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UniProtKB - O43240 (KLK10_HUMAN)
Protein
Kallikrein-10
Gene
KLK10
Organism
Homo sapiens (Human)
Status
Functioni
Has a tumor-suppressor role for NES1 in breast and prostate cancer.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 86 | Charge relay systemBy similarity | 1 | |
Active sitei | 137 | Charge relay systemBy similarity | 1 | |
Active sitei | 229 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
- serine-type peptidase activity Source: ProtInc
GO - Biological processi
- cell cycle Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Cell cycle |
Enzyme and pathway databases
BRENDAi | 3.4.21.B41, 2681 |
PathwayCommonsi | O43240 |
SignaLinki | O43240 |
Protein family/group databases
MEROPSi | S01.246 |
Names & Taxonomyi
Protein namesi | Recommended name: Kallikrein-10 (EC:3.4.21.-)Alternative name(s): Normal epithelial cell-specific 1 Protease serine-like 1 |
Gene namesi | Name:KLK10 Synonyms:NES1, PRSSL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6358, KLK10 |
MIMi | 602673, gene |
neXtProti | NX_O43240 |
VEuPathDBi | HostDB:ENSG00000129451 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: ProtInc
Other locations
- secretory granule Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 5655 |
OpenTargetsi | ENSG00000129451 |
PharmGKBi | PA30147 |
Miscellaneous databases
Pharosi | O43240, Tbio |
Genetic variation databases
BioMutai | KLK10 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000027953 | 31 – 276 | Kallikrein-10Add BLAST | 246 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | ? ↔ 263 | PROSITE-ProRule annotation | ||
Glycosylationi | 39 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 52 ↔ 162 | PROSITE-ProRule annotation | ||
Disulfide bondi | 71 ↔ 87 | PROSITE-ProRule annotation | ||
Disulfide bondi | 169 ↔ 235 | PROSITE-ProRule annotation | ||
Disulfide bondi | 201 ↔ 215 | PROSITE-ProRule annotation | ||
Disulfide bondi | 225 ↔ 250 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | O43240 |
MassIVEi | O43240 |
MaxQBi | O43240 |
PaxDbi | O43240 |
PeptideAtlasi | O43240 |
PRIDEi | O43240 |
ProteomicsDBi | 48821 |
PTM databases
GlyGeni | O43240, 1 site |
iPTMneti | O43240 |
PhosphoSitePlusi | O43240 |
Expressioni
Tissue specificityi
Expressed in breast, ovary and prostate.
Developmental stagei
Down-regulated during breast cancer progression.
Gene expression databases
Bgeei | ENSG00000129451, Expressed in lower esophagus mucosa and 139 other tissues |
ExpressionAtlasi | O43240, baseline and differential |
Genevisiblei | O43240, HS |
Organism-specific databases
HPAi | ENSG00000129451, Group enriched (esophagus, vagina) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 111636, 209 interactors |
IntActi | O43240, 16 interactors |
STRINGi | 9606.ENSP00000311746 |
Miscellaneous databases
RNActi | O43240, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | O43240 |
SMRi | O43240 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 274 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 228 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT01040000240653 |
HOGENOMi | CLU_006842_1_1_1 |
InParanoidi | O43240 |
OMAi | NNKPLWA |
OrthoDBi | 1314811at2759 |
PhylomeDBi | O43240 |
TreeFami | TF331065 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O43240-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAPHLHLSA ASGARALAKL LPLLMAQLWA AEAALLPQND TRLDPEAYGS
60 70 80 90 100
PCARGSQPWQ VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH
110 120 130 140 150
LLLLQGEQLR RTTRSVVHPK YHQGSGPILP RRTDEHDLML LKLARPVVLG
160 170 180 190 200
PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR RVKYNKGLTC SSITILSPKE
210 220 230 240 250
CEVFYPGVVT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ GILSWGVYPC
260 270
GSAQHPAVYT QICKYMSWIN KVIRSN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R132 | M0R132_HUMAN | Kallikrein-10 | KLK10 | 143 | Annotation score: | ||
M0R2S4 | M0R2S4_HUMAN | Kallikrein-10 | KLK10 | 43 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027979 | 50 | S → A3 PublicationsCorresponds to variant dbSNP:rs3745535Ensembl. | 1 | |
