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UniProtKB - O43157 (PLXB1_HUMAN)

Protein

Plexin-B1

Gene

PLXNB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1815Important for interaction with RAC1 and RND11

GO - Molecular functioni

  • GTPase activating protein binding Source: BHF-UCL
  • GTPase activator activity Source: Reactome
  • semaphorin receptor activity Source: UniProtKB
  • semaphorin receptor binding Source: UniProtKB
  • signaling receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-416482 G alpha (12/13) signalling events
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
SIGNORiO43157

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-B1
Alternative name(s):
Semaphorin receptor SEP
Gene namesi
Name:PLXNB1
Synonyms:KIAA0407, PLXN5, SEP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000164050.12
HGNCiHGNC:9103 PLXNB1
MIMi601053 gene
neXtProtiNX_O43157

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1490ExtracellularSequence analysisAdd BLAST1471
Transmembranei1491 – 1511HelicalSequence analysisAdd BLAST21
Topological domaini1512 – 2135CytoplasmicSequence analysisAdd BLAST624

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi139D → K: Strongly reduced interaction with SEMA4D. 1 Publication1
Mutagenesisi1302 – 1305RRRR → AAAA: Abolishes cleavage by proprotein convertases. 1 Publication4
Mutagenesisi1815L → F or P: Abolishes interaction with RAC1 and RND1. 1 Publication1
Mutagenesisi1884 – 1885WH → SS: Loss of cytoskeleton remodeling in response to SEMA4D. 1 Publication2

Organism-specific databases

DisGeNETi5364
OpenTargetsiENSG00000164050
PharmGKBiPA33429

Polymorphism and mutation databases

BioMutaiPLXNB1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002467120 – 2135Plexin-B1Add BLAST2116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi79 ↔ 88PROSITE-ProRule annotation
Disulfide bondi111 ↔ 119PROSITE-ProRule annotation
Disulfide bondi252 ↔ 377PROSITE-ProRule annotation
Disulfide bondi268 ↔ 322PROSITE-ProRule annotation
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi340 ↔ 364PROSITE-ProRule annotation
Disulfide bondi482 ↔ 499PROSITE-ProRule annotation
Disulfide bondi488 ↔ 533PROSITE-ProRule annotation
Disulfide bondi491 ↔ 508PROSITE-ProRule annotation
Disulfide bondi502 ↔ 514PROSITE-ProRule annotation
Glycosylationi543N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi570 ↔ 588PROSITE-ProRule annotation
Glycosylationi1183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1253N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi1330N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.2 Publications
Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1305 – 1306Cleavage; by proprotein convertases2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO43157
MaxQBiO43157
PaxDbiO43157
PeptideAtlasiO43157
PRIDEiO43157
ProteomicsDBi48777
48778 [O43157-2]
48779 [O43157-3]

PTM databases

GlyConnecti1612
iPTMnetiO43157
PhosphoSitePlusiO43157

Expressioni

Tissue specificityi

Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.1 Publication

Gene expression databases

BgeeiENSG00000164050 Expressed in 189 organ(s), highest expression level in right uterine tube
CleanExiHS_PLXNB1
GenevisibleiO43157 HS

Organism-specific databases

HPAiHPA040586

Interactioni

Subunit structurei

Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Interacts with ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RRAS, RHOD, RND1, NRP1 and NRP2.By similarity13 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi111377, 22 interactors
CORUMiO43157
DIPiDIP-36742N
IntActiO43157, 19 interactors
MINTiO43157
STRINGi9606.ENSP00000296440

Structurei

Secondary structure

12135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43157
SMRiO43157
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43157

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 479SemaPROSITE-ProRule annotationAdd BLAST460
Domaini1070 – 1160IPT/TIG 1Add BLAST91
Domaini1162 – 1249IPT/TIG 2Add BLAST88
Domaini1252 – 1375IPT/TIG 3Add BLAST124

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1507 – 1539Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi678 – 829Pro-richAdd BLAST152
Compositional biasi1302 – 1305Poly-Arg4

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231376
HOVERGENiHBG053404
InParanoidiO43157
KOiK06821
OMAiGHVQYDG
OrthoDBiEOG091G00EK
PhylomeDBiO43157
TreeFamiTF312962

