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UniProtKB - O43149 (ZZEF1_HUMAN)
Protein
Zinc finger ZZ-type and EF-hand domain-containing protein 1
Gene
ZZEF1
Organism
Homo sapiens (Human)
Status
Functioni
Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 1783 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1786 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1797 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1800 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1806 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1809 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1819 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1823 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1832 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1835 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1846 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1849 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1855 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1858 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1868 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1872 | Zinc 4PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1778 – 1833 | ZZ-type 1PROSITE-ProRule annotationAdd BLAST | 56 | |
Zinc fingeri | 1827 – 1882 | ZZ-type 2PROSITE-ProRule annotationAdd BLAST | 56 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- lysine-acetylated histone binding Source: UniProtKB
- methylated histone binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O43149 |
SignaLinki | O43149 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger ZZ-type and EF-hand domain-containing protein 1 |
Gene namesi | Name:ZZEF1 Synonyms:KIAA0399 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29027, ZZEF1 |
MIMi | 619459, gene |
neXtProti | NX_O43149 |
VEuPathDBi | HostDB:ENSG00000074755 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1833 | D → A: Loss of histone H3 binding. 1 Publication | 1 | |
Mutagenesisi | 1853 | D → A: Loss of histone H3 binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23140 |
OpenTargetsi | ENSG00000074755 |
PharmGKBi | PA134938508 |
Miscellaneous databases
Pharosi | O43149, Tdark |
Genetic variation databases
BioMutai | ZZEF1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000289000 | 2 – 2961 | Zinc finger ZZ-type and EF-hand domain-containing protein 1Add BLAST | 2960 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine2 Publications | 1 | |
Modified residuei | 240 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1475 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1488 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1509 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1512 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1518 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1521 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1523 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1537 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1540 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2444 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2667 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, Lipoprotein, Myristate, PhosphoproteinProteomic databases
EPDi | O43149 |
jPOSTi | O43149 |
MassIVEi | O43149 |
MaxQBi | O43149 |
PaxDbi | O43149 |
PeptideAtlasi | O43149 |
PRIDEi | O43149 |
ProteomicsDBi | 48767 [O43149-1] 48768 [O43149-2] 48769 [O43149-3] |
PTM databases
GlyGeni | O43149, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | O43149 |
