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Entry version 146 (13 Feb 2019)
Sequence version 6 (05 May 2009)
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Protein

Zinc finger ZZ-type and EF-hand domain-containing protein 1

Gene

ZZEF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1777 – 1825ZZ-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri1826 – 1872ZZ-type 2PROSITE-ProRule annotationAdd BLAST47

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger ZZ-type and EF-hand domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZZEF1
Synonyms:KIAA0399
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000074755.14

Human Gene Nomenclature Database

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HGNCi
HGNC:29027 ZZEF1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43149

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23140

Open Targets

More...
OpenTargetsi
ENSG00000074755

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134938508

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZZEF1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002890002 – 2961Zinc finger ZZ-type and EF-hand domain-containing protein 1Add BLAST2960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine2 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei240PhosphoserineCombined sources1
Modified residuei1475PhosphoserineCombined sources1
Modified residuei1488PhosphoserineBy similarity1
Modified residuei1509PhosphoserineCombined sources1
Modified residuei1512PhosphothreonineCombined sources1
Modified residuei1518PhosphoserineCombined sources1
Modified residuei1521PhosphothreonineBy similarity1
Modified residuei1523PhosphothreonineCombined sources1
Modified residuei1537PhosphoserineCombined sources1
Modified residuei1540PhosphoserineCombined sources1
Modified residuei2444PhosphoserineCombined sources1
Modified residuei2667N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43149

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43149

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43149

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43149

PeptideAtlas

More...
PeptideAtlasi
O43149

PRoteomics IDEntifications database

More...
PRIDEi
O43149

ProteomicsDB human proteome resource

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ProteomicsDBi
48767
48768 [O43149-2]
48769 [O43149-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43149

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43149

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at low levels in cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074755 Expressed in 224 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43149 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43149 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031778
HPA031790

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116757, 72 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
O43149

Protein interaction database and analysis system

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IntActi
O43149, 14 interactors

Molecular INTeraction database

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MINTi
O43149

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O43149

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O43149

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 146EF-handPROSITE-ProRule annotationAdd BLAST36
Domaini226 – 405DOCPROSITE-ProRule annotationAdd BLAST180

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1777 – 1825ZZ-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri1826 – 1872ZZ-type 2PROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410II3P Eukaryota
ENOG410XS5C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155045

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000155817

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108782

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43149

Identification of Orthologs from Complete Genome Data

More...
OMAi
MMNVTEQ

Database of Orthologous Groups

More...
OrthoDBi
6958at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43149

TreeFam database of animal gene trees

More...
TreeFami
TF331572

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR008979 Galactose-bd-like_sf
IPR000433 Znf_ZZ
IPR040099 ZZEF1

