UniProtKB - O43159 (RRP8_HUMAN)

BLAST

>sp|O43159|RRP8_HUMAN Ribosomal RNA-processing protein 8 OS=Homo sapiens OX=9606 GN=RRP8 PE=1 SV=2
MFEEPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLC
ISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQA
LVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPP
HTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGALRA
RMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIA
RDLRQRPASLVVADFGCGDCRLASSIRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVA
VFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDVRTFLRAVTKLGFKIVSKDLT
NSHFFLFDFQKTGPPLVGPKAQLSGLQLQPCLYKRR

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History
Entry version 156 (07 Nov 2018)
Sequence version 2 (26 Apr 2005)
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Protein

Ribosomal RNA-processing protein 8

Gene

RRP8

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD⁺/NADP⁺ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	281	S-adenosyl-L-methionineCombined sources1 Publication	1
Binding siteⁱ	316	S-adenosyl-L-methionine; via carbonyl oxygenCombined sources1 Publication	1
Binding siteⁱ	334	S-adenosyl-L-methionineCombined sources1 Publication	1
Binding siteⁱ	346	S-adenosyl-L-methionineCombined sources1 Publication	1
Binding siteⁱ	347	S-adenosyl-L-methionineCombined sources1 Publication	1
Binding siteⁱ	363	S-adenosyl-L-methionine; via carbonyl oxygenCombined sources1 Publication	1

GO - Molecular functionⁱ

methylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18485871
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
S-adenosylmethionine-dependent methyltransferase activity
Source: UniProtKB
Traceable author statementⁱ
- 18485871

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to glucose starvation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21471221
chromatin silencing at rDNA
Source: UniProtKB
Inferred from direct assayⁱ
- 18485871
intrinsic apoptotic signaling pathway by p53 class mediator
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21471221
positive regulation of cell cycle arrest
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21471221
regulation of transcription by glucose
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21471221
rRNA processing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, Methyltransferase, Repressor, Transferase
Biological process	rRNA processing, Transcription, Transcription regulation
Ligand	S-adenosyl-L-methionine

Enzyme and pathway databases

Reactomeⁱ	R-HSA-427359 SIRT1 negatively regulates rRNA expression

Reactomeⁱ

R-HSA-427359 SIRT1 negatively regulates rRNA expression

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribosomal RNA-processing protein 8 (EC:2.1.1.-) Alternative name(s): Cerebral protein 1 Nucleomethylin
Gene namesⁱ	Name:RRP8 Synonyms:KIAA0409, NML ORF Names:hucep-1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000132275.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29030 RRP8
MIMⁱ	615818 gene
neXtProtⁱ	NX_O43159

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23378
Open Targets More...OpenTargetsⁱ	ENSG00000132275
PharmGKBⁱ	PA164725550

Polymorphism and mutation databases

BioMutaⁱ	RRP8

BioMutaⁱ

RRP8

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084090	1 – 456	Ribosomal RNA-processing protein 8Add BLAST		456

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	62	PhosphoserineCombined sources	1
Modified residueⁱ	64	PhosphoserineCombined sources	1
Modified residueⁱ	104	PhosphoserineCombined sources	1
Modified residueⁱ	171	PhosphoserineCombined sources	1
Modified residueⁱ	176	PhosphoserineCombined sources	1
Modified residueⁱ	223	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O43159
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43159
PaxDbⁱ	O43159
PeptideAtlas More...PeptideAtlasⁱ	O43159
PRIDEⁱ	O43159
ProteomicsDBⁱ	48780

2D gel databases

SWISS-2DPAGEⁱ	O43159

SWISS-2DPAGEⁱ

O43159

PTM databases

iPTMnetⁱ	O43159
PhosphoSitePlusⁱ	O43159

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000132275 Expressed in 190 organ(s), highest expression level in lower esophagus muscularis layer
CleanExⁱ	HS_KIAA0409
ExpressionAtlasⁱ	O43159 baseline and differential
Genevisibleⁱ	O43159 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038487 HPA057562

HPAⁱ

HPA038487
HPA057562

Interactionⁱ

Subunit structureⁱ

Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SIRT1	Q96EB6	3	EBI-2008793,EBI-1802965
SUV39H1	O43463	3	EBI-2008793,EBI-349968

GO - Molecular functionⁱ

methylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18485871

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116954, 131 interactors
ComplexPortalⁱ	CPX-467 eNoSc complex
Database of interacting proteins More...DIPⁱ	DIP-46686N
IntActⁱ	O43159, 14 interactors
Molecular INTeraction database More...MINTⁱ	O43159
STRINGⁱ	9606.ENSP00000254605

