DYNC1LI2

Functionⁱ

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	61 – 68	ATPSequence analysis		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
dynein heavy chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
microtubule motor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
cellular response to nerve growth factor stimulus Source: Ensembl
centrosome localization Source: Ensembl
ER to Golgi vesicle-mediated transport Source: Reactome
microtubule-based movement
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
microtubule cytoskeleton organization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homooligomerization Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Motor protein
Biological process	Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2132295 MHC class II antigen presentation R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-5663220 RHO GTPases Activate Formins R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-68877 Mitotic Prometaphase

Reactomeⁱ

R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877 Mitotic Prometaphase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytoplasmic dynein 1 light intermediate chain 2 Alternative name(s): Dynein light intermediate chain 2, cytosolic Short name: LIC-2 LIC53/55
Gene namesⁱ	Name:DYNC1LI2 Synonyms:DNCLI2, LIC2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135720.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2966 DYNC1LI2
MIMⁱ	611406 gene
neXtProtⁱ	NX_O43237

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1783
Open Targets More...OpenTargetsⁱ	ENSG00000135720
PharmGKBⁱ	PA27438

Polymorphism and mutation databases

BioMutaⁱ	DYNC1LI2

BioMutaⁱ

DYNC1LI2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000114670	1 – 492	Cytoplasmic dynein 1 light intermediate chain 2Add BLAST		492

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	194	PhosphoserineCombined sources	1
Modified residueⁱ	383	PhosphoserineCombined sources	1
Modified residueⁱ	391	PhosphoserineCombined sources	1
Modified residueⁱ	397	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	441	PhosphothreonineCombined sources	1
Modified residueⁱ	443	PhosphoserineCombined sources	1
Modified residueⁱ	446	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	O43237
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43237
PaxDbⁱ	O43237
PeptideAtlas More...PeptideAtlasⁱ	O43237
PRIDEⁱ	O43237
ProteomicsDBⁱ	48820

PTM databases

iPTMnetⁱ	O43237
PhosphoSitePlusⁱ	O43237

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000135720 Expressed in 246 organ(s), highest expression level in brain
CleanExⁱ	HS_DYNC1LI2
ExpressionAtlasⁱ	O43237 baseline and differential
Genevisibleⁱ	O43237 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA057201

HPAⁱ

HPA057201

Interactionⁱ

Subunit structureⁱ

Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity).By similarity

GO - Molecular functionⁱ

dynein heavy chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108120, 44 interactors
IntActⁱ	O43237, 21 interactors
Molecular INTeraction database More...MINTⁱ	O43237
STRINGⁱ	9606.ENSP00000258198

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	39 – 45	Combined sources	7
Beta strandⁱ	55 – 60	Combined sources	6
Helixⁱ	67 – 74	Combined sources	8
Beta strandⁱ	83 – 85	Combined sources	3
Beta strandⁱ	89 – 93	Combined sources	5
Beta strandⁱ	96 – 98	Combined sources	3
Beta strandⁱ	102 – 106	Combined sources	5
Helixⁱ	116 – 120	Combined sources	5
Turnⁱ	125 – 127	Combined sources	3
Beta strandⁱ	128 – 135	Combined sources	8
Beta strandⁱ	139 – 141	Combined sources	3
Helixⁱ	142 – 163	Combined sources	22
Beta strandⁱ	164 – 166	Combined sources	3
Helixⁱ	169 – 181	Combined sources	13
Beta strandⁱ	184 – 186	Combined sources	3
Beta strandⁱ	225 – 230	Combined sources	6
Helixⁱ	237 – 243	Combined sources	7
Helixⁱ	248 – 265	Combined sources	18
Helixⁱ	280 – 288	Combined sources	9
Beta strandⁱ	303 – 307	Combined sources	5
Helixⁱ	319 – 323	Combined sources	5
Beta strandⁱ	326 – 328	Combined sources	3
Helixⁱ	336 – 339	Combined sources	4
Helixⁱ	362 – 370	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	O43237
SMRⁱ	O43237
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the dynein light intermediate chain family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3905 Eukaryota ENOG410XQS4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008295
HOGENOMⁱ	HOG000236263
HOVERGENⁱ	HBG005546
InParanoidⁱ	O43237
KEGG Orthology (KO) More...KOⁱ	K10416
OMAⁱ	PEEGYQG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B3J
PhylomeDBⁱ	O43237
TreeFamⁱ	TF352602