The PANTHER Classification System

More...
PANTHERi
PTHR22772:SF4 PTHR22772:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03256 ANAPC10, 1 hit
PF00569 ZZ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01337 APC10, 1 hit
SM00054 EFh, 1 hit
SM00291 ZnF_ZZ, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF49785 SSF49785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51284 DOC, 1 hit
PS50222 EF_HAND_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43149-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNAPSHSSE DEAAAAGGEG WGPHQDWAAV SGTTPGPGVA APALPPAAAL
60 70 80 90 100
LEPARLREAA AALLPTPPCE SLVSRHRGAL FRWLEERLGR GEESVTLEQF
110 120 130 140 150
RELLEARGAG CSSEQFEEAF AQFDAEGDGT VDAENMLEAL KNSSGANLQG
160 170 180 190 200
ELSHIIRQLQ ACSLVPGFTD IFSESKEGLD IHSSMILRFL HRNRLSSAVM
210 220 230 240 250
PYPMLEHCNN MCTMRSSVLK ESLDQLVQKE KESPGDLTRS PEMDKLKSVA
260 270 280 290 300
KCYAYIETSS NSADIDKMTN GETSSYWQSD GSACSHWIRL KMKPDVVLRH
310 320 330 340 350
LSIAVAATDQ SYMPQQVTVA VGRNASDLQE VRDVHIPSNV TGYVTLLENA
360 370 380 390 400
NVSQLYVQIN IKRCLSDGCD TRIHGLRAVG FQRVKKSGVS VSDASAIWYW
410 420 430 440 450
SLLTSLVTAS METNPAFVQT VLHNTQKALR HMPPLSLSPG STDFSTFLSP
460 470 480 490 500
NVLEEVDSFL IRITSCCSTP EVELTLLAFA LARGSVAKVM SSLCTITDHL
510 520 530 540 550
DTQYDASSLI LSMASVRQNL LLKYGKPLQL TLQACDVKGK EDKSGPENLL
560 570 580 590 600
VEPWTRDGFL TETGKTRAST IFSTGTESAF QVTQIRIMVR RGGIGAQCGL
610 620 630 640 650
VFAYNSSSDK FCAEEHFKRF EKYDKWKLQE LRQFVKSRIG CSSDDLGEDD
660 670 680 690 700
PIGWFELEEE WDEADVKLQQ CRVAKYLMVK FLCTRQESAE RLGVQGLTIS
710 720 730 740 750
GYLRPARAEA EQSVTCAHCR KDTEESVCGA TLLLRTLQFI QQLAHDLVQQ
760 770 780 790 800
KESGLKYKSF LDFAGLDLQI FWNFYSKLKQ NPREECVSAQ TLLLQLLQSC
810 820 830 840 850
FSVLQGDVLA ASEEEKAPIQ SPKGVEAAKE LYTHLCDVVD KVDGDSVPME
860 870 880 890 900
ILKQEVRNTL LNGAAIFFPN RQTRRNHLFT MMNVTEQEHK QSLQLTFRSL
910 920 930 940 950
CTYFSDKDPG GLLLLPEKND LAKMNISEVL AVMDTLVSVA ARECELLMLS
960 970 980 990 1000
GAPGEVGSVL FSLFWSVQGS LLSWCYLQLK STDSGAKDLA VDLIEKYVGQ
1010 1020 1030 1040 1050
FLASMRAILE SLFSQYSGKT IVERLCNSVF SMAARQLVIF LLDFCTLDIP
1060 1070 1080 1090 1100
HCVLLREFSV LTELLKKLCS GPEGGLRKLD VETWQQEQPV VLHTWTKESA
1110 1120 1130 1140 1150
HNYENNCHEV SVFVSPGATY FEVEFDDRCE TEKRYDYLEF TDARGRKTRY
1160 1170 1180 1190 1200
DTKVGTDKWP KKVTFKAGPR LQFLFHSDSS HNEWGYKFTV TACGLPDVAV
1210 1220 1230 1240 1250
SWGLDLQLLV SRLMGRLASQ CMALKSVRQL GSNMVVPQAK MALVLSSPLW
1260 1270 1280 1290 1300
KPVFRHQVCP ELELEASWPT HPHRNSKEVK NIPDDPCRHF LLDFAQSEPA
1310 1320 1330 1340 1350
QNFCGPYSEL FKGFIQACRK QAPKTDIVAG STIDQAVNAT FAALVYRTPD
1360 1370 1380 1390 1400
LYEKLQKYVN SGGKIALSEE FAQVYSLADG IRIWMLEMKQ KSLMSLGNEA
1410 1420 1430 1440 1450
EEKHSSEATE VNPESLAKEC IEKSLLLLKF LPTGISSKES CEKLETADET
1460 1470 1480 1490 1500
SHLQPLNKRQ RTSSVVEEHF QASVSPTEAA PPATGDQSPG LGTQPKLPSS
1510 1520 1530 1540 1550
SGLPAADVSP ATAEEPLSPS TPTRRPPFTR GRLRLLSFRS MEEARLVPTV
1560 1570 1580 1590 1600
KEKYPVLKDV MDFIKDQSLS HRSVVKVLSL RKAQAQSILE VLKITQHCAE
1610 1620 1630 1640 1650
SLGQPHCFHP PFILFLLELL TCQKDFTNYF GHLEGCGADL HKEIRDTYYQ
1660 1670 1680 1690 1700
LVLFLVKAVK GFSSLNDRSL LPALSCVQTA LLHLLDMGWE PNDLAFFVDI
1710 1720 1730 1740 1750
QLPDLLMKMS QENISVHDSV ISQWSEEDEL ADAKQNSEWM DECQDGMFEA
1760 1770 1780 1790 1800
WYEKIAQEDP EKQRKMHMFI ARYCDLLNVD ISCDGCDEIA PWHRYRCLQC
1810 1820 1830 1840 1850
SDMDLCKTCF LGGVKPEGHG DDHEMVNMEF TCDHCQGLII GRRMNCNVCD
1860 1870 1880 1890 1900
DFDLCYGCYA AKKYSYGHLP THSITAHPMV TIRISDRQRL IQPYIHNYSW
1910 1920 1930 1940 1950
LLFAALALYS AHLASAEDVD GEKLDPQTRS SATTLRSQCM QLVGDCLMKA
1960 1970 1980 1990 2000
HQGKGLKALA LLGVLPDGDS SLEDQALPVT VPTGASEEQL EKKAVQGAEL
2010 2020 2030 2040 2050
SEAGNGKRAV HEEIRPVDFK QRNKADKGVS LSKDPSCQTQ ISDSPADASP
2060 2070 2080 2090 2100
PTGLPDAEDS EVSSQKPIEE KAVTPSPEQV FAECSQKRIL GLLAAMLPPL
2110 2120 2130 2140 2150
KSGPTVPLID LEHVLPLMFQ VVISNAGHLN ETYHLTLGLL GQLIIRLLPA
2160 2170 2180 2190 2200
EVDAAVIKVL SAKHNLFAAG DSSIVPDGWK TTHLLFSLGA VCLDSRVGLD
2210 2220 2230 2240 2250
WACSMAEILR SLNSAPLWRD VIATFTDHCI KQLPFQLKHT NIFTLLVLVG
2260 2270 2280 2290 2300
FPQVLCVGTR CVYMDNANEP HNVIILKHFT EKNRAVIVDV KTRKRKTVKD
2310 2320 2330 2340 2350
YQLVQKGGGQ ECGDSRAQLS QYSQHFAFIA SHLLQSSMDS HCPEAVEATW
2360 2370 2380 2390 2400
VLSLALKGLY KTLKAHGFEE IRATFLQTDL LKLLVKKCSK GTGFSKTWLL
2410 2420 2430 2440 2450
RDLEILSIML YSSKKEINAL AEHGDLELDE RGDREEEVER PVSSPGDPEQ
2460 2470 2480 2490 2500
KKLDPLEGLD EPTRICFLMA HDALNAPLHI LRAIYELQMK KTDYFFLEVQ
2510 2520 2530 2540 2550
KRFDGDELTT DERIRSLAQR WQPSKSLRLE EQSAKAVDTD MIILPCLSRP
2560 2570 2580 2590 2600
ARCDQATAES NPVTQKLISS TESELQQSYA KQRRSKSAAL LHKELNCKSK
2610 2620 2630 2640 2650
RAVRDYLFRV NEATAVLYAR HVLASLLAEW PSHVPVSEDI LELSGPAHMT
2660 2670 2680 2690 2700
YILDMFMQLE EKHEWEKILQ KVLQGCREDM LGTMALAACQ FMEEPGMEVQ
2710 2720 2730 2740 2750
VRESKHPYNN NTNFEDKVHI PGAIYLSIKF DSQCNTEEGC DELAMSSSSD
2760 2770 2780 2790 2800
FQQDRHSFSG SQQKWKDFEL PGDTLYYRFT SDMSNTEWGY RFTVTAGHLG
2810 2820 2830 2840 2850
RFQTGFEILK QMLSEERVVP HLPLAKIWEW LVGVACRQTG HQRLKAIHLL
2860 2870 2880 2890 2900
LRIVRCCGHS DLCDLALLKP LWQLFTHMEY GLFEDVTQPG ILLPLHRALT
2910 2920 2930 2940 2950
ELFFVTENRA QELGVLQDYL LALTTDDHLL RCAAQALQNI AAISLAINYP
2960
NKATRLWNVE C
Length:2,961
Mass (Da):331,075
Last modified:May 5, 2009 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DB2EB72C16BC168
GO
Isoform 2 (identifier: O43149-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1613: Missing.
     2405-2424: ILSIMLYSSKKEINALAEHG → VRDERDSCSSFLVQMCWPRS
     2425-2961: Missing.

