UniProtKB - O43278 (SPIT1_HUMAN)

BLAST

>sp|O43278|SPIT1_HUMAN Kunitz-type protease inhibitor 1 OS=Homo sapiens OX=9606 GN=SPINT1 PE=1 SV=2
MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPG
FVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLIN
CLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLV
LKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTV
LSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILAC
RGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNC
PDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFT
YGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVV
AILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL

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History
Entry version 180 (12 Sep 2018)
Sequence version 2 (15 Mar 2005)
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Protein

Kunitz-type protease inhibitor 1

Gene

SPINT1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	260 – 261	Reactive bondBy similarity		2
Siteⁱ	401 – 402	Reactive bondBy similarity		2

GO - Molecular functionⁱ

serine-type endopeptidase inhibitor activity
Source: ProtInc
Traceable author statementⁱ
- 9045658

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

branching involved in labyrinthine layer morphogenesis Source: Ensembl
cellular response to BMP stimulus Source: Ensembl
extracellular matrix organization Source: Ensembl
negative regulation of neural precursor cell proliferation Source: Ensembl
neural tube closure Source: Ensembl
placenta blood vessel development Source: Ensembl
positive regulation of glial cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protease inhibitor, Serine protease inhibitor

Molecular function

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6806942 MET Receptor Activation R-HSA-8852405 Signaling by MST1

Reactomeⁱ

R-HSA-6806942 MET Receptor Activation
R-HSA-8852405 Signaling by MST1

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I02.007

MEROPSⁱ

I02.007

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kunitz-type protease inhibitor 1 Alternative name(s): Hepatocyte growth factor activator inhibitor type 1 Short name: HAI-1
Gene namesⁱ	Name:SPINT1 Synonyms:HAI1 ORF Names:UNQ223/PRO256
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000166145.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11246 SPINT1
MIMⁱ	605123 gene
neXtProtⁱ	NX_O43278

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6692
Open Targets More...OpenTargetsⁱ	ENSG00000166145
PharmGKBⁱ	PA36076

Polymorphism and mutation databases

BioMutaⁱ	SPINT1

BioMutaⁱ

SPINT1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 35	1 PublicationAdd BLAST		35
ChainⁱPRO_0000016883	36 – 529	Kunitz-type protease inhibitor 1Add BLAST		494

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	66	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	235	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	250 ↔ 300	1 Publication
Disulfide bondⁱ	259 ↔ 283	1 Publication
Disulfide bondⁱ	275 ↔ 296	1 Publication
Disulfide bondⁱ	335 ↔ 347	By similarity
Disulfide bondⁱ	342 ↔ 360	By similarity
Disulfide bondⁱ	354 ↔ 369	By similarity
Disulfide bondⁱ	391 ↔ 441	By similarity
Disulfide bondⁱ	400 ↔ 424	By similarity
Disulfide bondⁱ	416 ↔ 437	By similarity
Glycosylationⁱ	523	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	O43278
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43278
PaxDbⁱ	O43278
PeptideAtlas More...PeptideAtlasⁱ	O43278
PRIDEⁱ	O43278
ProteomicsDBⁱ	48846 48847 [O43278-2]

PTM databases

iPTMnetⁱ	O43278
PhosphoSitePlusⁱ	O43278
SwissPalmⁱ	O43278

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000166145 Expressed in 171 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_SPINT1
ExpressionAtlasⁱ	O43278 baseline and differential
Genevisibleⁱ	O43278 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA006903 HPA031178

HPAⁱ

HPA006903
HPA031178

Interactionⁱ

Subunit structureⁱ

Interacts with HGFAC.1 Publication

Protein-protein interaction databases

BioGridⁱ	112570, 5 interactors
Database of interacting proteins More...DIPⁱ	DIP-37949N
IntActⁱ	O43278, 17 interactors
Molecular INTeraction database More...MINTⁱ	O43278
STRINGⁱ	9606.ENSP00000342098