Family and domain databases

InterProⁱ	View protein in InterPro IPR008467 Dynein1_light_intermed_chain IPR022780 Dynein_light_int_chain IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR12688 PTHR12688, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05783 DLIC, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O43237-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK 
        60         70         80         90        100
LPSGKNILVF GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD 
       110        120        130        140        150
HTRCNVWILD GDLYHKGLLK FAVSAESLPE TLVIFVADMS RPWTVMESLQ 
       160        170        180        190        200
KWASVLREHI DKMKIPPEKM RELERKFVKD FQDYMEPEEG CQGSPQRRGP 
       210        220        230        240        250
LTSGSDEENV ALPLGDNVLT HNLGIPVLVV CTKCDAVSVL EKEHDYRDEH 
       260        270        280        290        300
LDFIQSHLRR FCLQYGAALI YTSVKEEKNL DLLYKYIVHK TYGFHFTTPA 
       310        320        330        340        350
LVVEKDAVFI PAGWDNEKKI AILHENFTTV KPEDAYEDFI VKPPVRKLVH 
       360        370        380        390        400
DKELAAEDEQ VFLMKQQSLL AKQPATPTRA SESPARGPSG SPRTQGRGGP 
       410        420        430        440        450
ASVPSSSPGT SVKKPDPNIK NNAASEGVLA SFFNSLLSKK TGSPGSPGAG 
       460        470        480        490 
GVQSTAKKSG QKTVLSNVQE ELDRMTRKPD SMVTNSSTEN EA

Length:492

Mass (Da):54,099

Last modified:June 1, 1998 - v1

Checksum:ⁱAF7B4E49E3983DCC

GO

Isoform 2 (identifier: O43237-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
100-177: DHTRCNVWIL...EKMRELERKF → V

« Hide

        10         20         30         40         50
MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK 
        60         70         80         90        100
LPSGKNILVF GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDV 
       110        120        130        140        150
VKDFQDYMEP EEGCQGSPQR RGPLTSGSDE ENVALPLGDN VLTHNLGIPV 
       160        170        180        190        200
LVVCTKCDAV SVLEKEHDYR DEHLDFIQSH LRRFCLQYGA ALIYTSVKEE 
       210        220        230        240        250
KNLDLLYKYI VHKTYGFHFT TPALVVEKDA VFIPAGWDNE KKIAILHENF 
       260        270        280        290        300
TTVKPEDAYE DFIVKPPVRK LVHDKELAAE DEQVFLMKQQ SLLAKQPATP 
       310        320        330        340        350
TRASESPARG PSGSPRTQGR GGPASVPSSS PGTSVKKPDP NIKNNAASEG 
       360        370        380        390        400
VLASFFNSLL SKKTGSPGSP GAGGVQSTAK KSGQKTVLSN VQEELDRMTR 
       410 
KPDSMVTNSS TENEA

Note: No experimental confirmation available.

Show »

