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Protein

Signal-induced proliferation-associated 1-like protein 1

Gene

SIPA1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-induced proliferation-associated 1-like protein 1
Short name:
SIPA1-like protein 1
Alternative name(s):
High-risk human papilloma viruses E6 oncoproteins targeted protein 1
Short name:
E6-targeted protein 1
Gene namesi
Name:SIPA1L1
Synonyms:E6TP1, KIAA0440
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000197555.9
HGNCiHGNC:20284 SIPA1L1
MIMi617504 gene
neXtProtiNX_O43166

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi26037
OpenTargetsiENSG00000197555
PharmGKBiPA134940118

Polymorphism and mutation databases

BioMutaiSIPA1L1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567461 – 1804Signal-induced proliferation-associated 1-like protein 1Add BLAST1804

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei1078PhosphoserineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1116PhosphoserineCombined sources1
Modified residuei1127PhosphoserineBy similarity1
Modified residuei1149PhosphoserineCombined sources1
Modified residuei1170PhosphoserineCombined sources1
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1255PhosphoserineCombined sources1
Modified residuei1270PhosphoserineCombined sources1
Modified residuei1326Phosphoserine; by PLK2By similarity1
Modified residuei1330Phosphothreonine; by PLK2By similarity1
Modified residuei1349Phosphoserine; by CDK5By similarity1
Modified residuei1366PhosphoserineCombined sources1
Modified residuei1390PhosphoserineCombined sources1
Modified residuei1391PhosphoserineCombined sources1
Modified residuei1412PhosphoserineCombined sources1
Modified residuei1431PhosphoserineCombined sources1
Modified residuei1433PhosphoserineCombined sources1
Modified residuei1528PhosphoserineCombined sources1
Modified residuei1549PhosphoserineCombined sources1
Modified residuei1551PhosphothreonineCombined sources1
Modified residuei1554PhosphoserineCombined sources1
Modified residuei1565PhosphoserineCombined sources1
Modified residuei1568PhosphoserineCombined sources1
Modified residuei1585PhosphoserineCombined sources1
Modified residuei1588PhosphoserineCombined sources1
Modified residuei1601Asymmetric dimethylarginineBy similarity1
Modified residuei1603PhosphoserineBy similarity1
Modified residuei1645PhosphoserineBy similarity1
Modified residuei1647PhosphoserineBy similarity1
Modified residuei1650PhosphoserineBy similarity1
Modified residuei1708PhosphoserineBy similarity1
Modified residuei1711PhosphoserineBy similarity1
Modified residuei1728PhosphoserineBy similarity1
Modified residuei1729PhosphoserineBy similarity1
Modified residuei1734PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2.By similarity
Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43166
MaxQBiO43166
PaxDbiO43166
PeptideAtlasiO43166
PRIDEiO43166
ProteomicsDBi48783
48784 [O43166-2]

PTM databases

iPTMnetiO43166
PhosphoSitePlusiO43166

Miscellaneous databases

PMAP-CutDBiO43166

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000197555 Expressed in 228 organ(s), highest expression level in caudate nucleus
CleanExiHS_SIPA1L1
ExpressionAtlasiO43166 baseline and differential
GenevisibleiO43166 HS

Organism-specific databases

HPAiHPA002875

Interactioni

Subunit structurei

Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with HPV E6.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117503, 100 interactors
IntActiO43166, 22 interactors
MINTiO43166
STRINGi9606.ENSP00000450832

Structurei

3D structure databases

ProteinModelPortaliO43166
SMRiO43166
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini613 – 830Rap-GAPPROSITE-ProRule annotationAdd BLAST218
Domaini967 – 1045PDZPROSITE-ProRule annotationAdd BLAST79

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1735 – 1795Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi107 – 143Ser-richAdd BLAST37
Compositional biasi1154 – 1157Poly-Ser4
Compositional biasi1291 – 1486Ser-richAdd BLAST196