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	50 – 53	Combined sources	4
Beta strandⁱ	54 – 56	Combined sources	3
Beta strandⁱ	61 – 63	Combined sources	3
Helixⁱ	66 – 69	Combined sources	4
Turnⁱ	70 – 72	Combined sources	3
Beta strandⁱ	75 – 77	Combined sources	3
Helixⁱ	84 – 93	Combined sources	10
Beta strandⁱ	99 – 104	Combined sources	6
Beta strandⁱ	106 – 108	Combined sources	3
Beta strandⁱ	113 – 119	Combined sources	7
Beta strandⁱ	131 – 133	Combined sources	3
Beta strandⁱ	135 – 142	Combined sources	8
Turnⁱ	143 – 145	Combined sources	3
Helixⁱ	146 – 149	Combined sources	4
Turnⁱ	150 – 152	Combined sources	3
Beta strandⁱ	169 – 173	Combined sources	5
Beta strandⁱ	177 – 180	Combined sources	4
Beta strandⁱ	190 – 196	Combined sources	7
Beta strandⁱ	199 – 201	Combined sources	3
Beta strandⁱ	209 – 212	Combined sources	4
Beta strandⁱ	215 – 222	Combined sources	8
Beta strandⁱ	234 – 240	Combined sources	7
Helixⁱ	246 – 250	Combined sources	5
Beta strandⁱ	263 – 268	Combined sources	6
Turnⁱ	270 – 272	Combined sources	3
Beta strandⁱ	273 – 280	Combined sources	8
Beta strandⁱ	282 – 284	Combined sources	3
Beta strandⁱ	290 – 292	Combined sources	3
Helixⁱ	293 – 300	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	O43278
SMRⁱ	O43278
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O43278

EvolutionaryTraceⁱ

O43278

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	57 – 140	MANSCPROSITE-ProRule annotationAdd BLAST	84
Domainⁱ	250 – 300	BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST	51
Domainⁱ	334 – 370	LDL-receptor class APROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	391 – 441	BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST	51

Domainⁱ

This inhibitor contains two inhibitory domains.

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG4295 Eukaryota ENOG410XQNP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00740000114929
HOGENOMⁱ	HOG000128104
HOVERGENⁱ	HBG061664
InParanoidⁱ	O43278
KEGG Orthology (KO) More...KOⁱ	K15619
OMAⁱ	ECKLACR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0612
PhylomeDBⁱ	O43278
TreeFamⁱ	TF325867

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00109 KU, 2 hits cd00112 LDLa, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit 4.10.410.10, 2 hits
InterProⁱ	View protein in InterPro IPR013783 Ig-like_fold IPR002223 Kunitz_BPTI IPR036880 Kunitz_BPTI_sf IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR013980 MANSC_dom IPR011106 MANSC_N IPR020901 Prtase_inh_Kunz-CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00014 Kunitz_BPTI, 2 hits PF00057 Ldl_recept_a, 1 hit PF07502 MANEC, 1 hit
PRINTSⁱ	PR00759 BASICPTASE
SMARTⁱ	View protein in SMART SM00131 KU, 2 hits SM00192 LDLa, 1 hit SM00765 MANEC, 1 hit
SUPFAMⁱ	SSF57362 SSF57362, 2 hits SSF57424 SSF57424, 1 hit
PROSITEⁱ	View protein in PROSITE PS00280 BPTI_KUNITZ_1, 2 hits PS50279 BPTI_KUNITZ_2, 2 hits PS01209 LDLRA_1, 1 hit PS50068 LDLRA_2, 1 hit PS50986 MANSC, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: O43278-1) [UniParc]FASTA Add to basket