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	244 – 260	Combined sources	17
Helixⁱ	263 – 272	Combined sources	10
Helixⁱ	274 – 288	Combined sources	15
Beta strandⁱ	291 – 293	Combined sources	3
Helixⁱ	295 – 304	Combined sources	10
Beta strandⁱ	312 – 316	Combined sources	5
Helixⁱ	321 – 325	Combined sources	5
Beta strandⁱ	330 – 336	Combined sources	7
Beta strandⁱ	342 – 345	Combined sources	4
Beta strandⁱ	357 – 364	Combined sources	8
Helixⁱ	371 – 381	Combined sources	11
Beta strandⁱ	382 – 392	Combined sources	11
Helixⁱ	394 – 396	Combined sources	3
Helixⁱ	400 – 409	Combined sources	10
Beta strandⁱ	412 – 418	Combined sources	7
Beta strandⁱ	425 – 431	Combined sources	7
Helixⁱ	444 – 446	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	O43159
SMRⁱ	O43159
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

O43159

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	65 – 70	Poly-Glu		6

Sequence similaritiesⁱ

Belongs to the methyltransferase superfamily. RRP8 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3045 Eukaryota ENOG4111J8Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006189
HOGENOMⁱ	HOG000164004
InParanoidⁱ	O43159
KEGG Orthology (KO) More...KOⁱ	K14850
OMAⁱ	QTGPKAW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0K2R
PhylomeDBⁱ	O43159
TreeFamⁱ	TF313749

Family and domain databases

InterProⁱ	View protein in InterPro IPR007823 RRP8 IPR029063 SAM-dependent_MTases IPR023576 UbiE/COQ5_MeTrFase_CS
PANTHERⁱ	PTHR12787 PTHR12787, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05148 Methyltransf_8, 1 hit
SUPFAMⁱ	SSF53335 SSF53335, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

O43159-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFEEPEWAEA APVAAGLGPV ISRPPPAASS QNKGSKRRQL LATLRALEAA 
        60         70         80         90        100
SLSQHPPSLC ISDSEEEEEE RKKKCPKKAS FASASAEVGK KGKKKCQKQG 
       110        120        130        140        150
PPCSDSEEEV ERKKKCHKQA LVGSDSAEDE KRKRKCQKHA PINSAQHLDN 
       160        170        180        190        200
VDQTGPKAWK GSTTNDPPKQ SPGSTSPKPP HTLSRKQWRN RQKNKRRCKN 
       210        220        230        240        250
KFQPPQVPDQ APAEAPTEKT EVSPVPRTDS HEARAGALRA RMAQRLDGAR 
       260        270        280        290        300
FRYLNEQLYS GPSSAAQRLF QEDPEAFLLY HRGFQSQVKK WPLQPVDRIA 
       310        320        330        340        350
RDLRQRPASL VVADFGCGDC RLASSIRNPV HCFDLASLDP RVTVCDMAQV 
       360        370        380        390        400
PLEDESVDVA VFCLSLMGTN IRDFLEEANR VLKPGGLLKV AEVSSRFEDV 
       410        420        430        440        450
RTFLRAVTKL GFKIVSKDLT NSHFFLFDFQ KTGPPLVGPK AQLSGLQLQP 

CLYKRR

Length:456

Mass (Da):50,715

Last modified:April 26, 2005 - v2

Checksum:ⁱ49251E2A488DA1C4

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PPP6	E9PPP6_HUMAN	Ribosomal RNA-processing protein 8 Ribosomal RNA-processing protein 8	RRP8	140	Annotation score:
E9PPY3	E9PPY3_HUMAN	Ribosomal RNA-processing protein 8 Ribosomal RNA-processing protein 8	RRP8	306	Annotation score:
E9PS87	E9PS87_HUMAN	Ribosomal RNA-processing protein 8 Ribosomal RNA-processing protein 8	RRP8	78	Annotation score:

Sequence cautionⁱ

The sequence BAA23705 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051034	145	A → P. Corresponds to variant dbSNP:rs11040934Ensembl.		1
Natural variantⁱVAR_051035	329	P → S. Corresponds to variant dbSNP:rs17834692Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D87060 mRNA Translation: BAB46916.1 AB007869 mRNA Translation: BAA23705.1 Different initiation. BC001071 mRNA Translation: AAH01071.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31411.1
NCBI Reference Sequences More...RefSeqⁱ	NP_056139.1, NM_015324.3
UniGeneⁱ	Hs.652255

Genome annotation databases

Ensemblⁱ	ENST00000254605; ENSP00000254605; ENSG00000132275
GeneIDⁱ	23378
KEGGⁱ	hsa:23378
UCSC genome browser More...UCSCⁱ	uc001med.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43159	Ribosomal RNA-processing protein 8		HUMAN		306	UniRef100_O43159
UPI000187C1FF		HUMAN		215

