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Entry version 145 (07 Oct 2020)
Sequence version 4 (13 Nov 2019)
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Protein

Methylcytosine dioxygenase TET3

Gene

TET3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization (PubMed:31928709). Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes (PubMed:23217707). In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT (PubMed:23353889). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034).By similarity4 Publications

Caution

Subsequent steps in cytosine demethylation are subject to discussion. According to a first model cytosine demethylation occurs through deamination of 5hmC into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. According to another model, cytosine demethylation is rather mediated via conversion of 5hmC into 5fC and 5caC, followed by excision by TDG.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi57ZincCombined sources1 Publication1
Metal bindingi60ZincCombined sources1 Publication1
Metal bindingi63ZincCombined sources1 Publication1
Metal bindingi69ZincCombined sources1 Publication1
Metal bindingi72ZincCombined sources1 Publication1
Metal bindingi75ZincCombined sources1 Publication1
Metal bindingi84ZincCombined sources1 Publication1
Metal bindingi89ZincCombined sources1 Publication1
Metal bindingi828Zinc 1By similarity1
Metal bindingi830Zinc 1By similarity1
Metal bindingi888Zinc 2By similarity1
Metal bindingi914Zinc 1; via pros nitrogenBy similarity1
Metal bindingi916Zinc 1By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei9562-oxoglutarateBy similarity1
Metal bindingi966Zinc 2By similarity1
Metal bindingi968Zinc 2By similarity1
Metal bindingi984Zinc 3By similarity1
Metal bindingi993Zinc 3By similarity1
Metal bindingi1053Zinc 3By similarity1
Binding sitei10692-oxoglutarateBy similarity1
Metal bindingi1075Zinc 2; via tele nitrogenBy similarity1
Metal bindingi1077Iron; catalyticBy similarity1
Metal bindingi1079Iron; catalyticBy similarity1
Binding sitei1082SubstrateBy similarity1
Binding sitei11112-oxoglutarateBy similarity1
Metal bindingi1673Iron; catalyticBy similarity1
Metal bindingi1704Zinc 3; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri50 – 90CXXC-typePROSITE-ProRule annotation1 PublicationAdd BLAST41

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, Dioxygenase, DNA-binding, Oxidoreductase
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O43151

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5221030, TET1,2,3 and TDG demethylate DNA

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O43151

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methylcytosine dioxygenase TET3Curated (EC:1.14.11.n21 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TET3Imported
Synonyms:KIAA0401
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187605.15

Human Gene Nomenclature Database

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HGNCi
HGNC:28313, TET3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613555, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43151

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Beck-Fahrner syndrome (BEFAHRS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA developmental disorder characterized by mild to severe intellectual disability, global developmental delay, hypotonia, autistic traits, movement disorders, growth abnormalities including overgrowth or poor growth, and facial dysmorphism. Both autosomal dominant and autosomal recessive inheritance has been reported.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083831752R → C in BEFAHRS; unknown pathological significance; no effect on methylcytosine dioxygenase activity. 1 Publication1
Natural variantiVAR_083832851T → M in BEFAHRS. 1 Publication1
Natural variantiVAR_083833908V → L in BEFAHRS; decreases methylcytosine dioxygenase activity. 1 Publication1
Natural variantiVAR_0838341072F → C in BEFAHRS; decreases methylcytosine dioxygenase activity. 1 Publication1
Natural variantiVAR_0838351076A → T in BEFAHRS; decreases methylcytosine dioxygenase activity. 1 Publication1
Natural variantiVAR_0838361089V → M in BEFAHRS; decreases methylcytosine dioxygenase activity. 1 Publication1
Natural variantiVAR_0838371677P → L in BEFAHRS. 1 Publication1
Natural variantiVAR_0838381695 – 1795Missing in BEFAHRS. 1 PublicationAdd BLAST101

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1077 – 1079HKD → YKA: Abolishes methylcytosine dioxygenase activity. 1 Publication3

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
200424
MIMi618798, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000187605

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162405645

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O43151, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TET3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507501 – 1795Methylcytosine dioxygenase TET3Add BLAST1795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki491Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1188Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1219Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1397Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1561Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43151

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O43151

MaxQB - The MaxQuant DataBase

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MaxQBi
O43151

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O43151

PeptideAtlas

More...
PeptideAtlasi
O43151

PRoteomics IDEntifications database

More...
PRIDEi
O43151

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
48772 [O43151-1]
48773 [O43151-2]
48774 [O43151-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43151

