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UniProtKB - O43278 (SPIT1_HUMAN)

Entry version 196 (10 Feb 2021)
Sequence version 2 (15 Mar 2005)
Previous versions | rss
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Protein

Kunitz-type protease inhibitor 1

Gene

SPINT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei260 – 261Reactive bondBy similarity2
Sitei401 – 402Reactive bondBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43278

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6806942, MET Receptor Activation
R-HSA-8852405, Signaling by MST1

Protein family/group databases

MEROPS protease database

More...MEROPSi		I02.007

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kunitz-type protease inhibitor 1
Alternative name(s):
Hepatocyte growth factor activator inhibitor type 1
Short name:
HAI-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPINT1
Synonyms:HAI1
ORF Names:UNQ223/PRO256
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11246, SPINT1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605123, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43278

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166145.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6692

Open Targets

More...OpenTargetsi		ENSG00000166145

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36076

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43278, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPINT1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 351 PublicationAdd BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001688336 – 529Kunitz-type protease inhibitor 1Add BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi250 ↔ 3001 Publication
Disulfide bondi259 ↔ 2831 Publication
Disulfide bondi275 ↔ 2961 Publication
Disulfide bondi335 ↔ 347By similarity
Disulfide bondi342 ↔ 360By similarity
Disulfide bondi354 ↔ 369By similarity
Disulfide bondi391 ↔ 441By similarity
Disulfide bondi400 ↔ 424By similarity
Disulfide bondi416 ↔ 437By similarity
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43278

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43278

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43278

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43278

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43278

PeptideAtlas

More...PeptideAtlasi		O43278

PRoteomics IDEntifications database

More...PRIDEi		O43278

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48846 [O43278-1]
48847 [O43278-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O43278, 6 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43278

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43278

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O43278

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166145, Expressed in lower esophagus mucosa and 186 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43278, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43278, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166145, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HGFAC.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112570, 25 interactors

Database of interacting proteins

More...DIPi		DIP-37949N

Protein interaction database and analysis system

More...IntActi		O43278, 23 interactors

Molecular INTeraction database

More...MINTi		O43278

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000342098

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43278, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1529
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		O43278

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43278

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O43278

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 140MANSCPROSITE-ProRule annotationAdd BLAST84
Domaini250 – 300BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini334 – 370LDL-receptor class APROSITE-ProRule annotationAdd BLAST37
Domaini391 – 441BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

This inhibitor contains two inhibitory domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4295, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161683

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43278

Identification of Orthologs from Complete Genome Data

More...OMAi		QRKGFHR

Database of Orthologous Groups

More...OrthoDBi		687721at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43278

TreeFam database of animal gene trees

More...TreeFami		TF325867

Family and domain databases

Conserved Domains Database

More...CDDi		cd00109, KU, 2 hits
cd00112, LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
4.10.400.10, 1 hit
4.10.410.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR013980, MANSC_dom
IPR011106, MANSC_N
IPR020901, Prtase_inh_Kunz-CS
IPR042482, Spint1

The PANTHER Classification System

More...PANTHERi		PTHR46750, PTHR46750, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00014, Kunitz_BPTI, 2 hits
PF00057, Ldl_recept_a, 1 hit
PF07502, MANEC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00759, BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00131, KU, 2 hits
SM00192, LDLa, 1 hit
SM00765, MANEC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57362, SSF57362, 2 hits
SSF57424, SSF57424, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00280, BPTI_KUNITZ_1, 2 hits
PS50279, BPTI_KUNITZ_2, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS50986, MANSC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43278-1) [UniParc]FASTAAdd to basket
Also known as: HAI-1B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPARTMARA RLAPAGIPAV ALWLLCTLGL QGTQAGPPPA PPGLPAGADC 
        60         70         80         90        100
LNSFTAGVPG FVLDTNASVS NGATFLESPT VRRGWDCVRA CCTTQNCNLA 
       110        120        130        140        150
LVELQPDRGE DAIAACFLIN CLYEQNFVCK FAPREGFINY LTREVYRSYR 
       160        170        180        190        200
QLRTQGFGGS GIPKAWAGID LKVQPQEPLV LKDVENTDWR LLRGDTDVRV 
       210        220        230        240        250
ERKDPNQVEL WGLKEGTYLF QLTVTSSDHP EDTANVTVTV LSTKQTEDYC 
       260        270        280        290        300
LASNKVGRCR GSFPRWYYDP TEQICKSFVY GGCLGNKNNY LREEECILAC 
       310        320        330        340        350
RGVQGGPLRG SSGAQATFPQ GPSMERRHPV CSGTCQPTQF RCSNGCCIDS 
       360        370        380        390        400
FLECDDTPNC PDASDEAACE KYTSGFDELQ RIHFPSDKGH CVDLPDTGLC 
       410        420        430        440        450
KESIPRWYYN PFSEHCARFT YGGCYGNKNN FEEEQQCLES CRGISKKDVF 
       460        470        480        490        500
GLRREIPIPS TGSVEMAVAV FLVICIVVVV AILGYCFFKN QRKDFHGHHH 
       510        520 
HPPPTPASST VSTTEDTEHL VYNHTTRPL
Length:529
Mass (Da):58,398
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA87F286C23C73422
GO
Isoform 2 (identifier: O43278-2) [UniParc]FASTAAdd to basket
Also known as: HAI-1A

The sequence of this isoform differs from the canonical sequence as follows:
     306-321: Missing.

Show »
Length:513
Mass (Da):56,885
Checksum:iD6E05F3A5885CDDD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BVD9H3BVD9_HUMAN
Kunitz-type protease inhibitor 1
SPINT1
472Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNW5H3BNW5_HUMAN
Kunitz-type protease inhibitor 1
SPINT1
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMB6H3BMB6_HUMAN
Kunitz-type protease inhibitor 1
SPINT1
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR01H3BR01_HUMAN
Kunitz-type protease inhibitor 1
SPINT1
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSM2H3BSM2_HUMAN
Kunitz-type protease inhibitor 1
SPINT1
313Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTQ8H3BTQ8_HUMAN
Kunitz-type protease inhibitor 1
SPINT1
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti469A → T (Ref. 2) Curated1
Sequence conflicti469A → T (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050065123Y → C. Corresponds to variant dbSNP:rs11549915Ensembl.1
Natural variantiVAR_050066142T → R. Corresponds to variant dbSNP:rs12323939Ensembl.1
Natural variantiVAR_050067337P → L. Corresponds to variant dbSNP:rs7165897EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013019306 – 321Missing in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB000095 mRNA Translation: BAA25014.1
AY296715 mRNA Translation: AAP44001.1
AY358969 mRNA Translation: AAQ89328.1
BT007425 mRNA Translation: AAP36093.1
BC004140 mRNA Translation: AAH04140.1
BC018702 mRNA Translation: AAH18702.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10067.1 [O43278-1]
CCDS45231.1 [O43278-2]

NCBI Reference Sequences

More...RefSeqi		NP_001027539.1, NM_001032367.1 [O43278-2]
NP_003701.1, NM_003710.3 [O43278-2]
NP_857593.1, NM_181642.2 [O43278-1]
XP_006720720.1, XM_006720657.1 [O43278-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344051; ENSP00000342098; ENSG00000166145 [O43278-1]
ENST00000562057; ENSP00000457076; ENSG00000166145 [O43278-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6692

