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Protein

TELO2-interacting protein 1 homolog

Gene

TTI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.3 Publications

GO - Biological processi

  • regulation of TOR signaling Source: UniProtKB

Enzyme and pathway databases

SIGNORiO43156

Names & Taxonomyi

Protein namesi
Recommended name:
TELO2-interacting protein 1 homolog
Alternative name(s):
Protein SMG10
Gene namesi
Name:TTI1
Synonyms:KIAA0406, SMG10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101407.12
HGNCiHGNC:29029 TTI1
MIMi614425 gene
neXtProtiNX_O43156

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi828S → A: Abolishes phosphorylation by CK2 in response to growth factor deprivation and subsequent ubiquitination and degradation. 1 Publication1

Organism-specific databases

DisGeNETi9675
OpenTargetsiENSG00000101407
PharmGKBiPA165392722

Polymorphism and mutation databases

BioMutaiTTI1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507511 – 1089TELO2-interacting protein 1 homologAdd BLAST1089

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei459PhosphoserineCombined sources1
Modified residuei828Phosphoserine; by CK2Combined sources1 Publication1

Post-translational modificationi

Phosphorylated at Ser-828 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2; leading to selective ubiquitination of mTORC1-associated protein.1 Publication
Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation, leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded, leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43156
MaxQBiO43156
PaxDbiO43156
PeptideAtlasiO43156
PRIDEiO43156
ProteomicsDBi48776

PTM databases

iPTMnetiO43156
PhosphoSitePlusiO43156

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000101407 Expressed in 227 organ(s), highest expression level in amniotic fluid
CleanExiHS_KIAA0406
ExpressionAtlasiO43156 baseline and differential
GenevisibleiO43156 HS

Organism-specific databases

HPAiCAB034230
HPA068338

Interactioni

Subunit structurei

Component of the TTT complex composed of TELO2, TTI1 and TTI2 (PubMed:20801936). Interacts with ATM, ATR, MTOR, PRKDC, RUVBL1, SMG1, TELO2, TRRAP AND TTI2 (PubMed:20371770, PubMed:20427287, PubMed:20810650). Component of the mTORC1 and mTORC2 complexes (PubMed:23263282). Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014).6 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115030, 52 interactors
DIPiDIP-50660N
IntActiO43156, 25 interactors
STRINGi9606.ENSP00000362546

Structurei

3D structure databases

ProteinModelPortaliO43156
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi833 – 836Poly-Glu4

Sequence similaritiesi

Belongs to the tti1 family.Curated

Phylogenomic databases

eggNOGiKOG4524 Eukaryota
ENOG410XSN6 LUCA
GeneTreeiENSGT00390000009748
HOGENOMiHOG000234009
HOVERGENiHBG052183
InParanoidiO43156
KOiK20403
OMAiNQNSDYL
OrthoDBiEOG091G06Y4
PhylomeDBiO43156
TreeFamiTF315296

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR016441 Tti1
PIRSFiPIRSF005250 UCP005250, 1 hit
SUPFAMiSSF48371 SSF48371, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O43156-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVFDTPEEA FGVLRPVCVQ LTKTQTVENV EHLQTRLQAV SDSALQELQQ
60 70 80 90 100
YILFPLRFTL KTPGPKRERL IQSVVECLTF VLSSTCVKEQ ELLQELFSEL
110 120 130 140 150
SACLYSPSSQ KPAAVSEELK LAVIQGLSTL MHSAYGDIIL TFYEPSILPR
160 170 180 190 200
LGFAVSLLLG LAEQEKSKQI KIAALKCLQV LLLQCDCQDH PRSLDELEQK
210 220 230 240 250
QLGDLFASFL PGISTALTRL ITGDFKQGHS IVVSSLKIFY KTVSFIMADE
260 270 280 290 300
QLKRISKVQA KPAVEHRVAE LMVYREADWV KKTGDKLTIL IKKIIECVSV
310 320 330 340 350
HPHWKVRLEL VELVEDLLLK CSQSLVECAG PLLKALVGLV NDESPEIQAQ
360 370 380 390 400
CNKVLRHFAD QKVVVGNKAL ADILSESLHS LATSLPRLMN SQDDQGKFST
410 420 430 440 450
LSLLLGYLKL LGPKINFVLN SVAHLQRLSK ALIQVLELDV ADIKIVEERR
460 470 480 490 500
WNSDDLNASP KTSATQPWNR IQRRYFRFFT DERIFMLLRQ VCQLLGYYGN
510 520 530 540 550
LYLLVDHFME LYHQSVVYRK QAAMILNELV TGAAGLEVED LHEKHIKTNP
560 570 580 590 600
EELREIVTSI LEEYTSQENW YLVTCLETEE MGEELMMEHP GLQAITSGEH
610 620 630 640 650
TCQVTSFLAF SKPSPTICSM NSNIWQICIQ LEGIGQFAYA LGKDFCLLLM
660 670 680 690 700
SALYPVLEKA GDQTLLISQV ATSTMMDVCR ACGYDSLQHL INQNSDYLVN
710 720 730 740 750
GISLNLRHLA LHPHTPKVLE VMLRNSDANL LPLVADVVQD VLATLDQFYD
760 770 780 790 800
KRAASFVSVL HALMAALAQW FPDTGNLGHL QEQSLGEEGS HLNQRPAALE
810 820 830 840 850
KSTTTAEDIE QFLLNYLKEK DVADGNVSDF DNEEEEQSVP PKVDENDTRP
860 870 880 890 900
DVEPPLPLQI QIAMDVMERC IHLLSDKNLQ IRLKVLDVLD LCVVVLQSHK
910 920 930 940 950
NQLLPLAHQA WPSLVHRLTR DAPLAVLRAF KVLRTLGSKC GDFLRSRFCK
960 970 980 990 1000
DVLPKLAGSL VTQAPISARA GPVYSHTLAF KLQLAVLQGL GPLCERLDLG
1010 1020 1030 1040 1050
EGDLNKVADA CLIYLSVKQP VKLQEAARSV FLHLMKVDPD STWFLLNELY
1060 1070 1080
CPVQFTPPHP SLHPVQLHGA SGQQNPYTTN VLQLLKELQ
Length:1,089
Mass (Da):122,069
Last modified:October 10, 2002 - v3
Checksum:i27F4D3EFAC18A54E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT32A0A087WT32_HUMAN
TELO2-interacting protein 1 homolog
TTI1
32Annotation score:

