH471065 Genomic DNA Translation: EAW67409.1 BC109206 mRNA Translation: AAI09207.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS73401.1 [O43280-2] CCDS73402.1 [O43280-1]
PIRⁱ	JC6504
NCBI Reference Sequences More...RefSeqⁱ	NP_001287994.1, NM_001301065.1 [O43280-2] NP_009111.2, NM_007180.2 [O43280-1]
UniGeneⁱ	Hs.129712

Genome annotation databases

Ensemblⁱ	ENST00000264029; ENSP00000264029; ENSG00000118094 [O43280-1] ENST00000397925; ENSP00000381020; ENSG00000118094 [O43280-2]
GeneIDⁱ	11181
KEGGⁱ	hsa:11181
UCSC genome browser More...UCSCⁱ	uc031ygn.2 human [O43280-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43280	Trehalase		MACMU		597	UniRef90_O43280
Trehalase		CERAT		583
Trehalase		PANTR		583
Trehalase		PONAB		583
Trehalase		SAIBB		583
+29
O43280-2	Trehalase		PANTR		552	UniRef90_O43280-2
Trehalase		SAIBB		552
Trehalase		CALJA		552
Trehalase		MACMU		552
Trehalase		Cebus capucinus imitator		552
+12

Protein	Similar proteins		Species	Score	Length	Source
O43280	Trehalase		MACMU		597	UniRef50_O43280
Trehalase		CALJA		583
Trehalase		MACFA		583
Trehalase		PAPAN		583
Trehalase		PANTR		583
+39
O43280-2	Trehalase		MANLE		552	UniRef50_O43280-2
Trehalase		PAPAN		552
Trehalase		NOMLE		552
Trehalase		MACMU		552
Trehalase		CERAT		552
+54

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Trehalase entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000824 mRNA Translation: BAA24381.1 AK223140 mRNA Translation: BAD96860.1 AK223143 mRNA Translation: BAD96863.1 CH471065 Genomic DNA Translation: EAW67409.1 BC109206 mRNA Translation: AAI09207.1
CCDSⁱ	CCDS73401.1 [O43280-2] CCDS73402.1 [O43280-1]
PIRⁱ	JC6504
RefSeqⁱ	NP_001287994.1, NM_001301065.1 [O43280-2] NP_009111.2, NM_007180.2 [O43280-1]
UniGeneⁱ	Hs.129712

3D structure databases

ProteinModelPortalⁱ	O43280
SMRⁱ	O43280
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116351, 1 interactor
STRINGⁱ	9606.ENSP00000264029

Chemistry databases

BindingDBⁱ	O43280
ChEMBLⁱ	CHEMBL3087

Protein family/group databases

CAZyⁱ	GH37 Glycoside Hydrolase Family 37

CAZyⁱ

GH37 Glycoside Hydrolase Family 37

PTM databases

iPTMnetⁱ	O43280
PhosphoSitePlusⁱ	O43280

Polymorphism and mutation databases

BioMutaⁱ	TREH

BioMutaⁱ

TREH

Proteomic databases

PaxDbⁱ	O43280
PeptideAtlasⁱ	O43280
PRIDEⁱ	O43280
ProteomicsDBⁱ	48848 48849 [O43280-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11181
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000264029; ENSP00000264029; ENSG00000118094 [O43280-1] ENST00000397925; ENSP00000381020; ENSG00000118094 [O43280-2]
GeneIDⁱ	11181
KEGGⁱ	hsa:11181
UCSCⁱ	uc031ygn.2 human [O43280-1]

Organism-specific databases

CTDⁱ	11181
DisGeNETⁱ	11181
EuPathDBⁱ	HostDB:ENSG00000118094.11
GeneCardsⁱ	TREH
H-InvDBⁱ	HIX0010188
HGNCⁱ	HGNC:12266 TREH
HPAⁱ	HPA039913 HPA042045
MalaCardsⁱ	TREH
MIMⁱ	275360 gene 612119 phenotype
neXtProtⁱ	NX_O43280
OpenTargetsⁱ	ENSG00000118094
Orphanetⁱ	103909 Trehalase deficiency
PharmGKBⁱ	PA36946
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0602 Eukaryota COG1626 LUCA
GeneTreeⁱ	ENSGT00390000006949
HOGENOMⁱ	HOG000215465
HOVERGENⁱ	HBG014956
InParanoidⁱ	O43280
KOⁱ	K01194
OMAⁱ	NRYWDAS
OrthoDBⁱ	EOG091G0341
PhylomeDBⁱ	O43280
TreeFamⁱ	TF314239

Enzyme and pathway databases

Reactomeⁱ	R-HSA-189085 Digestion of dietary carbohydrate

Reactomeⁱ

R-HSA-189085 Digestion of dietary carbohydrate

Miscellaneous databases

GenomeRNAiⁱ	11181
Protein Ontology More...PROⁱ	PR:O43280
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000118094 Expressed in 83 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_TREH
ExpressionAtlasⁱ	O43280 baseline and differential
Genevisibleⁱ	O43280 HS

Family and domain databases

Gene3Dⁱ	1.50.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR008928 6-hairpin_glycosidase_sf IPR012341 6hp_glycosidase-like_sf IPR001661 Glyco_hydro_37 IPR018232 Glyco_hydro_37_CS
PANTHERⁱ	PTHR23403 PTHR23403, 1 hit
Pfamⁱ	View protein in Pfam PF01204 Trehalase, 1 hit
PRINTSⁱ	PR00744 GLHYDRLASE37
SUPFAMⁱ	SSF48208 SSF48208, 1 hit
PROSITEⁱ	View protein in PROSITE PS00927 TREHALASE_1, 1 hit PS00928 TREHALASE_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TREA_HUMAN
Accessionⁱ	O43280Primary (citable) accession number: O43280 Secondary accession number(s): Q32MB9, Q53FY8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	September 23, 2008
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries

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UniProtKB - O43280 (TREA_HUMAN)

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Trehalase

TREH

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