Length:415

Mass (Da):45,005

Checksum:ⁱ758F32BAD4482709

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B4E2E0	B4E2E0_HUMAN	cDNA FLJ54239, highly similar to Cy... cDNA FLJ54239, highly similar to Cytoplasmic dynein 1 light intermediate chain 2	DYNC1LI2	271	Annotation score:
H3BUM4	H3BUM4_HUMAN	Cytoplasmic dynein 1 light intermed... Cytoplasmic dynein 1 light intermediate chain 2	DYNC1LI2	186	Annotation score:
J3KRZ2	J3KRZ2_HUMAN	Cytoplasmic dynein 1 light intermed... Cytoplasmic dynein 1 light intermediate chain 2	DYNC1LI2	92	Annotation score:
J3KRI4	J3KRI4_HUMAN	Cytoplasmic dynein 1 light intermed... Cytoplasmic dynein 1 light intermediate chain 2	DYNC1LI2	167	Annotation score:
J3KSD2	J3KSD2_HUMAN	Cytoplasmic dynein 1 light intermed... Cytoplasmic dynein 1 light intermediate chain 2	DYNC1LI2	49	Annotation score:
H3BU48	H3BU48_HUMAN	Cytoplasmic dynein 1 light intermed... Cytoplasmic dynein 1 light intermediate chain 2	DYNC1LI2	56	Annotation score:
J3QKK5	J3QKK5_HUMAN	Cytoplasmic dynein 1 light intermed... Cytoplasmic dynein 1 light intermediate chain 2	DYNC1LI2	40	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	458	K → N in AAH25959 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054663	100 – 177	DHTRC…LERKF → V in isoform 2. 1 PublicationAdd BLAST		78

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF035812 mRNA Translation: AAB88513.1 AK291766 mRNA Translation: BAF84455.1 AK303031 mRNA Translation: BAG64156.1 AC018557 Genomic DNA No translation available. AC044802 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83039.1 BC025959 mRNA Translation: AAH25959.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10818.1 [O43237-1] CCDS67049.1 [O43237-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273086.1, NM_001286157.1 [O43237-2] NP_006132.1, NM_006141.2 [O43237-1]
UniGeneⁱ	Hs.369068

Genome annotation databases

Ensemblⁱ	ENST00000258198; ENSP00000258198; ENSG00000135720 [O43237-1] ENST00000443351; ENSP00000394289; ENSG00000135720 [O43237-2]
GeneIDⁱ	1783
KEGGⁱ	hsa:1783
UCSC genome browser More...UCSCⁱ	uc002eqb.2 human [O43237-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43237	Dynein, cytoplasmic 1, light intermediate chain 2, isoform CRA_a		HUMAN		492	UniRef100_O43237
Uncharacterized protein		MACMU		492
DYNC1LI2 isoform 1		PONAB		492
Uncharacterized protein		CERAT		492
Uncharacterized protein		RHIRO		492
+7
O43237-2	Uncharacterized protein		MACMU		415	UniRef100_F6WNX7
DYNC1LI2 isoform 2		PONAB		415
Uncharacterized protein		CERAT		415
Uncharacterized protein		RHIRO		415
Uncharacterized protein		PAPAN		415
+6

Protein	Similar proteins		Species	Score	Length	Source
O43237	Cytoplasmic dynein 1 light intermediate chain 2		MACFA		492	UniRef90_O43237
Cytoplasmic dynein 1 light intermediate chain 2		MOUSE		492
Cytoplasmic dynein 1 light intermediate chain 2		PONAB		492
Dynein, cytoplasmic 1, light intermediate chain 2, isoform CRA_a		HUMAN		492
Uncharacterized protein		MACMU		492
+115
O43237-2	Uncharacterized protein		MACMU		415	UniRef90_F6WNX7
DYNC1LI2 isoform 2		PONAB		415
Uncharacterized protein		CERAT		415
Uncharacterized protein		RHIRO		415
Uncharacterized protein		PAPAN		415
+35

Protein	Similar proteins		Species	Score	Length	Source
O43237	Cytoplasmic dynein 1 light intermediate chain 2		MACFA		492	UniRef50_O43237
Cytoplasmic dynein 1 light intermediate chain 2		MOUSE		492
Cytoplasmic dynein 1 light intermediate chain 2		PONAB		492
Dynein, cytoplasmic 1, light intermediate chain 2, isoform CRA_a		HUMAN		492
Uncharacterized protein		MACMU		492
+178
O43237-2	Uncharacterized protein		CHICK		404	UniRef50_H9L0H8
cytoplasmic dynein 1 light intermediate chain 2 isoform X3		TURTR		415
Uncharacterized protein		MACMU		415
DYNC1LI2 isoform 2		PONAB		415
Uncharacterized protein		CERAT		415
+45

