UniProtKB - O43182 (RHG06_HUMAN)
Protein
Rho GTPase-activating protein 6
Gene
ARHGAP6
Organism
Homo sapiens (Human)
Status
Functioni
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.1 Publication
Miscellaneous
ARHGAP6 gene undergoes X inactivation.
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- phospholipase activator activity Source: BHF-UCL
- phospholipase binding Source: BHF-UCL
- SH3 domain binding Source: UniProtKB-KW
GO - Biological processi
- actin filament polymerization Source: UniProtKB
- activation of phospholipase C activity Source: BHF-UCL
- focal adhesion assembly Source: Ensembl
- negative regulation of focal adhesion assembly Source: BHF-UCL
- negative regulation of stress fiber assembly Source: BHF-UCL
- positive regulation of phospholipase activity Source: BHF-UCL
- regulation of small GTPase mediated signal transduction Source: Reactome
- Rho protein signal transduction Source: ProtInc
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | O43182 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
SIGNORi | O43182 |
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein 6Alternative name(s): Rho-type GTPase-activating protein 6 Rho-type GTPase-activating protein RhoGAPX-1 |
Gene namesi | Name:ARHGAP6 Synonyms:RHOGAP6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000047648.21 |
HGNCi | HGNC:676, ARHGAP6 |
MIMi | 300118, gene |
neXtProti | NX_O43182 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Cytoskeleton
- actin cytoskeleton Source: BHF-UCL
- actin filament Source: UniProtKB
Cytosol
- cytosol Source: HPA
Other locations
- cytoplasm Source: BHF-UCL
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 395 |
OpenTargetsi | ENSG00000047648 |
PharmGKBi | PA24960 |
Miscellaneous databases
Pharosi | O43182, Tbio |
Polymorphism and mutation databases
BioMutai | ARHGAP6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056704 | 1 – 974 | Rho GTPase-activating protein 6Add BLAST | 974 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 37 | PhosphoserineBy similarity | 1 | |
Modified residuei | 264 | PhosphoserineCombined sources | 1 | |
Modified residuei | 363 | PhosphoserineCombined sources | 1 | |
Modified residuei | 667 | PhosphoserineCombined sources | 1 | |
Modified residuei | 673 | PhosphoserineCombined sources | 1 | |
Modified residuei | 680 | PhosphoserineCombined sources | 1 | |
Modified residuei | 711 | PhosphoserineCombined sources | 1 | |
Modified residuei | 754 | PhosphoserineCombined sources | 1 | |
Modified residuei | 772 | PhosphoserineCombined sources | 1 | |
Modified residuei | 777 | PhosphoserineCombined sources | 1 | |
Modified residuei | 786 | PhosphoserineCombined sources | 1 | |
Modified residuei | 820 | PhosphoserineCombined sources | 1 | |
Modified residuei | 928 | PhosphoserineCombined sources | 1 | |
Modified residuei | 931 | PhosphoserineCombined sources | 1 | |
Modified residuei | 939 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O43182 |
MassIVEi | O43182 |
MaxQBi | O43182 |
PaxDbi | O43182 |
PeptideAtlasi | O43182 |
PRIDEi | O43182 |
ProteomicsDBi | 48794 [O43182-1] 48795 [O43182-2] 48796 [O43182-3] 48797 [O43182-4] 48798 [O43182-5] |
TopDownProteomicsi | O43182-5 [O43182-5] |
PTM databases
iPTMneti | O43182 |
PhosphoSitePlusi | O43182 |
Expressioni
Tissue specificityi
Highly expressed in kidney, heart and skeletal muscle followed by retina, lymphoblast, placenta, lung, brain, pancreas and liver.
