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UniProtKB - O43149 (ZZEF1_HUMAN)

Entry version 162 (23 Feb 2022)
Sequence version 6 (05 May 2009)
Previous versions | rss
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Protein

Zinc finger ZZ-type and EF-hand domain-containing protein 1

Gene

ZZEF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1783Zinc 1PROSITE-ProRule annotation1
Metal bindingi1786Zinc 1PROSITE-ProRule annotation1
Metal bindingi1797Zinc 2PROSITE-ProRule annotation1
Metal bindingi1800Zinc 2PROSITE-ProRule annotation1
Metal bindingi1806Zinc 1PROSITE-ProRule annotation1
Metal bindingi1809Zinc 1PROSITE-ProRule annotation1
Metal bindingi1819Zinc 2PROSITE-ProRule annotation1
Metal bindingi1823Zinc 2PROSITE-ProRule annotation1
Metal bindingi1832Zinc 3PROSITE-ProRule annotation1
Metal bindingi1835Zinc 3PROSITE-ProRule annotation1
Metal bindingi1846Zinc 4PROSITE-ProRule annotation1
Metal bindingi1849Zinc 4PROSITE-ProRule annotation1
Metal bindingi1855Zinc 3PROSITE-ProRule annotation1
Metal bindingi1858Zinc 3PROSITE-ProRule annotation1
Metal bindingi1868Zinc 4PROSITE-ProRule annotation1
Metal bindingi1872Zinc 4PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1778 – 1833ZZ-type 1PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri1827 – 1882ZZ-type 2PROSITE-ProRule annotationAdd BLAST56

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43149

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O43149

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger ZZ-type and EF-hand domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZZEF1
Synonyms:KIAA0399
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29027, ZZEF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		619459, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43149

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000074755

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1833D → A: Loss of histone H3 binding. 1 Publication1
Mutagenesisi1853D → A: Loss of histone H3 binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		23140

Open Targets

More...OpenTargetsi		ENSG00000074755

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134938508

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43149, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZZEF1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002890002 – 2961Zinc finger ZZ-type and EF-hand domain-containing protein 1Add BLAST2960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine2 Publications1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei240PhosphoserineCombined sources1
Modified residuei1475PhosphoserineCombined sources1
Modified residuei1488PhosphoserineBy similarity1
Modified residuei1509PhosphoserineCombined sources1
Modified residuei1512PhosphothreonineCombined sources1
Modified residuei1518PhosphoserineCombined sources1
Modified residuei1521PhosphothreonineBy similarity1
Modified residuei1523PhosphothreonineCombined sources1
Modified residuei1537PhosphoserineCombined sources1
Modified residuei1540PhosphoserineCombined sources1
Modified residuei2444PhosphoserineCombined sources1
Modified residuei2667N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43149

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43149

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43149

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43149

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43149

PeptideAtlas

More...PeptideAtlasi		O43149

PRoteomics IDEntifications database

More...PRIDEi		O43149

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48767 [O43149-1]
48768 [O43149-2]
48769 [O43149-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O43149, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43149

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O43149

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43149

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at low levels in cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000074755, Expressed in sural nerve and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43149, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43149, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000074755, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KLF6 and KLF9 (PubMed:33227311).

Interacts via (ZZ-type 2 zinc finger) with histone H3 trimethylated at 'Lys-4' (H3K4me3) and histone H3 acetylated at 'Lys-4' (H3K4ac) (PubMed:33227311).

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116757, 121 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		O43149

Protein interaction database and analysis system

More...IntActi		O43149, 56 interactors

Molecular INTeraction database

More...MINTi		O43149

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000371051

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43149, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43149

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 146EF-handPROSITE-ProRule annotationAdd BLAST36
Domaini226 – 405DOCPROSITE-ProRule annotationAdd BLAST180

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 41DisorderedSequence analysisAdd BLAST41
Regioni1446 – 1531DisorderedSequence analysisAdd BLAST86
Regioni1994 – 2078DisorderedSequence analysisAdd BLAST85
Regioni2426 – 2455DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1456 – 1500Polar residuesSequence analysisAdd BLAST45
Compositional biasi2005 – 2029Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi2032 – 2047Polar residuesSequence analysisAdd BLAST16

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1778 – 1833ZZ-type 1PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri1827 – 1882ZZ-type 2PROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1426, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155045

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000703_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43149

Identification of Orthologs from Complete Genome Data

More...OMAi		MMNVTEQ

Database of Orthologous Groups

More...OrthoDBi		6958at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43149

