UniProtKB - O43237 (DC1L2_HUMAN)
Cytoplasmic dynein 1 light intermediate chain 2
DYNC1LI2
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 61 – 68 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- dynein heavy chain binding Source: GO_Central
- identical protein binding Source: Ensembl
- motor activity Source: UniProtKB-KW
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
- cellular response to nerve growth factor stimulus Source: Ensembl
- centrosome localization Source: Ensembl
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- microtubule-based movement Source: GO_Central
- microtubule cytoskeleton organization Source: GO_Central
Keywordsi
Molecular function | Motor protein |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O43237 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2132295, MHC class II antigen presentation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-5663220, RHO GTPases Activate Formins R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic R-HSA-68877, Mitotic Prometaphase R-HSA-9609690, HCMV Early Events R-HSA-9646399, Aggrephagy R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
Names & Taxonomyi
Protein namesi | Recommended name: Cytoplasmic dynein 1 light intermediate chain 2Alternative name(s): Dynein light intermediate chain 2, cytosolic Short name: LIC-2 LIC53/55 |
Gene namesi | Name:DYNC1LI2 Synonyms:DNCLI2, LIC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2966, DYNC1LI2 |
MIMi | 611406, gene |
neXtProti | NX_O43237 |
VEuPathDBi | HostDB:ENSG00000135720.12 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- centrosome Source: UniProtKB
- cytoplasmic dynein complex Source: GO_Central
- microtubule Source: UniProtKB-KW
Cytosol
- cytosol Source: Reactome
Endosome
- late endosome Source: Ensembl
Lysosome
- lysosome Source: Ensembl
Other locations
- kinetochore Source: Ensembl
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Dynein, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 1783 |
OpenTargetsi | ENSG00000135720 |
PharmGKBi | PA27438 |
Miscellaneous databases
Pharosi | O43237, Tbio |
Genetic variation databases
BioMutai | DYNC1LI2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114670 | 1 – 492 | Cytoplasmic dynein 1 light intermediate chain 2Add BLAST | 492 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 194 | PhosphoserineCombined sources | 1 | |
Modified residuei | 383 | PhosphoserineCombined sources | 1 | |
Modified residuei | 391 | PhosphoserineCombined sources | 1 | |
Modified residuei | 397 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 441 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 443 | PhosphoserineCombined sources | 1 | |
Modified residuei | 446 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | O43237 |
jPOSTi | O43237 |
MassIVEi | O43237 |
MaxQBi | O43237 |
PaxDbi | O43237 |
PeptideAtlasi | O43237 |
PRIDEi | O43237 |
ProteomicsDBi | 48820 [O43237-1] 5614 |
PTM databases
iPTMneti | O43237 |
MetOSitei | O43237 |
PhosphoSitePlusi | O43237 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135720, Expressed in brain and 258 other tissues |
ExpressionAtlasi | O43237, baseline and differential |
Genevisiblei | O43237, HS |
Organism-specific databases
HPAi | ENSG00000135720, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates.
Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity).
By similarityGO - Molecular functioni
- dynein heavy chain binding Source: GO_Central
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108120, 101 interactors |
ComplexPortali | CPX-5025, Cytoplasmic dynein complex, variant 1 |
IntActi | O43237, 27 interactors |
MINTi | O43237 |
STRINGi | 9606.ENSP00000258198 |
Miscellaneous databases
RNActi | O43237, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O43237 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3905, Eukaryota |
GeneTreei | ENSGT00390000008295 |
HOGENOMi | CLU_021937_2_1_1 |
InParanoidi | O43237 |
OMAi | RDMEQKF |
PhylomeDBi | O43237 |
TreeFami | TF352602 |
Family and domain databases
InterProi | View protein in InterPro IPR008467, Dynein1_light_intermed_chain IPR022780, Dynein_light_int_chain IPR027417, P-loop_NTPase |
PANTHERi | PTHR12688, PTHR12688, 1 hit |
Pfami | View protein in Pfam PF05783, DLIC, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK
60 70 80 90 100
LPSGKNILVF GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD
110 120 130 140 150
HTRCNVWILD GDLYHKGLLK FAVSAESLPE TLVIFVADMS RPWTVMESLQ
160 170 180 190 200
KWASVLREHI DKMKIPPEKM RELERKFVKD FQDYMEPEEG CQGSPQRRGP
210 220 230 240 250
LTSGSDEENV ALPLGDNVLT HNLGIPVLVV CTKCDAVSVL EKEHDYRDEH
260 270 280 290 300
LDFIQSHLRR FCLQYGAALI YTSVKEEKNL DLLYKYIVHK TYGFHFTTPA
310 320 330 340 350
LVVEKDAVFI PAGWDNEKKI AILHENFTTV KPEDAYEDFI VKPPVRKLVH
360 370 380 390 400
DKELAAEDEQ VFLMKQQSLL AKQPATPTRA SESPARGPSG SPRTQGRGGP
410 420 430 440 450
ASVPSSSPGT SVKKPDPNIK NNAASEGVLA SFFNSLLSKK TGSPGSPGAG
460 470 480 490
GVQSTAKKSG QKTVLSNVQE ELDRMTRKPD SMVTNSSTEN EA
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KRI4 | J3KRI4_HUMAN | Dynein light intermediate chain | DYNC1LI2 | 167 | Annotation score: | ||
