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UniProtKB - O43182 (RHG06_HUMAN)

Entry version 177 (02 Dec 2020)
Sequence version 3 (03 Oct 2006)
Previous versions | rss
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Protein

Rho GTPase-activating protein 6

Gene

ARHGAP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.1 Publication

Miscellaneous

ARHGAP6 gene undergoes X inactivation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43182

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-194840, Rho GTPase cycle

SIGNOR Signaling Network Open Resource

More...SIGNORi		O43182

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 6
Alternative name(s):
Rho-type GTPase-activating protein 6
Rho-type GTPase-activating protein RhoGAPX-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP6
Synonyms:RHOGAP6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000047648.21

Human Gene Nomenclature Database

More...HGNCi		HGNC:676, ARHGAP6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300118, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43182

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		395

Open Targets

More...OpenTargetsi		ENSG00000047648

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24960

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43182, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ARHGAP6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567041 – 974Rho GTPase-activating protein 6Add BLAST974

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei37PhosphoserineBy similarity1
Modified residuei264PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei680PhosphoserineCombined sources1
Modified residuei711PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei772PhosphoserineCombined sources1
Modified residuei777PhosphoserineCombined sources1
Modified residuei786PhosphoserineCombined sources1
Modified residuei820PhosphoserineCombined sources1
Modified residuei928PhosphoserineCombined sources1
Modified residuei931PhosphoserineCombined sources1
Modified residuei939PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43182

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43182

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43182

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43182

PeptideAtlas

More...PeptideAtlasi		O43182

PRoteomics IDEntifications database

More...PRIDEi		O43182

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48794 [O43182-1]
48795 [O43182-2]
48796 [O43182-3]
48797 [O43182-4]
48798 [O43182-5]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O43182-5 [O43182-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43182

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43182

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney, heart and skeletal muscle followed by retina, lymphoblast, placenta, lung, brain, pancreas and liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000047648, Expressed in seminal vesicle and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43182, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43182, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000047648, Tissue enhanced (ductus deferens, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106888, 2 interactors

Protein interaction database and analysis system

More...IntActi		O43182, 2 interactors

Molecular INTeraction database

More...MINTi		O43182

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000338967

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43182, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43182

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini401 – 602Rho-GAPPROSITE-ProRule annotationAdd BLAST202

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi342 – 352SH3-bindingAdd BLAST11

Keywords - Domaini

SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2710, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153904

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012874_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43182

Database of Orthologous Groups

More...OrthoDBi		419555at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43182

TreeFam database of animal gene trees

More...TreeFami		TF316710

Family and domain databases

Conserved Domains Database

More...CDDi		cd04376, RhoGAP_ARHGAP6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041852, ARHGAP6_RhoGAP
IPR008936, Rho_GTPase_activation_prot
IPR030772, RhoGAP6
IPR037863, RHOGAP6/36
IPR000198, RhoGAP_dom