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43151

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal brain but not adult brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187605, Expressed in oocyte and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43151, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43151, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000187605, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HCFC1 and OGT.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
128327, 11 interactors

Protein interaction database and analysis system

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IntActi
O43151, 30 interactors

Molecular INTeraction database

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MINTi
O43151

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386869

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O43151, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11795
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43151

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni985 – 998Interaction with DNABy similarityAdd BLAST14
Regioni1688 – 16902-oxoglutarate bindingBy similarity3
Regioni1694 – 1696Substrate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CXXC zinc finger mediates binding to CpG-DNA (PubMed:29276034). It mediates binding to DNA sequences containing unmethylated cytosine or 5-carboxylcytosine in 5'-CCG-3' DNA sequence motifs (By similarity).By similarity1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TET family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri50 – 90CXXC-typePROSITE-ProRule annotation1 PublicationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QURD, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000157631

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001618_3_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43151

Identification of Orthologs from Complete Genome Data

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OMAi
VMVGGFQ

Database for complete collections of gene phylogenies

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PhylomeDBi
O43151

TreeFam database of animal gene trees

More...
TreeFami
TF342373

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024779, 2OGFeDO_noxygenase_dom
IPR040175, TET1/2/3
IPR002857, Znf_CXXC

The PANTHER Classification System

More...
PANTHERi
PTHR23358, PTHR23358, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12851, Tet_JBP, 1 hit
PF02008, zf-CXXC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01333, Tet_JBP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51058, ZF_CXXC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 4 (identifier: O43151-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQFQVPLAV QPDLPGLYDF PQRQVMVGSF PGSGLSMAGS ESQLRGGGDG
60 70 80 90 100
RKKRKRCGTC EPCRRLENCG ACTSCTNRRT HQICKLRKCE VLKKKVGLLK
110 120 130 140 150
EVEIKAGEGA GPWGQGAAVK TGSELSPVDG PVPGQMDSGP VYHGDSRQLS
160 170 180 190 200
ASGVPVNGAR EPAGPSLLGT GGPWRVDQKP DWEAAPGPAH TARLEDAHDL
210 220 230 240 250
VAFSAVAEAV SSYGALSTRL YETFNREMSR EAGNNSRGPR PGPEGCSAGS
260 270 280 290 300
EDLDTLQTAL ALARHGMKPP NCNCDGPECP DYLEWLEGKI KSVVMEGGEE
310 320 330 340 350
RPRLPGPLPP GEAGLPAPST RPLLSSEVPQ ISPQEGLPLS QSALSIAKEK
360 370 380 390 400
NISLQTAIAI EALTQLSSAL PQPSHSTPQA SCPLPEALSP PAPFRSPQSY
410 420 430 440 450
LRAPSWPVVP PEEHSSFAPD SSAFPPATPR TEFPEAWGTD TPPATPRSSW
460 470 480 490 500
PMPRPSPDPM AELEQLLGSA SDYIQSVFKR PEALPTKPKV KVEAPSSSPA
510 520 530 540 550
PAPSPVLQRE APTPSSEPDT HQKAQTALQQ HLHHKRSLFL EQVHDTSFPA
560 570 580 590 600
PSEPSAPGWW PPPSSPVPRL PDRPPKEKKK KLPTPAGGPV GTEKAAPGIK
610 620 630 640 650
PSVRKPIQIK KSRPREAQPL FPPVRQIVLE GLRSPASQEV QAHPPAPLPA
660 670 680 690 700
SQGSAVPLPP EPSLALFAPS PSRDSLLPPT QEMRSPSPMT ALQPGSTGPL
710 720 730 740 750
PPADDKLEEL IRQFEAEFGD SFGLPGPPSV PIQDPENQQT CLPAPESPFA
760 770 780 790 800
TRSPKQIKIE SSGAVTVLST TCFHSEEGGQ EATPTKAENP LTPTLSGFLE
810 820 830 840 850
SPLKYLDTPT KSLLDTPAKR AQAEFPTCDC VEQIVEKDEG PYYTHLGSGP
860 870 880 890 900
TVASIRELME ERYGEKGKAI RIEKVIYTGK EGKSSRGCPI AKWVIRRHTL
910 920 930 940 950
EEKLLCLVRH RAGHHCQNAV IVILILAWEG IPRSLGDTLY QELTDTLRKY
960 970 980 990 1000
GNPTSRRCGL NDDRTCACQG KDPNTCGASF SFGCSWSMYF NGCKYARSKT
1010 1020 1030 1040 1050
PRKFRLAGDN PKEEEVLRKS FQDLATEVAP LYKRLAPQAY QNQVTNEEIA
1060 1070 1080 1090 1100
IDCRLGLKEG RPFAGVTACM DFCAHAHKDQ HNLYNGCTVV CTLTKEDNRC
1110 1120 1130 1140 1150
VGKIPEDEQL HVLPLYKMAN TDEFGSEENQ NAKVGSGAIQ VLTAFPREVR
1160 1170 1180 1190 1200
RLPEPAKSCR QRQLEARKAA AEKKKIQKEK LSTPEKIKQE ALELAGITSD
1210 1220 1230 1240 1250
PGLSLKGGLS QQGLKPSLKV EPQNHFSSFK YSGNAVVESY SVLGNCRPSD
1260 1270 1280 1290 1300
PYSMNSVYSY HSYYAQPSLT SVNGFHSKYA LPSFSYYGFP SSNPVFPSQF
1310 1320 1330 1340 1350
LGPGAWGHSG SSGSFEKKPD LHALHNSLSP AYGGAEFAEL PSQAVPTDAH
1360 1370 1380 1390 1400
HPTPHHQQPA YPGPKEYLLP KAPLLHSVSR DPSPFAQSSN CYNRSIKQEP
1410 1420 1430 1440 1450
VDPLTQAEPV PRDAGKMGKT PLSEVSQNGG PSHLWGQYSG GPSMSPKRTN
1460 1470 1480 1490 1500
GVGGSWGVFS SGESPAIVPD KLSSFGASCL APSHFTDGQW GLFPGEGQQA
1510 1520 1530 1540 1550
ASHSGGRLRG KPWSPCKFGN STSALAGPSL TEKPWALGAG DFNSALKGSP
1560 1570 1580 1590 1600
GFQDKLWNPM KGEEGRIPAA GASQLDRAWQ SFGLPLGSSE KLFGALKSEE
1610 1620 1630 1640 1650
KLWDPFSLEE GPAEEPPSKG AVKEEKGGGG AEEEEEELWS DSEHNFLDEN
1660 1670 1680 1690 1700
IGGVAVAPAH GSILIECARR ELHATTPLKK PNRCHPTRIS LVFYQHKNLN
1710 1720 1730 1740 1750
QPNHGLALWE AKMKQLAERA RARQEEAARL GLGQQEAKLY GKKRKWGGTV
1760 1770 1780 1790
VAEPQQKEKK GVVPTRQALA VPTDSAVTVS SYAYTKVTGP YSRWI
Length:1,795
Mass (Da):193,705
Last modified:November 13, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D1041E2C45C4F18
GO
Isoform 2 (identifier: O43151-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1575-1690: Missing.

