PJA2

Functionⁱ

Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450).3 Publications

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	634 – 675	RING-type; atypicalPROSITE-ProRule annotationAdd BLAST		42

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
protein kinase A catalytic subunit binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21423175
protein kinase A regulatory subunit binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21423175
ubiquitin protein ligase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin-protein transferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21423175

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

hippo signaling Source: InterPro
inflammatory response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28471450
innate immune response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28471450
long-term memory Source: UniProtKB
positive regulation of JNK cascade
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28471450
positive regulation of p38MAPK cascade
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28471450
positive regulation of toll-like receptor 2 signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28471450
protein ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 21423175
regulation of macrophage activation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28471450
regulation of protein kinase A signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21423175

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E3 ubiquitin-protein ligase Praja-2 (EC:2.3.2.27) Short name: Praja2 Alternative name(s): RING finger protein 131 RING-type E3 ubiquitin transferase Praja-2Curated
Gene namesⁱ	Name:PJA2 Synonyms:KIAA0438, RNF131
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198961.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17481 PJA2
neXtProtⁱ	NX_O43164

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9867
Open Targets More...OpenTargetsⁱ	ENSG00000198961
PharmGKBⁱ	PA134873520

Polymorphism and mutation databases

BioMutaⁱ	PJA2

BioMutaⁱ

PJA2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000278230	2 – 708	E3 ubiquitin-protein ligase Praja-2Add BLAST		707

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserine1 Publication	1
Modified residueⁱ	196	PhosphoserineCombined sources	1
Modified residueⁱ	246	PhosphothreonineCombined sources	1
Modified residueⁱ	253	PhosphoserineCombined sources	1
Modified residueⁱ	309	PhosphoserineCombined sources	1
Modified residueⁱ	323	PhosphoserineCombined sources	1
Modified residueⁱ	342	Phosphoserine; by PKA1 Publication	1
Modified residueⁱ	389	Phosphothreonine; by PKA1 Publication	1
Modified residueⁱ	432	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O43164
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43164
PaxDbⁱ	O43164
PeptideAtlas More...PeptideAtlasⁱ	O43164
PRIDEⁱ	O43164
ProteomicsDBⁱ	48781 48782 [O43164-2]

PTM databases

iPTMnetⁱ	O43164
PhosphoSitePlusⁱ	O43164

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198961 Expressed in 240 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_PJA2
Genevisibleⁱ	O43164 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040347 HPA057636

HPAⁱ

HPA040347
HPA057636

Interactionⁱ

Subunit structureⁱ

Binds ubiquitin-conjugating enzymes (E2s). In vitro, interacts with the ubiquitin-conjugating enzyme, UBE2D2. The phosphorylated form interacts with PRKAR1A, PRKAR2A and PRKAR2B. Binds the catalytic subunits of cAMP-dependent protein kinase. Interacts with MFHAS1 (PubMed:28471450).3 Publications

GO - Molecular functionⁱ

protein kinase A catalytic subunit binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21423175
protein kinase A regulatory subunit binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21423175

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115200, 36 interactors
Database of interacting proteins More...DIPⁱ	DIP-47040N
IntActⁱ	O43164, 30 interactors
Molecular INTeraction database More...MINTⁱ	O43164
STRINGⁱ	9606.ENSP00000354775

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43164
SMRⁱ	O43164
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	531 – 708	Interaction with PRKAR1A, PRKAR2A and PRKAR2B1 PublicationAdd BLAST		178

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	634 – 675	RING-type; atypicalPROSITE-ProRule annotationAdd BLAST		42

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0800 Eukaryota ENOG41121N2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062967
HOGENOMⁱ	HOG000230900
HOVERGENⁱ	HBG003815
InParanoidⁱ	O43164
KEGG Orthology (KO) More...KOⁱ	K10634
OMAⁱ	VRKKQQN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0306
PhylomeDBⁱ	O43164
TreeFamⁱ	TF330711