The PANTHER Classification System

More...PANTHERi		PTHR12635, PTHR12635, 1 hit
PTHR12635:SF6, PTHR12635:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: O43182-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAQSLLHSV FSCSSPASSS AASAKGFSKR KLRQTRSLDP ALIGGCGSDE 
        60         70         80         90        100
AGAEGSARGA TAGRLYSPSL PAESLGPRLA SSSRGPPPRA TRLPPPGPLC 
       110        120        130        140        150
SSFSTPSTPQ EKSPSGSFHF DYEVPLGRGG LKKSMAWDLP SVLAGPASSR 
       160        170        180        190        200
SASSILCSSG GGPNGIFASP RRWLQQRKFQ SPPDSRGHPY VVWKSEGDFT 
       210        220        230        240        250
WNSMSGRSVR LRSVPIQSLS ELERARLQEV AFYQLQQDCD LSCQITIPKD 
       260        270        280        290        300
GQKRKKSLRK KLDSLGKEKN KDKEFIPQAF GMPLSQVIAN DRAYKLKQDL 
       310        320        330        340        350
QRDEQKDASD FVASLLPFGN KRQNKELSSS NSSLSSTSET PNESTSPNTP 
       360        370        380        390        400
EPAPRARRRG AMSVDSITDL DDNQSRLLEA LQLSLPAEAQ SKKEKARDKK 
       410        420        430        440        450
LSLNPIYRQV PRLVDSCCQH LEKHGLQTVG IFRVGSSKKR VRQLREEFDR 
       460        470        480        490        500
GIDVSLEEEH SVHDVAALLK EFLRDMPDPL LTRELYTAFI NTLLLEPEEQ 
       510        520        530        540        550
LGTLQLLIYL LPPCNCDTLH RLLQFLSIVA RHADDNISKD GQEVTGNKMT 
       560        570        580        590        600
SLNLATIFGP NLLHKQKSSD KEFSVQSSAR AEESTAIIAV VQKMIENYEA 
       610        620        630        640        650
LFMVPPDLQN EVLISLLETD PDVVDYLLRR KASQSSSPDM LQSEVSFSVG 
       660        670        680        690        700
GRHSSTDSNK ASSGDISPYD NNSPVLSERS LLAMQEDAAP GGSEKLYRVP 
       710        720        730        740        750
GQFMLVGHLS SSKSRESSPG PRLGKDLSEE PFDIWGTWHS TLKSGSKDPG 
       760        770        780        790        800
MTGSSGDIFE SSSLRAGPCS LSQGNLSPNW PRWQGSPAEL DSDTQGARRT 
       810        820        830        840        850
QAAAPATEGR AHPAVSRACS TPHVQVAGKA ERPTARSEQY LTLSGAHDLS 
       860        870        880        890        900
ESELDVAGLQ SRATPQCQRP HGSGRDDKRP PPPYPGPGKP AAAAAWIQGP 
       910        920        930        940        950
PEGVETPTDQ GGQAAEREQQ VTQKKLSSAN SLPAGEQDSP RLGDAGWLDW 
       960        970 
QRERWQIWEL LSTDNPDALP ETLV
Length:974
Mass (Da):105,947
Last modified:October 3, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEE22EB54F019E30
GO
Isoform 1 (identifier: O43182-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     726-765: DLSEEPFDIW...GDIFESSSLR → GNWSLASRRW...SSSLPYLMFL
     766-974: Missing.

Show »
Length:765
Mass (Da):83,926
Checksum:i992B50A957E7019E
GO
Isoform 2 (identifier: O43182-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     196-196: E → ELELYDLQILGTKPPMNSDTHRNFDPTATLRNQ
     637-658: SPDMLQSEVSFSVGGRHSSTDS → TSSVLPAAVQACPQYPASMFTP
     659-974: Missing.

Show »
Length:690
Mass (Da):75,918
Checksum:iEE1801C208E48DB9
GO
Isoform 4 (identifier: O43182-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.

Show »
Length:771
Mass (Da):84,844
Checksum:iA7CAEADB29590AAF
GO
Isoform 5 (identifier: O43182-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     726-765: DLSEEPFDIW...GDIFESSSLR → GNWSLASRRW...SSSLPYLMFL
     766-974: Missing.

Show »
Length:562
Mass (Da):62,822
Checksum:i96707FB1D7CBFC62
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYE6H7BYE6_HUMAN
Rho GTPase-activating protein 6
ARHGAP6
601Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DN07B4DN07_HUMAN
Rho GTPase-activating protein 6
ARHGAP6
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti231A → P in AAF43261 (PubMed:10699171).Curated1
Sequence conflicti231A → P in AAD55087 (PubMed:10699171).Curated1
Sequence conflicti231A → P in AAC98539 (PubMed:9417914).Curated1
Sequence conflicti231A → P in AAC98540 (PubMed:9417914).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024453791D → E1 PublicationCorresponds to variant dbSNP:rs1009758Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0016371 – 203Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_001638196E → ELELYDLQILGTKPPMNSDT HRNFDPTATLRNQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_001639637 – 658SPDML…SSTDS → TSSVLPAAVQACPQYPASMF TP in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_001640659 – 974Missing in isoform 2. 1 PublicationAdd BLAST316
Alternative sequenceiVSP_001641726 – 765DLSEE…SSSLR → GNWSLASRRWPKQATLLLLH VAWCGALRTFSSSLPYLMFL in isoform 1 and isoform 5. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_001642766 – 974Missing in isoform 1 and isoform 5. 2 PublicationsAdd BLAST209

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF117067 mRNA Translation: AAF43261.1
AF177663 mRNA Translation: AAD53166.1
AF177665 mRNA Translation: AAD55087.1
AF012272 mRNA Translation: AAC98539.2
AF022212 mRNA Translation: AAC98540.2
BC150635 mRNA Translation: AAI50636.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14140.1 [O43182-1]
CCDS14141.1 [O43182-4]
CCDS14142.1 [O43182-2]

Protein sequence database of the Protein Information Resource

More...PIRi		E59434

NCBI Reference Sequences

More...RefSeqi		NP_001274171.1, NM_001287242.1
NP_006116.2, NM_006125.2 [O43182-2]
NP_038267.1, NM_013423.2 [O43182-4]
NP_038286.2, NM_013427.2 [O43182-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000303025; ENSP00000302312; ENSG00000047648 [O43182-4]
ENST00000337414; ENSP00000338967; ENSG00000047648 [O43182-1]
ENST00000380718; ENSP00000370094; ENSG00000047648 [O43182-2]
ENST00000380736; ENSP00000370112; ENSG00000047648 [O43182-4]
ENST00000495242; ENSP00000435767; ENSG00000047648 [O43182-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		395

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:395

UCSC genome browser

More...UCSCi		uc004cum.2, human [O43182-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117067 mRNA Translation: AAF43261.1
AF177663 mRNA Translation: AAD53166.1
AF177665 mRNA Translation: AAD55087.1
AF012272 mRNA Translation: AAC98539.2
AF022212 mRNA Translation: AAC98540.2
BC150635 mRNA Translation: AAI50636.1
CCDSiCCDS14140.1 [O43182-1]
CCDS14141.1 [O43182-4]
CCDS14142.1 [O43182-2]
PIRiE59434
RefSeqiNP_001274171.1, NM_001287242.1
NP_006116.2, NM_006125.2 [O43182-2]
NP_038267.1, NM_013423.2 [O43182-4]
NP_038286.2, NM_013427.2 [O43182-1]

3D structure databases

SMRiO43182
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106888, 2 interactors
IntActiO43182, 2 interactors
MINTiO43182
STRINGi9606.ENSP00000338967

PTM databases

iPTMnetiO43182
PhosphoSitePlusiO43182

Polymorphism and mutation databases

BioMutaiARHGAP6

Proteomic databases

jPOSTiO43182
MassIVEiO43182
MaxQBiO43182
PaxDbiO43182
PeptideAtlasiO43182
PRIDEiO43182
ProteomicsDBi48794 [O43182-1]
48795 [O43182-2]
48796 [O43182-3]
48797 [O43182-4]
48798 [O43182-5]
TopDownProteomicsiO43182-5 [O43182-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23727, 58 antibodies

Genome annotation databases

EnsembliENST00000303025; ENSP00000302312; ENSG00000047648 [O43182-4]
ENST00000337414; ENSP00000338967; ENSG00000047648 [O43182-1]
ENST00000380718; ENSP00000370094; ENSG00000047648 [O43182-2]
ENST00000380736; ENSP00000370112; ENSG00000047648 [O43182-4]
ENST00000495242; ENSP00000435767; ENSG00000047648 [O43182-3]
GeneIDi395
KEGGihsa:395
UCSCiuc004cum.2, human [O43182-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		395
DisGeNETi395
EuPathDBiHostDB:ENSG00000047648.21

GeneCards: human genes, protein and diseases

More...GeneCardsi		ARHGAP6
HGNCiHGNC:676, ARHGAP6
HPAiENSG00000047648, Tissue enhanced (ductus deferens, seminal vesicle)
MIMi300118, gene
neXtProtiNX_O43182
OpenTargetsiENSG00000047648
PharmGKBiPA24960

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2710, Eukaryota
GeneTreeiENSGT00940000153904
HOGENOMiCLU_012874_0_0_1
InParanoidiO43182
OrthoDBi419555at2759
PhylomeDBiO43182
TreeFamiTF316710

Enzyme and pathway databases

PathwayCommonsiO43182
ReactomeiR-HSA-194840, Rho GTPase cycle
SIGNORiO43182

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		395, 7 hits in 468 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ARHGAP6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		395
PharosiO43182, Tbio

Protein Ontology

More...PROi		PR:O43182
RNActiO43182, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000047648, Expressed in seminal vesicle and 220 other tissues
ExpressionAtlasiO43182, baseline and differential
GenevisibleiO43182, HS

Family and domain databases

CDDicd04376, RhoGAP_ARHGAP6, 1 hit
Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR041852, ARHGAP6_RhoGAP
IPR008936, Rho_GTPase_activation_prot
IPR030772, RhoGAP6
IPR037863, RHOGAP6/36
IPR000198, RhoGAP_dom
PANTHERiPTHR12635, PTHR12635, 1 hit
PTHR12635:SF6, PTHR12635:SF6, 1 hit
PfamiView protein in Pfam
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238, RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG06_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43182
Secondary accession number(s): B2RWQ0
, O43437, Q9P1B3, Q9UK81, Q9UK82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2006
Last modified: December 2, 2020
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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