Also known as: HAI-1B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPARTMARA RLAPAGIPAV ALWLLCTLGL QGTQAGPPPA PPGLPAGADC 
        60         70         80         90        100
LNSFTAGVPG FVLDTNASVS NGATFLESPT VRRGWDCVRA CCTTQNCNLA 
       110        120        130        140        150
LVELQPDRGE DAIAACFLIN CLYEQNFVCK FAPREGFINY LTREVYRSYR 
       160        170        180        190        200
QLRTQGFGGS GIPKAWAGID LKVQPQEPLV LKDVENTDWR LLRGDTDVRV 
       210        220        230        240        250
ERKDPNQVEL WGLKEGTYLF QLTVTSSDHP EDTANVTVTV LSTKQTEDYC 
       260        270        280        290        300
LASNKVGRCR GSFPRWYYDP TEQICKSFVY GGCLGNKNNY LREEECILAC 
       310        320        330        340        350
RGVQGGPLRG SSGAQATFPQ GPSMERRHPV CSGTCQPTQF RCSNGCCIDS 
       360        370        380        390        400
FLECDDTPNC PDASDEAACE KYTSGFDELQ RIHFPSDKGH CVDLPDTGLC 
       410        420        430        440        450
KESIPRWYYN PFSEHCARFT YGGCYGNKNN FEEEQQCLES CRGISKKDVF 
       460        470        480        490        500
GLRREIPIPS TGSVEMAVAV FLVICIVVVV AILGYCFFKN QRKDFHGHHH 
       510        520 
HPPPTPASST VSTTEDTEHL VYNHTTRPL

Length:529

Mass (Da):58,398

Last modified:March 15, 2005 - v2

Checksum:ⁱA87F286C23C73422

Isoform 2 (identifier: O43278-2) [UniParc]FASTA Add to basket

Also known as: HAI-1A

The sequence of this isoform differs from the canonical sequence as follows:
306-321: Missing.

« Hide

        10         20         30         40         50
MAPARTMARA RLAPAGIPAV ALWLLCTLGL QGTQAGPPPA PPGLPAGADC 
        60         70         80         90        100
LNSFTAGVPG FVLDTNASVS NGATFLESPT VRRGWDCVRA CCTTQNCNLA 
       110        120        130        140        150
LVELQPDRGE DAIAACFLIN CLYEQNFVCK FAPREGFINY LTREVYRSYR 
       160        170        180        190        200
QLRTQGFGGS GIPKAWAGID LKVQPQEPLV LKDVENTDWR LLRGDTDVRV 
       210        220        230        240        250
ERKDPNQVEL WGLKEGTYLF QLTVTSSDHP EDTANVTVTV LSTKQTEDYC 
       260        270        280        290        300
LASNKVGRCR GSFPRWYYDP TEQICKSFVY GGCLGNKNNY LREEECILAC 
       310        320        330        340        350
RGVQGPSMER RHPVCSGTCQ PTQFRCSNGC CIDSFLECDD TPNCPDASDE 
       360        370        380        390        400
AACEKYTSGF DELQRIHFPS DKGHCVDLPD TGLCKESIPR WYYNPFSEHC 
       410        420        430        440        450
ARFTYGGCYG NKNNFEEEQQ CLESCRGISK KDVFGLRREI PIPSTGSVEM 
       460        470        480        490        500
AVAVFLVICI VVVVAILGYC FFKNQRKDFH GHHHHPPPTP ASSTVSTTED 
       510 
TEHLVYNHTT RPL

Show »

