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Protein

Plexin-B1

Gene

PLXNB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1815Important for interaction with RAC1 and RND11

GO - Molecular functioni

  • GTPase activating protein binding Source: BHF-UCL
  • GTPase activator activity Source: Reactome
  • semaphorin receptor activity Source: UniProtKB
  • semaphorin receptor binding Source: UniProtKB
  • signaling receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-416482 G alpha (12/13) signalling events
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
SIGNORiO43157

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-B1
Alternative name(s):
Semaphorin receptor SEP
Gene namesi
Name:PLXNB1
Synonyms:KIAA0407, PLXN5, SEP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000164050.12
HGNCiHGNC:9103 PLXNB1
MIMi601053 gene
neXtProtiNX_O43157

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1490ExtracellularSequence analysisAdd BLAST1471
Transmembranei1491 – 1511HelicalSequence analysisAdd BLAST21
Topological domaini1512 – 2135CytoplasmicSequence analysisAdd BLAST624

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi139D → K: Strongly reduced interaction with SEMA4D. 1 Publication1
Mutagenesisi1302 – 1305RRRR → AAAA: Abolishes cleavage by proprotein convertases. 1 Publication4
Mutagenesisi1815L → F or P: Abolishes interaction with RAC1 and RND1. 1 Publication1
Mutagenesisi1884 – 1885WH → SS: Loss of cytoskeleton remodeling in response to SEMA4D. 1 Publication2

Organism-specific databases

DisGeNETi5364
OpenTargetsiENSG00000164050
PharmGKBiPA33429

Polymorphism and mutation databases

BioMutaiPLXNB1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002467120 – 2135Plexin-B1Add BLAST2116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi79 ↔ 88PROSITE-ProRule annotation
Disulfide bondi111 ↔ 119PROSITE-ProRule annotation
Disulfide bondi252 ↔ 377PROSITE-ProRule annotation
Disulfide bondi268 ↔ 322PROSITE-ProRule annotation
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi340 ↔ 364PROSITE-ProRule annotation
Disulfide bondi482 ↔ 499PROSITE-ProRule annotation
Disulfide bondi488 ↔ 533PROSITE-ProRule annotation
Disulfide bondi491 ↔ 508PROSITE-ProRule annotation
Disulfide bondi502 ↔ 514PROSITE-ProRule annotation
Glycosylationi543N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi570 ↔ 588PROSITE-ProRule annotation
Glycosylationi1183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1253N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi1330N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.2 Publications
Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1305 – 1306Cleavage; by proprotein convertases2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO43157
MaxQBiO43157
PaxDbiO43157
PeptideAtlasiO43157
PRIDEiO43157
ProteomicsDBi48777
48778 [O43157-2]
48779 [O43157-3]

PTM databases

GlyConnecti1612
iPTMnetiO43157
PhosphoSitePlusiO43157

Expressioni

Tissue specificityi

Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.1 Publication

Gene expression databases

BgeeiENSG00000164050 Expressed in 189 organ(s), highest expression level in right uterine tube
CleanExiHS_PLXNB1
GenevisibleiO43157 HS

Organism-specific databases

HPAiHPA040586

Interactioni

Subunit structurei

Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Interacts with ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RRAS, RHOD, RND1, NRP1 and NRP2.By similarity13 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111377, 22 interactors
CORUMiO43157
DIPiDIP-36742N
IntActiO43157, 19 interactors
MINTiO43157
STRINGi9606.ENSP00000296440

Structurei

Secondary structure

12135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43157
SMRiO43157
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43157

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 479SemaPROSITE-ProRule annotationAdd BLAST460
Domaini1070 – 1160IPT/TIG 1Add BLAST91
Domaini1162 – 1249IPT/TIG 2Add BLAST88
Domaini1252 – 1375IPT/TIG 3Add BLAST124

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1507 – 1539Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi678 – 829Pro-richAdd BLAST152
Compositional biasi1302 – 1305Poly-Arg4

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231376
HOVERGENiHBG053404
InParanoidiO43157
KOiK06821
OMAiGHVQYDG
OrthoDBiEOG091G00EK
PhylomeDBiO43157
TreeFamiTF312962