TreeFam database of animal gene trees

More...TreeFami		TF331572

Family and domain databases

Conserved Domains Database

More...CDDi		cd00051, EFh, 1 hit
cd02343, ZZ_EF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.60.90, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR008979, Galactose-bd-like_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
IPR040099, ZZEF1
IPR041986, ZZEF1_ZZ

The PANTHER Classification System

More...PANTHERi		PTHR22772:SF4, PTHR22772:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03256, ANAPC10, 1 hit
PF00569, ZZ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01337, APC10, 1 hit
SM00054, EFh, 1 hit
SM00291, ZnF_ZZ, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit
SSF49785, SSF49785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51284, DOC, 1 hit
PS50222, EF_HAND_2, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43149-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNAPSHSSE DEAAAAGGEG WGPHQDWAAV SGTTPGPGVA APALPPAAAL 
        60         70         80         90        100
LEPARLREAA AALLPTPPCE SLVSRHRGAL FRWLEERLGR GEESVTLEQF 
       110        120        130        140        150
RELLEARGAG CSSEQFEEAF AQFDAEGDGT VDAENMLEAL KNSSGANLQG 
       160        170        180        190        200
ELSHIIRQLQ ACSLVPGFTD IFSESKEGLD IHSSMILRFL HRNRLSSAVM 
       210        220        230        240        250
PYPMLEHCNN MCTMRSSVLK ESLDQLVQKE KESPGDLTRS PEMDKLKSVA 
       260        270        280        290        300
KCYAYIETSS NSADIDKMTN GETSSYWQSD GSACSHWIRL KMKPDVVLRH 
       310        320        330        340        350
LSIAVAATDQ SYMPQQVTVA VGRNASDLQE VRDVHIPSNV TGYVTLLENA 
       360        370        380        390        400
NVSQLYVQIN IKRCLSDGCD TRIHGLRAVG FQRVKKSGVS VSDASAIWYW 
       410        420        430        440        450
SLLTSLVTAS METNPAFVQT VLHNTQKALR HMPPLSLSPG STDFSTFLSP 
       460        470        480        490        500
NVLEEVDSFL IRITSCCSTP EVELTLLAFA LARGSVAKVM SSLCTITDHL 
       510        520        530        540        550
DTQYDASSLI LSMASVRQNL LLKYGKPLQL TLQACDVKGK EDKSGPENLL 
       560        570        580        590        600
VEPWTRDGFL TETGKTRAST IFSTGTESAF QVTQIRIMVR RGGIGAQCGL 
       610        620        630        640        650
VFAYNSSSDK FCAEEHFKRF EKYDKWKLQE LRQFVKSRIG CSSDDLGEDD 
       660        670        680        690        700
PIGWFELEEE WDEADVKLQQ CRVAKYLMVK FLCTRQESAE RLGVQGLTIS 
       710        720        730        740        750
GYLRPARAEA EQSVTCAHCR KDTEESVCGA TLLLRTLQFI QQLAHDLVQQ 
       760        770        780        790        800
KESGLKYKSF LDFAGLDLQI FWNFYSKLKQ NPREECVSAQ TLLLQLLQSC 
       810        820        830        840        850
FSVLQGDVLA ASEEEKAPIQ SPKGVEAAKE LYTHLCDVVD KVDGDSVPME 
       860        870        880        890        900
ILKQEVRNTL LNGAAIFFPN RQTRRNHLFT MMNVTEQEHK QSLQLTFRSL 
       910        920        930        940        950
CTYFSDKDPG GLLLLPEKND LAKMNISEVL AVMDTLVSVA ARECELLMLS 
       960        970        980        990       1000
GAPGEVGSVL FSLFWSVQGS LLSWCYLQLK STDSGAKDLA VDLIEKYVGQ 
      1010       1020       1030       1040       1050
FLASMRAILE SLFSQYSGKT IVERLCNSVF SMAARQLVIF LLDFCTLDIP 
      1060       1070       1080       1090       1100
HCVLLREFSV LTELLKKLCS GPEGGLRKLD VETWQQEQPV VLHTWTKESA 
      1110       1120       1130       1140       1150
HNYENNCHEV SVFVSPGATY FEVEFDDRCE TEKRYDYLEF TDARGRKTRY 
      1160       1170       1180       1190       1200
DTKVGTDKWP KKVTFKAGPR LQFLFHSDSS HNEWGYKFTV TACGLPDVAV 
      1210       1220       1230       1240       1250
SWGLDLQLLV SRLMGRLASQ CMALKSVRQL GSNMVVPQAK MALVLSSPLW 
      1260       1270       1280       1290       1300
KPVFRHQVCP ELELEASWPT HPHRNSKEVK NIPDDPCRHF LLDFAQSEPA 
      1310       1320       1330       1340       1350
QNFCGPYSEL FKGFIQACRK QAPKTDIVAG STIDQAVNAT FAALVYRTPD 
