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Protein

Zinc finger HIT domain-containing protein 1

Gene

ZNHIT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri117 – 149HIT-typePROSITE-ProRule annotationAdd BLAST33

GO - Molecular functioni

  • histone deacetylase binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • nucleosome binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiO43257

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger HIT domain-containing protein 1
Alternative name(s):
Cyclin-G1-binding protein 1
Zinc finger protein subfamily 4A member 1
p18 Hamlet
Gene namesi
Name:ZNHIT1
Synonyms:CGBP1, ZNFN4A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106400.11
HGNCiHGNC:21688 ZNHIT1
neXtProtiNX_O43257

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi103T → A: Impairs the p38 MAPK-mediated phosphorylation of ZNHIT1. 1 Publication1
Mutagenesisi124S → A: No change in the in vitro MAPK14/MAPK11-induced phosphorylation level of ZNHIT1. 1

Organism-specific databases

OpenTargetsiENSG00000106400
PharmGKBiPA134947251

Polymorphism and mutation databases

BioMutaiZNHIT1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735461 – 154Zinc finger HIT domain-containing protein 1Add BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103Phosphothreonine; by MAPK11 and MAPK141 Publication1

Post-translational modificationi

Phosphorylated on Thr by MAPK11 or MAPK14.1 Publication
Stres-induced ZNHIT1 is mainly regulated at the level of protein.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO43257
MaxQBiO43257
PaxDbiO43257
PeptideAtlasiO43257
PRIDEiO43257
ProteomicsDBi48839

PTM databases

iPTMnetiO43257
PhosphoSitePlusiO43257

Expressioni

Tissue specificityi

Expressed abundantly in liver, but weakly in skeletal muscle, ovary and small intestine.1 Publication

Inductioni

Induced by DNA damage.1 Publication

Gene expression databases

BgeeiENSG00000106400 Expressed in 228 organ(s), highest expression level in right lobe of liver
CleanExiHS_ZNHIT1
GenevisibleiO43257 HS

Organism-specific databases

HPAiHPA019043

Interactioni

Subunit structurei

Interacts with MAPK11 and MAPK14. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. Interacts with NR1D1 and NR2D2.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115730, 30 interactors
ComplexPortaliCPX-974 SRCAP histone exchanging complex
CORUMiO43257
IntActiO43257, 38 interactors
MINTiO43257
STRINGi9606.ENSP00000304593

Structurei

3D structure databases

ProteinModelPortaliO43257
SMRiO43257
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni72 – 110Interaction with NR1D21 PublicationAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili23 – 39Sequence analysisAdd BLAST17

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 47Nuclear localization signal10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi66 – 70Poly-Lys5

Sequence similaritiesi

Belongs to the ZNHIT1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri117 – 149HIT-typePROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3362 Eukaryota
ENOG4111HZU LUCA
GeneTreeiENSGT00390000018426
HOGENOMiHOG000264917
HOVERGENiHBG054274
InParanoidiO43257
KOiK11663
OMAiPCGARYC
OrthoDBiEOG091G0OU8
PhylomeDBiO43257
TreeFamiTF314330

Family and domain databases

InterProiView protein in InterPro
IPR039723 Vps71/ZNHIT1
IPR007529 Znf_HIT
PANTHERiPTHR13093 PTHR13093, 1 hit
PfamiView protein in Pfam
PF04438 zf-HIT, 1 hit
PROSITEiView protein in PROSITE
PS51083 ZF_HIT, 1 hit

Sequencei

Sequence statusi: Complete.

O43257-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEKKTSVRS QDPGQRRVLD RAARQRRINR QLEALENDNF QDDPHAGLPQ
60 70 80 90 100
LGKRLPQFDD DADTGKKKKK TRGDHFKLRF RKNFQALLEE QNLSVAEGPN
110 120 130 140 150
YLTACAGPPS RPQRPFCAVC GFPSPYTCVS CGARYCTVRC LGTHQETRCL

KWTV
Length:154
Mass (Da):17,536
Last modified:June 1, 1998 - v1
Checksum:i6A45F05249DC07A6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035719134R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs369664812Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093571 mRNA Translation: AAF03558.1
U61837 mRNA Translation: AAB88578.1
CR456992 mRNA Translation: CAG33273.1
AC004876 Genomic DNA Translation: AAD45833.1
CH471197 Genomic DNA Translation: EAW50209.1
BC017333 mRNA Translation: AAH17333.1
CCDSiCCDS5716.1
RefSeqiNP_006340.1, NM_006349.2
UniGeneiHs.211079

Genome annotation databases

EnsembliENST00000305105; ENSP00000304593; ENSG00000106400
GeneIDi10467
KEGGihsa:10467
UCSCiuc003uye.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093571 mRNA Translation: AAF03558.1
U61837 mRNA Translation: AAB88578.1
CR456992 mRNA Translation: CAG33273.1
AC004876 Genomic DNA Translation: AAD45833.1
CH471197 Genomic DNA Translation: EAW50209.1
BC017333 mRNA Translation: AAH17333.1
CCDSiCCDS5716.1
RefSeqiNP_006340.1, NM_006349.2
UniGeneiHs.211079

3D structure databases

ProteinModelPortaliO43257
SMRiO43257
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115730, 30 interactors
ComplexPortaliCPX-974 SRCAP histone exchanging complex
CORUMiO43257
IntActiO43257, 38 interactors
MINTiO43257
STRINGi9606.ENSP00000304593

PTM databases

iPTMnetiO43257
PhosphoSitePlusiO43257

Polymorphism and mutation databases

BioMutaiZNHIT1

Proteomic databases

EPDiO43257
MaxQBiO43257
PaxDbiO43257
PeptideAtlasiO43257
PRIDEiO43257
ProteomicsDBi48839

Protocols and materials databases

DNASUi10467
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305105; ENSP00000304593; ENSG00000106400
GeneIDi10467
KEGGihsa:10467
UCSCiuc003uye.4 human

Organism-specific databases

CTDi10467
EuPathDBiHostDB:ENSG00000106400.11
GeneCardsiZNHIT1
HGNCiHGNC:21688 ZNHIT1
HPAiHPA019043
neXtProtiNX_O43257
OpenTargetsiENSG00000106400
PharmGKBiPA134947251
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3362 Eukaryota
ENOG4111HZU LUCA
GeneTreeiENSGT00390000018426
HOGENOMiHOG000264917
HOVERGENiHBG054274
InParanoidiO43257
KOiK11663
OMAiPCGARYC
OrthoDBiEOG091G0OU8
PhylomeDBiO43257
TreeFamiTF314330

Enzyme and pathway databases

SIGNORiO43257

Miscellaneous databases

ChiTaRSiZNHIT1 human
GenomeRNAii10467
PROiPR:O43257

Gene expression databases

BgeeiENSG00000106400 Expressed in 228 organ(s), highest expression level in right lobe of liver
CleanExiHS_ZNHIT1
GenevisibleiO43257 HS

Family and domain databases

InterProiView protein in InterPro
IPR039723 Vps71/ZNHIT1
IPR007529 Znf_HIT
PANTHERiPTHR13093 PTHR13093, 1 hit
PfamiView protein in Pfam
PF04438 zf-HIT, 1 hit
PROSITEiView protein in PROSITE
PS51083 ZF_HIT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZNHI1_HUMAN
AccessioniPrimary (citable) accession number: O43257
Secondary accession number(s): Q6IB12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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