Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cationic amino acid transporter 4

Gene

SLC7A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • basic amino acid transmembrane transporter activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.3.6 the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cationic amino acid transporter 4
Short name:
CAT-4
Short name:
CAT4
Alternative name(s):
Solute carrier family 7 member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC7A4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000099960.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11062 SLC7A4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603752 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43246

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Transmembranei508 – 528HelicalSequence analysisAdd BLAST21
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Transmembranei567 – 587HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6545

Open Targets

More...
OpenTargetsi
ENSG00000099960

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35922

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00125 L-Arginine
DB00123 L-Lysine
DB00129 L-Ornithine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC7A4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000542691 – 635Cationic amino acid transporter 4Add BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei422PhosphoserineBy similarity1
Modified residuei427PhosphoserineBy similarity1
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi601N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43246

PeptideAtlas

More...
PeptideAtlasi
O43246

PRoteomics IDEntifications database

More...
PRIDEi
O43246

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48823

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43246

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43246

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099960 Expressed in 84 organ(s), highest expression level in chorionic villus

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC7A4

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O43246 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43246 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031023

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000372390

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O43246

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1286 Eukaryota
COG0531 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154637

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000250623

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000280

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43246

KEGG Orthology (KO)

More...
KOi
K13866

Identification of Orthologs from Complete Genome Data

More...
OMAi
AVTWVRF

Database of Orthologous Groups

More...
OrthoDBi
600052at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43246

TreeFam database of animal gene trees

More...
TreeFami
TF315212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002293 AA/rel_permease1
IPR029485 CAT_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006060 AA_transporter, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O43246-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGLPTIAS LARLCQKLNR LKPLEDSTME TSLRRCLSTL DLTLLGVGGM
60 70 80 90 100
VGSGLYVLTG AVAKEVAGPA VLLSFGVAAV ASLLAALCYA EFGARVPRTG
110 120 130 140 150
SAYLFTYVSM GELWAFLIGW NVLLEYIIGG AAVARAWSGY LDSMFSHSIR
160 170 180 190 200
NFTETHVGSW QVPLLGHYPD FLAAGIILLA SAFVSCGARV SSWLNHTFSA
210 220 230 240 250
ISLLVILFIV ILGFILAQPH NWSADEGGFA PFGFSGVMAG TASCFYAFVG
260 270 280 290 300
FDVIAASSEE AQNPRRSVPL AIAISLAIAA GAYILVSTVL TLMVPWHSLD
310 320 330 340 350
PDSALADAFY QRGYRWAGFI VAAGSICAMN TVLLSLLFSL PRIVYAMAAD
360 370 380 390 400
GLFFQVFAHV HPRTQVPVAG TLAFGLLTAF LALLLDLESL VQFLSLGTLL
410 420 430 440 450
AYTFVATSII VLRFQKSSPP SSPGPASPGP LTKQQSSFSD HLQLVGTVHA
460 470 480 490 500
SVPEPGELKP ALRPYLGFLD GYSPGAVVTW ALGVMLASAI TIGCVLVFGN
510 520 530 540 550
STLHLPHWGY ILLLLLTSVM FLLSLLVLGA HQQQYREDLF QIPMVPLIPA
560 570 580 590 600
LSIVLNICLM LKLSYLTWVR FSIWLLMGLA VYFGYGIRHS KENQRELPGL
610 620 630
NSTHYVVFPR GSLEETVQAM QPPSQAPAQD PGHME
Length:635
Mass (Da):68,268
Last modified:March 15, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E36605489C6EFE9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JM63C9JM63_HUMAN
Cationic amino acid transporter 4
SLC7A4
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155 – 192THVGS…ARVSS → DPRGFLAGAPPGPLPGLPGC WHHPPWPLPLSPVEPACPP in CAA04263 (PubMed:9598310).CuratedAdd BLAST38

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04815528T → I2 PublicationsCorresponds to variant dbSNP:rs2072550Ensembl.1
Natural variantiVAR_048156349A → T2 PublicationsCorresponds to variant dbSNP:rs2270384Ensembl.1
Natural variantiVAR_060989608F → Y. Corresponds to variant dbSNP:rs55700350Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ000730 mRNA Translation: CAA04263.1
CR456580 mRNA Translation: CAG30466.1
BC008814 mRNA Translation: AAH08814.1
BC062565 mRNA Translation: AAH62565.1
BC107160 mRNA Translation: AAI07161.1
BC107161 mRNA Translation: AAI07162.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33608.1

NCBI Reference Sequences

More...
RefSeqi
NP_004164.2, NM_004173.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.197116

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000382932; ENSP00000372390; ENSG00000099960
ENST00000403586; ENSP00000384278; ENSG00000099960

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6545

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6545

UCSC genome browser

More...
UCSCi
uc002zud.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000730 mRNA Translation: CAA04263.1
CR456580 mRNA Translation: CAG30466.1
BC008814 mRNA Translation: AAH08814.1
BC062565 mRNA Translation: AAH62565.1
BC107160 mRNA Translation: AAI07161.1
BC107161 mRNA Translation: AAI07162.1
CCDSiCCDS33608.1
RefSeqiNP_004164.2, NM_004173.2
UniGeneiHs.197116

3D structure databases

ProteinModelPortaliO43246
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000372390

Chemistry databases

DrugBankiDB00125 L-Arginine
DB00123 L-Lysine
DB00129 L-Ornithine

Protein family/group databases

TCDBi2.A.3.3.6 the amino acid-polyamine-organocation (apc) family

PTM databases

iPTMnetiO43246
PhosphoSitePlusiO43246

Polymorphism and mutation databases

BioMutaiSLC7A4

Proteomic databases

PaxDbiO43246
PeptideAtlasiO43246
PRIDEiO43246
ProteomicsDBi48823

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6545
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382932; ENSP00000372390; ENSG00000099960
ENST00000403586; ENSP00000384278; ENSG00000099960
GeneIDi6545
KEGGihsa:6545
UCSCiuc002zud.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6545
DisGeNETi6545
EuPathDBiHostDB:ENSG00000099960.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC7A4
HGNCiHGNC:11062 SLC7A4
HPAiHPA031023
MIMi603752 gene
neXtProtiNX_O43246
OpenTargetsiENSG00000099960
PharmGKBiPA35922

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1286 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00940000154637
HOGENOMiHOG000250623
HOVERGENiHBG000280
InParanoidiO43246
KOiK13866
OMAiAVTWVRF
OrthoDBi600052at2759
PhylomeDBiO43246
TreeFamiTF315212

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC7A4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6545

Protein Ontology

More...
PROi
PR:O43246

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000099960 Expressed in 84 organ(s), highest expression level in chorionic villus
CleanExiHS_SLC7A4
ExpressionAtlasiO43246 baseline and differential
GenevisibleiO43246 HS

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR029485 CAT_C
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTR4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43246
Secondary accession number(s): Q0P5U2
, Q3KNQ6, Q4VC45, Q6IBY8, Q96H88
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 15, 2005
Last modified: January 16, 2019
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again