      1360       1370       1380       1390       1400
LYEKLQKYVN SGGKIALSEE FAQVYSLADG IRIWMLEMKQ KSLMSLGNEA 
      1410       1420       1430       1440       1450
EEKHSSEATE VNPESLAKEC IEKSLLLLKF LPTGISSKES CEKLETADET 
      1460       1470       1480       1490       1500
SHLQPLNKRQ RTSSVVEEHF QASVSPTEAA PPATGDQSPG LGTQPKLPSS 
      1510       1520       1530       1540       1550
SGLPAADVSP ATAEEPLSPS TPTRRPPFTR GRLRLLSFRS MEEARLVPTV 
      1560       1570       1580       1590       1600
KEKYPVLKDV MDFIKDQSLS HRSVVKVLSL RKAQAQSILE VLKITQHCAE 
      1610       1620       1630       1640       1650
SLGQPHCFHP PFILFLLELL TCQKDFTNYF GHLEGCGADL HKEIRDTYYQ 
      1660       1670       1680       1690       1700
LVLFLVKAVK GFSSLNDRSL LPALSCVQTA LLHLLDMGWE PNDLAFFVDI 
      1710       1720       1730       1740       1750
QLPDLLMKMS QENISVHDSV ISQWSEEDEL ADAKQNSEWM DECQDGMFEA 
      1760       1770       1780       1790       1800
WYEKIAQEDP EKQRKMHMFI ARYCDLLNVD ISCDGCDEIA PWHRYRCLQC 
      1810       1820       1830       1840       1850
SDMDLCKTCF LGGVKPEGHG DDHEMVNMEF TCDHCQGLII GRRMNCNVCD 
      1860       1870       1880       1890       1900
DFDLCYGCYA AKKYSYGHLP THSITAHPMV TIRISDRQRL IQPYIHNYSW 
      1910       1920       1930       1940       1950
LLFAALALYS AHLASAEDVD GEKLDPQTRS SATTLRSQCM QLVGDCLMKA 
      1960       1970       1980       1990       2000
HQGKGLKALA LLGVLPDGDS SLEDQALPVT VPTGASEEQL EKKAVQGAEL 
      2010       2020       2030       2040       2050
SEAGNGKRAV HEEIRPVDFK QRNKADKGVS LSKDPSCQTQ ISDSPADASP 
      2060       2070       2080       2090       2100
PTGLPDAEDS EVSSQKPIEE KAVTPSPEQV FAECSQKRIL GLLAAMLPPL 
      2110       2120       2130       2140       2150
KSGPTVPLID LEHVLPLMFQ VVISNAGHLN ETYHLTLGLL GQLIIRLLPA 
      2160       2170       2180       2190       2200
EVDAAVIKVL SAKHNLFAAG DSSIVPDGWK TTHLLFSLGA VCLDSRVGLD 
      2210       2220       2230       2240       2250
WACSMAEILR SLNSAPLWRD VIATFTDHCI KQLPFQLKHT NIFTLLVLVG 
      2260       2270       2280       2290       2300
FPQVLCVGTR CVYMDNANEP HNVIILKHFT EKNRAVIVDV KTRKRKTVKD 
      2310       2320       2330       2340       2350
YQLVQKGGGQ ECGDSRAQLS QYSQHFAFIA SHLLQSSMDS HCPEAVEATW 
      2360       2370       2380       2390       2400
VLSLALKGLY KTLKAHGFEE IRATFLQTDL LKLLVKKCSK GTGFSKTWLL 
      2410       2420       2430       2440       2450
RDLEILSIML YSSKKEINAL AEHGDLELDE RGDREEEVER PVSSPGDPEQ 
      2460       2470       2480       2490       2500
KKLDPLEGLD EPTRICFLMA HDALNAPLHI LRAIYELQMK KTDYFFLEVQ 
      2510       2520       2530       2540       2550
KRFDGDELTT DERIRSLAQR WQPSKSLRLE EQSAKAVDTD MIILPCLSRP 
      2560       2570       2580       2590       2600
ARCDQATAES NPVTQKLISS TESELQQSYA KQRRSKSAAL LHKELNCKSK 
      2610       2620       2630       2640       2650
RAVRDYLFRV NEATAVLYAR HVLASLLAEW PSHVPVSEDI LELSGPAHMT 
      2660       2670       2680       2690       2700
YILDMFMQLE EKHEWEKILQ KVLQGCREDM LGTMALAACQ FMEEPGMEVQ 
      2710       2720       2730       2740       2750
VRESKHPYNN NTNFEDKVHI PGAIYLSIKF DSQCNTEEGC DELAMSSSSD 
      2760       2770       2780       2790       2800
FQQDRHSFSG SQQKWKDFEL PGDTLYYRFT SDMSNTEWGY RFTVTAGHLG 
      2810       2820       2830       2840       2850
RFQTGFEILK QMLSEERVVP HLPLAKIWEW LVGVACRQTG HQRLKAIHLL 
      2860       2870       2880       2890       2900
LRIVRCCGHS DLCDLALLKP LWQLFTHMEY GLFEDVTQPG ILLPLHRALT 
      2910       2920       2930       2940       2950
ELFFVTENRA QELGVLQDYL LALTTDDHLL RCAAQALQNI AAISLAINYP 
      2960 
NKATRLWNVE C
Length:2,961
Mass (Da):331,075
Last modified:May 5, 2009 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DB2EB72C16BC168
GO
Isoform 2 (identifier: O43149-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1613: Missing.
     2405-2424: ILSIMLYSSKKEINALAEHG → VRDERDSCSSFLVQMCWPRS
     2425-2961: Missing.

