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UniProtKB - O43181 (NDUS4_HUMAN)

Entry version 181 (07 Apr 2021)
Sequence version 1 (01 Jun 1998)
Previous versions | rss
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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Gene

NDUFS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:ENSG00000164258-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43181

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-611105, Respiratory electron transport
R-HSA-6799198, Complex I biogenesis

SIGNOR Signaling Network Open Resource

More...SIGNORi		O43181

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Alternative name(s):
Complex I-18 kDa
Short name:
CI-18 kDa
Complex I-AQDQ
Short name:
CI-AQDQ
NADH-ubiquinone oxidoreductase 18 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDUFS4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7711, NDUFS4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602694, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43181

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000164258.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial complex I deficiency, nuclear type 1 (MC1DN1)7 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of mitochondrial complex I deficiency, the most common biochemical signature of mitochondrial disorders, a group of highly heterogeneous conditions characterized by defective oxidative phosphorylation, which collectively affects 1 in 5-10000 live births. Clinical disorders have variable severity, ranging from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07894315 – 175Missing in MC1DN1; loss of mitochondrial respiratory complex I; altered nonsense mediated mRNA decay. 2 PublicationsAdd BLAST161
Natural variantiVAR_07894497 – 175Missing in MC1DN1. 1 PublicationAdd BLAST79
Natural variantiVAR_078945106 – 175Missing in MC1DN1. 1 PublicationAdd BLAST70
Natural variantiVAR_078946119D → H in MC1DN1. 1 PublicationCorresponds to variant dbSNP:rs747359752EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi173S → A: Loss of phosphorylation. 1 Publication1

Keywords - Diseasei

Disease variant, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		4724

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		NDUFS4

MalaCards human disease database

More...MalaCardsi		NDUFS4
MIMi252010, phenotype

Open Targets

More...OpenTargetsi		ENSG00000164258

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2609, Isolated complex I deficiency
255241, Leigh syndrome with leukodystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31521

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43181, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2363065

Drug and drug target database

More...DrugBanki		DB00157, NADH

DrugCentral

More...DrugCentrali		O43181

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NDUFS4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 42MitochondrionBy similarityAdd BLAST42
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002003843 – 175NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialAdd BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei173Phosphoserine; by PKA1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43181

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43181

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43181

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43181

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43181

PeptideAtlas

More...PeptideAtlasi		O43181

PRoteomics IDEntifications database

More...PRIDEi		O43181

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48793

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O43181

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		O43181

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		O43181

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43181

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43181

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164258, Expressed in quadriceps femoris and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43181, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43181, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000164258, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.

Interacts with BCAP31 and TOMM40; the interaction mediates its translocation to the mitochondria; the interaction with BCAP31 is direct (PubMed:31206022).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110803, 164 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-577, Mitochondrial respiratory chain complex I

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O43181

Protein interaction database and analysis system

More...IntActi		O43181, 46 interactors

Molecular INTeraction database

More...MINTi		O43181

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000296684

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O43181

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43181, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43181

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I NDUFS4 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3389, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013835

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_077196_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43181

Identification of Orthologs from Complete Genome Data

More...OMAi		DYMQGTI

Database of Orthologous Groups

More...OrthoDBi		1507807at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43181

TreeFam database of animal gene trees

More...TreeFami		TF105619

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.160.190, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006885, NADH_UbQ_FeS_4_mit
IPR038532, NDUFS4-like_sf

The PANTHER Classification System

More...PANTHERi		PTHR12219, PTHR12219, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04800, ETC_C1_NDUFA4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O43181-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVSMSVVL RQTLWRRRAV AVAALSVSRV PTRSLRTSTW RLAQDQTQDT 
        60         70         80         90        100
QLITVDEKLD ITTLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME 
       110        120        130        140        150
FDTRERWENP LMGWASTADP LSNMVLTFST KEDAVSFAEK NGWSYDIEER 
       160        170 
KVPKPKSKSY GANFSWNKRT RVSTK
Length:175
Mass (Da):20,108
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE5B51DBDD76231E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9M8H0Y9M8_HUMAN
NADH dehydrogenase [ubiquinone] iro...
NDUFS4
116Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R916D6R916_HUMAN
NADH dehydrogenase [ubiquinone] iro...
NDUFS4
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REP1D6REP1_HUMAN
NADH dehydrogenase [ubiquinone] iro...
NDUFS4
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RI09D6RI09_HUMAN
NADH dehydrogenase Fe-S protein 4 1...
NDUFS4
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39T → S in AAH05270 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07894315 – 175Missing in MC1DN1; loss of mitochondrial respiratory complex I; altered nonsense mediated mRNA decay. 2 PublicationsAdd BLAST161
Natural variantiVAR_07894497 – 175Missing in MC1DN1. 1 PublicationAdd BLAST79
Natural variantiVAR_078945106 – 175Missing in MC1DN1. 1 PublicationAdd BLAST70
Natural variantiVAR_078946119D → H in MC1DN1. 1 PublicationCorresponds to variant dbSNP:rs747359752EnsemblClinVar.1
Natural variantiVAR_012037174T → P. Corresponds to variant dbSNP:rs1044692Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF020351 mRNA Translation: AAB87865.1
BC005270 mRNA Translation: AAH05270.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3960.1