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:811
Mass (Da):90,468
Checksum:iA3138EDEFE4A6139
GO
Isoform 3 (identifier: O43149-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     882-882: M → MK
     1079-1084: LDVETW → VTRVST
     1085-2961: Missing.

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:1,085
Mass (Da):119,964
Checksum:i276FA1193DC16093
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L141I3L141_HUMAN
Zinc finger ZZ-type and EF-hand dom...
ZZEF1
812Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3Q3I3L3Q3_HUMAN
Zinc finger ZZ-type and EF-hand dom...
ZZEF1
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1Q8I3L1Q8_HUMAN
Zinc finger ZZ-type and EF-hand dom...
ZZEF1
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2N1I3L2N1_HUMAN
Zinc finger ZZ-type and EF-hand dom...
ZZEF1
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA23695 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA91834 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti959V → A in BAA23695 (PubMed:9455477).Curated1
Sequence conflicti959V → A in AAI51837 (PubMed:15489334).Curated1
Sequence conflicti1929R → H in BAA91834 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03255130V → A1 PublicationCorresponds to variant dbSNP:rs1454121Ensembl.1
Natural variantiVAR_0325521021I → V. Corresponds to variant dbSNP:rs16953687Ensembl.1
Natural variantiVAR_0325531437S → A. Corresponds to variant dbSNP:rs4790555Ensembl.1
Natural variantiVAR_0325541972L → P2 PublicationsCorresponds to variant dbSNP:rs781852Ensembl.1
Natural variantiVAR_0325552014I → V2 PublicationsCorresponds to variant dbSNP:rs781831Ensembl.1
Natural variantiVAR_0325562051P → S. Corresponds to variant dbSNP:rs1006954Ensembl.1
Natural variantiVAR_0325572301Y → H. Corresponds to variant dbSNP:rs34357158Ensembl.1
Natural variantiVAR_0325582303L → P. Corresponds to variant dbSNP:rs35638819Ensembl.1
Natural variantiVAR_0325592369E → Q2 PublicationsCorresponds to variant dbSNP:rs711177Ensembl.1
Natural variantiVAR_0325602421A → T. Corresponds to variant dbSNP:rs781861Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0422681 – 1613Missing in isoform 2. 1 PublicationAdd BLAST1613
Alternative sequenceiVSP_036989882M → MK in isoform 3. 1 Publication1
Alternative sequenceiVSP_0258701079 – 1084LDVETW → VTRVST in isoform 3. 1 Publication6
Alternative sequenceiVSP_0258711085 – 2961Missing in isoform 3. 1 PublicationAdd BLAST1877
Alternative sequenceiVSP_0422692405 – 2424ILSIM…LAEHG → VRDERDSCSSFLVQMCWPRS in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0422702425 – 2961Missing in isoform 2. 1 PublicationAdd BLAST537