MetOSitei | O43149 |
PhosphoSitePlusi | O43149 |
Expressioni
Tissue specificityi
Expressed at low levels in cerebellum.1 Publication
Gene expression databases
Bgeei | ENSG00000074755, Expressed in sural nerve and 234 other tissues |
ExpressionAtlasi | O43149, baseline and differential |
Genevisiblei | O43149, HS |
Organism-specific databases
HPAi | ENSG00000074755, Low tissue specificity |
Interactioni
Subunit structurei
GO - Molecular functioni
- lysine-acetylated histone binding Source: UniProtKB
- methylated histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116757, 121 interactors |
ELMi | O43149 |
IntActi | O43149, 56 interactors |
MINTi | O43149 |
STRINGi | 9606.ENSP00000371051 |
Miscellaneous databases
RNActi | O43149, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 111 – 146 | EF-handPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 226 – 405 | DOCPROSITE-ProRule annotationAdd BLAST | 180 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 41 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 1446 – 1531 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 1994 – 2078 | DisorderedSequence analysisAdd BLAST | 85 | |
Regioni | 2426 – 2455 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1456 – 1500 | Polar residuesSequence analysisAdd BLAST | 45 | |
Compositional biasi | 2005 – 2029 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 2032 – 2047 | Polar residuesSequence analysisAdd BLAST | 16 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1778 – 1833 | ZZ-type 1PROSITE-ProRule annotationAdd BLAST | 56 | |
Zinc fingeri | 1827 – 1882 | ZZ-type 2PROSITE-ProRule annotationAdd BLAST | 56 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1426, Eukaryota |
GeneTreei | ENSGT00940000155045 |
HOGENOMi | CLU_000703_0_0_1 |
InParanoidi | O43149 |
OMAi | MMNVTEQ |
OrthoDBi | 6958at2759 |
PhylomeDBi | O43149 |
TreeFami | TF331572 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit cd02343, ZZ_EF, 1 hit |
Gene3Di | 3.30.60.90, 2 hits |
InterProi | View protein in InterPro IPR004939, APC_su10/DOC_dom IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR008979, Galactose-bd-like_sf IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf IPR040099, ZZEF1 IPR041986, ZZEF1_ZZ |
PANTHERi | PTHR22772:SF4, PTHR22772:SF4, 1 hit |
Pfami | View protein in Pfam PF03256, ANAPC10, 1 hit PF00569, ZZ, 2 hits |
SMARTi | View protein in SMART SM01337, APC10, 1 hit SM00054, EFh, 1 hit SM00291, ZnF_ZZ, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49785, SSF49785, 1 hit |
PROSITEi | View protein in PROSITE PS51284, DOC, 1 hit PS50222, EF_HAND_2, 1 hit PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O43149-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGNAPSHSSE DEAAAAGGEG WGPHQDWAAV SGTTPGPGVA APALPPAAAL
60 70 80 90 100
LEPARLREAA AALLPTPPCE SLVSRHRGAL FRWLEERLGR GEESVTLEQF
110 120 130 140 150
RELLEARGAG CSSEQFEEAF AQFDAEGDGT VDAENMLEAL KNSSGANLQG
160 170 180 190 200
ELSHIIRQLQ ACSLVPGFTD IFSESKEGLD IHSSMILRFL HRNRLSSAVM
210 220 230 240 250
PYPMLEHCNN MCTMRSSVLK ESLDQLVQKE KESPGDLTRS PEMDKLKSVA
260 270 280 290 300
KCYAYIETSS NSADIDKMTN GETSSYWQSD GSACSHWIRL KMKPDVVLRH
310 320 330 340 350
LSIAVAATDQ SYMPQQVTVA VGRNASDLQE VRDVHIPSNV TGYVTLLENA
360 370 380 390 400
NVSQLYVQIN IKRCLSDGCD TRIHGLRAVG FQRVKKSGVS VSDASAIWYW
410 420 430 440 450
SLLTSLVTAS METNPAFVQT VLHNTQKALR HMPPLSLSPG STDFSTFLSP
460 470 480 490 500
NVLEEVDSFL IRITSCCSTP EVELTLLAFA LARGSVAKVM SSLCTITDHL
510 520 530 540 550