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O43157-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPALGPALLQ ALWAGWVLTL QPLPPTAFTP NGTYLQHLAR DPTSGTLYLG
60 70 80 90 100
ATNFLFQLSP GLQLEATVST GPVLDSRDCL PPVMPDECPQ AQPTNNPNQL
110 120 130 140 150
LLVSPGALVV CGSVHQGVCE QRRLGQLEQL LLRPERPGDT QYVAANDPAV
160 170 180 190 200
STVGLVAQGL AGEPLLFVGR GYTSRGVGGG IPPITTRALW PPDPQAAFSY
210 220 230 240 250
EETAKLAVGR LSEYSHHFVS AFARGASAYF LFLRRDLQAQ SRAFRAYVSR
260 270 280 290 300
VCLRDQHYYS YVELPLACEG GRYGLIQAAA VATSREVAHG EVLFAAFSSA
310 320 330 340 350
APPTVGRPPS AAAGASGASA LCAFPLDEVD RLANRTRDAC YTREGRAEDG
360 370 380 390 400
TEVAYIEYDV NSDCAQLPVD TLDAYPCGSD HTPSPMASRV PLEATPILEW
410 420 430 440 450
PGIQLTAVAV TMEDGHTIAF LGDSQGQLHR VYLGPGSDGH PYSTQSIQQG
460 470 480 490 500
SAVSRDLTFD GTFEHLYVMT QSTLLKVPVA SCAQHLDCAS CLAHRDPYCG
510 520 530 540 550
WCVLLGRCSR RSECSRGQGP EQWLWSFQPE LGCLQVAAMS PANISREETR
560 570 580 590 600
EVFLSVPDLP PLWPGESYSC HFGEHQSPAL LTGSGVMCPS PDPSEAPVLP
610 620 630 640 650
RGADYVSVSV ELRFGAVVIA KTSLSFYDCV AVTELRPSAQ CQACVSSRWG
660 670 680 690 700
CNWCVWQHLC THKASCDAGP MVASHQSPLV SPDPPARGGP SPSPPTAPKA
710 720 730 740 750
LATPAPDTLP VEPGAPSTAT ASDISPGASP SLLSPWGPWA GSGSISSPGS
760 770 780 790 800
TGSPLHEEPS PPSPQNGPGT AVPAPTDFRP SATPEDLLAS PLSPSEVAAV
810 820 830 840 850
PPADPGPEAL HPTVPLDLPP ATVPATTFPG AMGSVKPALD WLTREGGELP
860 870 880 890 900
EADEWTGGDA PAFSTSTLLS GDGDSAELEG PPAPLILPSS LDYQYDTPGL
910 920 930 940 950
WELEEATLGA SSCPCVESVQ GSTLMPVHVE REIRLLGRNL HLFQDGPGDN
960 970 980 990 1000
ECVMELEGLE VVVEARVECE PPPDTQCHVT CQQHQLSYEA LQPELRVGLF
1010 1020 1030 1040 1050
LRRAGRLRVD SAEGLHVVLY DCSVGHGDCS RCQTAMPQYG CVWCEGERPR
1060 1070 1080 1090 1100
CVTREACGEA EAVATQCPAP LIHSVEPLTG PVDGGTRVTI RGSNLGQHVQ
1110 1120 1130 1140 1150
DVLGMVTVAG VPCAVDAQEY EVSSSLVCIT GASGEEVAGA TAVEVPGRGR
1160 1170 1180 1190 1200
GVSEHDFAYQ DPKVHSIFPA RGPRAGGTRL TLNGSKLLTG RLEDIRVVVG
1210 1220 1230 1240 1250
DQPCHLLPEQ QSEQLRCETS PRPTPATLPV AVWFGATERR LQRGQFKYTL
1260 1270 1280 1290 1300
DPNITSAGPT KSFLSGGREI CVRGQNLDVV QTPRIRVTVV SRMLQPSQGL
1310 1320 1330 1340 1350
GRRRRVVPET ACSLGPSCSS QQFEEPCHVN SSQLITCRTP ALPGLPEDPW
1360 1370 1380 1390 1400
VRVEFILDNL VFDFATLNPT PFSYEADPTL QPLNPEDPTM PFRHKPGSVF
1410 1420 1430 1440 1450
SVEGENLDLA MSKEEVVAMI GDGPCVVKTL TRHHLYCEPP VEQPLPRHHA
1460 1470 1480 1490 1500
LREAPDSLPE FTVQMGNLRF SLGHVQYDGE SPGAFPVAAQ VGLGVGTSLL
1510 1520 1530 1540 1550
ALGVIIIVLM YRRKSKQALR DYKKVQIQLE NLESSVRDRC KKEFTDLMTE
1560 1570 1580 1590 1600
MTDLTSDLLG SGIPFLDYKV YAERIFFPGH RESPLHRDLG VPESRRPTVE
1610 1620 1630 1640 1650
QGLGQLSNLL NSKLFLTKFI HTLESQRTFS ARDRAYVASL LTVALHGKLE
1660 1670 1680 1690 1700
YFTDILRTLL SDLVAQYVAK NPKLMLRRTE TVVEKLLTNW MSICLYTFVR
1710 1720 1730 1740 1750
DSVGEPLYML FRGIKHQVDK GPVDSVTGKA KYTLNDNRLL REDVEYRPLT
1760 1770 1780 1790 1800
LNALLAVGPG AGEAQGVPVK VLDCDTISQA KEKMLDQLYK GVPLTQRPDP
1810 1820 1830 1840 1850
RTLDVEWRSG VAGHLILSDE DVTSEVQGLW RRLNTLQHYK VPDGATVALV
1860 1870 1880 1890 1900
PCLTKHVLRE NQDYVPGERT PMLEDVDEGG IRPWHLVKPS DEPEPPRPRR
1910 1920 1930 1940 1950
GSLRGGERER AKAIPEIYLT RLLSMKGTLQ KFVDDLFQVI LSTSRPVPLA
1960 1970 1980 1990 2000
VKYFFDLLDE QAQQHGISDQ DTIHIWKTNS LPLRFWINII KNPQFVFDVQ
2010 2020 2030 2040 2050
TSDNMDAVLL VIAQTFMDAC TLADHKLGRD SPINKLLYAR DIPRYKRMVE
2060 2070 2080 2090 2100
RYYADIRQTV PASDQEMNSV LAELSWNYSG DLGARVALHE LYKYINKYYD
2110 2120 2130
QIITALEEDG TAQKMQLGYR LQQIAAAVEN KVTDL
Length:2,135
Mass (Da):232,298
Last modified:August 31, 2004 - v3
Checksum:i12A81B68AF1D340F
GO
Isoform 2 (identifier: O43157-2) [UniParc]FASTAAdd to basket
Also known as: Isoform R