Note: Incomplete sequence.Curated
Show »
Length:811
Mass (Da):90,468
Checksum:iA3138EDEFE4A6139
GO
Isoform 3 (identifier: O43149-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     882-882: M → MK
     1079-1084: LDVETW → VTRVST
     1085-2961: Missing.

Note: May be due to an intron retention.Curated
Show »
Length:1,085
Mass (Da):119,964
Checksum:i276FA1193DC16093
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L141I3L141_HUMAN
Zinc finger ZZ-type and EF-hand dom...
ZZEF1
812Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1Q8I3L1Q8_HUMAN
Zinc finger ZZ-type and EF-hand dom...
ZZEF1
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3Q3I3L3Q3_HUMAN
Zinc finger ZZ-type and EF-hand dom...
ZZEF1
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2N1I3L2N1_HUMAN
Zinc finger ZZ-type and EF-hand dom...
ZZEF1
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA23695 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA91834 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti959V → A in BAA23695 (PubMed:9455477).Curated1
Sequence conflicti959V → A in AAI51837 (PubMed:15489334).Curated1
Sequence conflicti1929R → H in BAA91834 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03255130V → A1 PublicationCorresponds to variant dbSNP:rs1454121Ensembl.1
Natural variantiVAR_0325521021I → V. Corresponds to variant dbSNP:rs16953687Ensembl.1
Natural variantiVAR_0325531437S → A. Corresponds to variant dbSNP:rs4790555Ensembl.1
Natural variantiVAR_0325541972L → P2 PublicationsCorresponds to variant dbSNP:rs781852Ensembl.1
Natural variantiVAR_0325552014I → V2 PublicationsCorresponds to variant dbSNP:rs781831Ensembl.1
Natural variantiVAR_0325562051P → S. Corresponds to variant dbSNP:rs1006954Ensembl.1
Natural variantiVAR_0325572301Y → H. Corresponds to variant dbSNP:rs34357158Ensembl.1
Natural variantiVAR_0325582303L → P. Corresponds to variant dbSNP:rs35638819Ensembl.1
Natural variantiVAR_0325592369E → Q2 PublicationsCorresponds to variant dbSNP:rs711177Ensembl.1
Natural variantiVAR_0325602421A → T. Corresponds to variant dbSNP:rs781861Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0422681 – 1613Missing in isoform 2. 1 PublicationAdd BLAST1613
Alternative sequenceiVSP_036989882M → MK in isoform 3. 1 Publication1
Alternative sequenceiVSP_0258701079 – 1084LDVETW → VTRVST in isoform 3. 1 Publication6
Alternative sequenceiVSP_0258711085 – 2961Missing in isoform 3. 1 PublicationAdd BLAST1877
Alternative sequenceiVSP_0422692405 – 2424ILSIM…LAEHG → VRDERDSCSSFLVQMCWPRS in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0422702425 – 2961Missing in isoform 2. 1 PublicationAdd BLAST537