Natural variantiVAR_027980 | 149 | L → P3 PublicationsCorresponds to variant dbSNP:rs2075690Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF024605 mRNA Translation: AAB81602.1 AF055481 Genomic DNA Translation: AAC14266.1 AF243527 Genomic DNA Translation: AAG33363.1 AY561635 mRNA Translation: AAS66976.1 AC011473 Genomic DNA Translation: AAG23256.1 BC002710 mRNA Translation: AAH02710.1 |
CCDSi | CCDS12817.1 |
RefSeqi | NP_001070968.1, NM_001077500.1 NP_002767.2, NM_002776.4 NP_665895.1, NM_145888.2 XP_005259118.1, XM_005259061.3 XP_005259119.1, XM_005259062.3 XP_006723350.1, XM_006723287.3 XP_006723352.1, XM_006723289.3 XP_016882482.1, XM_017026993.1 |
Genome annotation databases
Ensembli | ENST00000309958.7; ENSP00000311746.2; ENSG00000129451.12 ENST00000358789.8; ENSP00000351640.2; ENSG00000129451.12 ENST00000391805.5; ENSP00000375681.1; ENSG00000129451.12 |
GeneIDi | 5655 |
KEGGi | hsa:5655 |
MANE-Selecti | ENST00000358789.8; ENSP00000351640.2; NM_145888.3; NP_665895.1 |
UCSCi | uc002puy.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF024605 mRNA Translation: AAB81602.1 AF055481 Genomic DNA Translation: AAC14266.1 AF243527 Genomic DNA Translation: AAG33363.1 AY561635 mRNA Translation: AAS66976.1 AC011473 Genomic DNA Translation: AAG23256.1 BC002710 mRNA Translation: AAH02710.1 |
CCDSi | CCDS12817.1 |
RefSeqi | NP_001070968.1, NM_001077500.1 NP_002767.2, NM_002776.4 NP_665895.1, NM_145888.2 XP_005259118.1, XM_005259061.3 XP_005259119.1, XM_005259062.3 XP_006723350.1, XM_006723287.3 XP_006723352.1, XM_006723289.3 XP_016882482.1, XM_017026993.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5LPE | X-ray | 2.65 | A/B | 43-276 | [»] | |
5LPF | X-ray | 2.70 | A/B | 43-276 | [»] | |
AlphaFoldDBi | O43240 | |||||
SMRi | O43240 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111636, 209 interactors |
IntActi | O43240, 16 interactors |
STRINGi | 9606.ENSP00000311746 |
Protein family/group databases
MEROPSi | S01.246 |
PTM databases
GlyGeni | O43240, 1 site |
iPTMneti | O43240 |
PhosphoSitePlusi | O43240 |
Genetic variation databases
BioMutai | KLK10 |
Proteomic databases
EPDi | O43240 |
MassIVEi | O43240 |
MaxQBi | O43240 |
PaxDbi | O43240 |
PeptideAtlasi | O43240 |
PRIDEi | O43240 |
ProteomicsDBi | 48821 |
Protocols and materials databases
Antibodypediai | 1705, 363 antibodies from 29 providers |
DNASUi | 5655 |
Genome annotation databases
Ensembli | ENST00000309958.7; ENSP00000311746.2; ENSG00000129451.12 ENST00000358789.8; ENSP00000351640.2; ENSG00000129451.12 ENST00000391805.5; ENSP00000375681.1; ENSG00000129451.12 |
GeneIDi | 5655 |
KEGGi | hsa:5655 |
MANE-Selecti | ENST00000358789.8; ENSP00000351640.2; NM_145888.3; NP_665895.1 |
UCSCi | uc002puy.4, human |
Organism-specific databases
CTDi | 5655 |
DisGeNETi | 5655 |
GeneCardsi | KLK10 |
HGNCi | HGNC:6358, KLK10 |
HPAi | ENSG00000129451, Group enriched (esophagus, vagina) |
MIMi | 602673, gene |
neXtProti | NX_O43240 |
OpenTargetsi | ENSG00000129451 |
PharmGKBi | PA30147 |
VEuPathDBi | HostDB:ENSG00000129451 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT01040000240653 |
HOGENOMi | CLU_006842_1_1_1 |
InParanoidi | O43240 |
OMAi | NNKPLWA |
OrthoDBi | 1314811at2759 |
PhylomeDBi | O43240 |
TreeFami | TF331065 |
Enzyme and pathway databases
BRENDAi | 3.4.21.B41, 2681 |
PathwayCommonsi | O43240 |
SignaLinki | O43240 |
Miscellaneous databases
BioGRID-ORCSi | 5655, 10 hits in 1071 CRISPR screens |
ChiTaRSi | KLK10, human |
GeneWikii | KLK10 |
GenomeRNAii | 5655 |
Pharosi | O43240, Tbio |
PROi | PR:O43240 |
RNActi | O43240, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000129451, Expressed in lower esophagus mucosa and 139 other tissues |
ExpressionAtlasi | O43240, baseline and differential |
Genevisiblei | O43240, HS |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KLK10_HUMAN | |
Accessioni | O43240Primary (citable) accession number: O43240 Secondary accession number(s): A6NC12 Q9GZW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 11, 2011 | |
Last modified: | May 25, 2022 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families