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Protein

Leucine-rich repeat transmembrane protein FLRT2

Gene

FLRT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-5654687 Downstream signaling of activated FGFR1

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane protein FLRT2
Alternative name(s):
Fibronectin-like domain-containing leucine-rich transmembrane protein 2
Gene namesi
Name:FLRT2
Synonyms:KIAA0405
ORF Names:UNQ232/PRO265
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000185070.10
HGNCiHGNC:3761 FLRT2
MIMi604807 gene
neXtProtiNX_O43155

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 541ExtracellularSequence analysisAdd BLAST506
Transmembranei542 – 562HelicalSequence analysisAdd BLAST21
Topological domaini563 – 660CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Extracellular matrix, Membrane, Microsome, Secreted, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi23768
OpenTargetsiENSG00000185070
PharmGKBiPA28178

Polymorphism and mutation databases

BioMutaiFLRT2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 351 PublicationAdd BLAST35
ChainiPRO_000002127936 – 660Leucine-rich repeat transmembrane protein FLRT2Add BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 42By similarity
Disulfide bondi40 ↔ 49By similarity
Glycosylationi202N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi314 ↔ 339By similarity
Disulfide bondi316 ↔ 360By similarity
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi521N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.2 Publications
Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO43155
PaxDbiO43155
PeptideAtlasiO43155
PRIDEiO43155
ProteomicsDBi48775

PTM databases

iPTMnetiO43155
PhosphoSitePlusiO43155

Expressioni

Tissue specificityi

Expressed in pancreas, skeletal muscle, brain, and heart.1 Publication

Gene expression databases

BgeeiENSG00000185070
CleanExiHS_FLRT2
GenevisibleiO43155 HS

Interactioni

Subunit structurei

Self-associates (via leucine-rich repeats), giving rise to homooligomers. Interacts with FGFR1. Interacts with FGFR2. Interacts (via extracellular domain) with ADGRL1/LPHN1. Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain). Interacts (via extracellular domain) with UNC5D (via the first Ig-like domain). Can also interact (via extracellular domain) with UNC5B, but with much lower affinity. Interacts (via extracellular domain) with FN1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117268, 1 interactor
IntActiO43155, 3 interactors
MINTiO43155
STRINGi9606.ENSP00000332879

Structurei

3D structure databases

ProteinModelPortaliO43155
SMRiO43155
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 63LRRNTAdd BLAST28
Repeati64 – 85LRR 1Add BLAST22
Repeati89 – 109LRR 2Add BLAST21
Repeati110 – 131LRR 3Add BLAST22
Repeati134 – 155LRR 4Add BLAST22
Repeati160 – 181LRR 5Add BLAST22
Repeati182 – 202LRR 6Add BLAST21
Repeati205 – 225LRR 7Add BLAST21
Repeati231 – 252LRR 8Add BLAST22
Repeati253 – 274LRR 9Add BLAST22
Repeati277 – 298LRR 10Add BLAST22
Domaini310 – 362LRRCTAdd BLAST53
Domaini419 – 517Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST99

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHC8 Eukaryota
ENOG4111ID7 LUCA
GeneTreeiENSGT00920000148996
HOGENOMiHOG000290188
HOVERGENiHBG051629
InParanoidiO43155
KOiK16362
OMAiFPAELHN
OrthoDBiEOG091G05YU
PhylomeDBiO43155
TreeFamiTF315838

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF13855 LRR_8, 3 hits
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 7 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLQTTKWPS HGAFFLKSWL IISLGLYSQV SKLLACPSVC RCDRNFVYCN
60 70 80 90 100
ERSLTSVPLG IPEGVTVLYL HNNQINNAGF PAELHNVQSV HTVYLYGNQL
110 120 130 140 150
DEFPMNLPKN VRVLHLQENN IQTISRAALA QLLKLEELHL DDNSISTVGV
160 170 180 190 200
EDGAFREAIS LKLLFLSKNH LSSVPVGLPV DLQELRVDEN RIAVISDMAF
210 220 230 240 250
QNLTSLERLI VDGNLLTNKG IAEGTFSHLT KLKEFSIVRN SLSHPPPDLP
260 270 280 290 300
GTHLIRLYLQ DNQINHIPLT AFSNLRKLER LDISNNQLRM LTQGVFDNLS
310 320 330 340 350
NLKQLTARNN PWFCDCSIKW VTEWLKYIPS SLNVRGFMCQ GPEQVRGMAV
360 370 380 390 400
RELNMNLLSC PTTTPGLPLF TPAPSTASPT TQPPTLSIPN PSRSYTPPTP
410 420 430 440 450
TTSKLPTIPD WDGRERVTPP ISERIQLSIH FVNDTSIQVS WLSLFTVMAY
460 470 480 490 500
KLTWVKMGHS LVGGIVQERI VSGEKQHLSL VNLEPRSTYR ICLVPLDAFN
510 520 530 540 550
YRAVEDTICS EATTHASYLN NGSNTASSHE QTTSHSMGSP FLLAGLIGGA
560 570 580 590 600
VIFVLVVLLS VFCWHMHKKG RYTSQKWKYN RGRRKDDYCE AGTKKDNSIL
610 620 630 640 650
EMTETSFQIV SLNNDQLLKG DFRLQPIYTP NGGINYTDCH IPNNMRYCNS
660
SVPDLEHCHT
Length:660
Mass (Da):74,049
Last modified:June 1, 1998 - v1
Checksum:i9B15F283B0D5F778
GO

Sequence cautioni

The sequence BAA23701 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050996486R → Q1 PublicationCorresponds to variant dbSNP:rs17646457Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169676 mRNA Translation: AAF28460.1
AY358287 mRNA Translation: AAQ88654.1
AB007865 mRNA Translation: BAA23701.2 Different initiation.
BC126249 mRNA Translation: AAI26250.1
BC130290 mRNA Translation: AAI30291.1
BC143936 mRNA Translation: AAI43937.1
CCDSiCCDS9877.1
RefSeqiNP_001333072.1, NM_001346143.1
NP_001333073.1, NM_001346144.1
NP_001333074.1, NM_001346145.1
NP_001333075.1, NM_001346146.1
NP_037363.1, NM_013231.5
XP_005267547.1, XM_005267490.3
XP_011534913.1, XM_011536611.2
XP_016876618.1, XM_017021129.1
XP_016876619.1, XM_017021130.1
XP_016876620.1, XM_017021131.1
XP_016876621.1, XM_017021132.1
XP_016876622.1, XM_017021133.1
XP_016876623.1, XM_017021134.1
XP_016876624.1, XM_017021135.1
UniGeneiHs.533710
Hs.624735
Hs.680351
Hs.729224
Hs.744139

Genome annotation databases

EnsembliENST00000330753; ENSP00000332879; ENSG00000185070
ENST00000554746; ENSP00000451050; ENSG00000185070
GeneIDi23768
KEGGihsa:23768
UCSCiuc001xvr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFLRT2_HUMAN
AccessioniPrimary (citable) accession number: O43155
Secondary accession number(s): A0AV84, B7ZLP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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