UniProtKB - O43157 (PLXB1_HUMAN)
Plexin-B1
PLXNB1
Functioni
Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513).
Plays a role in GABAergic synapse development (By similarity).
Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity).
Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733).
Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496).
By similarity6 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 1815 | Important for interaction with RAC1 and RND1 | 1 |
GO - Molecular functioni
- GTPase activating protein binding Source: BHF-UCL
- GTPase activator activity Source: Reactome
- semaphorin receptor activity Source: UniProtKB
- semaphorin receptor binding Source: UniProtKB
- transmembrane signaling receptor activity Source: UniProtKB
GO - Biological processi
- cell migration Source: UniProtKB
- inhibitory synapse assembly Source: UniProtKB
- intracellular signal transduction Source: UniProtKB
- negative regulation of cell adhesion Source: UniProtKB
- negative regulation of osteoblast proliferation Source: BHF-UCL
- neuron projection morphogenesis Source: UniProtKB
- ossification involved in bone maturation Source: BHF-UCL
- positive regulation of axonogenesis Source: GO_Central
- positive regulation of GTPase activity Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- regulation of cell migration Source: GO_Central
- regulation of cell shape Source: UniProtKB
- regulation of cytoskeleton organization Source: UniProtKB
- regulation of GTPase activity Source: GO_Central
- semaphorin-plexin signaling pathway Source: UniProtKB
- semaphorin-plexin signaling pathway involved in axon guidance Source: GO_Central
- semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis Source: BHF-UCL
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | O43157 |
Reactomei | R-HSA-416482, G alpha (12/13) signalling events R-HSA-416550, Sema4D mediated inhibition of cell attachment and migration R-HSA-416572, Sema4D induced cell migration and growth-cone collapse R-HSA-9013405, RHOD GTPase cycle |
SignaLinki | O43157 |
SIGNORi | O43157 |
Names & Taxonomyi
Protein namesi | Recommended name: Plexin-B1Alternative name(s): Semaphorin receptor SEP |
Gene namesi | Name:PLXNB1 Synonyms:KIAA0407, PLXN5, SEP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9103, PLXNB1 |
MIMi | 601053, gene |
neXtProti | NX_O43157 |
VEuPathDBi | HostDB:ENSG00000164050 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- semaphorin receptor complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 1490 | ExtracellularSequence analysisAdd BLAST | 1471 | |
Transmembranei | 1491 – 1511 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1512 – 2135 | CytoplasmicSequence analysisAdd BLAST | 624 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 139 | D → K: Strongly reduced interaction with SEMA4D. 1 Publication | 1 | |
Mutagenesisi | 1302 – 1305 | RRRR → AAAA: Abolishes cleavage by proprotein convertases. 1 Publication | 4 | |
Mutagenesisi | 1815 | L → F or P: Abolishes interaction with RAC1 and RND1. 1 Publication | 1 | |