Gene expression databases
Bgeei | ENSG00000047648, Expressed in seminal vesicle and 220 other tissues |
ExpressionAtlasi | O43182, baseline and differential |
Genevisiblei | O43182, HS |
Organism-specific databases
HPAi | ENSG00000047648, Tissue enhanced (ductus deferens, seminal vesicle) |
Interactioni
GO - Molecular functioni
- phospholipase binding Source: BHF-UCL
- SH3 domain binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 106888, 2 interactors |
IntActi | O43182, 2 interactors |
MINTi | O43182 |
STRINGi | 9606.ENSP00000338967 |
Miscellaneous databases
RNActi | O43182, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 401 – 602 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 202 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 342 – 352 | SH3-bindingAdd BLAST | 11 |
Keywords - Domaini
SH3-bindingPhylogenomic databases
eggNOGi | KOG2710, Eukaryota |
GeneTreei | ENSGT00940000153904 |
HOGENOMi | CLU_012874_0_0_1 |
InParanoidi | O43182 |
OrthoDBi | 419555at2759 |
PhylomeDBi | O43182 |
TreeFami | TF316710 |
Family and domain databases
CDDi | cd04376, RhoGAP_ARHGAP6, 1 hit |
Gene3Di | 1.10.555.10, 1 hit |
InterProi | View protein in InterPro IPR041852, ARHGAP6_RhoGAP IPR008936, Rho_GTPase_activation_prot IPR030772, RhoGAP6 IPR037863, RHOGAP6/36 IPR000198, RhoGAP_dom |
PANTHERi | PTHR12635, PTHR12635, 1 hit PTHR12635:SF6, PTHR12635:SF6, 1 hit |
Pfami | View protein in Pfam PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 3 (identifier: O43182-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAQSLLHSV FSCSSPASSS AASAKGFSKR KLRQTRSLDP ALIGGCGSDE
60 70 80 90 100
AGAEGSARGA TAGRLYSPSL PAESLGPRLA SSSRGPPPRA TRLPPPGPLC
110 120 130 140 150
SSFSTPSTPQ EKSPSGSFHF DYEVPLGRGG LKKSMAWDLP SVLAGPASSR
160 170 180 190 200
SASSILCSSG GGPNGIFASP RRWLQQRKFQ SPPDSRGHPY VVWKSEGDFT
210 220 230 240 250
WNSMSGRSVR LRSVPIQSLS ELERARLQEV AFYQLQQDCD LSCQITIPKD
260 270 280 290 300
GQKRKKSLRK KLDSLGKEKN KDKEFIPQAF GMPLSQVIAN DRAYKLKQDL
310 320 330 340 350
QRDEQKDASD FVASLLPFGN KRQNKELSSS NSSLSSTSET PNESTSPNTP
360 370 380 390 400
EPAPRARRRG AMSVDSITDL DDNQSRLLEA LQLSLPAEAQ SKKEKARDKK
410 420 430 440 450
LSLNPIYRQV PRLVDSCCQH LEKHGLQTVG IFRVGSSKKR VRQLREEFDR
460 470 480 490 500
GIDVSLEEEH SVHDVAALLK EFLRDMPDPL LTRELYTAFI NTLLLEPEEQ
510 520 530 540 550
LGTLQLLIYL LPPCNCDTLH RLLQFLSIVA RHADDNISKD GQEVTGNKMT
560 570 580 590 600
SLNLATIFGP NLLHKQKSSD KEFSVQSSAR AEESTAIIAV VQKMIENYEA
610 620 630 640 650
LFMVPPDLQN EVLISLLETD PDVVDYLLRR KASQSSSPDM LQSEVSFSVG
660 670 680 690 700
GRHSSTDSNK ASSGDISPYD NNSPVLSERS LLAMQEDAAP GGSEKLYRVP
710 720 730 740 750
GQFMLVGHLS SSKSRESSPG PRLGKDLSEE PFDIWGTWHS TLKSGSKDPG
760 770 780 790 800
MTGSSGDIFE SSSLRAGPCS LSQGNLSPNW PRWQGSPAEL DSDTQGARRT
810 820 830 840 850
QAAAPATEGR AHPAVSRACS TPHVQVAGKA ERPTARSEQY LTLSGAHDLS
860 870 880 890 900
ESELDVAGLQ SRATPQCQRP HGSGRDDKRP PPPYPGPGKP AAAAAWIQGP
910 920 930 940 950