Show »
Length:1,679
Mass (Da):181,060
Checksum:i40F58F33AFE5A166
GO
Isoform 3 (identifier: O43151-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-1795: Missing.

Show »
Length:862
Mass (Da):91,826
Checksum:iD95CAB622C6E2A13
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5H1ZRP3A0A5H1ZRP3_HUMAN
Methylcytosine dioxygenase TET
TET3
1,702Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH22243 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAO33386 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAX93057 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062235712R → Q. Corresponds to variant dbSNP:rs57955681EnsemblClinVar.1
Natural variantiVAR_083831752R → C in BEFAHRS; unknown pathological significance; no effect on methylcytosine dioxygenase activity. 1 Publication1
Natural variantiVAR_083832851T → M in BEFAHRS. 1 Publication1
Natural variantiVAR_083833908V → L in BEFAHRS; decreases methylcytosine dioxygenase activity. 1 Publication1
Natural variantiVAR_0838341072F → C in BEFAHRS; decreases methylcytosine dioxygenase activity. 1 Publication1
Natural variantiVAR_0838351076A → T in BEFAHRS; decreases methylcytosine dioxygenase activity. 1 Publication1
Natural variantiVAR_0838361089V → M in BEFAHRS; decreases methylcytosine dioxygenase activity. 1 Publication1
Natural variantiVAR_0838371677P → L in BEFAHRS. 1 Publication1
Natural variantiVAR_0838381695 – 1795Missing in BEFAHRS. 1 PublicationAdd BLAST101