Sequence cautioni

The sequence BAA23702 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034033450R → H. Corresponds to variant dbSNP:rs36059660Ensembl.1
Natural variantiVAR_014082671A → V. Corresponds to variant dbSNP:rs1057238Ensembl.1
Natural variantiVAR_049509751K → E. Corresponds to variant dbSNP:rs6091654Ensembl.1
Natural variantiVAR_014083979A → T. Corresponds to variant dbSNP:rs1064275Ensembl.1
Natural variantiVAR_0340341028R → K. Corresponds to variant dbSNP:rs34900517Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007866 mRNA Translation: BAA23702.2 Different initiation.
BR000854 mRNA Translation: FAA00688.1
AL109823 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76047.1
CH471077 Genomic DNA Translation: EAW76048.1
BC013121 mRNA Translation: AAH13121.1
BC013755 mRNA Translation: AAH13755.1
CCDSiCCDS13300.1
PIRiT00052
RefSeqiNP_001290386.1, NM_001303457.1
NP_055472.1, NM_014657.2
UniGeneiHs.655481

Genome annotation databases

EnsembliENST00000373447; ENSP00000362546; ENSG00000101407
ENST00000373448; ENSP00000362547; ENSG00000101407
ENST00000449821; ENSP00000407270; ENSG00000101407
GeneIDi9675
KEGGihsa:9675
UCSCiuc002xhl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007866 mRNA Translation: BAA23702.2 Different initiation.
BR000854 mRNA Translation: FAA00688.1
AL109823 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76047.1
CH471077 Genomic DNA Translation: EAW76048.1
BC013121 mRNA Translation: AAH13121.1
BC013755 mRNA Translation: AAH13755.1
CCDSiCCDS13300.1
PIRiT00052
RefSeqiNP_001290386.1, NM_001303457.1
NP_055472.1, NM_014657.2
UniGeneiHs.655481

3D structure databases

ProteinModelPortaliO43156
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115030, 52 interactors
DIPiDIP-50660N
IntActiO43156, 25 interactors
STRINGi9606.ENSP00000362546

PTM databases

iPTMnetiO43156
PhosphoSitePlusiO43156

Polymorphism and mutation databases

BioMutaiTTI1

Proteomic databases

EPDiO43156
MaxQBiO43156
PaxDbiO43156
PeptideAtlasiO43156
PRIDEiO43156
ProteomicsDBi48776

Protocols and materials databases

DNASUi9675
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373447; ENSP00000362546; ENSG00000101407
ENST00000373448; ENSP00000362547; ENSG00000101407
ENST00000449821; ENSP00000407270; ENSG00000101407
GeneIDi9675
KEGGihsa:9675
UCSCiuc002xhl.4 human

Organism-specific databases

CTDi9675
DisGeNETi9675
EuPathDBiHostDB:ENSG00000101407.12
GeneCardsiTTI1
HGNCiHGNC:29029 TTI1
HPAiCAB034230
HPA068338
MIMi614425 gene
neXtProtiNX_O43156
OpenTargetsiENSG00000101407
PharmGKBiPA165392722
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4524 Eukaryota
ENOG410XSN6 LUCA
GeneTreeiENSGT00390000009748
HOGENOMiHOG000234009
HOVERGENiHBG052183
InParanoidiO43156
KOiK20403
OMAiNQNSDYL
OrthoDBiEOG091G06Y4
PhylomeDBiO43156
TreeFamiTF315296

Enzyme and pathway databases

SIGNORiO43156

Miscellaneous databases

ChiTaRSiTTI1 human
GenomeRNAii9675
PROiPR:O43156
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101407 Expressed in 227 organ(s), highest expression level in amniotic fluid
CleanExiHS_KIAA0406
ExpressionAtlasiO43156 baseline and differential
GenevisibleiO43156 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR016441 Tti1
PIRSFiPIRSF005250 UCP005250, 1 hit
SUPFAMiSSF48371 SSF48371, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTTI1_HUMAN
AccessioniPrimary (citable) accession number: O43156
Secondary accession number(s): D6W4K3
, Q5JX67, Q96A38, Q9BR47, Q9H4K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: October 10, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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