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB007859 mRNA Translation: BAA23695.4 Different initiation.
AK001683 mRNA Translation: BAA91834.1 Different initiation.
AK127482 mRNA Translation: BAC86999.1
AC067815 Genomic DNA No translation available.
AC087292 Genomic DNA No translation available.
BC067099 mRNA Translation: AAH67099.1
BC151836 mRNA Translation: AAI51837.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11043.1 [O43149-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T00048

NCBI Reference Sequences

More...RefSeqi		NP_055928.3, NM_015113.3 [O43149-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000381638; ENSP00000371051; ENSG00000074755

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23140

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000381638.7; ENSP00000371051.2; NM_015113.4; NP_055928.3

UCSC genome browser

More...UCSCi		uc002fxe.4, human [O43149-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007859 mRNA Translation: BAA23695.4 Different initiation.
AK001683 mRNA Translation: BAA91834.1 Different initiation.
AK127482 mRNA Translation: BAC86999.1
AC067815 Genomic DNA No translation available.
AC087292 Genomic DNA No translation available.
BC067099 mRNA Translation: AAH67099.1
BC151836 mRNA Translation: AAI51837.1
CCDSiCCDS11043.1 [O43149-1]
PIRiT00048
RefSeqiNP_055928.3, NM_015113.3 [O43149-1]

3D structure databases

SMRiO43149
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116757, 121 interactors
ELMiO43149
IntActiO43149, 56 interactors
MINTiO43149
STRINGi9606.ENSP00000371051

PTM databases

GlyGeniO43149, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiO43149
MetOSiteiO43149
PhosphoSitePlusiO43149

Genetic variation databases

BioMutaiZZEF1

Proteomic databases

EPDiO43149
jPOSTiO43149
MassIVEiO43149
MaxQBiO43149
PaxDbiO43149
PeptideAtlasiO43149
PRIDEiO43149
ProteomicsDBi48767 [O43149-1]
48768 [O43149-2]
48769 [O43149-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23205, 29 antibodies from 9 providers

The DNASU plasmid repository

More...DNASUi		23140

Genome annotation databases

EnsembliENST00000381638; ENSP00000371051; ENSG00000074755
GeneIDi23140
KEGGihsa:23140
MANE-SelectiENST00000381638.7; ENSP00000371051.2; NM_015113.4; NP_055928.3
UCSCiuc002fxe.4, human [O43149-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23140
DisGeNETi23140

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZZEF1
HGNCiHGNC:29027, ZZEF1
HPAiENSG00000074755, Low tissue specificity
MIMi619459, gene
neXtProtiNX_O43149
OpenTargetsiENSG00000074755
PharmGKBiPA134938508
VEuPathDBiHostDB:ENSG00000074755

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1426, Eukaryota
GeneTreeiENSGT00940000155045
HOGENOMiCLU_000703_0_0_1
InParanoidiO43149
OMAiMMNVTEQ
OrthoDBi6958at2759
PhylomeDBiO43149
TreeFamiTF331572

Enzyme and pathway databases

PathwayCommonsiO43149
SignaLinkiO43149

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23140, 3 hits in 1049 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZZEF1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23140
PharosiO43149, Tdark

Protein Ontology

More...PROi		PR:O43149
RNActiO43149, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000074755, Expressed in sural nerve and 234 other tissues
ExpressionAtlasiO43149, baseline and differential
GenevisibleiO43149, HS

Family and domain databases

CDDicd00051, EFh, 1 hit
cd02343, ZZ_EF, 1 hit
Gene3Di3.30.60.90, 2 hits
InterProiView protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR008979, Galactose-bd-like_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
IPR040099, ZZEF1
IPR041986, ZZEF1_ZZ
PANTHERiPTHR22772:SF4, PTHR22772:SF4, 1 hit
PfamiView protein in Pfam
PF03256, ANAPC10, 1 hit
PF00569, ZZ, 2 hits
SMARTiView protein in SMART
SM01337, APC10, 1 hit
SM00054, EFh, 1 hit
SM00291, ZnF_ZZ, 2 hits
SUPFAMiSSF47473, SSF47473, 1 hit
SSF49785, SSF49785, 1 hit
PROSITEiView protein in PROSITE
PS51284, DOC, 1 hit
PS50222, EF_HAND_2, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZZEF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43149
Secondary accession number(s): A7MBM5
, Q6NXG0, Q6ZRA1, Q6ZSF4, Q9NVB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 5, 2009
Last modified: February 23, 2022
This is version 162 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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