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O43157-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPALGPALLQ ALWAGWVLTL QPLPPTAFTP NGTYLQHLAR DPTSGTLYLG 
        60         70         80         90        100
ATNFLFQLSP GLQLEATVST GPVLDSRDCL PPVMPDECPQ AQPTNNPNQL 
       110        120        130        140        150
LLVSPGALVV CGSVHQGVCE QRRLGQLEQL LLRPERPGDT QYVAANDPAV 
       160        170        180        190        200
STVGLVAQGL AGEPLLFVGR GYTSRGVGGG IPPITTRALW PPDPQAAFSY 
       210        220        230        240        250
EETAKLAVGR LSEYSHHFVS AFARGASAYF LFLRRDLQAQ SRAFRAYVSR 
       260        270        280        290        300
VCLRDQHYYS YVELPLACEG GRYGLIQAAA VATSREVAHG EVLFAAFSSA 
       310        320        330        340        350
APPTVGRPPS AAAGASGASA LCAFPLDEVD RLANRTRDAC YTREGRAEDG 
       360        370        380        390        400
TEVAYIEYDV NSDCAQLPVD TLDAYPCGSD HTPSPMASRV PLEATPILEW 
       410        420        430        440        450
PGIQLTAVAV TMEDGHTIAF LGDSQGQLHR VYLGPGSDGH PYSTQSIQQG 
       460        470        480        490        500
SAVSRDLTFD GTFEHLYVMT QSTLLKVPVA SCAQHLDCAS CLAHRDPYCG 
       510        520        530        540        550
WCVLLGRCSR RSECSRGQGP EQWLWSFQPE LGCLQVAAMS PANISREETR 
       560        570        580        590        600
EVFLSVPDLP PLWPGESYSC HFGEHQSPAL LTGSGVMCPS PDPSEAPVLP 
       610        620        630        640        650
RGADYVSVSV ELRFGAVVIA KTSLSFYDCV AVTELRPSAQ CQACVSSRWG 
       660        670        680        690        700
CNWCVWQHLC THKASCDAGP MVASHQSPLV SPDPPARGGP SPSPPTAPKA 
       710        720        730        740        750
LATPAPDTLP VEPGAPSTAT ASDISPGASP SLLSPWGPWA GSGSISSPGS 
       760        770        780        790        800
TGSPLHEEPS PPSPQNGPGT AVPAPTDFRP SATPEDLLAS PLSPSEVAAV 
       810        820        830        840        850
PPADPGPEAL HPTVPLDLPP ATVPATTFPG AMGSVKPALD WLTREGGELP 
       860        870        880        890        900
EADEWTGGDA PAFSTSTLLS GDGDSAELEG PPAPLILPSS LDYQYDTPGL 
       910        920        930        940        950
WELEEATLGA SSCPCVESVQ GSTLMPVHVE REIRLLGRNL HLFQDGPGDN 
       960        970        980        990       1000
ECVMELEGLE VVVEARVECE PPPDTQCHVT CQQHQLSYEA LQPELRVGLF 
      1010       1020       1030       1040       1050
LRRAGRLRVD SAEGLHVVLY DCSVGHGDCS RCQTAMPQYG CVWCEGERPR 
      1060       1070       1080       1090       1100
CVTREACGEA EAVATQCPAP LIHSVEPLTG PVDGGTRVTI RGSNLGQHVQ 
      1110       1120       1130       1140       1150
DVLGMVTVAG VPCAVDAQEY EVSSSLVCIT GASGEEVAGA TAVEVPGRGR 
      1160       1170       1180       1190       1200
GVSEHDFAYQ DPKVHSIFPA RGPRAGGTRL TLNGSKLLTG RLEDIRVVVG 
      1210       1220       1230       1240       1250
DQPCHLLPEQ QSEQLRCETS PRPTPATLPV AVWFGATERR LQRGQFKYTL 
      1260       1270       1280       1290       1300
DPNITSAGPT KSFLSGGREI CVRGQNLDVV QTPRIRVTVV SRMLQPSQGL 
      1310       1320       1330       1340       1350
GRRRRVVPET ACSLGPSCSS QQFEEPCHVN SSQLITCRTP ALPGLPEDPW 
      1360       1370       1380       1390       1400
VRVEFILDNL VFDFATLNPT PFSYEADPTL QPLNPEDPTM PFRHKPGSVF 
      1410       1420       1430       1440       1450
SVEGENLDLA MSKEEVVAMI GDGPCVVKTL TRHHLYCEPP VEQPLPRHHA 
      1460       1470       1480       1490       1500
LREAPDSLPE FTVQMGNLRF SLGHVQYDGE SPGAFPVAAQ VGLGVGTSLL 
      1510       1520       1530       1540       1550
ALGVIIIVLM YRRKSKQALR DYKKVQIQLE NLESSVRDRC KKEFTDLMTE 
      1560       1570       1580       1590       1600
MTDLTSDLLG SGIPFLDYKV YAERIFFPGH RESPLHRDLG VPESRRPTVE 
      1610       1620       1630       1640       1650
QGLGQLSNLL NSKLFLTKFI HTLESQRTFS ARDRAYVASL LTVALHGKLE 
      1660       1670       1680       1690       1700
YFTDILRTLL SDLVAQYVAK NPKLMLRRTE TVVEKLLTNW MSICLYTFVR 
      1710       1720       1730       1740       1750
DSVGEPLYML FRGIKHQVDK GPVDSVTGKA KYTLNDNRLL REDVEYRPLT 
      1760       1770       1780       1790       1800
LNALLAVGPG AGEAQGVPVK VLDCDTISQA KEKMLDQLYK GVPLTQRPDP 
      1810       1820       1830       1840       1850
RTLDVEWRSG VAGHLILSDE DVTSEVQGLW RRLNTLQHYK VPDGATVALV 
      1860       1870       1880       1890       1900
PCLTKHVLRE NQDYVPGERT PMLEDVDEGG IRPWHLVKPS DEPEPPRPRR 
      1910       1920       1930       1940       1950
GSLRGGERER AKAIPEIYLT RLLSMKGTLQ KFVDDLFQVI LSTSRPVPLA 
      1960       1970       1980       1990       2000
VKYFFDLLDE QAQQHGISDQ DTIHIWKTNS LPLRFWINII KNPQFVFDVQ 
      2010       2020       2030       2040       2050
TSDNMDAVLL VIAQTFMDAC TLADHKLGRD SPINKLLYAR DIPRYKRMVE 
      2060       2070       2080       2090       2100
RYYADIRQTV PASDQEMNSV LAELSWNYSG DLGARVALHE LYKYINKYYD 
      2110       2120       2130 
QIITALEEDG TAQKMQLGYR LQQIAAAVEN KVTDL
Length:2,135
Mass (Da):232,298
Last modified:August 31, 2004 - v3
Checksum:i12A81B68AF1D340F
GO
Isoform 2 (identifier: O43157-2) [UniParc]FASTAAdd to basket
Also known as: Isoform R