Mutagenesisi | 1884 – 1885 | WH → SS: Loss of cytoskeleton remodeling in response to SEMA4D. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 5364 |
OpenTargetsi | ENSG00000164050 |
PharmGKBi | PA33429 |
Miscellaneous databases
Pharosi | O43157, Tbio |
Genetic variation databases
BioMutai | PLXNB1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000024671 | 20 – 2135 | Plexin-B1Add BLAST | 2116 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 79 ↔ 88 | PROSITE-ProRule annotation | ||
Disulfide bondi | 111 ↔ 119 | PROSITE-ProRule annotation | ||
Disulfide bondi | 252 ↔ 377 | PROSITE-ProRule annotation | ||
Disulfide bondi | 268 ↔ 322 | PROSITE-ProRule annotation | ||
Glycosylationi | 334 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 340 ↔ 364 | PROSITE-ProRule annotation | ||
Disulfide bondi | 482 ↔ 499 | PROSITE-ProRule annotation | ||
Disulfide bondi | 488 ↔ 533 | PROSITE-ProRule annotation | ||
Disulfide bondi | 491 ↔ 508 | PROSITE-ProRule annotation | ||
Disulfide bondi | 502 ↔ 514 | PROSITE-ProRule annotation | ||
Glycosylationi | 543 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 570 ↔ 588 | PROSITE-ProRule annotation | ||
Glycosylationi | 1183 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1253 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Glycosylationi | 1330 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 1305 – 1306 | Cleavage; by proprotein convertases | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | O43157 |
jPOSTi | O43157 |
MassIVEi | O43157 |
MaxQBi | O43157 |
PaxDbi | O43157 |
PeptideAtlasi | O43157 |
PRIDEi | O43157 |
ProteomicsDBi | 48777 [O43157-1] 48778 [O43157-2] 48779 [O43157-3] |
PTM databases
GlyConnecti | 1612, 7 N-Linked glycans (2 sites) |
GlyGeni | O43157, 10 sites, 10 N-linked glycans (2 sites), 2 O-linked glycans (4 sites) |
iPTMneti | O43157 |
PhosphoSitePlusi | O43157 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000164050, Expressed in right uterine tube and 203 other tissues |
Genevisiblei | O43157, HS |
Organism-specific databases
HPAi | ENSG00000164050, Low tissue specificity |
Interactioni
Subunit structurei
Monomer, and heterodimer with PLXNB2 after proteolytic processing (PubMed:12533544, PubMed:17916560, PubMed:18411422, PubMed:18275816, PubMed:19843518, PubMed:20877282, PubMed:21912513). Binds RAC1 that has been activated by GTP binding (PubMed:11035813, PubMed:17916560, PubMed:18275816, PubMed:19843518). Interaction with SEMA4D promotes binding of cytoplasmic ligands (PubMed:10520995, PubMed:12198496, PubMed:19843518).
Interacts with PLXNA1 (By similarity).
Interacts with ARHGEF11 and ARHGEF12 (PubMed:12196628).
Interacts with ERBB2 (PubMed:15210733).
Interacts with MET (PubMed:12198496, PubMed:15184888).
Interacts with MST1R (PubMed:15184888).
Interacts with RRAS (PubMed:19843518).
Interacts with RHOD (PubMed:17916560).
Interacts with RND1 (PubMed:12730235, PubMed:17916560, PubMed:18275816, PubMed:19843518).
Interacts with NRP1 and NRP2 (PubMed:10520995).
By similarity14 PublicationsBinary interactionsi
O43157
With | #Exp. | IntAct |
---|---|---|
MET [P08581] | 7 | EBI-1111488,EBI-1039152 |
MST1R [Q04912] | 3 | EBI-1111488,EBI-2637518 |