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00760000119182
HOGENOMiHOG000154319
HOVERGENiHBG056135
InParanoidiO43166
KOiK17701
OMAiKAMEIDC
OrthoDBiEOG091G016P
PhylomeDBiO43166
TreeFamiTF318626

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR030770 SIPA1L1
IPR021818 SIPA1L_C
PANTHERiPTHR15711:SF10 PTHR15711:SF10, 1 hit
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
PF11881 SPAR_C, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43166-1) [UniParc]FASTAAdd to basket
Also known as: E6TP1 beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSLKRSQTE RPLATDRASV VGTDGTPKVH TDDFYMRRFR SQNGSLGSSV
60 70 80 90 100
MAPVGPPRSE GSHHITSTPG VPKMGVRARI ADWPPRKENI KESSRSSQEI
110 120 130 140 150
ETSSCLDSLS SKSSPVSQGS SVSLNSNDSA MLKSIQNTLK NKTRPSENMD
160 170 180 190 200
SRFLMPEAYP SSPRKALRRI RQRSNSDITI SELDVDSFDE CISPTYKTGP
210 220 230 240 250
SLHREYGSTS SIDKQGTSGE SFFDLLKGYK DDKSDRGPTP TKLSDFLITG
260 270 280 290 300
GGKGSGFSLD VIDGPISQRE NLRLFKEREK PLKRRSKSET GDSSIFRKLR
310 320 330 340 350
NAKGEELGKS SDLEDNRSED SVRPWTCPKC FAHYDVQSIL FDLNEAIMNR
360 370 380 390 400
HNVIKRRNTT TGASAAAVAS LVSGPLSHSA SFSSPMGSTE DLNSKGSLSM
410 420 430 440 450
DQGDDKSNEL VMSCPYFRNE IGGEGERKIS LSKSNSGSFS GCESASFEST
460 470 480 490 500
LSSHCTNAGV AVLEVPKENL VLHLDRVKRY IVEHVDLGAY YYRKFFYQKE
510 520 530 540 550
HWNYFGADEN LGPVAVSIRR EKPDEMKENG SPYNYRIIFR TSELMTLRGS
560 570 580 590 600
VLEDAIPSTA KHSTARGLPL KEVLEHVVPE LNVQCLRLAF NTPKVTEQLM
610 620 630 640 650
KLDEQGLNYQ QKVGIMYCKA GQSTEEEMYN NESAGPAFEE FLQLLGERVR
660 670 680 690 700
LKGFEKYRAQ LDTKTDSTGT HSLYTTYKDY EIMFHVSTML PYTPNNKQQL
710 720 730 740 750
LRKRHIGNDI VTIVFQEPGA QPFSPKNIRS HFQHVFVIVR VHNPCSDSVC
760 770 780 790 800
YSVAVTRSRD VPSFGPPIPK GVTFPKSNVF RDFLLAKVIN AENAAHKSEK
810 820 830 840 850
FRAMATRTRQ EYLKDLAEKN VTNTPIDPSG KFPFISLASK KKEKSKPYPG
860 870 880 890 900
AELSSMGAIV WAVRAEDYNK AMELDCLLGI SNEFIVLIEQ ETKSVVFNCS
910 920 930 940 950
CRDVIGWTST DTSLKIFYER GECVSVGSFI NIEEIKEIVK RLQFVSKGCE
960 970 980 990 1000
SVEMTLRRNG LGQLGFHVNY EGIVADVEPY GYAWQAGLRQ GSRLVEICKV
1010 1020 1030 1040 1050
AVATLSHEQM IDLLRTSVTV KVVIIPPHDD CTPRRSCSET YRMPVMEYKM
1060 1070 1080 1090 1100
NEGVSYEFKF PFRNNNKWQR NASKGPHSPQ VPSQVQSPMT SRLNAGKGDG
1110 1120 1130 1140 1150
KMPPPERAAN IPRSISSDGR PLERRLSPGS DIYVTVSSMA LARSQCRNSP
1160 1170 1180 1190 1200
SNLSSSSDTG SVGGTYRQKS MPEGFGVSRR SPASIDRQNT QSDIGGSGKS
1210 1220 1230 1240 1250
TPSWQRSEDS IADQMAYSYR GPQDFNSFVL EQHEYTEPTC HLPAVSKVLP
1260 1270 1280 1290 1300
AFRESPSGRL MRQDPVVHLS PNKQGHSDSH YSSHSSSNTL SSNASSAHSD
1310 1320 1330 1340 1350
EKWYDGDRTE SELNSYNYLQ GTSADSGIDT TSYGPSHGST ASLGAATSSP
1360 1370 1380 1390 1400
RSGPGKEKVA PLWHSSSEVI SMADRTLETE SHGLDRKTES SLSLDIHSKS
1410 1420 1430 1440 1450
QAGSTPLTRE NSTFSINDAA SHTSTMSSRH SASPVVFTSA RSSPKEELHP
1460 1470 1480 1490 1500
AAPSQLAPSF SSSSSSSSGP RSFYPRQGAT SKYLIGWKKP EGTINSVGFM
1510 1520 1530 1540 1550
DTRKRHQSDG NEIAHTRLRA STRDLRASPK PTSKSTIEED LKKLIDLESP
1560 1570 1580 1590 1600
TPESQKSFKF HALSSPQSPF PSTPTSRRAL HRTLSDESIY NSQREHFFTS
1610 1620 1630 1640 1650
RASLLDQALP NDVLFSSTYP SLPKSLPLRR PSYTLGMKSL HGEFSASDSS
1660 1670 1680 1690 1700
LTDIQETRRQ PMPDPGLMPL PDTAADLDWS NLVDAAKAYE VQRASFFAAS
1710 1720 1730 1740 1750
DENHRPLSAA SNSDQLEDQA LAQMKPYSSS KDSSPTLASK VDQLEGMLKM
1760 1770 1780 1790 1800
LREDLKKEKE DKAHLQAEVQ HLREDNLRLQ EESQNASDKL KKFTEWVFNT

IDMS
Length:1,804
Mass (Da):200,029
Last modified:October 3, 2006 - v4
Checksum:i91AB6AB4E7F47B2F
GO
Isoform 2 (identifier: O43166-2) [UniParc]FASTAAdd to basket
Also known as: E6TP1 alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1216-1236: Missing.

Show »
Length:1,783
Mass (Da):197,495
Checksum:i8C9FB14DBD867FCC
GO
Isoform 3 (identifier: O43166-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1216-1236: Missing.
     1728-1728: Missing.

Note: No experimental confirmation available.
Show »
Length:1,782
Mass (Da):197,408
Checksum:iDFF4318DCB195EC5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GYF8F5GYF8_HUMAN
Signal-induced proliferation-associ...
SIPA1L1
1,257Annotation score:
H0YJY2H0YJY2_HUMAN
Signal-induced proliferation-associ...
SIPA1L1
261Annotation score:
G3V4Z3G3V4Z3_HUMAN
Signal-induced proliferation-associ...
SIPA1L1
32Annotation score:

Sequence cautioni

The sequence BAA23712 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1387K → R in AK122930 (PubMed:14702039).Curated1
Sequence conflicti1722A → P in BAA23712 (PubMed:9455477).Curated1
Sequence conflicti1730Missing in BAA23712 (PubMed:9455477).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04915256P → T. Corresponds to variant dbSNP:rs12884638Ensembl.1
Natural variantiVAR_035549996E → D in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0109171216 – 1236Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_0547741728Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090989 mRNA Translation: AAD12543.1
AF090990 mRNA Translation: AAD12544.1
AB007900 mRNA Translation: BAA23712.2 Different initiation.
AK122930 mRNA No translation available.
AC004974 Genomic DNA Translation: AAC83179.1
AC004900 Genomic DNA No translation available.
AC004968 Genomic DNA No translation available.
AC005476 Genomic DNA No translation available.
AC005994 Genomic DNA No translation available.
AL391735 Genomic DNA No translation available.
CCDSiCCDS61490.1 [O43166-2]
CCDS61491.1 [O43166-3]
CCDS9807.1 [O43166-1]
RefSeqiNP_001271174.1, NM_001284245.1 [O43166-2]
NP_001271175.1, NM_001284246.1 [O43166-3]
NP_056371.1, NM_015556.2 [O43166-1]
XP_005267573.1, XM_005267516.4 [O43166-1]
XP_011534932.1, XM_011536630.1 [O43166-1]
XP_011534933.1, XM_011536631.1 [O43166-1]
XP_011534934.1, XM_011536632.1 [O43166-1]
XP_011534937.1, XM_011536635.2 [O43166-1]
XP_016876648.1, XM_017021159.1
XP_016876649.1, XM_017021160.1
XP_016876650.1, XM_017021161.1
XP_016876651.1, XM_017021162.1
XP_016876652.1, XM_017021163.1 [O43166-1]
XP_016876653.1, XM_017021164.1
XP_016876654.1, XM_017021165.1
XP_016876655.1, XM_017021166.1
XP_016876656.1, XM_017021167.1
XP_016876657.1, XM_017021168.1
XP_016876658.1, XM_017021169.1
XP_016876659.1, XM_017021170.1
XP_016876660.1, XM_017021171.1
XP_016876661.1, XM_017021172.1
XP_016876662.1, XM_017021173.1
XP_016876663.1, XM_017021174.1
XP_016876664.1, XM_017021175.1
XP_016876665.1, XM_017021176.1
XP_016876666.1, XM_017021177.1 [O43166-1]
XP_016876667.1, XM_017021178.1 [O43166-1]
XP_016876668.1, XM_017021179.1 [O43166-1]
XP_016876669.1, XM_017021180.1 [O43166-1]
XP_016876675.1, XM_017021186.1
XP_016876676.1, XM_017021187.1
XP_016876677.1, XM_017021188.1
XP_016876678.1, XM_017021189.1
XP_016876679.1, XM_017021190.1
XP_016876680.1, XM_017021191.1
XP_016876681.1, XM_017021192.1
XP_016876682.1, XM_017021193.1
UniGeneiHs.654657

Genome annotation databases

EnsembliENST00000358550; ENSP00000351352; ENSG00000197555 [O43166-3]
ENST00000381232; ENSP00000370630; ENSG00000197555 [O43166-2]
ENST00000555818; ENSP00000450832; ENSG00000197555 [O43166-1]
GeneIDi26037
KEGGihsa:26037
UCSCiuc001xms.5 human [O43166-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090989 mRNA Translation: AAD12543.1
AF090990 mRNA Translation: AAD12544.1
AB007900 mRNA Translation: BAA23712.2 Different initiation.
AK122930 mRNA No translation available.
AC004974 Genomic DNA Translation: AAC83179.1
AC004900 Genomic DNA No translation available.
AC004968 Genomic DNA No translation available.
AC005476 Genomic DNA No translation available.
AC005994 Genomic DNA No translation available.
AL391735 Genomic DNA No translation available.
CCDSiCCDS61490.1 [O43166-2]
CCDS61491.1 [O43166-3]
CCDS9807.1 [O43166-1]
RefSeqiNP_001271174.1, NM_001284245.1 [O43166-2]
NP_001271175.1, NM_001284246.1 [O43166-3]
NP_056371.1, NM_015556.2 [O43166-1]
XP_005267573.1, XM_005267516.4 [O43166-1]
XP_011534932.1, XM_011536630.1 [O43166-1]
XP_011534933.1, XM_011536631.1 [O43166-1]
XP_011534934.1, XM_011536632.1 [O43166-1]
XP_011534937.1, XM_011536635.2 [O43166-1]
XP_016876648.1, XM_017021159.1
XP_016876649.1, XM_017021160.1
XP_016876650.1, XM_017021161.1
XP_016876651.1, XM_017021162.1
XP_016876652.1, XM_017021163.1 [O43166-1]
XP_016876653.1, XM_017021164.1
XP_016876654.1, XM_017021165.1
XP_016876655.1, XM_017021166.1
XP_016876656.1, XM_017021167.1
XP_016876657.1, XM_017021168.1
XP_016876658.1, XM_017021169.1
XP_016876659.1, XM_017021170.1
XP_016876660.1, XM_017021171.1
XP_016876661.1, XM_017021172.1
XP_016876662.1, XM_017021173.1
XP_016876663.1, XM_017021174.1
XP_016876664.1, XM_017021175.1
XP_016876665.1, XM_017021176.1
XP_016876666.1, XM_017021177.1 [O43166-1]
XP_016876667.1, XM_017021178.1 [O43166-1]
XP_016876668.1, XM_017021179.1 [O43166-1]
XP_016876669.1, XM_017021180.1 [O43166-1]
XP_016876675.1, XM_017021186.1
XP_016876676.1, XM_017021187.1
XP_016876677.1, XM_017021188.1
XP_016876678.1, XM_017021189.1
XP_016876679.1, XM_017021190.1
XP_016876680.1, XM_017021191.1
XP_016876681.1, XM_017021192.1
XP_016876682.1, XM_017021193.1
UniGeneiHs.654657

3D structure databases

ProteinModelPortaliO43166
SMRiO43166
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117503, 100 interactors
IntActiO43166, 22 interactors
MINTiO43166
STRINGi9606.ENSP00000450832

PTM databases

iPTMnetiO43166
PhosphoSitePlusiO43166

Polymorphism and mutation databases

BioMutaiSIPA1L1

Proteomic databases

EPDiO43166
MaxQBiO43166
PaxDbiO43166
PeptideAtlasiO43166
PRIDEiO43166
ProteomicsDBi48783
48784 [O43166-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358550; ENSP00000351352; ENSG00000197555 [O43166-3]
ENST00000381232; ENSP00000370630; ENSG00000197555 [O43166-2]
ENST00000555818; ENSP00000450832; ENSG00000197555 [O43166-1]
GeneIDi26037
KEGGihsa:26037
UCSCiuc001xms.5 human [O43166-1]

Organism-specific databases

CTDi26037
DisGeNETi26037
EuPathDBiHostDB:ENSG00000197555.9
GeneCardsiSIPA1L1
HGNCiHGNC:20284 SIPA1L1
HPAiHPA002875
MIMi617504 gene
neXtProtiNX_O43166
OpenTargetsiENSG00000197555
PharmGKBiPA134940118
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00760000119182
HOGENOMiHOG000154319
HOVERGENiHBG056135
InParanoidiO43166
KOiK17701
OMAiKAMEIDC
OrthoDBiEOG091G016P
PhylomeDBiO43166
TreeFamiTF318626

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiSIPA1L1 human
GeneWikiiSIPA1L1
GenomeRNAii26037
PMAP-CutDBiO43166
PROiPR:O43166
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197555 Expressed in 228 organ(s), highest expression level in caudate nucleus
CleanExiHS_SIPA1L1
ExpressionAtlasiO43166 baseline and differential
GenevisibleiO43166 HS

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR030770 SIPA1L1
IPR021818 SIPA1L_C
PANTHERiPTHR15711:SF10 PTHR15711:SF10, 1 hit
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
PF11881 SPAR_C, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSI1L1_HUMAN
AccessioniPrimary (citable) accession number: O43166
Secondary accession number(s): J3KP19
, O95321, Q9UDU4, Q9UNU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 164 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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