The sequence of this isoform differs from the canonical sequence as follows:
     688-870: Missing.

Show »
Length:1,952
Mass (Da):214,411
Checksum:iFCAD0630E128EE9C
GO
Isoform 3 (identifier: O43157-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     677-729: SPLVSPDPPA...TASDISPGAS → VMETQQSLRA...PVWRAFRAPR
     730-2135: Missing.

Show »
Length:729
Mass (Da):78,395
Checksum:i4AE56E0EDBAE6D75
GO

Sequence cautioni

The sequence BAA23703 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1297S → N in CAB57277 (PubMed:8570614).Curated1
Sequence conflicti1625S → T in CAB57277 (PubMed:8570614).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050598389R → W. Corresponds to variant dbSNP:rs34050056Ensembl.1
Natural variantiVAR_050599753S → L. Corresponds to variant dbSNP:rs35592743Ensembl.1
Natural variantiVAR_0360741891D → V in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011513677 – 729SPLVS…SPGAS → VMETQQSLRALPPPSSSRPA STTSMTPPGSGSWKRRPWGQ APAPVWRAFRAPR in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_011514688 – 870Missing in isoform 2. 1 PublicationAdd BLAST183
Alternative sequenceiVSP_011515730 – 2135Missing in isoform 3. 1 PublicationAdd BLAST1406