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034192863 – 1795Missing in isoform 3. 1 PublicationAdd BLAST933
Alternative sequenceiVSP_0216281575 – 1690Missing in isoform 2. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HQ220209 mRNA Translation: ADU77107.1
AC110801 Genomic DNA No translation available.
AC073263 Genomic DNA Translation: AAX93057.1 Sequence problems.
AC073046 Genomic DNA No translation available.
AF466365 mRNA Translation: AAO33386.1 Different initiation.
BC022243 mRNA Translation: AAH22243.1 Different initiation.
AB007861 mRNA Translation: BAA23697.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46339.2 [O43151-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001274420.1, NM_001287491.1 [O43151-1]
XP_005264244.1, XM_005264187.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409262; ENSP00000386869; ENSG00000187605 [O43151-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
200424

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:200424

UCSC genome browser

More...
UCSCi
uc002skb.6, human [O43151-1]
uc061kse.1, human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ220209 mRNA Translation: ADU77107.1
AC110801 Genomic DNA No translation available.
AC073263 Genomic DNA Translation: AAX93057.1 Sequence problems.
AC073046 Genomic DNA No translation available.
AF466365 mRNA Translation: AAO33386.1 Different initiation.
BC022243 mRNA Translation: AAH22243.1 Different initiation.
AB007861 mRNA Translation: BAA23697.1
CCDSiCCDS46339.2 [O43151-1]
RefSeqiNP_001274420.1, NM_001287491.1 [O43151-1]
XP_005264244.1, XM_005264187.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z3CX-ray1.57C49-98[»]
SMRiO43151
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi128327, 11 interactors
IntActiO43151, 30 interactors
MINTiO43151
STRINGi9606.ENSP00000386869

PTM databases

iPTMnetiO43151
PhosphoSitePlusiO43151

Polymorphism and mutation databases

BioMutaiTET3

Proteomic databases

jPOSTiO43151
MassIVEiO43151
MaxQBiO43151
PaxDbiO43151
PeptideAtlasiO43151
PRIDEiO43151
ProteomicsDBi48772 [O43151-1]
48773 [O43151-2]
48774 [O43151-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31410, 319 antibodies

The DNASU plasmid repository

More...
DNASUi
200424

Genome annotation databases

EnsembliENST00000409262; ENSP00000386869; ENSG00000187605 [O43151-1]
GeneIDi200424
KEGGihsa:200424
UCSCiuc002skb.6, human [O43151-1]
uc061kse.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
200424
DisGeNETi200424
EuPathDBiHostDB:ENSG00000187605.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TET3
HGNCiHGNC:28313, TET3
HPAiENSG00000187605, Tissue enhanced (brain)
MIMi613555, gene
618798, phenotype
neXtProtiNX_O43151
OpenTargetsiENSG00000187605
PharmGKBiPA162405645

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QURD, Eukaryota
GeneTreeiENSGT00940000157631
HOGENOMiCLU_001618_3_0_1
InParanoidiO43151
OMAiVMVGGFQ
PhylomeDBiO43151
TreeFamiTF342373

Enzyme and pathway databases

PathwayCommonsiO43151
ReactomeiR-HSA-5221030, TET1,2,3 and TDG demethylate DNA
SIGNORiO43151

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
200424, 5 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TET3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
200424
PharosiO43151, Tbio

Protein Ontology

More...
PROi
PR:O43151
RNActiO43151, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187605, Expressed in oocyte and 222 other tissues
ExpressionAtlasiO43151, baseline and differential
GenevisibleiO43151, HS

Family and domain databases

InterProiView protein in InterPro
IPR024779, 2OGFeDO_noxygenase_dom
IPR040175, TET1/2/3
IPR002857, Znf_CXXC
PANTHERiPTHR23358, PTHR23358, 2 hits
PfamiView protein in Pfam
PF12851, Tet_JBP, 1 hit
PF02008, zf-CXXC, 1 hit
SMARTiView protein in SMART
SM01333, Tet_JBP, 1 hit
PROSITEiView protein in PROSITE
PS51058, ZF_CXXC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTET3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43151
Secondary accession number(s): A6NEI3
, J3KNF3, K9JJH7, Q86Z24, Q8TBM9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 13, 2019
Last modified: October 7, 2020
This is version 145 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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