The sequence of this isoform differs from the canonical sequence as follows:
     688-870: Missing.

Show »
Length:1,952
Mass (Da):214,411
Checksum:iFCAD0630E128EE9C
GO
Isoform 3 (identifier: O43157-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     677-729: SPLVSPDPPA...TASDISPGAS → VMETQQSLRA...PVWRAFRAPR
     730-2135: Missing.

Show »
Length:729
Mass (Da):78,395
Checksum:i4AE56E0EDBAE6D75
GO

Sequence cautioni

The sequence BAA23703 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1297S → N in CAB57277 (PubMed:8570614).Curated1
Sequence conflicti1625S → T in CAB57277 (PubMed:8570614).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050598389R → W. Corresponds to variant dbSNP:rs34050056Ensembl.1
Natural variantiVAR_050599753S → L. Corresponds to variant dbSNP:rs35592743Ensembl.1
Natural variantiVAR_0360741891D → V in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011513677 – 729SPLVS…SPGAS → VMETQQSLRALPPPSSSRPA STTSMTPPGSGSWKRRPWGQ APAPVWRAFRAPR in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_011514688 – 870Missing in isoform 2. 1 PublicationAdd BLAST183
Alternative sequenceiVSP_011515730 – 2135Missing in isoform 3. 1 PublicationAdd BLAST1406

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007867 mRNA Translation: BAA23703.2 Different initiation.
AJ011414 mRNA Translation: CAB56221.1
AJ011415 mRNA Translation: CAB56222.1
X87904 mRNA Translation: CAB57277.1
CH471055 Genomic DNA Translation: EAW64865.1
BC146793 mRNA Translation: AAI46794.1
CCDSiCCDS2765.1 [O43157-1]
RefSeqiNP_001123554.1, NM_001130082.2 [O43157-1]
NP_002664.2, NM_002673.5 [O43157-1]
XP_016862120.1, XM_017006631.1 [O43157-1]
UniGeneiHs.476209

Genome annotation databases

EnsembliENST00000296440; ENSP00000296440; ENSG00000164050 [O43157-1]
ENST00000358536; ENSP00000351338; ENSG00000164050 [O43157-1]
ENST00000449094; ENSP00000395987; ENSG00000164050 [O43157-3]
ENST00000456774; ENSP00000414199; ENSG00000164050 [O43157-2]
GeneIDi5364
KEGGihsa:5364
UCSCiuc003csu.3 human [O43157-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007867 mRNA Translation: BAA23703.2 Different initiation.
AJ011414 mRNA Translation: CAB56221.1
AJ011415 mRNA Translation: CAB56222.1
X87904 mRNA Translation: CAB57277.1
CH471055 Genomic DNA Translation: EAW64865.1
BC146793 mRNA Translation: AAI46794.1
CCDSiCCDS2765.1 [O43157-1]
RefSeqiNP_001123554.1, NM_001130082.2 [O43157-1]
NP_002664.2, NM_002673.5 [O43157-1]
XP_016862120.1, XM_017006631.1 [O43157-1]
UniGeneiHs.476209

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JPHNMR-A1743-1862[»]
2OS6NMR-B2128-2135[»]
2R2OX-ray2.00A/B1743-1862[»]
2REXX-ray2.30A/C1743-1862[»]
3HM6X-ray2.40X1511-2135[»]
3OL2X-ray2.99B20-535[»]
3SU8X-ray3.20X1533-2135[»]
3SUAX-ray4.39D/E/F1511-2135[»]
5B4WX-ray2.60A/B/C/D/E/F20-535[»]
ProteinModelPortaliO43157
SMRiO43157
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111377, 22 interactors
CORUMiO43157
DIPiDIP-36742N
IntActiO43157, 19 interactors
MINTiO43157
STRINGi9606.ENSP00000296440

PTM databases

GlyConnecti1612
iPTMnetiO43157
PhosphoSitePlusiO43157

Polymorphism and mutation databases

BioMutaiPLXNB1

Proteomic databases

EPDiO43157
MaxQBiO43157
PaxDbiO43157
PeptideAtlasiO43157
PRIDEiO43157
ProteomicsDBi48777
48778 [O43157-2]
48779 [O43157-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296440; ENSP00000296440; ENSG00000164050 [O43157-1]
ENST00000358536; ENSP00000351338; ENSG00000164050 [O43157-1]
ENST00000449094; ENSP00000395987; ENSG00000164050 [O43157-3]
ENST00000456774; ENSP00000414199; ENSG00000164050 [O43157-2]
GeneIDi5364
KEGGihsa:5364
UCSCiuc003csu.3 human [O43157-1]

Organism-specific databases

CTDi5364
DisGeNETi5364
EuPathDBiHostDB:ENSG00000164050.12
GeneCardsiPLXNB1
HGNCiHGNC:9103 PLXNB1
HPAiHPA040586
MIMi601053 gene
neXtProtiNX_O43157
OpenTargetsiENSG00000164050
PharmGKBiPA33429
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231376
HOVERGENiHBG053404
InParanoidiO43157
KOiK06821
OMAiGHVQYDG
OrthoDBiEOG091G00EK
PhylomeDBiO43157
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-HSA-416482 G alpha (12/13) signalling events
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
SIGNORiO43157

Miscellaneous databases

ChiTaRSiPLXNB1 human
EvolutionaryTraceiO43157
GeneWikiiPLXNB1
GenomeRNAii5364
PROiPR:O43157
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164050 Expressed in 189 organ(s), highest expression level in right uterine tube
CleanExiHS_PLXNB1
GenevisibleiO43157 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLXB1_HUMAN
AccessioniPrimary (citable) accession number: O43157
Secondary accession number(s): A6H8Y2
, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 7, 2018
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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