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007867 mRNA Translation: BAA23703.2 Different initiation.
AJ011414 mRNA Translation: CAB56221.1
AJ011415 mRNA Translation: CAB56222.1
X87904 mRNA Translation: CAB57277.1
CH471055 Genomic DNA Translation: EAW64865.1
BC146793 mRNA Translation: AAI46794.1
CCDSiCCDS2765.1 [O43157-1]
RefSeqiNP_001123554.1, NM_001130082.2 [O43157-1]
NP_002664.2, NM_002673.5 [O43157-1]
XP_016862120.1, XM_017006631.1 [O43157-1]
UniGeneiHs.476209

Genome annotation databases

EnsembliENST00000296440; ENSP00000296440; ENSG00000164050 [O43157-1]
ENST00000358536; ENSP00000351338; ENSG00000164050 [O43157-1]
ENST00000449094; ENSP00000395987; ENSG00000164050 [O43157-3]
ENST00000456774; ENSP00000414199; ENSG00000164050 [O43157-2]
GeneIDi5364
KEGGihsa:5364
UCSCiuc003csu.3 human [O43157-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007867 mRNA Translation: BAA23703.2 Different initiation.
AJ011414 mRNA Translation: CAB56221.1
AJ011415 mRNA Translation: CAB56222.1
X87904 mRNA Translation: CAB57277.1
CH471055 Genomic DNA Translation: EAW64865.1
BC146793 mRNA Translation: AAI46794.1
CCDSiCCDS2765.1 [O43157-1]
RefSeqiNP_001123554.1, NM_001130082.2 [O43157-1]
NP_002664.2, NM_002673.5 [O43157-1]
XP_016862120.1, XM_017006631.1 [O43157-1]
UniGeneiHs.476209

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JPHNMR-A1743-1862[»]
2OS6NMR-B2128-2135[»]
2R2OX-ray2.00A/B1743-1862[»]
2REXX-ray2.30A/C1743-1862[»]
3HM6X-ray2.40X1511-2135[»]
3OL2X-ray2.99B20-535[»]
3SU8X-ray3.20X1533-2135[»]
3SUAX-ray4.39D/E/F1511-2135[»]
5B4WX-ray2.60A/B/C/D/E/F20-535[»]
ProteinModelPortaliO43157
SMRiO43157
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111377, 22 interactors
CORUMiO43157
DIPiDIP-36742N
IntActiO43157, 19 interactors
MINTiO43157
STRINGi9606.ENSP00000296440

PTM databases

GlyConnecti1612
iPTMnetiO43157
PhosphoSitePlusiO43157

Polymorphism and mutation databases

BioMutaiPLXNB1

Proteomic databases

EPDiO43157
MaxQBiO43157
PaxDbiO43157
PeptideAtlasiO43157
PRIDEiO43157
ProteomicsDBi48777
48778 [O43157-2]
48779 [O43157-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296440; ENSP00000296440; ENSG00000164050 [O43157-1]
ENST00000358536; ENSP00000351338; ENSG00000164050 [O43157-1]
ENST00000449094; ENSP00000395987; ENSG00000164050 [O43157-3]
ENST00000456774; ENSP00000414199; ENSG00000164050 [O43157-2]
GeneIDi5364
KEGGihsa:5364
UCSCiuc003csu.3 human [O43157-1]

Organism-specific databases

CTDi5364
DisGeNETi5364
EuPathDBiHostDB:ENSG00000164050.12
GeneCardsiPLXNB1
HGNCiHGNC:9103 PLXNB1
HPAiHPA040586
MIMi601053 gene
neXtProtiNX_O43157
OpenTargetsiENSG00000164050
PharmGKBiPA33429
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231376
HOVERGENiHBG053404
InParanoidiO43157
KOiK06821
OMAiGHVQYDG
OrthoDBiEOG091G00EK
PhylomeDBiO43157
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-HSA-416482 G alpha (12/13) signalling events
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
SIGNORiO43157

Miscellaneous databases

ChiTaRSiPLXNB1 human
EvolutionaryTraceiO43157
GeneWikiiPLXNB1
GenomeRNAii5364
PROiPR:O43157
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164050 Expressed in 189 organ(s), highest expression level in right uterine tube
CleanExiHS_PLXNB1
GenevisibleiO43157 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLXB1_HUMAN
AccessioniPrimary (citable) accession number: O43157
Secondary accession number(s): A6H8Y2
, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 7, 2018
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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