DTQYDASSLI LSMASVRQNL LLKYGKPLQL TLQACDVKGK EDKSGPENLL
560 570 580 590 600
VEPWTRDGFL TETGKTRAST IFSTGTESAF QVTQIRIMVR RGGIGAQCGL
610 620 630 640 650
VFAYNSSSDK FCAEEHFKRF EKYDKWKLQE LRQFVKSRIG CSSDDLGEDD
660 670 680 690 700
PIGWFELEEE WDEADVKLQQ CRVAKYLMVK FLCTRQESAE RLGVQGLTIS
710 720 730 740 750
GYLRPARAEA EQSVTCAHCR KDTEESVCGA TLLLRTLQFI QQLAHDLVQQ
760 770 780 790 800
KESGLKYKSF LDFAGLDLQI FWNFYSKLKQ NPREECVSAQ TLLLQLLQSC
810 820 830 840 850
FSVLQGDVLA ASEEEKAPIQ SPKGVEAAKE LYTHLCDVVD KVDGDSVPME
860 870 880 890 900
ILKQEVRNTL LNGAAIFFPN RQTRRNHLFT MMNVTEQEHK QSLQLTFRSL
910 920 930 940 950
CTYFSDKDPG GLLLLPEKND LAKMNISEVL AVMDTLVSVA ARECELLMLS
960 970 980 990 1000
GAPGEVGSVL FSLFWSVQGS LLSWCYLQLK STDSGAKDLA VDLIEKYVGQ
1010 1020 1030 1040 1050
FLASMRAILE SLFSQYSGKT IVERLCNSVF SMAARQLVIF LLDFCTLDIP
1060 1070 1080 1090 1100
HCVLLREFSV LTELLKKLCS GPEGGLRKLD VETWQQEQPV VLHTWTKESA
1110 1120 1130 1140 1150
HNYENNCHEV SVFVSPGATY FEVEFDDRCE TEKRYDYLEF TDARGRKTRY
1160 1170 1180 1190 1200
DTKVGTDKWP KKVTFKAGPR LQFLFHSDSS HNEWGYKFTV TACGLPDVAV
1210 1220 1230 1240 1250
SWGLDLQLLV SRLMGRLASQ CMALKSVRQL GSNMVVPQAK MALVLSSPLW
1260 1270 1280 1290 1300
KPVFRHQVCP ELELEASWPT HPHRNSKEVK NIPDDPCRHF LLDFAQSEPA
1310 1320 1330 1340 1350
QNFCGPYSEL FKGFIQACRK QAPKTDIVAG STIDQAVNAT FAALVYRTPD
1360 1370 1380 1390 1400
LYEKLQKYVN SGGKIALSEE FAQVYSLADG IRIWMLEMKQ KSLMSLGNEA
1410 1420 1430 1440 1450
EEKHSSEATE VNPESLAKEC IEKSLLLLKF LPTGISSKES CEKLETADET
1460 1470 1480 1490 1500
SHLQPLNKRQ RTSSVVEEHF QASVSPTEAA PPATGDQSPG LGTQPKLPSS
1510 1520 1530 1540 1550
SGLPAADVSP ATAEEPLSPS TPTRRPPFTR GRLRLLSFRS MEEARLVPTV
1560 1570 1580 1590 1600
KEKYPVLKDV MDFIKDQSLS HRSVVKVLSL RKAQAQSILE VLKITQHCAE
1610 1620 1630 1640 1650
SLGQPHCFHP PFILFLLELL TCQKDFTNYF GHLEGCGADL HKEIRDTYYQ
1660 1670 1680 1690 1700
LVLFLVKAVK GFSSLNDRSL LPALSCVQTA LLHLLDMGWE PNDLAFFVDI
1710 1720 1730 1740 1750
QLPDLLMKMS QENISVHDSV ISQWSEEDEL ADAKQNSEWM DECQDGMFEA
1760 1770 1780 1790 1800
WYEKIAQEDP EKQRKMHMFI ARYCDLLNVD ISCDGCDEIA PWHRYRCLQC
1810 1820 1830 1840 1850
SDMDLCKTCF LGGVKPEGHG DDHEMVNMEF TCDHCQGLII GRRMNCNVCD
1860 1870 1880 1890 1900
DFDLCYGCYA AKKYSYGHLP THSITAHPMV TIRISDRQRL IQPYIHNYSW
1910 1920 1930 1940 1950
LLFAALALYS AHLASAEDVD GEKLDPQTRS SATTLRSQCM QLVGDCLMKA
1960 1970 1980 1990 2000
HQGKGLKALA LLGVLPDGDS SLEDQALPVT VPTGASEEQL EKKAVQGAEL
2010 2020 2030 2040 2050
SEAGNGKRAV HEEIRPVDFK QRNKADKGVS LSKDPSCQTQ ISDSPADASP
2060 2070 2080 2090 2100
PTGLPDAEDS EVSSQKPIEE KAVTPSPEQV FAECSQKRIL GLLAAMLPPL
2110 2120 2130 2140 2150
KSGPTVPLID LEHVLPLMFQ VVISNAGHLN ETYHLTLGLL GQLIIRLLPA
2160 2170 2180 2190 2200
EVDAAVIKVL SAKHNLFAAG DSSIVPDGWK TTHLLFSLGA VCLDSRVGLD
2210 2220 2230 2240 2250
WACSMAEILR SLNSAPLWRD VIATFTDHCI KQLPFQLKHT NIFTLLVLVG
2260 2270 2280 2290 2300
FPQVLCVGTR CVYMDNANEP HNVIILKHFT EKNRAVIVDV KTRKRKTVKD
2310 2320 2330 2340 2350
YQLVQKGGGQ ECGDSRAQLS QYSQHFAFIA SHLLQSSMDS HCPEAVEATW
2360 2370 2380 2390 2400
VLSLALKGLY KTLKAHGFEE IRATFLQTDL LKLLVKKCSK GTGFSKTWLL
2410 2420 2430 2440 2450
RDLEILSIML YSSKKEINAL AEHGDLELDE RGDREEEVER PVSSPGDPEQ
2460 2470 2480 2490 2500
KKLDPLEGLD EPTRICFLMA HDALNAPLHI LRAIYELQMK KTDYFFLEVQ
2510 2520 2530 2540 2550
KRFDGDELTT DERIRSLAQR WQPSKSLRLE EQSAKAVDTD MIILPCLSRP
2560 2570 2580 2590 2600
ARCDQATAES NPVTQKLISS TESELQQSYA KQRRSKSAAL LHKELNCKSK
2610 2620 2630 2640 2650
RAVRDYLFRV NEATAVLYAR HVLASLLAEW PSHVPVSEDI LELSGPAHMT
2660 2670 2680 2690 2700
YILDMFMQLE EKHEWEKILQ KVLQGCREDM LGTMALAACQ FMEEPGMEVQ
2710 2720 2730 2740 2750
VRESKHPYNN NTNFEDKVHI PGAIYLSIKF DSQCNTEEGC DELAMSSSSD
2760 2770 2780 2790 2800