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6692

UCSC genome browser

More...UCSCi		uc001zna.4, human [O43278-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000095 mRNA Translation: BAA25014.1
AY296715 mRNA Translation: AAP44001.1
AY358969 mRNA Translation: AAQ89328.1
BT007425 mRNA Translation: AAP36093.1
BC004140 mRNA Translation: AAH04140.1
BC018702 mRNA Translation: AAH18702.1
CCDSiCCDS10067.1 [O43278-1]
CCDS45231.1 [O43278-2]
RefSeqiNP_001027539.1, NM_001032367.1 [O43278-2]
NP_003701.1, NM_003710.3 [O43278-2]
NP_857593.1, NM_181642.2 [O43278-1]
XP_006720720.1, XM_006720657.1 [O43278-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YC0X-ray2.60I245-303[»]
2MSXNMR-A47-152[»]
4ISLX-ray2.29B245-304[»]
4ISNX-ray2.45B245-307[»]
4ISOX-ray2.01B245-304[»]
5EZDX-ray2.10A/B168-303[»]
5H7VX-ray3.82A36-457[»]
BMRBiO43278
SMRiO43278
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112570, 25 interactors
DIPiDIP-37949N
IntActiO43278, 23 interactors
MINTiO43278
STRINGi9606.ENSP00000342098

Protein family/group databases

MEROPSiI02.007

PTM databases

GlyGeniO43278, 6 sites, 1 O-linked glycan (3 sites)
iPTMnetiO43278
PhosphoSitePlusiO43278
SwissPalmiO43278

Genetic variation databases

BioMutaiSPINT1

Proteomic databases

EPDiO43278
jPOSTiO43278
MassIVEiO43278
MaxQBiO43278
PaxDbiO43278
PeptideAtlasiO43278
PRIDEiO43278
ProteomicsDBi48846 [O43278-1]
48847 [O43278-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1540, 434 antibodies

The DNASU plasmid repository

More...DNASUi		6692

Genome annotation databases

EnsembliENST00000344051; ENSP00000342098; ENSG00000166145 [O43278-1]
ENST00000562057; ENSP00000457076; ENSG00000166145 [O43278-2]
GeneIDi6692
KEGGihsa:6692
UCSCiuc001zna.4, human [O43278-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6692
DisGeNETi6692

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPINT1
HGNCiHGNC:11246, SPINT1
HPAiENSG00000166145, Tissue enhanced (intestine)
MIMi605123, gene
neXtProtiNX_O43278
OpenTargetsiENSG00000166145
PharmGKBiPA36076
VEuPathDBiHostDB:ENSG00000166145.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4295, Eukaryota
GeneTreeiENSGT00940000161683
InParanoidiO43278
OMAiQRKGFHR
OrthoDBi687721at2759
PhylomeDBiO43278
TreeFamiTF325867

Enzyme and pathway databases

PathwayCommonsiO43278
ReactomeiR-HSA-6806942, MET Receptor Activation
R-HSA-8852405, Signaling by MST1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6692, 18 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPINT1, human
EvolutionaryTraceiO43278

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SPINT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6692
PharosiO43278, Tbio

Protein Ontology

More...PROi		PR:O43278
RNActiO43278, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166145, Expressed in lower esophagus mucosa and 186 other tissues
ExpressionAtlasiO43278, baseline and differential
GenevisibleiO43278, HS

Family and domain databases

CDDicd00109, KU, 2 hits
cd00112, LDLa, 1 hit
Gene3Di2.60.40.10, 1 hit
4.10.400.10, 1 hit
4.10.410.10, 2 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR013980, MANSC_dom
IPR011106, MANSC_N
IPR020901, Prtase_inh_Kunz-CS
IPR042482, Spint1
PANTHERiPTHR46750, PTHR46750, 1 hit
PfamiView protein in Pfam
PF00014, Kunitz_BPTI, 2 hits
PF00057, Ldl_recept_a, 1 hit
PF07502, MANEC, 1 hit
PRINTSiPR00759, BASICPTASE
SMARTiView protein in SMART
SM00131, KU, 2 hits
SM00192, LDLa, 1 hit
SM00765, MANEC, 1 hit
SUPFAMiSSF57362, SSF57362, 2 hits
SSF57424, SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS00280, BPTI_KUNITZ_1, 2 hits
PS50279, BPTI_KUNITZ_2, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS50986, MANSC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43278
Secondary accession number(s): Q7Z7D2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: March 15, 2005
Last modified: February 10, 2021
This is version 196 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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