PEGVETPTDQ GGQAAEREQQ VTQKKLSSAN SLPAGEQDSP RLGDAGWLDW
960 970
QRERWQIWEL LSTDNPDALP ETLV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BYE6 | H7BYE6_HUMAN | Rho GTPase-activating protein 6 | ARHGAP6 | 601 | Annotation score: | ||
B4DN07 | B4DN07_HUMAN | Rho GTPase-activating protein 6 | ARHGAP6 | 604 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 231 | A → P in AAF43261 (PubMed:10699171).Curated | 1 | |
Sequence conflicti | 231 | A → P in AAD55087 (PubMed:10699171).Curated | 1 | |
Sequence conflicti | 231 | A → P in AAC98539 (PubMed:9417914).Curated | 1 | |
Sequence conflicti | 231 | A → P in AAC98540 (PubMed:9417914).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024453 | 791 | D → E1 PublicationCorresponds to variant dbSNP:rs1009758Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001637 | 1 – 203 | Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 203 | |
Alternative sequenceiVSP_001638 | 196 | E → ELELYDLQILGTKPPMNSDT HRNFDPTATLRNQ in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_001639 | 637 – 658 | SPDML…SSTDS → TSSVLPAAVQACPQYPASMF TP in isoform 2. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_001640 | 659 – 974 | Missing in isoform 2. 1 PublicationAdd BLAST | 316 | |
Alternative sequenceiVSP_001641 | 726 – 765 | DLSEE…SSSLR → GNWSLASRRWPKQATLLLLH VAWCGALRTFSSSLPYLMFL in isoform 1 and isoform 5. 2 PublicationsAdd BLAST | 40 | |
Alternative sequenceiVSP_001642 | 766 – 974 | Missing in isoform 1 and isoform 5. 2 PublicationsAdd BLAST | 209 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117067 mRNA Translation: AAF43261.1 AF177663 mRNA Translation: AAD53166.1 AF177665 mRNA Translation: AAD55087.1 AF012272 mRNA Translation: AAC98539.2 AF022212 mRNA Translation: AAC98540.2 BC150635 mRNA Translation: AAI50636.1 |
CCDSi | CCDS14140.1 [O43182-1] CCDS14141.1 [O43182-4] CCDS14142.1 [O43182-2] |
PIRi | E59434 |
RefSeqi | NP_001274171.1, NM_001287242.1 NP_006116.2, NM_006125.2 [O43182-2] NP_038267.1, NM_013423.2 [O43182-4] NP_038286.2, NM_013427.2 [O43182-1] |
Genome annotation databases
Ensembli | ENST00000303025; ENSP00000302312; ENSG00000047648 [O43182-4] ENST00000337414; ENSP00000338967; ENSG00000047648 [O43182-1] ENST00000380718; ENSP00000370094; ENSG00000047648 [O43182-2] ENST00000380736; ENSP00000370112; ENSG00000047648 [O43182-4] ENST00000495242; ENSP00000435767; ENSG00000047648 [O43182-3] |
GeneIDi | 395 |
KEGGi | hsa:395 |
UCSCi | uc004cum.2, human [O43182-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117067 mRNA Translation: AAF43261.1 AF177663 mRNA Translation: AAD53166.1 AF177665 mRNA Translation: AAD55087.1 AF012272 mRNA Translation: AAC98539.2 AF022212 mRNA Translation: AAC98540.2 BC150635 mRNA Translation: AAI50636.1 |
CCDSi | CCDS14140.1 [O43182-1] CCDS14141.1 [O43182-4] CCDS14142.1 [O43182-2] |
PIRi | E59434 |
RefSeqi | NP_001274171.1, NM_001287242.1 NP_006116.2, NM_006125.2 [O43182-2] NP_038267.1, NM_013423.2 [O43182-4] NP_038286.2, NM_013427.2 [O43182-1] |