Protein	Similar proteins		Species	Score	Length	Source
O43159	Ribosomal RNA-processing protein 8		HUMAN		306	UniRef90_O43159
Uncharacterized protein		PANPA		456
Uncharacterized protein		MANLE		456
Uncharacterized protein		RHIRO		456
RRP8 isoform 1		PONAB		456
+20

Protein	Similar proteins		Species	Score	Length	Source
O43159	Ribosomal RNA-processing protein 8		RAT		457	UniRef50_O43159
Ribosomal RNA-processing protein 8		MOUSE		457
Ribosomal RNA-processing protein 8		HUMAN		306
Uncharacterized protein		RHIRO		456
Ribosomal RNA processing 8, methyltransferase, homolog		PANTR		456
+187

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D87060 mRNA Translation: BAB46916.1 AB007869 mRNA Translation: BAA23705.1 Different initiation. BC001071 mRNA Translation: AAH01071.1
CCDSⁱ	CCDS31411.1
RefSeqⁱ	NP_056139.1, NM_015324.3
UniGeneⁱ	Hs.652255

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2ZFU	X-ray	2.00	A/B	242-456	[»]
ProteinModelPortalⁱ	O43159
SMRⁱ	O43159
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116954, 131 interactors
ComplexPortalⁱ	CPX-467 eNoSc complex
DIPⁱ	DIP-46686N
IntActⁱ	O43159, 14 interactors
MINTⁱ	O43159
STRINGⁱ	9606.ENSP00000254605

PTM databases

iPTMnetⁱ	O43159
PhosphoSitePlusⁱ	O43159

Polymorphism and mutation databases

BioMutaⁱ	RRP8

BioMutaⁱ

RRP8

2D gel databases

SWISS-2DPAGEⁱ	O43159

SWISS-2DPAGEⁱ

O43159

Proteomic databases

EPDⁱ	O43159
MaxQBⁱ	O43159
PaxDbⁱ	O43159
PeptideAtlasⁱ	O43159
PRIDEⁱ	O43159
ProteomicsDBⁱ	48780

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23378
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000254605; ENSP00000254605; ENSG00000132275
GeneIDⁱ	23378
KEGGⁱ	hsa:23378
UCSCⁱ	uc001med.4 human

Organism-specific databases

CTDⁱ	23378
DisGeNETⁱ	23378
EuPathDBⁱ	HostDB:ENSG00000132275.10
GeneCardsⁱ	RRP8
HGNCⁱ	HGNC:29030 RRP8
HPAⁱ	HPA038487 HPA057562
MIMⁱ	615818 gene
neXtProtⁱ	NX_O43159
OpenTargetsⁱ	ENSG00000132275
PharmGKBⁱ	PA164725550
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3045 Eukaryota ENOG4111J8Z LUCA
GeneTreeⁱ	ENSGT00390000006189
HOGENOMⁱ	HOG000164004
InParanoidⁱ	O43159
KOⁱ	K14850
OMAⁱ	QTGPKAW
OrthoDBⁱ	EOG091G0K2R
PhylomeDBⁱ	O43159
TreeFamⁱ	TF313749

Enzyme and pathway databases

Reactomeⁱ	R-HSA-427359 SIRT1 negatively regulates rRNA expression

Reactomeⁱ

R-HSA-427359 SIRT1 negatively regulates rRNA expression

Miscellaneous databases

EvolutionaryTraceⁱ	O43159
GeneWikiⁱ	KIAA0409
GenomeRNAiⁱ	23378
Protein Ontology More...PROⁱ	PR:O43159
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000132275 Expressed in 190 organ(s), highest expression level in lower esophagus muscularis layer
CleanExⁱ	HS_KIAA0409
ExpressionAtlasⁱ	O43159 baseline and differential
Genevisibleⁱ	O43159 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007823 RRP8 IPR029063 SAM-dependent_MTases IPR023576 UbiE/COQ5_MeTrFase_CS
PANTHERⁱ	PTHR12787 PTHR12787, 1 hit
Pfamⁱ	View protein in Pfam PF05148 Methyltransf_8, 1 hit
SUPFAMⁱ	SSF53335 SSF53335, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RRP8_HUMAN
Accessionⁱ	O43159Primary (citable) accession number: O43159 Secondary accession number(s): Q7KZ78, Q9BVM6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
	Last sequence update:	April 26, 2005
	Last modified:	November 7, 2018
	This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniRef

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Supporting data

UniProtKB - O43159 (RRP8_HUMAN)

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Ribosomal RNA-processing protein 8

RRP8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