J3KRZ2 | J3KRZ2_HUMAN | Dynein light intermediate chain | DYNC1LI2 | 92 | Annotation score: | ||
H3BUM4 | H3BUM4_HUMAN | Dynein light intermediate chain | DYNC1LI2 | 186 | Annotation score: | ||
B4E2E0 | B4E2E0_HUMAN | Dynein light intermediate chain | DYNC1LI2 | 271 | Annotation score: | ||
J3KSD2 | J3KSD2_HUMAN | Dynein light intermediate chain | DYNC1LI2 | 49 | Annotation score: | ||
J3QKK5 | J3QKK5_HUMAN | Cytoplasmic dynein 1 light intermed... | DYNC1LI2 | 40 | Annotation score: | ||
H3BU48 | H3BU48_HUMAN | Cytoplasmic dynein 1 light intermed... | DYNC1LI2 | 56 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 458 | K → N in AAH25959 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054663 | 100 – 177 | DHTRC…LERKF → V in isoform 2. 1 PublicationAdd BLAST | 78 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF035812 mRNA Translation: AAB88513.1 AK291766 mRNA Translation: BAF84455.1 AK303031 mRNA Translation: BAG64156.1 AC018557 Genomic DNA No translation available. AC044802 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83039.1 BC025959 mRNA Translation: AAH25959.1 |
CCDSi | CCDS10818.1 [O43237-1] CCDS67049.1 [O43237-2] |
RefSeqi | NP_001273086.1, NM_001286157.1 [O43237-2] NP_006132.1, NM_006141.2 [O43237-1] |
Genome annotation databases
Ensembli | ENST00000258198; ENSP00000258198; ENSG00000135720 [O43237-1] ENST00000443351; ENSP00000394289; ENSG00000135720 [O43237-2] |
GeneIDi | 1783 |
KEGGi | hsa:1783 |
UCSCi | uc002eqb.2, human [O43237-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF035812 mRNA Translation: AAB88513.1 AK291766 mRNA Translation: BAF84455.1 AK303031 mRNA Translation: BAG64156.1 AC018557 Genomic DNA No translation available. AC044802 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83039.1 BC025959 mRNA Translation: AAH25959.1 |
CCDSi | CCDS10818.1 [O43237-1] CCDS67049.1 [O43237-2] |
RefSeqi | NP_001273086.1, NM_001286157.1 [O43237-2] NP_006132.1, NM_006141.2 [O43237-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6F1T | electron microscopy | 3.50 | i/j/q/r | 1-492 | [»] | |
6F1Y | electron microscopy | 3.40 | j | 37-373 | [»] | |
6F38 | electron microscopy | 6.70 | i/j/q/r | 1-492 | [»] | |
6F3A | electron microscopy | 8.20 | j | 1-492 | [»] | |
SMRi | O43237 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108120, 101 interactors |
ComplexPortali | CPX-5025, Cytoplasmic dynein complex, variant 1 |
IntActi | O43237, 27 interactors |
MINTi | O43237 |
STRINGi | 9606.ENSP00000258198 |
PTM databases
iPTMneti | O43237 |
MetOSitei | O43237 |
PhosphoSitePlusi | O43237 |
Genetic variation databases
BioMutai | DYNC1LI2 |
Proteomic databases
EPDi | O43237 |
jPOSTi | O43237 |
MassIVEi | O43237 |
MaxQBi | O43237 |
PaxDbi | O43237 |
PeptideAtlasi | O43237 |
PRIDEi | O43237 |
ProteomicsDBi | 48820 [O43237-1] 5614 |
Protocols and materials databases
Antibodypediai | 29288, 110 antibodies |
DNASUi | 1783 |
Genome annotation databases
Ensembli | ENST00000258198; ENSP00000258198; ENSG00000135720 [O43237-1] ENST00000443351; ENSP00000394289; ENSG00000135720 [O43237-2] |
GeneIDi | 1783 |
KEGGi | hsa:1783 |
UCSCi | uc002eqb.2, human [O43237-1] |
Organism-specific databases
CTDi | 1783 |
DisGeNETi | 1783 |
GeneCardsi | DYNC1LI2 |
HGNCi | HGNC:2966, DYNC1LI2 |
HPAi | ENSG00000135720, Low tissue specificity |
MIMi | 611406, gene |
neXtProti | NX_O43237 |
OpenTargetsi | ENSG00000135720 |
PharmGKBi | PA27438 |
VEuPathDBi | HostDB:ENSG00000135720.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3905, Eukaryota |
GeneTreei | ENSGT00390000008295 |
HOGENOMi | CLU_021937_2_1_1 |
InParanoidi | O43237 |
OMAi | RDMEQKF |
PhylomeDBi | O43237 |
TreeFami | TF352602 |
Enzyme and pathway databases
PathwayCommonsi | O43237 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2132295, MHC class II antigen presentation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-5663220, RHO GTPases Activate Formins R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic R-HSA-68877, Mitotic Prometaphase R-HSA-9609690, HCMV Early Events R-HSA-9646399, Aggrephagy R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
Miscellaneous databases
BioGRID-ORCSi | 1783, 39 hits in 873 CRISPR screens |
ChiTaRSi | DYNC1LI2, human |
GeneWikii | DYNC1LI2 |
GenomeRNAii | 1783 |
Pharosi | O43237, Tbio |
PROi | PR:O43237 |
RNActi | O43237, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135720, Expressed in brain and 258 other tissues |
ExpressionAtlasi | O43237, baseline and differential |
Genevisiblei | O43237, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008467, Dynein1_light_intermed_chain IPR022780, Dynein_light_int_chain IPR027417, P-loop_NTPase |
PANTHERi | PTHR12688, PTHR12688, 1 hit |
Pfami | View protein in Pfam PF05783, DLIC, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DC1L2_HUMAN | |
Accessioni | O43237Primary (citable) accession number: O43237 Secondary accession number(s): A8K6V1, B4DZP4, Q8TAT3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | June 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families