Length:513

Mass (Da):56,885

Checksum:ⁱD6E05F3A5885CDDD

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
H3BVD9	H3BVD9_HUMAN	Kunitz-type protease inhibitor 1 Kunitz-type protease inhibitor 1	SPINT1	472	Annotation score:
H3BMB6	H3BMB6_HUMAN	Kunitz-type protease inhibitor 1 Kunitz-type protease inhibitor 1	SPINT1	294	Annotation score:
H3BNW5	H3BNW5_HUMAN	Kunitz-type protease inhibitor 1 Kunitz-type protease inhibitor 1	SPINT1	204	Annotation score:
H3BR01	H3BR01_HUMAN	Kunitz-type protease inhibitor 1 Kunitz-type protease inhibitor 1	SPINT1	240	Annotation score:
H3BTQ8	H3BTQ8_HUMAN	Kunitz-type protease inhibitor 1 Kunitz-type protease inhibitor 1	SPINT1	301	Annotation score:
H3BSM2	H3BSM2_HUMAN	Kunitz-type protease inhibitor 1 Kunitz-type protease inhibitor 1	SPINT1	313	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	469	A → T (Ref. 2) Curated		1
Sequence conflictⁱ	469	A → T (PubMed:12975309).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_050065	123	Y → C. Corresponds to variant dbSNP:rs11549915Ensembl.	1
Natural variantⁱVAR_050066	142	T → R. Corresponds to variant dbSNP:rs12323939Ensembl.	1
Natural variantⁱVAR_050067	337	P → L. Corresponds to variant dbSNP:rs7165897Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_013019	306 – 321	Missing in isoform 2. 2 PublicationsAdd BLAST		16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000095 mRNA Translation: BAA25014.1 AY296715 mRNA Translation: AAP44001.1 AY358969 mRNA Translation: AAQ89328.1 BT007425 mRNA Translation: AAP36093.1 BC004140 mRNA Translation: AAH04140.1 BC018702 mRNA Translation: AAH18702.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10067.1 [O43278-1] CCDS45231.1 [O43278-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001027539.1, NM_001032367.1 [O43278-2] NP_003701.1, NM_003710.3 [O43278-2] NP_857593.1, NM_181642.2 [O43278-1] XP_006720720.1, XM_006720657.1 [O43278-1]
UniGeneⁱ	Hs.233950

Genome annotation databases

Ensemblⁱ	ENST00000344051; ENSP00000342098; ENSG00000166145 [O43278-1] ENST00000562057; ENSP00000457076; ENSG00000166145 [O43278-2]
GeneIDⁱ	6692
KEGGⁱ	hsa:6692
UCSC genome browser More...UCSCⁱ	uc001zna.4 human [O43278-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43278	SPINT1 isoform 2		PANTR		529	UniRef100_O43278
Kunitz-type protease inhibitor 1 (Fragment)		HUMAN		301
SPINT1 isoform 4 (Fragment)		PANTR		302

Protein	Similar proteins		Species	Score	Length	Source
O43278	SPINT1 isoform 2		PANTR		529	UniRef90_O43278
Kunitz-type protease inhibitor 1 (Fragment)		HUMAN		301
Serine peptidase inhibitor, Kunitz type 1		Cebus capucinus imitator		531
SPINT1 isoform 1		PONAB		531
Serine peptidase inhibitor, Kunitz type 1		AOTNA		531
+33

Protein	Similar proteins		Species	Score	Length	Source
O43278	Kunitz-type protease inhibitor 1		MOUSE		507	UniRef50_O43278
SPINT1 isoform 2		PANTR		529
Kunitz-type protease inhibitor 1 (Fragment)		HUMAN		301
Serine peptidase inhibitor, Kunitz type 1		AOTNA		531
SPINT1 isoform 1		PONAB		531
+56

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000095 mRNA Translation: BAA25014.1 AY296715 mRNA Translation: AAP44001.1 AY358969 mRNA Translation: AAQ89328.1 BT007425 mRNA Translation: AAP36093.1 BC004140 mRNA Translation: AAH04140.1 BC018702 mRNA Translation: AAH18702.1
CCDSⁱ	CCDS10067.1 [O43278-1] CCDS45231.1 [O43278-2]
RefSeqⁱ	NP_001027539.1, NM_001032367.1 [O43278-2] NP_003701.1, NM_003710.3 [O43278-2] NP_857593.1, NM_181642.2 [O43278-1] XP_006720720.1, XM_006720657.1 [O43278-1]
UniGeneⁱ	Hs.233950

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1YC0	X-ray	2.60	I	245-303	[»]
	2MSX	NMR	-	A	47-152	[»]
	4ISL	X-ray	2.29	B	245-304	[»]
	4ISN	X-ray	2.45	B	245-307	[»]
	4ISO	X-ray	2.01	B	245-304	[»]
	5EZD	X-ray	2.10	A/B	168-303	[»]
	5H7V	X-ray	3.82	A	36-457	[»]
ProteinModelPortalⁱ	O43278
SMRⁱ	O43278
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112570, 5 interactors
DIPⁱ	DIP-37949N
IntActⁱ	O43278, 17 interactors
MINTⁱ	O43278
STRINGⁱ	9606.ENSP00000342098