RND1 [Q92730] | 4 | EBI-1111488,EBI-448618 |
RND2 [P52198] | 2 | EBI-1111488,EBI-1111436 |
RND3 [P61587] | 3 | EBI-1111488,EBI-1111534 |
Isoform 1 [O43157-1]
With | #Exp. | IntAct |
---|---|---|
RND1 [Q92730] | 2 | EBI-15880891,EBI-448618 |
SEMA4D - isoform 1 [Q92854-1] | 3 | EBI-15880891,EBI-15880903 |
GO - Molecular functioni
- GTPase activating protein binding Source: BHF-UCL
- semaphorin receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111377, 36 interactors |
CORUMi | O43157 |
DIPi | DIP-36742N |
IntActi | O43157, 23 interactors |
MINTi | O43157 |
STRINGi | 9606.ENSP00000351338 |
Miscellaneous databases
RNActi | O43157, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O43157 |
BMRBi | O43157 |
SMRi | O43157 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O43157 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 479 | SemaPROSITE-ProRule annotationAdd BLAST | 460 | |
Domaini | 1070 – 1160 | IPT/TIG 1Add BLAST | 91 | |
Domaini | 1162 – 1249 | IPT/TIG 2Add BLAST | 88 | |
Domaini | 1252 – 1375 | IPT/TIG 3Add BLAST | 124 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 671 – 829 | DisorderedSequence analysisAdd BLAST | 159 | |
Regioni | 849 – 884 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 1883 – 1908 | DisorderedSequence analysisAdd BLAST | 26 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1507 – 1539 | Sequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 683 – 701 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 740 – 754 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 755 – 769 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 798 – 819 | Pro residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3610, Eukaryota |
GeneTreei | ENSGT01020000230394 |
HOGENOMi | CLU_001436_1_1_1 |
InParanoidi | O43157 |
OMAi | DAFPCGS |
OrthoDBi | 90434at2759 |
PhylomeDBi | O43157 |
TreeFami | TF312962 |
Family and domain databases
Gene3Di | 1.10.506.10, 2 hits 2.130.10.10, 1 hit 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR031148, Plexin IPR013548, Plexin_cytoplasmic_RasGAP_dom IPR002165, Plexin_repeat IPR016201, PSI IPR008936, Rho_GTPase_activation_prot IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR041019, TIG1_plexin IPR041362, TIG2_plexin IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 1 hit |
Pfami | View protein in Pfam PF08337, Plexin_cytopl, 1 hit PF01437, PSI, 1 hit PF01403, Sema, 1 hit PF01833, TIG, 3 hits PF18020, TIG_2, 1 hit PF17960, TIG_plexin, 1 hit |
SMARTi | View protein in SMART SM00429, IPT, 3 hits SM00423, PSI, 3 hits SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48350, SSF48350, 1 hit SSF81296, SSF81296, 3 hits |
PROSITEi | View protein in PROSITE PS51004, SEMA, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPALGPALLQ ALWAGWVLTL QPLPPTAFTP NGTYLQHLAR DPTSGTLYLG
60 70 80 90 100
ATNFLFQLSP GLQLEATVST GPVLDSRDCL PPVMPDECPQ AQPTNNPNQL
110 120 130 140 150
LLVSPGALVV CGSVHQGVCE QRRLGQLEQL LLRPERPGDT QYVAANDPAV
160 170 180 190 200
STVGLVAQGL AGEPLLFVGR GYTSRGVGGG IPPITTRALW PPDPQAAFSY
210 220 230 240 250
EETAKLAVGR LSEYSHHFVS AFARGASAYF LFLRRDLQAQ SRAFRAYVSR
260 270 280 290 300
