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Protein

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

Gene

PAPSS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by chlorate (PubMed:9576487). The kinase activity is subject to inhibition by the substrate adenylyl sulfate (PubMed:17540769).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: sulfate assimilation

This protein is involved in the pathway sulfate assimilation, which is part of Sulfur metabolism.4 Publications
View all proteins of this organism that are known to be involved in the pathway sulfate assimilation and in Sulfur metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei101Adenylyl sulfateCombined sources1 Publication1
Binding sitei171Adenylyl sulfateCombined sources1 Publication1
Binding sitei207ATP 1; via carbonyl oxygenCombined sources3 Publications1
Binding sitei212ATP 1Combined sources1 Publication1
Binding sitei563ATP 2; via amide nitrogen and carbonyl oxygenCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi62 – 67ATP 1Combined sources3 Publications6
Nucleotide bindingi419 – 422ATP 2Combined sources1 Publication4
Nucleotide bindingi521 – 525ATP 2Combined sources1 Publication5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adenylylsulfate kinase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • nucleotidyltransferase activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • sulfate adenylyltransferase (ATP) activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Multifunctional enzyme, Nucleotidyltransferase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS06566-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.1.25 2681
2.7.7.4 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-174362 Transport and synthesis of PAPS
R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
R-HSA-6802952 Signaling by BRAF and RAF fusions

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O43252

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00097

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Short name:
PAPS synthase 1
Short name:
PAPSS 1
Alternative name(s):
Sulfurylase kinase 1
Short name:
SK 1
Short name:
SK1
Including the following 2 domains:
Sulfate adenylyltransferase (EC:2.7.7.44 Publications)
Alternative name(s):
ATP-sulfurylase
Sulfate adenylate transferase
Short name:
SAT
Adenylyl-sulfate kinase (EC:2.7.1.256 Publications)
Alternative name(s):
3'-phosphoadenosine-5'-phosphosulfate synthase
APS kinase
Adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenylylsulfate 3'-phosphotransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAPSS1
Synonyms:ATPSK1, PAPSS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000138801.8

Human Gene Nomenclature Database

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HGNCi
HGNC:8603 PAPSS1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603262 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O43252

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi37R → A: Abolishes inhibition by the substrate adenylyl sulfate. 1 Publication1
Mutagenesisi40R → A: Abolishes inhibition by the substrate adenylyl sulfate. 1 Publication1
Mutagenesisi425H → A: Loss of activity. 1 Publication1
Mutagenesisi426N → K: Increased activity. 1 Publication1
Mutagenesisi427 – 428GH → AA: Loss of activity. 2
Mutagenesisi427G → A: 30% decrease in activity. 1 Publication1
Mutagenesisi428H → A: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
9061

Open Targets

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OpenTargetsi
ENSG00000138801

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA384

Chemistry databases

Drug and drug target database

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DrugBanki
DB03708 Adenosine-5'-Phosphosulfate
DB04077 Glycerol

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PAPSS1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001059591 – 624Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1Add BLAST624

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei12N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O43252

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O43252

PeptideAtlas

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PeptideAtlasi
O43252

PRoteomics IDEntifications database

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PRIDEi
O43252

ProteomicsDB human proteome resource

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ProteomicsDBi
48837

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O43252

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O43252

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000138801 Expressed in 240 organ(s), highest expression level in endometrium

CleanEx database of gene expression profiles

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CleanExi
HS_PAPSS1

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43252 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA049781

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114522, 48 interactors

Protein interaction database and analysis system

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IntActi
O43252, 13 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000265174

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1624
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O43252

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43252

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O43252

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 225Adenylyl-sulfate kinase3 PublicationsAdd BLAST225
Regioni89 – 92Adenylyl sulfate bindingCombined sources1 Publication4
Regioni106 – 109Adenylyl sulfate bindingCombined sources2 Publications4
Regioni132 – 133Adenylyl sulfate bindingCombined sources2 Publications2
Regioni184 – 185Adenylyl sulfate bindingCombined sources2 Publications2
Regioni234 – 624Sulfate adenylyltransferase1 PublicationAdd BLAST391

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal first 50 residues are required for inhibition by the substrate adenylyl sulfate.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the APS kinase family.Curated
In the C-terminal section; belongs to the sulfate adenylyltransferase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0635 Eukaryota
KOG4238 Eukaryota
COG0529 LUCA
COG2046 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000009613

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053503

KEGG Orthology (KO)

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KOi
K13811

Identification of Orthologs from Complete Genome Data

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OMAi
CKEHPYI

Database of Orthologous Groups

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OrthoDBi
EOG091G07ZR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43252

TreeFam database of animal gene trees

More...
TreeFami
TF313143

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02027 APSK, 1 hit
cd00517 ATPS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.620, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00065 Adenylyl_sulf_kinase, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002891 APS_kinase
IPR025980 ATP-Sase_PUA-like_dom
IPR027417 P-loop_NTPase
IPR015947 PUA-like_sf
IPR014729 Rossmann-like_a/b/a_fold
IPR024951 Sulfurylase_cat_dom
IPR002650 Sulphate_adenylyltransferase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01747 ATP-sulfurylase, 1 hit
PF14306 PUA_2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit
SSF88697 SSF88697, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00455 apsK, 1 hit
TIGR00339 sopT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O43252-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIPGSLCKK VKLSNNAQNW GMQRATNVTY QAHHVSRNKR GQVVGTRGGF
60 70 80 90 100
RGCTVWLTGL SGAGKTTVSM ALEEYLVCHG IPCYTLDGDN IRQGLNKNLG
110 120 130 140 150
FSPEDREENV RRIAEVAKLF ADAGLVCITS FISPYTQDRN NARQIHEGAS
160 170 180 190 200
LPFFEVFVDA PLHVCEQRDV KGLYKKARAG EIKGFTGIDS EYEKPEAPEL
210 220 230 240 250
VLKTDSCDVN DCVQQVVELL QERDIVPVDA SYEVKELYVP ENKLHLAKTD
260 270 280 290 300
AETLPALKIN KVDMQWVQVL AEGWATPLNG FMREREYLQC LHFDCLLDGG
310 320 330 340 350
VINLSVPIVL TATHEDKERL DGCTAFALMY EGRRVAILRN PEFFEHRKEE
360 370 380 390 400
RCARQWGTTC KNHPYIKMVM EQGDWLIGGD LQVLDRVYWN DGLDQYRLTP
410 420 430 440 450
TELKQKFKDM NADAVFAFQL RNPVHNGHAL LMQDTHKQLL ERGYRRPVLL
460 470 480 490 500
LHPLGGWTKD DDVPLMWRMK QHAAVLEEGV LNPETTVVAI FPSPMMYAGP
510 520 530 540 550
TEVQWHCRAR MVAGANFYIV GRDPAGMPHP ETGKDLYEPS HGAKVLTMAP
560 570 580 590 600
GLITLEIVPF RVAAYNKKKK RMDYYDSEHH EDFEFISGTR MRKLAREGQK
610 620
PPEGFMAPKA WTVLTEYYKS LEKA
Length:624
Mass (Da):70,833
Last modified:October 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3DC9B943E68CDD6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti456G → A in CAA71413 (PubMed:9576487).Curated1
Sequence conflicti456Missing in AAC39894 (PubMed:9668121).Curated1
Sequence conflicti519 – 520IV → MC in AAD09325 (Ref. 4) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014065270L → F1 PublicationCorresponds to variant dbSNP:rs1127008Ensembl.1
Natural variantiVAR_014064587S → L3 PublicationsCorresponds to variant dbSNP:rs1127014Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y10387 mRNA Translation: CAA71413.1
U53447 Genomic DNA Translation: AAC39894.1
AF033026 mRNA Translation: AAC28429.1
AF016496 mRNA Translation: AAD09325.1
AF105227 mRNA Translation: AAF40236.1
AF097721
, AF097710, AF097711, AF097712, AF097713, AF097714, AF097715, AF097716, AF097717, AF097718, AF097719, AF097720 Genomic DNA Translation: AAF40235.1
AK292774 mRNA Translation: BAF85463.1
CR457028 mRNA Translation: CAG33309.1
CH471057 Genomic DNA Translation: EAX06210.1
BC011392 mRNA Translation: AAH11392.1
BC050627 mRNA Translation: AAH50627.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3676.1

Protein sequence database of the Protein Information Resource

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PIRi
JW0087

NCBI Reference Sequences

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RefSeqi
NP_005434.4, NM_005443.4
XP_011530702.1, XM_011532400.1
XP_011530703.1, XM_011532401.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.368610

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265174; ENSP00000265174; ENSG00000138801

Database of genes from NCBI RefSeq genomes

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GeneIDi
9061

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9061

UCSC genome browser

More...
UCSCi
uc003hyk.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10387 mRNA Translation: CAA71413.1
U53447 Genomic DNA Translation: AAC39894.1
AF033026 mRNA Translation: AAC28429.1
AF016496 mRNA Translation: AAD09325.1
AF105227 mRNA Translation: AAF40236.1
AF097721
, AF097710, AF097711, AF097712, AF097713, AF097714, AF097715, AF097716, AF097717, AF097718, AF097719, AF097720 Genomic DNA Translation: AAF40235.1
AK292774 mRNA Translation: BAF85463.1
CR457028 mRNA Translation: CAG33309.1
CH471057 Genomic DNA Translation: EAX06210.1
BC011392 mRNA Translation: AAH11392.1
BC050627 mRNA Translation: AAH50627.1
CCDSiCCDS3676.1
PIRiJW0087
RefSeqiNP_005434.4, NM_005443.4
XP_011530702.1, XM_011532400.1
XP_011530703.1, XM_011532401.1
UniGeneiHs.368610

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X6VX-ray1.75A/B1-624[»]
1XJQX-ray2.06A/B1-624[»]
1XNJX-ray1.98A/B1-624[»]
2OFWX-ray2.05A/B/C/D/E/F/G/H24-225[»]
2OFXX-ray1.90A/B25-227[»]
2PEYX-ray1.88A/B51-226[»]
2PEZX-ray1.40A/B51-226[»]
2QJFX-ray2.20A/B220-624[»]
ProteinModelPortaliO43252
SMRiO43252
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114522, 48 interactors
IntActiO43252, 13 interactors
STRINGi9606.ENSP00000265174

Chemistry databases

DrugBankiDB03708 Adenosine-5'-Phosphosulfate
DB04077 Glycerol

PTM databases

iPTMnetiO43252
PhosphoSitePlusiO43252

Polymorphism and mutation databases

BioMutaiPAPSS1

Proteomic databases

EPDiO43252
PaxDbiO43252
PeptideAtlasiO43252
PRIDEiO43252
ProteomicsDBi48837

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9061
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265174; ENSP00000265174; ENSG00000138801
GeneIDi9061
KEGGihsa:9061
UCSCiuc003hyk.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9061
DisGeNETi9061
EuPathDBiHostDB:ENSG00000138801.8

GeneCards: human genes, protein and diseases

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GeneCardsi
PAPSS1
HGNCiHGNC:8603 PAPSS1
HPAiHPA049781
MIMi603262 gene
neXtProtiNX_O43252
OpenTargetsiENSG00000138801
PharmGKBiPA384

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0635 Eukaryota
KOG4238 Eukaryota
COG0529 LUCA
COG2046 LUCA
GeneTreeiENSGT00390000009613
HOVERGENiHBG053503
KOiK13811
OMAiCKEHPYI
OrthoDBiEOG091G07ZR
PhylomeDBiO43252
TreeFamiTF313143

Enzyme and pathway databases

UniPathwayi
UPA00097

BioCyciMetaCyc:HS06566-MONOMER
BRENDAi2.7.1.25 2681
2.7.7.4 2681
ReactomeiR-HSA-174362 Transport and synthesis of PAPS
R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
R-HSA-6802952 Signaling by BRAF and RAF fusions
SABIO-RKiO43252

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PAPSS1 human
EvolutionaryTraceiO43252

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PAPSS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9061

Protein Ontology

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PROi
PR:O43252

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138801 Expressed in 240 organ(s), highest expression level in endometrium
CleanExiHS_PAPSS1
GenevisibleiO43252 HS

Family and domain databases

CDDicd02027 APSK, 1 hit
cd00517 ATPS, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00065 Adenylyl_sulf_kinase, 1 hit
InterProiView protein in InterPro
IPR002891 APS_kinase
IPR025980 ATP-Sase_PUA-like_dom
IPR027417 P-loop_NTPase
IPR015947 PUA-like_sf
IPR014729 Rossmann-like_a/b/a_fold
IPR024951 Sulfurylase_cat_dom
IPR002650 Sulphate_adenylyltransferase
PfamiView protein in Pfam
PF01747 ATP-sulfurylase, 1 hit
PF14306 PUA_2, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00455 apsK, 1 hit
TIGR00339 sopT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAPS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43252
Secondary accession number(s): O43841
, O75332, Q6IAX6, Q96FB1, Q96TF4, Q9P1P9, Q9UE98
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 10, 2002
Last modified: December 5, 2018
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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