Protein family/group databases

MEROPSⁱ	I02.007

MEROPSⁱ

I02.007

PTM databases

iPTMnetⁱ	O43278
PhosphoSitePlusⁱ	O43278
SwissPalmⁱ	O43278

Polymorphism and mutation databases

BioMutaⁱ	SPINT1

BioMutaⁱ

SPINT1

Proteomic databases

EPDⁱ	O43278
MaxQBⁱ	O43278
PaxDbⁱ	O43278
PeptideAtlasⁱ	O43278
PRIDEⁱ	O43278
ProteomicsDBⁱ	48846 48847 [O43278-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6692
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000344051; ENSP00000342098; ENSG00000166145 [O43278-1] ENST00000562057; ENSP00000457076; ENSG00000166145 [O43278-2]
GeneIDⁱ	6692
KEGGⁱ	hsa:6692
UCSCⁱ	uc001zna.4 human [O43278-1]

Organism-specific databases

CTDⁱ	6692
DisGeNETⁱ	6692
EuPathDBⁱ	HostDB:ENSG00000166145.14
GeneCardsⁱ	SPINT1
HGNCⁱ	HGNC:11246 SPINT1
HPAⁱ	HPA006903 HPA031178
MIMⁱ	605123 gene
neXtProtⁱ	NX_O43278
OpenTargetsⁱ	ENSG00000166145
PharmGKBⁱ	PA36076
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4295 Eukaryota ENOG410XQNP LUCA
GeneTreeⁱ	ENSGT00740000114929
HOGENOMⁱ	HOG000128104
HOVERGENⁱ	HBG061664
InParanoidⁱ	O43278
KOⁱ	K15619
OMAⁱ	ECKLACR
OrthoDBⁱ	EOG091G0612
PhylomeDBⁱ	O43278
TreeFamⁱ	TF325867

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6806942 MET Receptor Activation R-HSA-8852405 Signaling by MST1

Reactomeⁱ

R-HSA-6806942 MET Receptor Activation
R-HSA-8852405 Signaling by MST1

Miscellaneous databases

ChiTaRSⁱ	SPINT1 human
EvolutionaryTraceⁱ	O43278
GeneWikiⁱ	SPINT1
GenomeRNAiⁱ	6692
Protein Ontology More...PROⁱ	PR:O43278
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000166145 Expressed in 171 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_SPINT1
ExpressionAtlasⁱ	O43278 baseline and differential
Genevisibleⁱ	O43278 HS

Family and domain databases

CDDⁱ	cd00109 KU, 2 hits cd00112 LDLa, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit 4.10.410.10, 2 hits
InterProⁱ	View protein in InterPro IPR013783 Ig-like_fold IPR002223 Kunitz_BPTI IPR036880 Kunitz_BPTI_sf IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR013980 MANSC_dom IPR011106 MANSC_N IPR020901 Prtase_inh_Kunz-CS
Pfamⁱ	View protein in Pfam PF00014 Kunitz_BPTI, 2 hits PF00057 Ldl_recept_a, 1 hit PF07502 MANEC, 1 hit
PRINTSⁱ	PR00759 BASICPTASE
SMARTⁱ	View protein in SMART SM00131 KU, 2 hits SM00192 LDLa, 1 hit SM00765 MANEC, 1 hit
SUPFAMⁱ	SSF57362 SSF57362, 2 hits SSF57424 SSF57424, 1 hit
PROSITEⁱ	View protein in PROSITE PS00280 BPTI_KUNITZ_1, 2 hits PS50279 BPTI_KUNITZ_2, 2 hits PS01209 LDLRA_1, 1 hit PS50068 LDLRA_2, 1 hit PS50986 MANSC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPIT1_HUMAN
Accessionⁱ	O43278Primary (citable) accession number: O43278 Secondary accession number(s): Q7Z7D2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	March 15, 2005
	Last modified:	September 12, 2018
	This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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UniProtKB - O43278 (SPIT1_HUMAN)

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Kunitz-type protease inhibitor 1

SPINT1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