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR030639 Praja-2 IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR15710:SF5 PTHR15710:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13639 zf-RING_2, 1 hit
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS50089 ZF_RING_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: O43164-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQYTEKEPA AMDQESGKAV WPKPAGGYQT ITGRRYGRRH AYVSFKPCMT 
        60         70         80         90        100
RHERSLGRAG DDYEVLELDD VPKENSSGSS PLDQVDSSLP SEPIFEKSET 
       110        120        130        140        150
EIPTCGSALN QTTESSQSFV AVHHSEEGRD TLGSSTNLHN HSEGEYIPGA 
       160        170        180        190        200
CSASSVQNGI ALVHTDSYDP DGKHGEDNDH LQLSAEVVEG SRYQESLGNT 
       210        220        230        240        250
VFELENREAE AYTGLSPPVP SFNCEVRDEF EELDSVPLVK SSAGDTEFVH 
       260        270        280        290        300
QNSQEIQRSS QDEMVSTKQQ NNTSQERQTE HSPEDAACGP GHICSEQNTN 
       310        320        330        340        350
DREKNHGSSP EQVVRPKVRK LISSSQVDQE TGFNRHEAKQ RSVQRWREAL 
       360        370        380        390        400
EVEESGSDDL LIKCEEYDGE HDCMFLDPPY SRVITQRETE NNQMTSESGA 
       410        420        430        440        450
TAGRQEVDNT FWNGCGDYYQ LYDKDEDSSE CSDGEWSASL PHRFSGTEKD 
       460        470        480        490        500
QSSSDESWET LPGKDENEPE LQSDSSGPEE ENQELSLQEG EQTSLEEGEI 
       510        520        530        540        550
PWLQYNEVNE SSSDEGNEPA NEFAQPAFML DGNNNLEDDS SVSEDLDVDW 
       560        570        580        590        600
SLFDGFADGL GVAEAISYVD PQFLTYMALE ERLAQAMETA LAHLESLAVD 
       610        620        630        640        650
VEVANPPASK ESIDGLPETL VLEDHTAIGQ EQCCPICCSE YIKDDIATEL 
       660        670        680        690        700
PCHHFFHKPC VSIWLQKSGT CPVCRRHFPP AVIEASAAPS SEPDPDAPPS 

NDSIAEAP

Length:708

Mass (Da):78,214

Last modified:November 24, 2009 - v4

Checksum:ⁱ719B4A367C411735

GO

Isoform 2 (identifier: O43164-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
544-563: Missing.

« Hide

        10         20         30         40         50
MSQYTEKEPA AMDQESGKAV WPKPAGGYQT ITGRRYGRRH AYVSFKPCMT 
        60         70         80         90        100
RHERSLGRAG DDYEVLELDD VPKENSSGSS PLDQVDSSLP SEPIFEKSET 
       110        120        130        140        150
EIPTCGSALN QTTESSQSFV AVHHSEEGRD TLGSSTNLHN HSEGEYIPGA 
       160        170        180        190        200
CSASSVQNGI ALVHTDSYDP DGKHGEDNDH LQLSAEVVEG SRYQESLGNT 
       210        220        230        240        250
VFELENREAE AYTGLSPPVP SFNCEVRDEF EELDSVPLVK SSAGDTEFVH 
       260        270        280        290        300
QNSQEIQRSS QDEMVSTKQQ NNTSQERQTE HSPEDAACGP GHICSEQNTN 
       310        320        330        340        350
DREKNHGSSP EQVVRPKVRK LISSSQVDQE TGFNRHEAKQ RSVQRWREAL 
       360        370        380        390        400
EVEESGSDDL LIKCEEYDGE HDCMFLDPPY SRVITQRETE NNQMTSESGA 
       410        420        430        440        450
TAGRQEVDNT FWNGCGDYYQ LYDKDEDSSE CSDGEWSASL PHRFSGTEKD 
       460        470        480        490        500
QSSSDESWET LPGKDENEPE LQSDSSGPEE ENQELSLQEG EQTSLEEGEI 
       510        520        530        540        550
PWLQYNEVNE SSSDEGNEPA NEFAQPAFML DGNNNLEDDS SVSEAISYVD 
       560        570        580        590        600
PQFLTYMALE ERLAQAMETA LAHLESLAVD VEVANPPASK ESIDGLPETL 
       610        620        630        640        650
VLEDHTAIGQ EQCCPICCSE YIKDDIATEL PCHHFFHKPC VSIWLQKSGT 
       660        670        680 
CPVCRRHFPP AVIEASAAPS SEPDPDAPPS NDSIAEAP

Note: No experimental confirmation available.

Show »

Length:688

Mass (Da):76,091

Checksum:ⁱ34A652ACAF3A02FE

GO

Sequence cautionⁱ

The sequence BAA23710 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_057215	176	E → G. Corresponds to variant dbSNP:rs35224970Ensembl.	1
Natural variantⁱVAR_030698	297	Q → R2 PublicationsCorresponds to variant dbSNP:rs1045706Ensembl.	1
Natural variantⁱVAR_030699	705	A → T. Corresponds to variant dbSNP:rs246105Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_023198	544 – 563	Missing in isoform 2. 1 PublicationAdd BLAST		20

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB007898 mRNA Translation: BAA23710.2 Different initiation. AK291759 mRNA Translation: BAF84448.1 AC008467 Genomic DNA No translation available. AC010625 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49050.1 CH471086 Genomic DNA Translation: EAW49051.1 BC030826 mRNA Translation: AAH30826.1 CR749579 mRNA Translation: CAH18371.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4099.1 [O43164-1]
PIRⁱ	T00064
NCBI Reference Sequences More...RefSeqⁱ	NP_055634.3, NM_014819.4 [O43164-1] XP_016865588.1, XM_017010099.1 [O43164-1]
UniGeneⁱ	Hs.483036