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF035812 mRNA Translation: AAB88513.1 AK291766 mRNA Translation: BAF84455.1 AK303031 mRNA Translation: BAG64156.1 AC018557 Genomic DNA No translation available. AC044802 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83039.1 BC025959 mRNA Translation: AAH25959.1
CCDSⁱ	CCDS10818.1 [O43237-1] CCDS67049.1 [O43237-2]
RefSeqⁱ	NP_001273086.1, NM_001286157.1 [O43237-2] NP_006132.1, NM_006141.2 [O43237-1]
UniGeneⁱ	Hs.369068

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6F1T	electron microscopy	3.50	i/j/q/r	1-492	[»]
	6F1Y	electron microscopy	3.40	j	37-373	[»]
	6F38	electron microscopy	6.70	i/j/q/r	1-492	[»]
	6F3A	electron microscopy	8.20	j	1-492	[»]
ProteinModelPortalⁱ	O43237
SMRⁱ	O43237
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108120, 44 interactors
IntActⁱ	O43237, 21 interactors
MINTⁱ	O43237
STRINGⁱ	9606.ENSP00000258198

PTM databases

iPTMnetⁱ	O43237
PhosphoSitePlusⁱ	O43237

Polymorphism and mutation databases

BioMutaⁱ	DYNC1LI2

BioMutaⁱ

DYNC1LI2

Proteomic databases

EPDⁱ	O43237
MaxQBⁱ	O43237
PaxDbⁱ	O43237
PeptideAtlasⁱ	O43237
PRIDEⁱ	O43237
ProteomicsDBⁱ	48820

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1783
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000258198; ENSP00000258198; ENSG00000135720 [O43237-1] ENST00000443351; ENSP00000394289; ENSG00000135720 [O43237-2]
GeneIDⁱ	1783
KEGGⁱ	hsa:1783
UCSCⁱ	uc002eqb.2 human [O43237-1]

Organism-specific databases

CTDⁱ	1783
DisGeNETⁱ	1783
EuPathDBⁱ	HostDB:ENSG00000135720.12
GeneCardsⁱ	DYNC1LI2
HGNCⁱ	HGNC:2966 DYNC1LI2
HPAⁱ	HPA057201
MIMⁱ	611406 gene
neXtProtⁱ	NX_O43237
OpenTargetsⁱ	ENSG00000135720
PharmGKBⁱ	PA27438
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3905 Eukaryota ENOG410XQS4 LUCA
GeneTreeⁱ	ENSGT00390000008295
HOGENOMⁱ	HOG000236263
HOVERGENⁱ	HBG005546
InParanoidⁱ	O43237
KOⁱ	K10416
OMAⁱ	PEEGYQG
OrthoDBⁱ	EOG091G0B3J
PhylomeDBⁱ	O43237
TreeFamⁱ	TF352602

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2132295 MHC class II antigen presentation R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-5663220 RHO GTPases Activate Formins R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-68877 Mitotic Prometaphase

Reactomeⁱ

R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSⁱ	DYNC1LI2 human
GeneWikiⁱ	DYNC1LI2
GenomeRNAiⁱ	1783
Protein Ontology More...PROⁱ	PR:O43237
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135720 Expressed in 246 organ(s), highest expression level in brain
CleanExⁱ	HS_DYNC1LI2
ExpressionAtlasⁱ	O43237 baseline and differential
Genevisibleⁱ	O43237 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008467 Dynein1_light_intermed_chain IPR022780 Dynein_light_int_chain IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR12688 PTHR12688, 1 hit
Pfamⁱ	View protein in Pfam PF05783 DLIC, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DC1L2_HUMAN
Accessionⁱ	O43237Primary (citable) accession number: O43237 Secondary accession number(s): A8K6V1, B4DZP4, Q8TAT3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	June 1, 1998
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - O43237 (DC1L2_HUMAN)

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Cytoplasmic dynein 1 light intermediate chain 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Cytosol

Endosome

Lysosome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