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Protein

Motilin receptor

Gene

MLNR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for motilin.1 Publication

GO - Molecular functioni

  • G protein-coupled peptide receptor activity Source: GO_Central
  • hormone binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiO43193

Names & Taxonomyi

Protein namesi
Recommended name:
Motilin receptor
Alternative name(s):
G-protein coupled receptor 38
Gene namesi
Name:MLNR
Synonyms:GPR38, MTLR, MTLR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102539.5
HGNCiHGNC:4495 MLNR
MIMi602885 gene
neXtProtiNX_O43193

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini57 – 74CytoplasmicSequence analysisAdd BLAST18
Transmembranei75 – 94Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini95 – 112ExtracellularSequence analysisAdd BLAST18
Transmembranei113 – 134Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini135 – 157CytoplasmicSequence analysisAdd BLAST23
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 246ExtracellularSequence analysisAdd BLAST68
Transmembranei247 – 270Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini271 – 298CytoplasmicSequence analysisAdd BLAST28
Transmembranei299 – 320Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini321 – 334ExtracellularSequence analysisAdd BLAST14
Transmembranei335 – 358Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini359 – 412CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2862
OpenTargetsiENSG00000102539
PharmGKBiPA28884

Chemistry databases

ChEMBLiCHEMBL2203
DrugBankiDB00199 Erythromycin
GuidetoPHARMACOLOGYi297

Polymorphism and mutation databases

BioMutaiMLNR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698601 – 412Motilin receptorAdd BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 235PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43193
PRIDEiO43193
ProteomicsDBi48807
48808 [O43193-2]

PTM databases

iPTMnetiO43193
PhosphoSitePlusiO43193

Expressioni

Tissue specificityi

Expressed only in thyroid, stomach, and bone marrow.

Gene expression databases

BgeeiENSG00000102539 Expressed in 20 organ(s), highest expression level in fundus of stomach
CleanExiHS_MLNR
GenevisibleiO43193 HS

Interactioni

Protein-protein interaction databases

BioGridi109120, 1 interactor
STRINGi9606.ENSP00000218721

Chemistry databases

BindingDBiO43193

Structurei

3D structure databases

ProteinModelPortaliO43193
SMRiO43193
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000272571
HOVERGENiHBG006538
InParanoidiO43193
KOiK05266
OMAiRMMYFSQ
OrthoDBiEOG091G09KB
PhylomeDBiO43193
TreeFamiTF336314

Family and domain databases

CDDicd15132 7tmA_motilin_R, 1 hit
InterProiView protein in InterPro
IPR003905 GHS-R/MTLR
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR039132 MTLR
PANTHERiPTHR24243:SF3 PTHR24243:SF3, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01417 GHSRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: O43193-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSPWNGSDG PEGAREPPWP ALPPCDERRC SPFPLGALVP VTAVCLCLFV
60 70 80 90 100
VGVSGNVVTV MLIGRYRDMR TTTNLYLGSM AVSDLLILLG LPFDLYRLWR
110 120 130 140 150
SRPWVFGPLL CRLSLYVGEG CTYATLLHMT ALSVERYLAI CRPLRARVLV
160 170 180 190 200
TRRRVRALIA VLWAVALLSA GPFLFLVGVE QDPGISVVPG LNGTARIASS
210 220 230 240 250
PLASSPPLWL SRAPPPSPPS GPETAEAAAL FSRECRPSPA QLGALRVMLW
260 270 280 290 300
VTTAYFFLPF LCLSILYGLI GRELWSSRRP LRGPAASGRE RGHRQTVRVL
310 320 330 340 350
LVVVLAFIIC WLPFHVGRII YINTEDSRMM YFSQYFNIVA LQLFYLSASI
360 370 380 390 400
NPILYNLISK KYRAAAFKLL LARKSRPRGF HRSRDTAGEV AGDTGGDTVG
410
YTETSANVKT MG
Length:412
Mass (Da):45,344
Last modified:June 1, 1998 - v1
Checksum:iC13FF6165012DEF3
GO
Isoform B (identifier: O43193-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-412: LVVVLAFIIC...ETSANVKTMG → RKWSRRGSKD...FADDVLLSVL

Show »
Length:386
Mass (Da):42,026
Checksum:i40D07BB0CDD22BCB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001894301 – 412LVVVL…VKTMG → RKWSRRGSKDACLQSAPPGT AQTLGPLPLLAQLWAPLPAP FPISIPASTRRGGGSGIYNL LVALPRWQNHLHKHGRFADD VLLSVL in isoform B. CuratedAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034632 Genomic DNA Translation: AAC26081.1
AY603964 mRNA Translation: AAT35806.1
AL137000 Genomic DNA No translation available.
CCDSiCCDS9414.1 [O43193-1]
RefSeqiNP_001498.1, NM_001507.1 [O43193-1]
UniGeneiHs.248126

Genome annotation databases

EnsembliENST00000218721; ENSP00000218721; ENSG00000102539 [O43193-1]
GeneIDi2862
KEGGihsa:2862
UCSCiuc010tgj.2 human [O43193-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034632 Genomic DNA Translation: AAC26081.1
AY603964 mRNA Translation: AAT35806.1
AL137000 Genomic DNA No translation available.
CCDSiCCDS9414.1 [O43193-1]
RefSeqiNP_001498.1, NM_001507.1 [O43193-1]
UniGeneiHs.248126

3D structure databases

ProteinModelPortaliO43193
SMRiO43193
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109120, 1 interactor
STRINGi9606.ENSP00000218721

Chemistry databases

BindingDBiO43193
ChEMBLiCHEMBL2203
DrugBankiDB00199 Erythromycin
GuidetoPHARMACOLOGYi297

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO43193
PhosphoSitePlusiO43193

Polymorphism and mutation databases

BioMutaiMLNR

Proteomic databases

PaxDbiO43193
PRIDEiO43193
ProteomicsDBi48807
48808 [O43193-2]

Protocols and materials databases

DNASUi2862
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218721; ENSP00000218721; ENSG00000102539 [O43193-1]
GeneIDi2862
KEGGihsa:2862
UCSCiuc010tgj.2 human [O43193-1]

Organism-specific databases

CTDi2862
DisGeNETi2862
EuPathDBiHostDB:ENSG00000102539.5
GeneCardsiMLNR
HGNCiHGNC:4495 MLNR
MIMi602885 gene
neXtProtiNX_O43193
OpenTargetsiENSG00000102539
PharmGKBiPA28884
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000272571
HOVERGENiHBG006538
InParanoidiO43193
KOiK05266
OMAiRMMYFSQ
OrthoDBiEOG091G09KB
PhylomeDBiO43193
TreeFamiTF336314

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiO43193

Miscellaneous databases

GeneWikiiMotilin_receptor
GenomeRNAii2862
PROiPR:O43193
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102539 Expressed in 20 organ(s), highest expression level in fundus of stomach
CleanExiHS_MLNR
GenevisibleiO43193 HS

Family and domain databases

CDDicd15132 7tmA_motilin_R, 1 hit
InterProiView protein in InterPro
IPR003905 GHS-R/MTLR
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR039132 MTLR
PANTHERiPTHR24243:SF3 PTHR24243:SF3, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01417 GHSRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTLR_HUMAN
AccessioniPrimary (citable) accession number: O43193
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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