NCBI Reference Sequences

More...RefSeqi		NP_002486.1, NM_002495.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000296684; ENSP00000296684; ENSG00000164258

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4724

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4724

UCSC genome browser

More...UCSCi		uc003jpe.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020351 mRNA Translation: AAB87865.1
BC005270 mRNA Translation: AAH05270.1
CCDSiCCDS3960.1
RefSeqiNP_002486.1, NM_002495.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTBelectron microscopy3.40L58-175[»]
5XTDelectron microscopy3.70L58-175[»]
5XTHelectron microscopy3.90L58-175[»]
5XTIelectron microscopy17.40BL/L58-175[»]
SMRiO43181
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110803, 164 interactors
ComplexPortaliCPX-577, Mitochondrial respiratory chain complex I
CORUMiO43181
IntActiO43181, 46 interactors
MINTiO43181
STRINGi9606.ENSP00000296684

Chemistry databases

BindingDBiO43181
ChEMBLiCHEMBL2363065
DrugBankiDB00157, NADH
DrugCentraliO43181

PTM databases

CarbonylDBiO43181
iPTMnetiO43181
PhosphoSitePlusiO43181

Genetic variation databases

BioMutaiNDUFS4

2D gel databases

UCD-2DPAGEiO43181

Proteomic databases

EPDiO43181
jPOSTiO43181
MassIVEiO43181
MaxQBiO43181
PaxDbiO43181
PeptideAtlasiO43181
PRIDEiO43181
ProteomicsDBi48793
TopDownProteomicsiO43181

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1269, 294 antibodies

The DNASU plasmid repository

More...DNASUi		4724

Genome annotation databases

EnsembliENST00000296684; ENSP00000296684; ENSG00000164258
GeneIDi4724
KEGGihsa:4724
UCSCiuc003jpe.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4724
DisGeNETi4724

GeneCards: human genes, protein and diseases

More...GeneCardsi		NDUFS4
GeneReviewsiNDUFS4
HGNCiHGNC:7711, NDUFS4
HPAiENSG00000164258, Low tissue specificity
MalaCardsiNDUFS4
MIMi252010, phenotype
602694, gene
neXtProtiNX_O43181
OpenTargetsiENSG00000164258
Orphaneti2609, Isolated complex I deficiency
255241, Leigh syndrome with leukodystrophy
PharmGKBiPA31521
VEuPathDBiHostDB:ENSG00000164258.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3389, Eukaryota
GeneTreeiENSGT00390000013835
HOGENOMiCLU_077196_3_0_1
InParanoidiO43181
OMAiDYMQGTI
OrthoDBi1507807at2759
PhylomeDBiO43181
TreeFamiTF105619

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000164258-MONOMER
PathwayCommonsiO43181
ReactomeiR-HSA-611105, Respiratory electron transport
R-HSA-6799198, Complex I biogenesis
SIGNORiO43181

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4724, 6 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NDUFS4, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NDUFS4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4724
PharosiO43181, Tclin

Protein Ontology

More...PROi		PR:O43181
RNActiO43181, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000164258, Expressed in quadriceps femoris and 246 other tissues
ExpressionAtlasiO43181, baseline and differential
GenevisibleiO43181, HS

Family and domain databases

Gene3Di3.30.160.190, 1 hit
InterProiView protein in InterPro
IPR006885, NADH_UbQ_FeS_4_mit
IPR038532, NDUFS4-like_sf
PANTHERiPTHR12219, PTHR12219, 1 hit
PfamiView protein in Pfam
PF04800, ETC_C1_NDUFA4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDUS4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43181
Secondary accession number(s): Q9BS69
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: April 7, 2021
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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