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB007859 mRNA Translation: BAA23695.4 Different initiation.
AK001683 mRNA Translation: BAA91834.1 Different initiation.
AK127482 mRNA Translation: BAC86999.1
AC067815 Genomic DNA No translation available.
AC087292 Genomic DNA No translation available.
BC067099 mRNA Translation: AAH67099.1
BC151836 mRNA Translation: AAI51837.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11043.1 [O43149-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00048

NCBI Reference Sequences

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RefSeqi
NP_055928.3, NM_015113.3 [O43149-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.277624

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000381638; ENSP00000371051; ENSG00000074755 [O43149-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23140

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23140

UCSC genome browser

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UCSCi
uc002fxe.4 human [O43149-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007859 mRNA Translation: BAA23695.4 Different initiation.
AK001683 mRNA Translation: BAA91834.1 Different initiation.
AK127482 mRNA Translation: BAC86999.1
AC067815 Genomic DNA No translation available.
AC087292 Genomic DNA No translation available.
BC067099 mRNA Translation: AAH67099.1
BC151836 mRNA Translation: AAI51837.1
CCDSiCCDS11043.1 [O43149-1]
PIRiT00048
RefSeqiNP_055928.3, NM_015113.3 [O43149-1]
UniGeneiHs.277624

3D structure databases

ProteinModelPortaliO43149
SMRiO43149
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116757, 72 interactors
ELMiO43149
IntActiO43149, 14 interactors
MINTiO43149

PTM databases

iPTMnetiO43149
PhosphoSitePlusiO43149

Polymorphism and mutation databases

BioMutaiZZEF1

Proteomic databases

EPDiO43149
jPOSTiO43149
MaxQBiO43149
PaxDbiO43149
PeptideAtlasiO43149
PRIDEiO43149
ProteomicsDBi48767
48768 [O43149-2]
48769 [O43149-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381638; ENSP00000371051; ENSG00000074755 [O43149-1]
GeneIDi23140
KEGGihsa:23140
UCSCiuc002fxe.4 human [O43149-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23140
DisGeNETi23140
EuPathDBiHostDB:ENSG00000074755.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ZZEF1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0017584
HGNCiHGNC:29027 ZZEF1
HPAiHPA031778
HPA031790
neXtProtiNX_O43149
OpenTargetsiENSG00000074755
PharmGKBiPA134938508

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II3P Eukaryota
ENOG410XS5C LUCA
GeneTreeiENSGT00940000155045
HOGENOMiHOG000155817
HOVERGENiHBG108782
InParanoidiO43149
OMAiMMNVTEQ
OrthoDBi6958at2759
PhylomeDBiO43149
TreeFamiTF331572

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZZEF1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23140

Protein Ontology

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PROi
PR:O43149

Gene expression databases

BgeeiENSG00000074755 Expressed in 224 organ(s), highest expression level in intestine
ExpressionAtlasiO43149 baseline and differential
GenevisibleiO43149 HS

Family and domain databases

CDDicd00051 EFh, 1 hit
Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR008979 Galactose-bd-like_sf
IPR000433 Znf_ZZ
IPR040099 ZZEF1
PANTHERiPTHR22772:SF4 PTHR22772:SF4, 1 hit
PfamiView protein in Pfam
PF03256 ANAPC10, 1 hit
PF00569 ZZ, 2 hits
SMARTiView protein in SMART
SM01337 APC10, 1 hit
SM00054 EFh, 1 hit
SM00291 ZnF_ZZ, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF49785 SSF49785, 1 hit
PROSITEiView protein in PROSITE
PS51284 DOC, 1 hit
PS50222 EF_HAND_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZZEF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43149
Secondary accession number(s): A7MBM5
, Q6NXG0, Q6ZRA1, Q6ZSF4, Q9NVB9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 5, 2009
Last modified: February 13, 2019
This is version 146 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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