FQQDRHSFSG SQQKWKDFEL PGDTLYYRFT SDMSNTEWGY RFTVTAGHLG
2810 2820 2830 2840 2850
RFQTGFEILK QMLSEERVVP HLPLAKIWEW LVGVACRQTG HQRLKAIHLL
2860 2870 2880 2890 2900
LRIVRCCGHS DLCDLALLKP LWQLFTHMEY GLFEDVTQPG ILLPLHRALT
2910 2920 2930 2940 2950
ELFFVTENRA QELGVLQDYL LALTTDDHLL RCAAQALQNI AAISLAINYP
2960
NKATRLWNVE C
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L141 | I3L141_HUMAN | Zinc finger ZZ-type and EF-hand dom... | ZZEF1 | 812 | Annotation score: | ||
I3L1Q8 | I3L1Q8_HUMAN | Zinc finger ZZ-type and EF-hand dom... | ZZEF1 | 219 | Annotation score: | ||
I3L3Q3 | I3L3Q3_HUMAN | Zinc finger ZZ-type and EF-hand dom... | ZZEF1 | 148 | Annotation score: | ||
I3L2N1 | I3L2N1_HUMAN | Zinc finger ZZ-type and EF-hand dom... | ZZEF1 | 66 | Annotation score: |
Sequence cautioni
The sequence BAA23695 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA91834 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 959 | V → A in BAA23695 (PubMed:9455477).Curated | 1 | |
Sequence conflicti | 959 | V → A in AAI51837 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1929 | R → H in BAA91834 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032551 | 30 | V → A1 PublicationCorresponds to variant dbSNP:rs1454121Ensembl. | 1 | |
Natural variantiVAR_032552 | 1021 | I → V. Corresponds to variant dbSNP:rs16953687Ensembl. | 1 | |
Natural variantiVAR_032553 | 1437 | S → A. Corresponds to variant dbSNP:rs4790555Ensembl. | 1 | |
Natural variantiVAR_032554 | 1972 | L → P2 PublicationsCorresponds to variant dbSNP:rs781852Ensembl. | 1 | |
Natural variantiVAR_032555 | 2014 | I → V2 PublicationsCorresponds to variant dbSNP:rs781831Ensembl. | 1 | |
Natural variantiVAR_032556 | 2051 | P → S. Corresponds to variant dbSNP:rs1006954Ensembl. | 1 | |
Natural variantiVAR_032557 | 2301 | Y → H. Corresponds to variant dbSNP:rs34357158Ensembl. | 1 | |
Natural variantiVAR_032558 | 2303 | L → P. Corresponds to variant dbSNP:rs35638819Ensembl. | 1 | |
Natural variantiVAR_032559 | 2369 | E → Q2 PublicationsCorresponds to variant dbSNP:rs711177Ensembl. | 1 | |
Natural variantiVAR_032560 | 2421 | A → T. Corresponds to variant dbSNP:rs781861Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042268 | 1 – 1613 | Missing in isoform 2. 1 PublicationAdd BLAST | 1613 | |
Alternative sequenceiVSP_036989 | 882 | M → MK in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_025870 | 1079 – 1084 | LDVETW → VTRVST in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_025871 | 1085 – 2961 | Missing in isoform 3. 1 PublicationAdd BLAST | 1877 | |
Alternative sequenceiVSP_042269 | 2405 – 2424 | ILSIM…LAEHG → VRDERDSCSSFLVQMCWPRS in isoform 2. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_042270 | 2425 – 2961 | Missing in isoform 2. 1 PublicationAdd BLAST | 537 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007859 mRNA Translation: BAA23695.4 Different initiation. AK001683 mRNA Translation: BAA91834.1 Different initiation. AK127482 mRNA Translation: BAC86999.1 AC067815 Genomic DNA No translation available. AC087292 Genomic DNA No translation available. BC067099 mRNA Translation: AAH67099.1 BC151836 mRNA Translation: AAI51837.1 |
CCDSi | CCDS11043.1 [O43149-1] |
PIRi | T00048 |
RefSeqi | NP_055928.3, NM_015113.3 [O43149-1] |
Genome annotation databases
Ensembli | ENST00000381638; ENSP00000371051; ENSG00000074755 |
GeneIDi | 23140 |
KEGGi | hsa:23140 |
MANE-Selecti | ENST00000381638.7; ENSP00000371051.2; NM_015113.4; NP_055928.3 |