VCLRDQHYYS YVELPLACEG GRYGLIQAAA VATSREVAHG EVLFAAFSSA
310 320 330 340 350
APPTVGRPPS AAAGASGASA LCAFPLDEVD RLANRTRDAC YTREGRAEDG
360 370 380 390 400
TEVAYIEYDV NSDCAQLPVD TLDAYPCGSD HTPSPMASRV PLEATPILEW
410 420 430 440 450
PGIQLTAVAV TMEDGHTIAF LGDSQGQLHR VYLGPGSDGH PYSTQSIQQG
460 470 480 490 500
SAVSRDLTFD GTFEHLYVMT QSTLLKVPVA SCAQHLDCAS CLAHRDPYCG
510 520 530 540 550
WCVLLGRCSR RSECSRGQGP EQWLWSFQPE LGCLQVAAMS PANISREETR
560 570 580 590 600
EVFLSVPDLP PLWPGESYSC HFGEHQSPAL LTGSGVMCPS PDPSEAPVLP
610 620 630 640 650
RGADYVSVSV ELRFGAVVIA KTSLSFYDCV AVTELRPSAQ CQACVSSRWG
660 670 680 690 700
CNWCVWQHLC THKASCDAGP MVASHQSPLV SPDPPARGGP SPSPPTAPKA
710 720 730 740 750
LATPAPDTLP VEPGAPSTAT ASDISPGASP SLLSPWGPWA GSGSISSPGS
760 770 780 790 800
TGSPLHEEPS PPSPQNGPGT AVPAPTDFRP SATPEDLLAS PLSPSEVAAV
810 820 830 840 850
PPADPGPEAL HPTVPLDLPP ATVPATTFPG AMGSVKPALD WLTREGGELP
860 870 880 890 900
EADEWTGGDA PAFSTSTLLS GDGDSAELEG PPAPLILPSS LDYQYDTPGL
910 920 930 940 950
WELEEATLGA SSCPCVESVQ GSTLMPVHVE REIRLLGRNL HLFQDGPGDN
960 970 980 990 1000
ECVMELEGLE VVVEARVECE PPPDTQCHVT CQQHQLSYEA LQPELRVGLF
1010 1020 1030 1040 1050
LRRAGRLRVD SAEGLHVVLY DCSVGHGDCS RCQTAMPQYG CVWCEGERPR
1060 1070 1080 1090 1100
CVTREACGEA EAVATQCPAP LIHSVEPLTG PVDGGTRVTI RGSNLGQHVQ
1110 1120 1130 1140 1150
DVLGMVTVAG VPCAVDAQEY EVSSSLVCIT GASGEEVAGA TAVEVPGRGR
1160 1170 1180 1190 1200
GVSEHDFAYQ DPKVHSIFPA RGPRAGGTRL TLNGSKLLTG RLEDIRVVVG
1210 1220 1230 1240 1250
DQPCHLLPEQ QSEQLRCETS PRPTPATLPV AVWFGATERR LQRGQFKYTL
1260 1270 1280 1290 1300
DPNITSAGPT KSFLSGGREI CVRGQNLDVV QTPRIRVTVV SRMLQPSQGL
1310 1320 1330 1340 1350
GRRRRVVPET ACSLGPSCSS QQFEEPCHVN SSQLITCRTP ALPGLPEDPW
1360 1370 1380 1390 1400
VRVEFILDNL VFDFATLNPT PFSYEADPTL QPLNPEDPTM PFRHKPGSVF
1410 1420 1430 1440 1450
SVEGENLDLA MSKEEVVAMI GDGPCVVKTL TRHHLYCEPP VEQPLPRHHA
1460 1470 1480 1490 1500
LREAPDSLPE FTVQMGNLRF SLGHVQYDGE SPGAFPVAAQ VGLGVGTSLL
1510 1520 1530 1540 1550
ALGVIIIVLM YRRKSKQALR DYKKVQIQLE NLESSVRDRC KKEFTDLMTE
1560 1570 1580 1590 1600
MTDLTSDLLG SGIPFLDYKV YAERIFFPGH RESPLHRDLG VPESRRPTVE
1610 1620 1630 1640 1650
QGLGQLSNLL NSKLFLTKFI HTLESQRTFS ARDRAYVASL LTVALHGKLE
1660 1670 1680 1690 1700
YFTDILRTLL SDLVAQYVAK NPKLMLRRTE TVVEKLLTNW MSICLYTFVR
1710 1720 1730 1740 1750
DSVGEPLYML FRGIKHQVDK GPVDSVTGKA KYTLNDNRLL REDVEYRPLT
1760 1770 1780 1790 1800
LNALLAVGPG AGEAQGVPVK VLDCDTISQA KEKMLDQLYK GVPLTQRPDP
1810 1820 1830 1840 1850
RTLDVEWRSG VAGHLILSDE DVTSEVQGLW RRLNTLQHYK VPDGATVALV
1860 1870 1880 1890 1900
PCLTKHVLRE NQDYVPGERT PMLEDVDEGG IRPWHLVKPS DEPEPPRPRR
1910 1920 1930 1940 1950
GSLRGGERER AKAIPEIYLT RLLSMKGTLQ KFVDDLFQVI LSTSRPVPLA
1960 1970 1980 1990 2000
VKYFFDLLDE QAQQHGISDQ DTIHIWKTNS LPLRFWINII KNPQFVFDVQ
2010 2020 2030 2040 2050
TSDNMDAVLL VIAQTFMDAC TLADHKLGRD SPINKLLYAR DIPRYKRMVE
2060 2070 2080 2090 2100
RYYADIRQTV PASDQEMNSV LAELSWNYSG DLGARVALHE LYKYINKYYD
2110 2120 2130
QIITALEEDG TAQKMQLGYR LQQIAAAVEN KVTDL
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1297 | S → N in CAB57277 (PubMed:8570614).Curated | 1 | |
Sequence conflicti | 1625 | S → T in CAB57277 (PubMed:8570614).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050598 | 389 | R → W. Corresponds to variant dbSNP:rs34050056Ensembl. | 1 | |
Natural variantiVAR_050599 | 753 | S → L. Corresponds to variant dbSNP:rs35592743EnsemblClinVar. | 1 | |
Natural variantiVAR_036074 | 1891 | D → V in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011513 | 677 – 729 | SPLVS…SPGAS → VMETQQSLRALPPPSSSRPA STTSMTPPGSGSWKRRPWGQ APAPVWRAFRAPR in isoform 3. 1 PublicationAdd BLAST | 53 | |
Alternative sequenceiVSP_011514 | 688 – 870 | Missing in isoform 2. 1 PublicationAdd BLAST | 183 | |
Alternative sequenceiVSP_011515 | 730 – 2135 | Missing in isoform 3. 1 PublicationAdd BLAST | 1406 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007867 mRNA Translation: BAA23703.2 Different initiation. AJ011414 mRNA Translation: CAB56221.1 AJ011415 mRNA Translation: CAB56222.1 X87904 mRNA Translation: CAB57277.1 CH471055 Genomic DNA Translation: EAW64865.1 BC146793 mRNA Translation: AAI46794.1 |
CCDSi | CCDS2765.1 [O43157-1] |
RefSeqi | NP_001123554.1, NM_001130082.2 [O43157-1] NP_002664.2, NM_002673.5 [O43157-1] XP_016862120.1, XM_017006631.1 [O43157-1] |
Genome annotation databases
Ensembli | ENST00000296440.11; ENSP00000296440.6; ENSG00000164050.13 ENST00000358536.8; ENSP00000351338.4; ENSG00000164050.13 ENST00000449094.5; ENSP00000395987.1; ENSG00000164050.13 [O43157-3] ENST00000456774.5; ENSP00000414199.1; ENSG00000164050.13 [O43157-2] |
GeneIDi | 5364 |
KEGGi | hsa:5364 |
MANE-Selecti | ENST00000296440.11; ENSP00000296440.6; NM_001130082.3; NP_001123554.1 |
UCSCi | uc003csu.3, human [O43157-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007867 mRNA Translation: BAA23703.2 Different initiation. AJ011414 mRNA Translation: CAB56221.1 AJ011415 mRNA Translation: CAB56222.1 X87904 mRNA Translation: CAB57277.1 CH471055 Genomic DNA Translation: EAW64865.1 BC146793 mRNA Translation: AAI46794.1 |
CCDSi | CCDS2765.1 [O43157-1] |
RefSeqi | NP_001123554.1, NM_001130082.2 [O43157-1] NP_002664.2, NM_002673.5 [O43157-1] XP_016862120.1, XM_017006631.1 [O43157-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2JPH | NMR | - | A | 1743-1862 | [»] | |
2OS6 | NMR | - | B | 2128-2135 | [»] | |
2R2O | X-ray | 2.00 | A/B | 1743-1862 | [»] | |
2REX | X-ray | 2.30 | A/C | 1743-1862 | [»] | |
3HM6 | X-ray | 2.40 | X | 1511-2135 | [»] | |
3OL2 | X-ray | 2.99 | B | 20-535 | [»] | |
3SU8 | X-ray | 3.20 | X | 1533-2135 | [»] | |
3SUA | X-ray | 4.39 | D/E/F | 1511-2135 | [»] | |
5B4W | X-ray | 2.60 | A/B/C/D/E/F | 20-535 | [»] | |
AlphaFoldDBi | O43157 | |||||
BMRBi | O43157 | |||||
SMRi | O43157 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111377, 36 interactors |
CORUMi | O43157 |
DIPi | DIP-36742N |
IntActi | O43157, 23 interactors |
MINTi | O43157 |
STRINGi | 9606.ENSP00000351338 |
PTM databases
GlyConnecti | 1612, 7 N-Linked glycans (2 sites) |
GlyGeni | O43157, 10 sites, 10 N-linked glycans (2 sites), 2 O-linked glycans (4 sites) |
iPTMneti | O43157 |
PhosphoSitePlusi | O43157 |
Genetic variation databases
BioMutai | PLXNB1 |
Proteomic databases
EPDi | O43157 |
jPOSTi | O43157 |
MassIVEi | O43157 |
MaxQBi | O43157 |
PaxDbi | O43157 |
PeptideAtlasi | O43157 |
PRIDEi | O43157 |
ProteomicsDBi | 48777 [O43157-1] 48778 [O43157-2] 48779 [O43157-3] |
Protocols and materials databases
Antibodypediai | 49406, 287 antibodies from 31 providers |
DNASUi | 5364 |
Genome annotation databases
Ensembli | ENST00000296440.11; ENSP00000296440.6; ENSG00000164050.13 ENST00000358536.8; ENSP00000351338.4; ENSG00000164050.13 ENST00000449094.5; ENSP00000395987.1; ENSG00000164050.13 [O43157-3] ENST00000456774.5; ENSP00000414199.1; ENSG00000164050.13 [O43157-2] |
GeneIDi | 5364 |
KEGGi | hsa:5364 |
MANE-Selecti | ENST00000296440.11; ENSP00000296440.6; NM_001130082.3; NP_001123554.1 |
UCSCi | uc003csu.3, human [O43157-1] |
Organism-specific databases
CTDi | 5364 |
DisGeNETi | 5364 |
GeneCardsi | PLXNB1 |
HGNCi | HGNC:9103, PLXNB1 |
HPAi | ENSG00000164050, Low tissue specificity |
MIMi | 601053, gene |
neXtProti | NX_O43157 |
OpenTargetsi | ENSG00000164050 |
PharmGKBi | PA33429 |
VEuPathDBi | HostDB:ENSG00000164050 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3610, Eukaryota |
GeneTreei | ENSGT01020000230394 |
HOGENOMi | CLU_001436_1_1_1 |
InParanoidi | O43157 |
OMAi | DAFPCGS |
OrthoDBi | 90434at2759 |
PhylomeDBi | O43157 |
TreeFami | TF312962 |
Enzyme and pathway databases
PathwayCommonsi | O43157 |
Reactomei | R-HSA-416482, G alpha (12/13) signalling events R-HSA-416550, Sema4D mediated inhibition of cell attachment and migration R-HSA-416572, Sema4D induced cell migration and growth-cone collapse R-HSA-9013405, RHOD GTPase cycle |
SignaLinki | O43157 |
SIGNORi | O43157 |
Miscellaneous databases
BioGRID-ORCSi | 5364, 14 hits in 1082 CRISPR screens |
ChiTaRSi | PLXNB1, human |
EvolutionaryTracei | O43157 |
GeneWikii | PLXNB1 |
GenomeRNAii | 5364 |
Pharosi | O43157, Tbio |
PROi | PR:O43157 |
RNActi | O43157, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164050, Expressed in right uterine tube and 203 other tissues |
Genevisiblei | O43157, HS |
Family and domain databases
Gene3Di | 1.10.506.10, 2 hits 2.130.10.10, 1 hit 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR031148, Plexin IPR013548, Plexin_cytoplasmic_RasGAP_dom IPR002165, Plexin_repeat IPR016201, PSI IPR008936, Rho_GTPase_activation_prot IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR041019, TIG1_plexin IPR041362, TIG2_plexin IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 1 hit |
Pfami | View protein in Pfam PF08337, Plexin_cytopl, 1 hit PF01437, PSI, 1 hit PF01403, Sema, 1 hit PF01833, TIG, 3 hits PF18020, TIG_2, 1 hit PF17960, TIG_plexin, 1 hit |
SMARTi | View protein in SMART SM00429, IPT, 3 hits SM00423, PSI, 3 hits SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48350, SSF48350, 1 hit SSF81296, SSF81296, 3 hits |
PROSITEi | View protein in PROSITE PS51004, SEMA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLXB1_HUMAN | |
Accessioni | O43157Primary (citable) accession number: O43157 Secondary accession number(s): A6H8Y2 Q9UJ93 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | August 31, 2004 | |
Last modified: | May 25, 2022 | |
This is version 192 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families