3D structure databases
SMRi | O43182 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106888, 2 interactors |
IntActi | O43182, 2 interactors |
MINTi | O43182 |
STRINGi | 9606.ENSP00000338967 |
PTM databases
iPTMneti | O43182 |
PhosphoSitePlusi | O43182 |
Polymorphism and mutation databases
BioMutai | ARHGAP6 |
Proteomic databases
jPOSTi | O43182 |
MassIVEi | O43182 |
MaxQBi | O43182 |
PaxDbi | O43182 |
PeptideAtlasi | O43182 |
PRIDEi | O43182 |
ProteomicsDBi | 48794 [O43182-1] 48795 [O43182-2] 48796 [O43182-3] 48797 [O43182-4] 48798 [O43182-5] |
TopDownProteomicsi | O43182-5 [O43182-5] |
Protocols and materials databases
Antibodypediai | 23727, 58 antibodies |
Genome annotation databases
Ensembli | ENST00000303025; ENSP00000302312; ENSG00000047648 [O43182-4] ENST00000337414; ENSP00000338967; ENSG00000047648 [O43182-1] ENST00000380718; ENSP00000370094; ENSG00000047648 [O43182-2] ENST00000380736; ENSP00000370112; ENSG00000047648 [O43182-4] ENST00000495242; ENSP00000435767; ENSG00000047648 [O43182-3] |
GeneIDi | 395 |
KEGGi | hsa:395 |
UCSCi | uc004cum.2, human [O43182-1] |
Organism-specific databases
CTDi | 395 |
DisGeNETi | 395 |
EuPathDBi | HostDB:ENSG00000047648.21 |
GeneCardsi | ARHGAP6 |
HGNCi | HGNC:676, ARHGAP6 |
HPAi | ENSG00000047648, Tissue enhanced (ductus deferens, seminal vesicle) |
MIMi | 300118, gene |
neXtProti | NX_O43182 |
OpenTargetsi | ENSG00000047648 |
PharmGKBi | PA24960 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2710, Eukaryota |
GeneTreei | ENSGT00940000153904 |
HOGENOMi | CLU_012874_0_0_1 |
InParanoidi | O43182 |
OrthoDBi | 419555at2759 |
PhylomeDBi | O43182 |
TreeFami | TF316710 |
Enzyme and pathway databases
PathwayCommonsi | O43182 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
SIGNORi | O43182 |
Miscellaneous databases
BioGRID-ORCSi | 395, 7 hits in 468 CRISPR screens |
ChiTaRSi | ARHGAP6, human |
GenomeRNAii | 395 |
Pharosi | O43182, Tbio |
PROi | PR:O43182 |
RNActi | O43182, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000047648, Expressed in seminal vesicle and 220 other tissues |
ExpressionAtlasi | O43182, baseline and differential |
Genevisiblei | O43182, HS |
Family and domain databases
CDDi | cd04376, RhoGAP_ARHGAP6, 1 hit |
Gene3Di | 1.10.555.10, 1 hit |
InterProi | View protein in InterPro IPR041852, ARHGAP6_RhoGAP IPR008936, Rho_GTPase_activation_prot IPR030772, RhoGAP6 IPR037863, RHOGAP6/36 IPR000198, RhoGAP_dom |
PANTHERi | PTHR12635, PTHR12635, 1 hit PTHR12635:SF6, PTHR12635:SF6, 1 hit |
Pfami | View protein in Pfam PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHG06_HUMAN | |
Accessioni | O43182Primary (citable) accession number: O43182 Secondary accession number(s): B2RWQ0 Q9UK82 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | October 3, 2006 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations