Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 135 (12 Aug 2020)
Sequence version 2 (05 Jul 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Testis-expressed protein 33

Gene

TEX33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O43247

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Testis-expressed protein 33
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TEX33
Synonyms:C22orf33, EAN57
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185264.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28568, TEX33

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43247

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
339669

Open Targets

More...
OpenTargetsi
ENSG00000185264

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162378965

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O43247, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TEX33

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000869021 – 280Testis-expressed protein 33Add BLAST280

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O43247

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43247

PeptideAtlas

More...
PeptideAtlasi
O43247

PRoteomics IDEntifications database

More...
PRIDEi
O43247

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
48824 [O43247-1]
48825 [O43247-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43247

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43247

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185264, Expressed in testis and 55 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O43247, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43247, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000185264, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
130916, 9 interactors

Protein interaction database and analysis system

More...
IntActi
O43247, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386118

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O43247, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O43247

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S4AW, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013198

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_086691_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43247

Identification of Orthologs from Complete Genome Data

More...
OMAi
QKGSIIP

Database of Orthologous Groups

More...
OrthoDBi
1431133at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43247

TreeFam database of animal gene trees

More...
TreeFami
TF335904

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029234, TEX33

The PANTHER Classification System

More...
PANTHERi
PTHR31702, PTHR31702, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15400, TEX33, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O43247-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELGHGAGTT TFTRAHLNDK EGQQDLDPWK AAYSSLDTSK FKNQGLSSPQ
60 70 80 90 100
PLPLGASAQG SSLGQCHLKE IPPPPPTAAS RDSLGMDPQS RSLKNAGSRS
110 120 130 140 150
SSRENRATSG EGAQPCQGTD DGPSLGAQDQ RSTPTNQKGS IIPNNIRHKF
160 170 180 190 200
GSNVVDQLVS EEQAQKAIDE VFEGQKRASS WPSRTQNPVE ISSVFSDYYD
210 220 230 240 250
LGYNMRSNLF RGAAEETKSL MKASYTPEVI EKSVRDLEHW HGRKTDDLGR
260 270 280
WHQKNAMNLN LQKALEEKYG ENSKSKSSKY
Length:280
Mass (Da):30,725
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45647FA2FE223123
GO
Isoform 2 (identifier: O43247-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:195
Mass (Da):21,844
Checksum:iE6DE4B8BCBEE0D1A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6N4H0Y6N4_HUMAN
Testis-expressed protein 33
TEX33
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA72029 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0283511 – 85Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR456416 mRNA Translation: CAG30302.1
Z73420 Genomic DNA No translation available.
Z82180 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60128.1
BC042635 mRNA Translation: AAH42635.1
Y11142 Genomic DNA Translation: CAA72029.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13937.1 [O43247-2]
CCDS54524.1 [O43247-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001157329.1, NM_001163857.1 [O43247-1]
NP_848647.1, NM_178552.3 [O43247-2]
XP_011528467.1, XM_011530165.2 [O43247-1]
XP_011528468.1, XM_011530166.1 [O43247-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381821; ENSP00000371243; ENSG00000185264 [O43247-1]
ENST00000402860; ENSP00000385179; ENSG00000185264 [O43247-2]
ENST00000405091; ENSP00000386118; ENSG00000185264 [O43247-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
339669

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:339669

UCSC genome browser

More...
UCSCi
uc003aqe.4, human [O43247-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456416 mRNA Translation: CAG30302.1
Z73420 Genomic DNA No translation available.
Z82180 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60128.1
BC042635 mRNA Translation: AAH42635.1
Y11142 Genomic DNA Translation: CAA72029.1 Sequence problems.
CCDSiCCDS13937.1 [O43247-2]
CCDS54524.1 [O43247-1]
RefSeqiNP_001157329.1, NM_001163857.1 [O43247-1]
NP_848647.1, NM_178552.3 [O43247-2]
XP_011528467.1, XM_011530165.2 [O43247-1]
XP_011528468.1, XM_011530166.1 [O43247-2]

3D structure databases

SMRiO43247
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi130916, 9 interactors
IntActiO43247, 17 interactors
STRINGi9606.ENSP00000386118

PTM databases

iPTMnetiO43247
PhosphoSitePlusiO43247

Polymorphism and mutation databases

BioMutaiTEX33

Proteomic databases

MassIVEiO43247
PaxDbiO43247
PeptideAtlasiO43247
PRIDEiO43247
ProteomicsDBi48824 [O43247-1]
48825 [O43247-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
207, 67 antibodies

The DNASU plasmid repository

More...
DNASUi
339669

Genome annotation databases

EnsembliENST00000381821; ENSP00000371243; ENSG00000185264 [O43247-1]
ENST00000402860; ENSP00000385179; ENSG00000185264 [O43247-2]
ENST00000405091; ENSP00000386118; ENSG00000185264 [O43247-1]
GeneIDi339669
KEGGihsa:339669
UCSCiuc003aqe.4, human [O43247-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
339669
DisGeNETi339669
EuPathDBiHostDB:ENSG00000185264.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TEX33
HGNCiHGNC:28568, TEX33
HPAiENSG00000185264, Tissue enriched (testis)
neXtProtiNX_O43247
OpenTargetsiENSG00000185264
PharmGKBiPA162378965

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S4AW, Eukaryota
GeneTreeiENSGT00390000013198
HOGENOMiCLU_086691_0_0_1
InParanoidiO43247
OMAiQKGSIIP
OrthoDBi1431133at2759
PhylomeDBiO43247
TreeFamiTF335904

Enzyme and pathway databases

PathwayCommonsiO43247

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
339669, 2 hits in 866 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TEX33, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
339669
PharosiO43247, Tdark

Protein Ontology

More...
PROi
PR:O43247
RNActiO43247, protein

Gene expression databases

BgeeiENSG00000185264, Expressed in testis and 55 other tissues
ExpressionAtlasiO43247, baseline and differential
GenevisibleiO43247, HS

Family and domain databases

InterProiView protein in InterPro
IPR029234, TEX33
PANTHERiPTHR31702, PTHR31702, 1 hit
PfamiView protein in Pfam
PF15400, TEX33, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEX33_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43247
Secondary accession number(s): B1AH46
, Q6ICF2, Q8IVQ2, Q9Y4V8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 5, 2005
Last modified: August 12, 2020
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again