Genome annotation databases

Ensemblⁱ	ENST00000361189; ENSP00000354775; ENSG00000198961 [O43164-1] ENST00000361557; ENSP00000355284; ENSG00000198961 [O43164-1]
GeneIDⁱ	9867
KEGGⁱ	hsa:9867
UCSC genome browser More...UCSCⁱ	uc003kos.5 human [O43164-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43164	E3 ubiquitin-protein ligase Praja-2		PONAB		708	UniRef90_O43164
Uncharacterized protein		Cebus capucinus imitator		709
E3 ubiquitin-protein ligase Praja-2		CALJA		709
Praja ring finger ubiquitin ligase 2		SAIBB		709
E3 ubiquitin-protein ligase Praja-2		MACMU		708
+37

Protein	Similar proteins		Species	Score	Length	Source
O43164	E3 ubiquitin-protein ligase Praja-2		PONAB		708	UniRef50_O43164
E3 ubiquitin-protein ligase Praja-2		MOUSE		707
E3 ubiquitin-protein ligase Praja-2		RAT		707
E3 ubiquitin-protein ligase Praja-2		CALJA		709
Praja ring finger ubiquitin ligase 2		SAIBB		709
+159

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB007898 mRNA Translation: BAA23710.2 Different initiation. AK291759 mRNA Translation: BAF84448.1 AC008467 Genomic DNA No translation available. AC010625 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49050.1 CH471086 Genomic DNA Translation: EAW49051.1 BC030826 mRNA Translation: AAH30826.1 CR749579 mRNA Translation: CAH18371.1
CCDSⁱ	CCDS4099.1 [O43164-1]
PIRⁱ	T00064
RefSeqⁱ	NP_055634.3, NM_014819.4 [O43164-1] XP_016865588.1, XM_017010099.1 [O43164-1]
UniGeneⁱ	Hs.483036

3D structure databases

ProteinModelPortalⁱ	O43164
SMRⁱ	O43164
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115200, 36 interactors
DIPⁱ	DIP-47040N
IntActⁱ	O43164, 30 interactors
MINTⁱ	O43164
STRINGⁱ	9606.ENSP00000354775

PTM databases

iPTMnetⁱ	O43164
PhosphoSitePlusⁱ	O43164

Polymorphism and mutation databases

BioMutaⁱ	PJA2

BioMutaⁱ

PJA2

Proteomic databases

EPDⁱ	O43164
MaxQBⁱ	O43164
PaxDbⁱ	O43164
PeptideAtlasⁱ	O43164
PRIDEⁱ	O43164
ProteomicsDBⁱ	48781 48782 [O43164-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000361189; ENSP00000354775; ENSG00000198961 [O43164-1] ENST00000361557; ENSP00000355284; ENSG00000198961 [O43164-1]
GeneIDⁱ	9867
KEGGⁱ	hsa:9867
UCSCⁱ	uc003kos.5 human [O43164-1]

Organism-specific databases

CTDⁱ	9867
DisGeNETⁱ	9867
EuPathDBⁱ	HostDB:ENSG00000198961.9
GeneCardsⁱ	PJA2
H-InvDBⁱ	HIX0005075
HGNCⁱ	HGNC:17481 PJA2
HPAⁱ	HPA040347 HPA057636
neXtProtⁱ	NX_O43164
OpenTargetsⁱ	ENSG00000198961
PharmGKBⁱ	PA134873520
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0800 Eukaryota ENOG41121N2 LUCA
GeneTreeⁱ	ENSGT00530000062967
HOGENOMⁱ	HOG000230900
HOVERGENⁱ	HBG003815
InParanoidⁱ	O43164
KOⁱ	K10634
OMAⁱ	VRKKQQN
OrthoDBⁱ	EOG091G0306
PhylomeDBⁱ	O43164
TreeFamⁱ	TF330711

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSⁱ	PJA2 human
GeneWikiⁱ	PJA2
GenomeRNAiⁱ	9867
Protein Ontology More...PROⁱ	PR:O43164

Gene expression databases

Bgeeⁱ	ENSG00000198961 Expressed in 240 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_PJA2
Genevisibleⁱ	O43164 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR030639 Praja-2 IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR15710:SF5 PTHR15710:SF5, 1 hit
Pfamⁱ	View protein in Pfam PF13639 zf-RING_2, 1 hit
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PJA2_HUMAN
Accessionⁱ	O43164Primary (citable) accession number: O43164 Secondary accession number(s): A8K6U4 , D3DSZ5, Q68D49, Q8N1G5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
	Last sequence update:	November 24, 2009
	Last modified:	November 7, 2018
	This is version 157 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - O43164 (PJA2_HUMAN)

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E3 ubiquitin-protein ligase Praja-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Plasma membrane

Golgi apparatus

Other locations

Cytoskeleton

Endoplasmic reticulum

Golgi apparatus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