UCSCi | uc002fxe.4, human [O43149-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007859 mRNA Translation: BAA23695.4 Different initiation. AK001683 mRNA Translation: BAA91834.1 Different initiation. AK127482 mRNA Translation: BAC86999.1 AC067815 Genomic DNA No translation available. AC087292 Genomic DNA No translation available. BC067099 mRNA Translation: AAH67099.1 BC151836 mRNA Translation: AAI51837.1 |
CCDSi | CCDS11043.1 [O43149-1] |
PIRi | T00048 |
RefSeqi | NP_055928.3, NM_015113.3 [O43149-1] |
3D structure databases
SMRi | O43149 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116757, 121 interactors |
ELMi | O43149 |
IntActi | O43149, 56 interactors |
MINTi | O43149 |
STRINGi | 9606.ENSP00000371051 |
PTM databases
GlyGeni | O43149, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | O43149 |
MetOSitei | O43149 |
PhosphoSitePlusi | O43149 |
Genetic variation databases
BioMutai | ZZEF1 |
Proteomic databases
EPDi | O43149 |
jPOSTi | O43149 |
MassIVEi | O43149 |
MaxQBi | O43149 |
PaxDbi | O43149 |
PeptideAtlasi | O43149 |
PRIDEi | O43149 |
ProteomicsDBi | 48767 [O43149-1] 48768 [O43149-2] 48769 [O43149-3] |
Protocols and materials databases
Antibodypediai | 23205, 29 antibodies from 9 providers |
DNASUi | 23140 |
Genome annotation databases
Ensembli | ENST00000381638; ENSP00000371051; ENSG00000074755 |
GeneIDi | 23140 |
KEGGi | hsa:23140 |
MANE-Selecti | ENST00000381638.7; ENSP00000371051.2; NM_015113.4; NP_055928.3 |
UCSCi | uc002fxe.4, human [O43149-1] |
Organism-specific databases
CTDi | 23140 |
DisGeNETi | 23140 |
GeneCardsi | ZZEF1 |
HGNCi | HGNC:29027, ZZEF1 |
HPAi | ENSG00000074755, Low tissue specificity |
MIMi | 619459, gene |
neXtProti | NX_O43149 |
OpenTargetsi | ENSG00000074755 |
PharmGKBi | PA134938508 |
VEuPathDBi | HostDB:ENSG00000074755 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1426, Eukaryota |
GeneTreei | ENSGT00940000155045 |
HOGENOMi | CLU_000703_0_0_1 |
InParanoidi | O43149 |
OMAi | MMNVTEQ |
OrthoDBi | 6958at2759 |
PhylomeDBi | O43149 |
TreeFami | TF331572 |
Enzyme and pathway databases
PathwayCommonsi | O43149 |
SignaLinki | O43149 |
Miscellaneous databases
BioGRID-ORCSi | 23140, 3 hits in 1049 CRISPR screens |
ChiTaRSi | ZZEF1, human |
GenomeRNAii | 23140 |
Pharosi | O43149, Tdark |
PROi | PR:O43149 |
RNActi | O43149, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000074755, Expressed in sural nerve and 234 other tissues |
ExpressionAtlasi | O43149, baseline and differential |
Genevisiblei | O43149, HS |
Family and domain databases
CDDi | cd00051, EFh, 1 hit cd02343, ZZ_EF, 1 hit |
Gene3Di | 3.30.60.90, 2 hits |
InterProi | View protein in InterPro IPR004939, APC_su10/DOC_dom IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR008979, Galactose-bd-like_sf IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf IPR040099, ZZEF1 IPR041986, ZZEF1_ZZ |
PANTHERi | PTHR22772:SF4, PTHR22772:SF4, 1 hit |
Pfami | View protein in Pfam PF03256, ANAPC10, 1 hit PF00569, ZZ, 2 hits |
SMARTi | View protein in SMART SM01337, APC10, 1 hit SM00054, EFh, 1 hit SM00291, ZnF_ZZ, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49785, SSF49785, 1 hit |
PROSITEi | View protein in PROSITE PS51284, DOC, 1 hit PS50222, EF_HAND_2, 1 hit PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZZEF1_HUMAN | |
Accessioni | O43149Primary (citable) accession number: O43149 Secondary accession number(s): A7MBM5 Q9NVB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 23, 2022 | |
This is version 162 of the entry and version 6 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot